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抗惊厥作用     
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  anticonvulsant action
     The Pharmacodynamics Comparison Study of Supercritical-CO_2 Fluid Extractions of Chinese Herb on Anticonvulsant Action
     单味中草药超临界CO_2萃取物抗惊厥作用的药效学比较研究
短句来源
     Objective To compare the pharmacodynamics of five alcoholic extractives(Scorpion,SP、Centipede,CP、Stiff Silkorm,SS、Lumbricus,LB、Cicada Slough,CS)on anticonvulsion,and explore their mechanism of anticonvulsant action.
     目的比较五种单味中药醇提物(全蝎SP、僵蚕SS、地龙LB、蝉衣CS、蜈蚣CP)的抗惊厥作用,并探讨其作用机制。
短句来源
     Anticonvulsant action of ethanol extract of acorus gramineus soland
     石菖蒲醇提取物的抗惊厥作用
短句来源
     CONCLUSION GBP table had anticonvulsant action with significance.
     结论 GBP片剂有明显的抗惊厥作用
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     Anticonvulsant action of L-histidine in mice
     左旋组氨酸在小鼠的抗惊厥作用
短句来源
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  anticonvulsant effect
     Experimental study of the anticonvulsant effect of domestic zopiclone
     国产佐匹克隆抗惊厥作用的实验研究
短句来源
     Sedative and anticonvulsant effect of jujuboside A
     酸枣仁皂甙A镇静和抗惊厥作用试验
短句来源
     Results The anticonvulsant effect was observed after (30 min) of administration of EORTCD in dose-response dependently.
     结果中国林蛙卵油给予动物30 min,其抗惊厥作用效果最好。 中国林蛙卵油抗惊厥作用呈现良好的剂量-效应关系;
短句来源
     Methods The authors observed benzodiazepine receptors in amygdala kindled rats with tolerance to anticonvulsant effect of clonazepam by using autoradiography.
     方法采用放射自显影技术,观察了11只完全点燃大鼠对氯硝安定抗惊厥作用耐受及停药后大鼠脑内苯二氮类受体的变化。
短句来源
     We observed the anticonvulsant effect of taurine together with or withOut sodi-um phenobarbital,in mouse convulsion model induced with pentetrazol,and determined its influ-ences on GABA,taurine and glutamate level in the brains.
     以戊四氮(Pentetrazol,PTZ)诱发小鼠惊厥为模型,观察单用牛磺酸及联合用苯巴比妥钠的抗惊厥作用,并测定牛磺酸对脑中γ-氨基了丁酸(GABA)、牛磺酸(Taurine)、谷氨酸(Gluta-mate)水平的影响。
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  anticonvulsant activity
     Study on the Synthesis and the Anticonvulsant Activity of 2-Substituted Acyl-1-alkyl-5-phenyl-3-pyrazolidinones
     2-取代酰基-1-烷基-5-苯基-3-吡唑烷酮类化合物的合成及抗惊厥作用的研究
短句来源
     A Study of the Synthesis and the Anticonvulsant Activity of 2-substituted-1-n-butyl-5-phenyl-3-pyrazolidinones
     2-取代-1-正丁基-5-苯基-3-吡唑烷酮类化合物的合成及抗惊厥作用的研究
短句来源
     Synthesis and anticonvulsant activity of 1-substitued benzyl5-phenyl-3-pyrazolidinones
     1-取代苄基-5-苯基-3-吡唑烷酮衍生物的合成及抗惊厥作用
短句来源
     Anticonvulsant activity of 2 substituted 1 n butyl 5 phenyl 3 pyrazolidinones
     2-取代-1-正丁基-5-苯基-3-吡唑烷酮类化合物抗惊厥作用的研究
短句来源
     According to the structure mosaic theory, we incorporate triazole in the 1 and 2 position of 3,4-dihydro-2(1H)-quinolinone to optimize the anticonvulsant activity of compound 2f.
     其次,为了进一步提高化合物2f的抗惊厥作用,按照新药设计原理中结构拼合原理,在2f结构中3,4-二氢-2(1H)喹啉酮的1,2位并入了三唑环,以求得二者的协同作用。
短句来源
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  anticonvulsive action
     An Experimental Study on the Anticonvulsive Action of the Extraction from Radix Bupleuri
     柴胡萃取成分抗惊厥作用的实验研究
短句来源
     Anticonvulsive Action of N-(cinnamoyl)- α-methyl-piperidine
     N-(桂皮酰基)-α-甲基哌啶的抗惊厥作用
短句来源
     These results seem to suggest that the anticonvulsive action of edulinine is related to 5-HT and DA system in the brain.
     表明Ed抗惊厥作用与脑内5-MT,DA神经递质有关。
短句来源
     CONCLUSION Piperine has stronger anticonvulsive action.
     结论 胡椒碱有较强的抗惊厥作用
短句来源
     Methods:The saikosaponin and volatile oil of RB were obtained by CO2 supercritiatl extraction,and pentetrazol threshold attack model and maximal eletric shock model were applied to study the anticonvulsive action.
     方法:采用超临界CO2萃取法得到柴胡皂甙部分及挥发油部分,用戊四唑阈值发作模型(MSTT)及最大电休克模型(MES)来研究其抗惊厥作用
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  anticonvulsant action
The results suggest that NS has promising anticonvulsant action.
      
Evidence for an involvement of GABA in the mediation of the cerebellar cGMP decrease and the anticonvulsant action of diazepam
      
Anticonvulsant action of 1,3-dimethyl-5-aminoadamantane
      
These studies demonstrate an anticonvulsant action of memantine in rodents and suggest that dopaminergic mechanisms do not contribute to its mechanism of action.
      
The results are discussed in terms of the multiple mechanisms that can contribute to the anticonvulsant action of felbamate in the PTZ kindling model of epilepsy.
      
更多          
  anticonvulsant effect
The 50% effective dose (ED50) values and latencies for anticonvulsant effect for a given benzodiazepine were the same at the two times of treatment delay.
      
The anticonvulsant effect of inhibitors of GABA-T (R/S-γ-vinyl-GABA, ethanolamine-O-sulfate, gabaculine, aminooxyacetic acid) was enhanced by 10 mmol/kg glycine in animal seizure models which are based on a functional GABA deficit.
      
Our observation is the first example of the synergistic interaction of two inhibitory neuronal systems resulting in the amplification of the anticonvulsant effect.
      
Role of serotonin in the anticonvulsant effect of fluoxetine in genetically epilepsy-prone rats
      
This study was designed to demonstrate a role of serotonin in the anticonvulsant effect of fluoxetine, a serotonin reuptake inhibitor, in genetically epilepsy-prone rats.
      
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  anticonvulsant activity
Novel 5-substituted esters and homologous ester and amido derivatives of 4,5 dihydro-3,3-diethyl-2(3H)-furanone were synthesized and evaluated for anticonvulsant activity in rodents and for affinity to a site on the GABAA receptor complex ([3H]TBOB).
      
The data suggest that the esters and the homologs prepared are devoid of anticonvulsant activity.
      
The primary pharmacological screening revealed that the compounds obtained possess pronounced anticonvulsant activity at moderate toxicity.
      
Microwave-assisted synthesis, anticonvulsant activity and quantum mechanical modelling of N-(4-bromo-3-methylphenyl) semicarbazo
      
Synthesis and anticonvulsant activity of some potent 5,6-bis aryl 1,2,4-triazines
      
更多          
  anticonvulsive action
The suggestion is made that anticonvulsive action of phenothiazine derivatives differed from their general "central" effect.
      
We have established that all the studied compounds have pronounced sedative action (they prolong the life of mice under hypoxia conditions, they are phenamine antagonists, they exhibit anticonvulsive action and prevent retrograde amnesia).
      
The anticonvulsive action of lorazepam and the proconvulsive action of DMCM against picrotoxin-induced seizures and against pentylenetetrazol-induced seizures was inhibited by low doses of ZK 93426 and Ro 15-1788.
      
Influence of aminophylline and 8-(p-sulfophenyl)theophylline on the anticonvulsive action of diphenylhydantoin, phenobarbital, a
      
On the contrary, flunarizine (up to 20 mg/kg) did not modify the anticonvulsive action of these antiepileptic drugs.
      
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