Cartilage antitumor preparation (CATP) was isolated from a guanidine hydrochloride extract of bovine cartilage by acetone fractioned precipitation and ultrafiltration.
Shark cartilage antitumor preparation (SCATP) was extracted from shark cartilage by the method of guanidine hydrochloride extraction, acetone fractional precipitation, and ultrafiltration.
The T N F related apoptosis inducing ligand ,TRAIL is referred to as Apo2 ligand, Apo2L or death ligand, it belongs to tumor necrosis factor family and leads to tumor cell apoptosis selectively, but normal cell can run from TRAIL'S killing effect and it is hopeful that TRAIL becomes to a new anti - cancer drugs, so people are paying attention to it.
肿瘤坏死因子相关的凋亡诱导配体(TNF related apoptosis inducingligand,TRAIL)又称凋亡素2配体(Apo2 ligand,Apo2L)或死亡配体,属于肿瘤坏死因子家族,能选择性的诱导肿瘤细胞凋亡,而正常细胞则可以逃逸他的杀伤作用,有望成为一种新的抗肿瘤制剂,尤为引人关注。
Concentration curves of the cytogenetic action of the Soviet antitumor preparation photrin were studiedin 24-h cultures of human lymphocytes with an exposure of 1 h (concentrations from 10 to 70 μg/ml, interval 10 μg/ml).
The possible production of a new medicinal form of the antitumor preparation arglabine was studied by including it in lipoglycoprotein micelles isolated from wheat grains
It is, in fact, a powerful anti-tumor agent in a variety of murine experimental tumor models through its activation of specific or innate immune responses against neoplastic cells.
Demethyl-cantharidin is a new antincoplastic agent first developed in China.Mutagenicity tests were performed: Ames test (including TA92 and TA94 strains of Salmonella typhimurium, gene mutation in vitro), Chinese hamster lung cell test (chromosome aberrations in vitro), and micronucleus test in NIH strain of mice (chromosome aberrations in vivo). Nitroguamid, mitomycin C,daunorubicin, cyclophosphamide, qui-nacrine and aflatoxins were used as positive controls.The results showed that demethyl-cantharidin di...
The results of antitumor activity stimulated by AMC against S_(180) showed that the number of mice suffering from tumor was less, the development of tumor was later and the average weight of the tumor was lower in the experlmental group as compared with the controls, It indicated that AMC might be considerd as a new effective autitumor drug.
Cartilage antitumor preparation (CATP) was isolated from a guanidine hydrochloride extract of bovine cartilage by acetone fractioned precipitation and ultrafiltration. By the methods of 3H-TdR incorporation, tumor stem cell assay and the determination of mortality of cell, the effect of CATP on the tumor cell lines and bovine artery endothelial cells were investigated and the antitumor effect of CATP was observed by the experiment of transplanation of tumor into mice. The results were as follows; (1) CATP h...