Objective To compare the pharmacodynamics of five alcoholic extractives(Scorpion,SP、Centipede,CP、Stiff Silkorm,SS、Lumbricus,LB、Cicada Slough,CS)on anticonvulsion,and explore their mechanism of anticonvulsant action.
We observed the anticonvulsant effect of taurine together with or withOut sodi-um phenobarbital,in mouse convulsion model induced with pentetrazol,and determined its influ-ences on GABA,taurine and glutamate level in the brains.
Methods:The saikosaponin and volatile oil of RB were obtained by CO2 supercritiatl extraction,and pentetrazol threshold attack model and maximal eletric shock model were applied to study the anticonvulsive action.
The 50% effective dose (ED50) values and latencies for anticonvulsant effect for a given benzodiazepine were the same at the two times of treatment delay.
The anticonvulsant effect of inhibitors of GABA-T (R/S-γ-vinyl-GABA, ethanolamine-O-sulfate, gabaculine, aminooxyacetic acid) was enhanced by 10 mmol/kg glycine in animal seizure models which are based on a functional GABA deficit.
Our observation is the first example of the synergistic interaction of two inhibitory neuronal systems resulting in the amplification of the anticonvulsant effect.
Role of serotonin in the anticonvulsant effect of fluoxetine in genetically epilepsy-prone rats
This study was designed to demonstrate a role of serotonin in the anticonvulsant effect of fluoxetine, a serotonin reuptake inhibitor, in genetically epilepsy-prone rats.
Novel 5-substituted esters and homologous ester and amido derivatives of 4,5 dihydro-3,3-diethyl-2(3H)-furanone were synthesized and evaluated for anticonvulsant activity in rodents and for affinity to a site on the GABAA receptor complex ([3H]TBOB).
The data suggest that the esters and the homologs prepared are devoid of anticonvulsant activity.
The primary pharmacological screening revealed that the compounds obtained possess pronounced anticonvulsant activity at moderate toxicity.
Microwave-assisted synthesis, anticonvulsant activity and quantum mechanical modelling of N-(4-bromo-3-methylphenyl) semicarbazo
Synthesis and anticonvulsant activity of some potent 5,6-bis aryl 1,2,4-triazines
The suggestion is made that anticonvulsive action of phenothiazine derivatives differed from their general "central" effect.
We have established that all the studied compounds have pronounced sedative action (they prolong the life of mice under hypoxia conditions, they are phenamine antagonists, they exhibit anticonvulsive action and prevent retrograde amnesia).
The anticonvulsive action of lorazepam and the proconvulsive action of DMCM against picrotoxin-induced seizures and against pentylenetetrazol-induced seizures was inhibited by low doses of ZK 93426 and Ro 15-1788.
Influence of aminophylline and 8-(p-sulfophenyl)theophylline on the anticonvulsive action of diphenylhydantoin, phenobarbital, a
On the contrary, flunarizine (up to 20 mg/kg) did not modify the anticonvulsive action of these antiepileptic drugs.