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胚胎造血
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  embryonic hematopoiesis
     Involvement of Smad5 Gene in Regulation of Embryonic Hematopoiesis
     Smad5基因和胚胎造血发育的调控机制
短句来源
     Previous investigations indicate that in vitro differentiation of embryonic stem cells (ES cells) derived from 129 mice can mimic embryonic hematopoiesis to some extent.
     既往研究表明 ,12 9小鼠来源的胚胎干细胞系(embryonicstemcells,ES细胞 )的体外分化能在一定程度上模拟胚胎造血
短句来源
     In conclusion, MES 1 established from C57BL/6 mice was able to differentiate in vitro to a variety of hematopoietic precursors, thus could partly recapitulate embryonic hematopoiesis.
     结论 :自C5 7BL 6小鼠建立的ES细胞系MES 1体外定向造血细胞分化在一定程度上能模拟胚胎造血
短句来源
  “胚胎造血”译为未确定词的双语例句
     Studies on Differentiation of nthESC to HSC and Expression of Hematopoietic Related Markers in Hematopoietic Development of Human Embryo
     人nthESC向HSC诱导分化和胚胎造血标志物表达研究
短句来源
     Involvement of vascular endothelial growth factor,angiopoietin and their receptors in the process of human embryonic haematogenesis
     血管内皮生长因子及其受体和angiopoietin及其受体在人胚胎造血过程中的作用(英文)
短句来源
     An experiment study of expansion and culture of fetal blood hematopoietic stem/progenitor cells in vitro
     胚胎造血干/祖细胞体外培养及扩增的实验研究
短句来源
     Objective: To study the capacity for expansion and forming colonies in vitro of hematopoietic stem /progenitor cells of human fetal blood.
     目的:研究胚胎造血干/祖细胞体外培养及扩增效果。
短句来源
     Objective To study the expression and distribution of KDR,VEGF and CD34 in yolk sac and liver of human embryo at different development stage.
     目的研究人胚胎发育不同时期卵黄囊和胎肝内受体酪氨酸激酶(KDR)、血管内皮生长因子(VEGF)和CD34的分布及表达,为胚胎造血分化提供理论依据。
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  相似匹配句对
     Fetal liver hemopoiesis
     人胚胎时期的肝脏造血
短句来源
     Fetal Liver Haemopoiesis
     人胚胎时期的肝脏造血
短句来源
     THE CRYOPRESERVATION OF FISH EMBRYOS
     鱼类胚胎低温保存
短句来源
     Searching for Embryo Inside Dinosaur Egg Fossil
     寻找恐龙胚胎
短句来源
     THE MODULABILITY OF B-LYMPHOCYTES ON HAEMOPOIESIS
     B淋巴细胞的造血调控作用
短句来源
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  embryonic hematopoiesis
We investigated the expression of proliferative cell nuclear antigen (PCNA) in zebrafish to delineate the proliferative hematopoietic component during adult and embryonic hematopoiesis.
      
Defined by this terminology, embryonic hematopoiesis can be divided into three distinct stages.
      
Embryonic hematopoiesis begins in the yolk sac, moving to the fetal liver under the influence of GATA-2.
      
However, it is not clear whether the genes regulated during the lineage development program in embryonic hematopoiesis are found at the same locus.
      
In contrast, embryonic hematopoiesis is thought to consist of free floating cells in the vascular system.
      
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Upstream of the human e-globin gene is the Locus Control Region (LCR ) of the human β-globin cluster,which consists of four DNase-I hypersensitive sites (HS1-HS4). It has been reported in transgenic experiments that HS3 preferentially regulates e-globin gene expression. In order to elucidate the regulatory function of HS3 in the expression of globin gene, nuclear extracts from mouse hematopoietic tissues at several developmental stages were prepared and the binding of the nuclear factors to HS3 was analysed...

Upstream of the human e-globin gene is the Locus Control Region (LCR ) of the human β-globin cluster,which consists of four DNase-I hypersensitive sites (HS1-HS4). It has been reported in transgenic experiments that HS3 preferentially regulates e-globin gene expression. In order to elucidate the regulatory function of HS3 in the expression of globin gene, nuclear extracts from mouse hematopoietic tissues at several developmental stages were prepared and the binding of the nuclear factors to HS3 was analysed by using electrophoresis mobility shift assay(EMSA). Our results showed that the binding patterns of HS3 with nuclear extracts of mouse hematopoietic tissues at day13 and day18 of gestation were completely different; furthermore, by Southwestern Blot, the distinction between both stages was also demonstrated, It has been known that GATA and CACCC binding motifs are contained within HS3 core region. Using competitive gel-retardation as-

人β-簇珠蛋白基因LCR调控元件位于ε-珠蛋白基因5’上游20Kb内,由四个DNase-Ⅰ超敏感点(HS1-HS4)组成。已有转基因实验表明,HS3可能与发育早期的胚胎型ε-珠蛋白基因表达调控相关。基因调控是通过调控元件与调控因子的相互作用而完成的。为了揭示HS3的调控作用,我们选用了发育不同时期的小鼠胚胎造血组织作为材料,用凝胶电泳阻抑法,分析了调控因子与HS3的结合。我们的实验结果表明,怀孕13天和18天的小鼠胚胎造血组织的核蛋白因子与HS3的结合模式完全不同;同时我们用Southwestern Blot的方法进一步证明了这种差异性的存在。现已知HS3中有GA-TA和CACCC两类转录因子结合的motif,采用竞争实验分析,发现CACCC motif对结合区带没有竞争作用,而GATA有竞争作用;另外还存在没有被竞争的条带,我们推测它们可能是一类新的、发育时期专一性的核蛋白因子。Western Blot的实验结果表明,在基因调控过程中起到重要作用的红系转录因子GATA家族中的GATA-1和GATA-2的表达也具有时期专一性:即怀孕13天的小鼠造血组织中表达GATA-2,不表达GATA...

人β-簇珠蛋白基因LCR调控元件位于ε-珠蛋白基因5’上游20Kb内,由四个DNase-Ⅰ超敏感点(HS1-HS4)组成。已有转基因实验表明,HS3可能与发育早期的胚胎型ε-珠蛋白基因表达调控相关。基因调控是通过调控元件与调控因子的相互作用而完成的。为了揭示HS3的调控作用,我们选用了发育不同时期的小鼠胚胎造血组织作为材料,用凝胶电泳阻抑法,分析了调控因子与HS3的结合。我们的实验结果表明,怀孕13天和18天的小鼠胚胎造血组织的核蛋白因子与HS3的结合模式完全不同;同时我们用Southwestern Blot的方法进一步证明了这种差异性的存在。现已知HS3中有GA-TA和CACCC两类转录因子结合的motif,采用竞争实验分析,发现CACCC motif对结合区带没有竞争作用,而GATA有竞争作用;另外还存在没有被竞争的条带,我们推测它们可能是一类新的、发育时期专一性的核蛋白因子。Western Blot的实验结果表明,在基因调控过程中起到重要作用的红系转录因子GATA家族中的GATA-1和GATA-2的表达也具有时期专一性:即怀孕13天的小鼠造血组织中表达GATA-2,不表达GATA-1;而怀孕18天的小鼠造血组织中则表达GATA-1,不表达GA-TA-2。因此,我们推测,HS3很可能参与时期专一性的基因表达调控,其中时期专一性的蛋白因子可能起到了重要作用。

Objective\ To observe the effects of prenatal irradiation on functions of haematopoietic stromal cells. Methods \ Long-term effects of 2 0Gy 137 Cs γ-radiation at midterm gestation of mice on the haematopoietic stromal cells of their offspring were studied. Results \ The quantity of femoral bone marrow nucleated cells (BMNCs) in the irradiated offspring was markedly lower than that of the normal offspring ( P <0 01).And stromal expressions of the growth factors,granulocyte-macrophage colony-stimulating...

Objective\ To observe the effects of prenatal irradiation on functions of haematopoietic stromal cells. Methods \ Long-term effects of 2 0Gy 137 Cs γ-radiation at midterm gestation of mice on the haematopoietic stromal cells of their offspring were studied. Results \ The quantity of femoral bone marrow nucleated cells (BMNCs) in the irradiated offspring was markedly lower than that of the normal offspring ( P <0 01).And stromal expressions of the growth factors,granulocyte-macrophage colony-stimulating factor (GM-CSF) and stem cell factor (SCF),of the irradiated offspring were higher compared with those of the normal offspring ( P<0 05 ).At the same time,the ability to support heamatopoiesis by the stromal cells in irradiated offspring was higher than that in normal offspring. Conclusion \ The results suggest that irradiation with 2 0Gy 137 Cs γ-rays is sufficient to produce measurable effects on developing murine haematopoietic stromal cells.\;

目的 研究胚胎期 2 0Gy137Csγ射线照射后对子鼠造血基质细胞的远期影响。方法 建立胚胎期受辐射小鼠模型 ;以细胞计数检测股骨骨髓有核细胞 (BMNCs)数 ;用免疫组化ABC法检测基质细胞粒单系集落刺激因子 (GM CSF)和干细胞因子 (SCF)的表达 ;用体外小鼠骨髓细胞培养法以粒单细胞系祖细胞集落形成单位 (CFU GM )为指标观察基质细胞对正常骨髓造血的支持功能。结果 胚胎期受辐射小鼠BMNCs数明显低于正常小鼠 (P <0 0 1) ,其骨髓基质细胞生长因子GM CSF和SCF的表达均高于正常小鼠 (P <0 0 5 ) ,同时 ,胚胎期受辐射小鼠骨髓基质细胞对正常骨髓造血的支持能力也高于正常小鼠 (P <0 0 5 )。结论  2 0Gy137Csγ射线对发育中的小鼠胚胎的造血基质细胞产生了明显影响。

Eggs of silkworm, Bombyx mori were irradiated by 12C5+ ions, at the embryonic wings, where the hemopoietic organs attached. Changes in the development of the silkworm larvae and pupae, especially in the repair and regeneration of the hemopoietic organs represented by their morphological and functional characteristics, were observed. The results showed that the silkworm larvae and pupae developed from the irradiated eggs grew with the physiological obstruction due to exsanguinations, such as difficulty in their...

Eggs of silkworm, Bombyx mori were irradiated by 12C5+ ions, at the embryonic wings, where the hemopoietic organs attached. Changes in the development of the silkworm larvae and pupae, especially in the repair and regeneration of the hemopoietic organs represented by their morphological and functional characteristics, were observed. The results showed that the silkworm larvae and pupae developed from the irradiated eggs grew with the physiological obstruction due to exsanguinations, such as difficulty in their metamorphosis and their marked lower survival rates. After 100Gy irradiation, some of the larvae and pupae died during the periods of larval molting stages, pupation stage and eclosion stage. With increased doses, the deficiencies in the silkworm development became more significant. After 200Gy irradiation, the average hemocyte density for the 5th larvae decreased markedly, but the hemocyte density for some individuals were comparable to the control, and regenerated hemopoietic organs was found in these larvae. The results suggested that the silkworm larvae might be capable of self-repair and self-regeneration of the hemopoietic organs after the heave ion irradiation.

为了研究重离子射线照射后家蚕造血器官的修复再生作用,用碳离子射线局部照射家蚕接近孵化时紧贴翅原基内侧的胚胎造血器官,局部细微手术损伤造血器官,观察了对幼虫造血功能的影响,了解了造血器官的修复程度。100Gy以上剂量照射,家蚕出现变态困难,幼虫和蛹的生存率下降,眠中、化蛹或羽化时期出现死亡个体等缺血生理障碍,其影响程度随射线剂量增加而加重。200Gy照射组5龄存活幼虫血细胞含量下降,但其中部分个体的血细胞含量接近对照未照射处理,其体内出现了再生的造血器官。家蚕幼虫有很强的修复再生造血器官功能。

 
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