But the pathogene-sis of hepatic fibrosis is not clear completely. In this study the interaction between hepatic pathology and sera TGFβ1 FN and ALT was investigated via liver biopsy analysis and detections of TGFβ1 FN and ALT in 68 patients with chronic hepatitis B;
[Methods] As compared with colchicines, effect of RG in small and large dosages on serum transforming growth factor β (TGF β1 ), hydroxyproline (Hyp), collagen Ⅰ and Ⅲ , hepatic function and hepatic pathology were observed in rats.
Result: at the compound qingan decoction group(10g/kg, 20g/kg), the activity of ALT, AST and the content of MDA in liver homogenate cut down distinctly, the content of GSH stepped up distinctly, the liver pathology wound relieved obviously.
Methods Male New Zealand white rabbit was subcutaneously injected with carbon tetrachloride twice weekly,and the liver pathology and hepatic hydroxyproline content were examined 12 weeks after the injection.
Then the survival rates,liver function and liver histology of all rats were observed. Results:Survival rate of group I was higher than that of group II(46.7% vs 13.3% P<0.05),and their liver function and liver histology of group I were improved significantly as compared with group II.
After 17 days , hepatic index was evaluated, the levels of blood-fat, liver-fat, MDA, FFA, HYP and the activity of SOD, NO, Na-K ATP enzyme, Ca-Mg ATP enzyme in liver were measured, and hepatocyte cytochrome p450 II El expression and pathology of liver were detected.
Rat model was produced by adopting severe thoracic impact injury with unilateral femoral fracture. Dynamic changes of GC in plasma,GR and HSP70 in hepatic tissue,pathology of liver,hepatic function markers in blood serum after severe trauma were observed.
Methods: Animal models of hepatic encephalopathy were induced by three different doses of TAA by two intraperitoneal injections of TAA 200mg/kg, 250mg/kg, 350mg/kg of body weight respectively at 48 h intervals (n=12). Brainstem auditory evoked potentials (BAEP) and plasma endotoxin from portal vein of rats, serum ammonia, serum liver function and pathology of liver were examined.
Methods Rat model was developed by adopting severe thoracic impact injury accompanied with single femur fracture. Rats' injury was caused by 500 kPa (1?kPa=7.5?mm?Hg) driving pressure. The changes of hepatic tissue GR,HSP70,pathology of liver,hepatic function markers in blood serum after severe trauma in rats were observed.
Development of liver pathology was accompanied by adipose dystrophy, fibrosis, and an increase of triglycerides and lipid peroxidation products in the liver tissue.
On the other hand, the higher prevalence of HBsAg and anti-HCV antibodies in this sub-population should heighten the awareness of the possibility of chronic liver pathology.
In otherwise healthy hypogonadal men, measurement of total T will suffice, but in patients with conditions affecting binding proteins (eg, thyroid or liver pathology, nephrotic syndrome, obesity) measurement of Bio-T may be required.
Overall, the protective effect of F on selenite toxicity appears to be confined to liver pathology.
By the introduction of duplex sonography and contrast-medium-enhanced helical CT scan, liver pathology can be defined more precisely in the preoperative evaluation.