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正常功能     
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  normal function
     The normal function of the prion protein was firstly studied by the quantum chemistry method to shed light on the Cu(II)-binding modes for PrPc and the normal function of prion protein through the comparison of the antioxidant ability with the Cu,Zn-SOD and its mimics.
     本论文首先用量子化学计算方法对朊病毒(Prion)的正常功能进行了研究,确定了PrP~c-Cu~(2+0)络合模式,并通过与Cu,Zn-SOD及其模拟物的抗氧化能力的比较,讨论了Prion的正常功能
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     Human angiotensin converting enzyme(ACE) 2 has been recognized as the specific binding receptor of SARS-CoV spike protein(S protein), and the efficiency of their binding is relative to the replication and infection ability of SARS-CoV. The balance between ACE1 and ACE2 is crucial for the normal function of lung, in which the stability of functional ACE2 can attenuate the severity of ALI and ARDS.
     SARS-CoV可以结合人血管紧张素转换酶(ACE)2,二者结合效率与病毒感染复制能力相关。 ACE2与ACE1共同调控肾素-血管紧张素系统,二者的功能平衡维持肺的正常功能
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     Conclusion The expression of eNOS play an important role in maintain normal function of kidney.
     结论生理情况下 ,肾组织cNOS的表达量主要决定于eNOS的表达 ,其高表达对维持肾脏正常功能具有重要作用。
短句来源
     The normal ratio of Ca~(2+) of intra-cell to extra-cell is 1/20000. This ratio is a dynamic balance formed by various kinds of cellular organ, electrical difference and calcium channel. The balance is the basis to execute the normal function of cells.
     正常细胞处于静息状态时细胞内外Ca~2+比例是1/20000,这个比例是各种细胞器及钙通道所达成的动态平衡,这种平衡是细胞进行各种正常功能活动的基础。
短句来源
     The mechanism of cholesterol deficiency on inhibiting the proliferation of T lymphocytes was investigated on cell membrane fluidity by using fluorescence polarization measurement, 3H TdR incorporation test and flow cytometer analysis in Jurkat cells, in order to clarify the importance of cholesterol in maintaining the normal function of lymphocytes.
     :用荧光偏振技术、3H - Td R掺入法及流式细胞术等方法 ,从细胞膜脂流动性这一角度来探讨胆固醇缺乏抑制 Jurkat细胞增殖的机制 ,阐明胆固醇对维持淋巴细胞正常功能的重要性。
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  normal functions
     Theoretically, blockade of the mdm2-p53 interaction is able to resume the normal functions of p53. Therefore, mdm2 may be regarded as a new target in anti-cancer drug design.
     理论上阻断mdm2对p53的作用可恢复p53正常功能,因此mdm2可作为设计抗癌药物的新靶点。
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     Theoretically, blockade of the mdm2-p53 interaction is able to resume the normal functions of p53. Therefore, mdm2 may be regarded as a new target in anti-cancer drug design.
     理论上阻断mdm2对p53 的作用可恢复p53 正常功能,因此mdm2 可作为设计抗癌药物的新靶点。
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     Most of diseases were treated by dredging the metu, regulating the metu, balancing the metu, removing noxious substances from the metu, restoring the normal functions of the metu.
     大多数的疾病治疗都是如何疏通metu,调节metu,平衡metu,从metu中排除有害物质,恢复metu的正常功能
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     (1)The association of XY-bivalent and the rearranged autosomes interfere with or affect, by their contact, X chromosome normal functions.
     (1)XY-二价体与重排染色体联合,干扰或影响X染色体的正常功能,从而干扰精子发生。
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     Under normal circumstance disabled-2( Dab2) in human tissues participates in the signal transduction of the cell in order to allow the body to keep normal functions,but under some circumstances the absence of Dab2 influences the normal signal transduction path,leding to atypical cell changes.
     在正常情况下人体组织中的Disabled-2蛋白(Dab2)参与细胞的信号转导使机体保持正常功能,而在有些情况下Dab2蛋白的缺失影响正常信号转导途径,从而细胞发生异型性变化、癌变。
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  normal functional
     OBJECTIVE: To observe the main characteristics of function loss in healthy elderly people and analyze the influencing factors of the change of functional indexes in elderly people in normal functional status.
     目的观察健康老年人功能丧失的主要特征,分析老年人在正常功能状态下,功能指数变化的影响因素。
短句来源
     RESULTS: ① Normal functional status of elderly people is various due to the different age, gender, constitution, marital status, living situation, employment history, economic status and education background etc.
     结果①老年人正常功能状态因年龄、性别、体质、婚姻状况居住情况、就业史、经济状况、接受教育程度等不同而有明显差异。
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     Inactivation of Kupffer cells or not has no significant effect on TNF- a secreting in the early stage of Intestinal ischemia/reperfusion, but the normal functional states of Kupffer cells may protect the injury from intestinal I/R injury.
     是否封闭枯否氏细胞对肠缺血/再灌注早期1…N下一Q的产生无明显影响,但枯否氏细胞的正常功能状态对肠缺血/再灌注引起的损伤可能有保护作用。
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     Normal functional status of elderly people is related to social support, economic status, psychological and mental status.
     老年人正常功能状态与社会支持、经济状况、心理和精神状态有关。
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     Except normal functional wiring of protections during erection,the system voltage and load current should be used to check the correctness of inline polarity for protections after completion of erection and trial operation in order to find out wrong connection promptly and correct it.
     除了在安装时能够实现保护装置正常功能的接线外 ,还应在安装竣工后保护装置投入系统试运行时 ,用系统电压和负荷电流校验接入保护装置接线极性的正确性 ,以便及时发现、纠正错误接线。
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  normal functioning
     It is considered that expression of replicilse gene at RNA leveland /or protein level interferes with normal functioning of viral replicase complexs leading to effectly inhi-bition of viral replication in the cells of these transgenic plants.
     复制酶基因在RNA水平或者蛋白质水平上的表达,干扰了复制酶的正常功能,进而有效地抑制了病毒的复制,从而达到抗病的目的。
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     Sensory gating is an important property of the normal functioning brain, and is an operational ability of the brain to modulate sensory stimuli.
     感觉门控是大脑的一种正常功能,是指大脑对感觉刺激反应的调节能力。
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      normal function
    The brain is one of the most important organs in a biological body whose normal function depends heavily on an uninterrupted delivery of oxygen.
          
    This may interfere with the normal function of HSA, thus contributing to diabetic complications.
          
    Aggregate size distribution in the studied magnetic fluid is described by the log-normal function.
          
    It is concluded that the adaptive reserves of pregnant women must be increased for the normal function of the mammary glands after childbirth.
          
    Expression ofmyc broke the regulation of the cell cycle, in particular, canceled the G1 phase arrest for cells with damaged DNA, despite the normal function of protein p53 and induction of the p53-responsive genep21Waf1 in these cells.
          
    更多          
      normal functions
    Normal functions possessing angular boundary values almost everywhere
          
    In the present paper, we prove an analog of Khinchin's metric theorem in the case of linear Diophantine approximations of plane curves defined over the ring of -adic integers by means of (Mahler) normal functions.
          
    After three months, the patient had regained normal functions of the neck and shoulder and had no symptoms even when lifting heavy objects or performing overhead activities.
          
    Most NSAIDs (nonselective or traditional) not only inhibit prostaglandins at sites of inflammation but also inhibit prostaglandins that have important normal functions in other parts of the body.
          
    The author also presents the normal functions that these areas subserve and, whenever possible based on the evidence, infer how their dysfunction may contribute importantly to the symptomatology of PTSD.
          
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      normal functional
    A complete recovery was more frequent for CV than NINCDS GBS, but no difference was found regarding good outcome (defined by a satisfactory recovery and resumption of normal functional life).
          
    Avian magnetic compass: fast adjustment to intensities outside the normal functional window
          
    Excluding the patients who died within the first 6 h, 61% of the patients in the thiopental group survived cardiac arrest with normal cerebral performance, whereas only 37% in the standard treatment group showed normal functional outcome (p>amp;lt;0.03).
          
    Successful small bowel transplantation requires normal functional capacity of the graft and unaltered metabolism of the host.
          
    It is suggested that local circuit regulation of dopaminergic neurons within the graft may, at least in part, be responsible for the maintenance of a normal or close to normal functional activity.
          
    更多          
      normal functioning
    There is a link between adaptive evolution of genes and those changes in kinetic parameters of the signal cascade models, which are critical for normal functioning of these cascades.
          
    The suggestion is made that cell tolerance to heat shock depends on the normal functioning of mitochondria.
          
    In the last decade convincing evidence has been provided that brain insulin and insulin-receptor signaling are necessary for the normal functioning of neurons, although the neuronal effects of insulin remain rather disputable.
          
    This, in turn, testifies to the crucial role of TRPC3 in normal functioning of store-operated Ca2+ channels in A431 cells.
          
    Thus, an adequate balance of its components is necessary for the normal functioning of the vasculature.
          
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    Urinary concentrations of LH estimated by RIA, E_1(estrone),E_2(estradiol)E_3(es-triol)and P_2(pregnanediol)as determined by gas chromatography were studied in a groupof 10 normal women using siliastic vaginal rings impregnated with megestrol acetate.Theendometria curetted on the 21st day of the cycle were also examined under the light micro-scope.The results showed that 7 out of 10 cases were ovulatory;the hormonal profiles ofLH、E_1、E_2、E_3 and P_2 were similar to those of the normal,but the total amount of...

    Urinary concentrations of LH estimated by RIA, E_1(estrone),E_2(estradiol)E_3(es-triol)and P_2(pregnanediol)as determined by gas chromatography were studied in a groupof 10 normal women using siliastic vaginal rings impregnated with megestrol acetate.Theendometria curetted on the 21st day of the cycle were also examined under the light micro-scope.The results showed that 7 out of 10 cases were ovulatory;the hormonal profiles ofLH、E_1、E_2、E_3 and P_2 were similar to those of the normal,but the total amount of sexhormones excreted,except the LH concentration,was less,and the proportion of thethree estrogenic metabolites was E_3>E_1>E_2.The development of the endometria was slig-htly suppressed,though they were in the saecretory phases.Two cases were anovulatory;their urinary concentrations of LH、E_1、E_2、E_3 and P_2 did not exhibit the typical hormonalexcretory patterns as observed in normal ovulatory women.One case had irregularbreakthrough bleeding;the concentrations of LH、E_1,、E_2、E_3、and P_2 fluctuated dramati-cally throughout the cycle,and the proportion of the three estrogenic metabolites wasabnormal.The endometria curetted on the 21st day of the cycle from those anovulatorywomen using SVR still remained at the proliferative stage.This work indicated that SVR,in most cases,disturbed the function of the hypothalamic-pituitary-ovarian axis onlyslightly.It seems that SVR contraception exerts its influence chiefly on the developmentof the follicle and the normal function of the corpus luteum.

    利用气相层析和放射免疫法测定了10例使用甲地孕酮硅橡胶阴道环(下称硅甲环)妇女尿中的E_1、E_2、E_3、P_2和LH 的含量,并用光学显微镜观察了子宫内膜的变化。实验证明10例使用硅甲环妇女中:有7例排卵,尿中LH、E_1、E_2、E_3和P_2的分泌曲线与正常组相似,但分泌总量减少,尿中三种雌激素的比例为E_3>E_1>E_2,该组的子宫内膜虽属分泌期,但腺体发育较差;2例不排卵,LH、E_1、E_2、E_3和P_2不出现典型的分泌曲线;另1例不排卵兼有突破性出血,尿中LH、E_1、E_2、E_3及P_2的分泌量在整个周期中波动甚大,三种雌激素的比例异常,这类不排卵型的子宫内膜仍处于增生期。本工作表明硅甲环对妇女下丘脑—垂体—性腺轴的影响较小,其避孕环节主要是影响卵泡的发育和黄体的正常功能

    Refering to Miller's method, we had designed a perfusion system for the isolated rat liver. It consists of three parts: (1) the constant temperature apparatus, (2) the gas-exchange system and (3) the perfusion apparatus made of plexiglass (polymethyl methacrylate). In the upper part of the perfusion apparatus are a coiled glass tube for heating, a portal vein cannula, a themometer and a double-layered case filled with constant temperature water; in the lower part are to be found a funnel, a plate supporting...

    Refering to Miller's method, we had designed a perfusion system for the isolated rat liver. It consists of three parts: (1) the constant temperature apparatus, (2) the gas-exchange system and (3) the perfusion apparatus made of plexiglass (polymethyl methacrylate). In the upper part of the perfusion apparatus are a coiled glass tube for heating, a portal vein cannula, a themometer and a double-layered case filled with constant temperature water; in the lower part are to be found a funnel, a plate supporting the liver, a bile cannula, a perfusion cell linked up with the gas exit and a double-layered case filled with constant temperature water. Krebs-Ringer bicarbonate buffer solution containing glucose (0.15g/dl) was used as the perfusion medium. The perfusion rate was 2~3 ml/min/g, of liver. Simultaneously, 95%O_5%CO_2 was continuously passed through the medium. There was no necrosis focus in the liver after being perfused for four hours. Microscopical observation of the liver histotomy showed that the structure of the hepatocytes was normal. It had also been shown that by measuring the bile secretion and oxygen consumption the isolated rat liver might maintain its normal function for at least four hours.

    参照Miller等人的大鼠离体肝脏灌流方法,我们设计制作了一套灌流装置,此装置由三部分组成:超级恒温器(维持灌流系统恒温用)、气体交换系统及灌流仪(用有机玻璃制作:上部有加热弯管,肝门静脉插管,温度计及恒温水浴夹层;下部有放置肝脏的漏斗和平板、灌流室、胆汁引流管、通气口及恒温水浴夹层)。用含0.15%葡萄糖的Krebs-Ringer碳酸氢盐缓冲液为灌流介质,流速2~3毫升/分钟/克肝,灌流4小时,在灌流期间持续通入95%O_2-5%CO_2。灌流后肝脏无坏死灶出现,肝切片显微观察,结构基本正常。通过胆汁分泌量及耗氧量测定,证明本法可维持肝脏正常功能至少4小时。我们将灌流液浓缩后,作脂质测定及脂蛋白电泳分析:总胆固醇为0.062±0.008毫克/克肝(n=7,p=95%);有一条相当于大鼠血清极低密度脂蛋白(VLDL)及两条相当于高密度脂蛋白(HDL)的色带。本装置构造简单,保证恒温,流速较稳定,适用于物质代谢及其调节与药物代谢的研究。目前,我们已将此法用于大鼠肝脏脂质代谢、脂蛋白代谢及肝脏肝素可释放脂酶活性的研究(均见另文)。

    Refering to Miller's method,we had designed a perfusion system for the isolatedrat liver.It consists of three parts:(1)the constant temperature apparatus,(2)thegas-exchange system and(3)the perfusion apparatus made of plexiglass(polymethylmethacrylate).In the upper part of the perfusion apparatus are a coiled glass tubefor heating,a portal vein cannula,a themometer and a double-layered case filled withconstant temperature water;in the lower part are to be found a funnel,a plate suppo-rting the liver,a bile cannula,a...

    Refering to Miller's method,we had designed a perfusion system for the isolatedrat liver.It consists of three parts:(1)the constant temperature apparatus,(2)thegas-exchange system and(3)the perfusion apparatus made of plexiglass(polymethylmethacrylate).In the upper part of the perfusion apparatus are a coiled glass tubefor heating,a portal vein cannula,a themometer and a double-layered case filled withconstant temperature water;in the lower part are to be found a funnel,a plate suppo-rting the liver,a bile cannula,a perfusion cell linked up with the gas exit and a dou-ble-layered case filled with constant temperature water.Krebs-Ringer bicarbonatebuffer solution containing glucose(0.15g/dl)was used as the perfusion medium.Theperfusion rate was 2~3 ml/min/g.of liver.Simultaneously,95% O_2/5% CO_2 was con-tinuously passed through the medium.There was no necrosis focus in the liver afterbeing perfused for four hours.Microscopical observation of the liver histotomy showedthat the structure of the hepatocytes was normal.It had also been shown that bymeasuring the bile secretion and oxygen consumption the isolated rat liver mightmaintain its normal function for at least four hours.After the perfusate was concentrated,the lipids were determined.Total cholesterolwas 0.062±0.008 mg/g.of liver(n=7,Ⅹ±=SD).The concentrated perfusate wassimilar to rat plasma in their lipoprotein electrophoretogram with one band of verylow density lipoprotein(VLDL)and two bands of high density lipoprotein(HDL).This perfusion apparatus is simple,which can keep the temperature of the perfu-sion system and the perfusion rate constant.It is useful for the investigation ofmetabolism and its regulation or drug metabolism in the liver.We have used thismethod to investigate lipid and lipoprotein metabolism and the hepatic lipase activityof the isolated rat liver.

    参照Miller等人n 0]的大鼠离体肝脏灌流方法,我们设计制作了一套灌流装置,此装置由三部分组成:超级恒温器(维持灌流系统恒温用)、气体交换系统及灌流仪(用有机玻璃制作:上部有加热弯管,肝门静脉插管,温度计及恒温水浴夹层;下部有放置肝脏的漏斗和平板、灌流室、胆汁引流管、通气口及恒温水浴夹层)。用含O.15%葡萄糖的Krebs-Ringor碳酸氢盐缓冲液为灌流介质,流速2—3毫升/分钟/克肝,灌流4小时,在灌流期间持续通入95%Or-5%C020灌流后肝脏无坏死灶出现,肝切片显微观察,结构基本正常。通过胆汁分泌量及耗氧量测定,证明本法可维持肝脏正常功能至少4小时。我们将灌流液浓缩后,作脂质测定及脂蛋白电泳分析:总胆固醇为0.062±0.008毫克/克肝(n=7,p=95%);有一条相当于大鼠血清极低密度脂蛋白(VLDL)及两条相当于高密度脂蛋白(HDL)的色带。本装置构造简单,保证恒温,流速较稳定,适用于物质代谢及其调节与药物代谢的研究。目前,我们已将此法用于大鼠肝脏脂质代谢、脂蛋白代谢及肝脏肝素可释放脂酶活性的研究(均见另文)。

     
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