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These experiments in coordination with literature data, demonstrated that optical isomers of the antitumor preparation sarcolysin, i.
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A 5-hydroxytryptamine from Hippophae rhamnoides as an antitumor preparation in experiments on animals
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Concentration curves of the cytogenetic action of the Soviet antitumor preparation photrin were studiedin 24-h cultures of human lymphocytes with an exposure of 1 h (concentrations from 10 to 70 μg/ml, interval 10 μg/ml).
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Production of Lypoglycoprotein Micelles with Arglabine Antitumor Preparation
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The possible production of a new medicinal form of the antitumor preparation arglabine was studied by including it in lipoglycoprotein micelles isolated from wheat grains
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| | Demethyl-cantharidin is a new antincoplastic agent first developed in China.Mutagenicity tests were performed: Ames test (including TA92 and TA94 strains of Salmonella typhimurium, gene mutation in vitro), Chinese hamster lung cell test (chromosome aberrations in vitro), and micronucleus test in NIH strain of mice (chromosome aberrations in vivo). Nitroguamid, mitomycin C,daunorubicin, cyclophosphamide, qui-nacrine and aflatoxins were used as positive controls.The results showed that demethyl-cantharidin di... | | 作者近年按国际标准建立了药物短期致突变系列,这一系列包括用于测定基因(点)突变的Ames试验和测定染色体畸变的中国仓鼠肺细胞试验及微核试验。应用这一系列评价了我国创制的抗癌新药——去甲斑蟊素的致突变性.测试系统还将Ames新菌株、CHL-ED_(50)剂量法则、NIH敏感品系小鼠应用于这一系列。实验显示去甲斑蟊素既不诱发基因(点)突变,也不诱发染色体畸变,这是去甲斑蟊素与一般抗肿瘤制剂之不同点. | | 文摘来源 | | Cartilage antitumor preparation (CATP) was isolated from a guanidine hydrochloride extract of bovine cartilage by acetone fractioned precipitation and ultrafiltration. By the methods of 3H-TdR incorporation, tumor stem cell assay and the determination of mortality of cell, the effect of CATP on the tumor cell lines and bovine artery endothelial cells were investigated and the antitumor effect of CATP was observed by the experiment of transplanation of tumor into mice. The results were as follows; (1) CATP h... | | 小牛软骨经盐酸胍抽提、丙酮分级沉淀及膜超滤等步骤获得了软骨抗肿瘤制剂(Carti-lage Antitumor Preparation, CATP)。利用~3H-TdR参入、测定肿瘤干细胞及细胞死亡率等方法研究了CATP对肿瘤细胞及血管内皮细胞的抑制效应,并对小鼠移植性肿瘤进行了抗肿瘤作用的研究。结果表明:(1)合适浓度的CATP可显著地抑制肿瘤细胞和血管内皮细胞的生长,而不抑制正常细胞;(2)CATP对荷瘤小鼠肿瘤具有明显的抑制作用,抑瘤率为50%~60%。给药组小鼠胸腺重量明显增加,提示CATP可能具有免疫调节作用。实验结果为CATP的临床应用提供了依据。 | | 文摘来源 | | Shark cartilage antitumor preparation (SCATP) was extracted from shark cartilage by the method of guanidine hydrochloride extraction, acetone fractional precipitation, and ultrafiltration. By the method of RIA, it was showed that SCATP reduced the level of 6-Keto-PGF1α. and TXB2 in BALB/ c mice inoculated with C- 26/colon carcinoma. By the method of whole mount cell SEM, it was showed that SCATP inhibited the formation of cytockeleton in Hela cell, and made the cytoskeleton wrinkled or condensed. This sugge... | | 以鲨鱼软骨为原料,经盐酸胍抽提、丙酮分级沉淀、超滤等步骤得到鲨鱼软骨抗肿瘤制剂(SCATP)。采用放射免疫分析方法测定其对荷瘤小鼠血浆6-Keto-PGF1α和TXB2水平的影响,整装细胞扫描电镜技术测定SCATP对Hela细胞骨架的影响,常规方法测定SCATP对小鼠脾脏和胸腺的影响及对荷瘤小鼠的抑癌效应。结果显示,(1)当剂量达20mg/kg时,SCATP能使荷瘤小鼠血浆6-Keto-PGF1α非常显著下降(P<0.01),使TXB2水平显著下降(P<0.05);(2)SCATP能使Hela细胞骨架发生凝聚或固缩,并有明显的浓度依赖关系,提示SCATP能抑制肿瘤细胞的分裂增殖及运动迁移;(3)SCATP能刺激小鼠脾脏和胸腺,并显著抑制实验动物肿瘤的生长。 | | 文摘来源 | |   | | << 更多相关文摘 |
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