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蛋白药物
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  protein drug
     Study on Modified Guar Gum Microsphere as A Protein Drug Carrier
     改性瓜尔胶微球用作蛋白药物载体的研究
短句来源
     And the hydrogles were used as protein drug carrier to control the release of drug.
     并对这种环境敏感性水凝胶作为蛋白药物载体,在药物控制释放体系中的应用作了一些有意义的工作。
短句来源
     Research Development on The Protein Drug PEGylation Technology
     蛋白药物聚乙二醇化技术的研究进展
短句来源
     The protein drug PEGylation technology is a technology that chemically modifies protein drug by polyethylene glycol derivatives.
     蛋白药物聚乙二醇化技术是指一项利用聚乙二醇衍生物对蛋白药物进行化学修饰的技术。
短句来源
     [Conclusion] This study provides a base for improving long half-life of protein drug.
     结论本研究为开发长效蛋白药物奠定了良好的基础。
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  protein drugs
     These results will provide theoretical instruction for the efficient application of PTD-Tat in the field of the delivery of protein drugs.
     这些结论将为 PTD-Tat 在蛋白药物递送方面的有效应用提供理论指导。
短句来源
     Methods Microspheres were prepared by complex coacervation. Model protein drugs(BSA) and polymers (gelatin and arabic gum) were covalently labelled with a fluorescent marker prior to microsphere preparation.
     方法 微球用复凝聚法制备 ,牛血清白蛋白 (BSA)为模型蛋白药物和聚合物 (明胶与阿拉伯胶 )为成球材料 ,在制备微球前均共价标记了荧光物。
短句来源
     These results will provide theoretical instruction for the efficient application of PTD-Tat in the field of the delivery of protein drugs.
     该研究结果拓宽了PTD-Tat在蛋白药物递送方面的应用范围,为蛋白质疗法开辟了新的视野,并为其有效应用提供理论指导.
短句来源
     The research progress of PEG modified protein drugs
     聚乙二醇修饰蛋白药物研究进展
短句来源
     This paper reviews the recent advances in yeast expression systems used in recombinant protein drugs produced by gene engineering,such as the selection of yeast vector system and yeast expression strain, construction of multi-copy strain, the high yeast cell density culture, the recent situation of yeast system applied in expression gene,defect of yeast expression system and countermeasure,etc.
     本文主要从酵母载体系统的选择、酵母表达宿主的选择、多拷贝菌株的构建、高密度发酵培养酵母细胞、应用酵母系统表达外源基因的研究现状、酵母表达系统的缺陷及对策等几个方面综述了近年来酵母表达体系在基因工程重组蛋白药物开发方面的研究进展。
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  “蛋白药物”译为未确定词的双语例句
     The combinated IFNα_(2a) and THYα_1 is more powerful than the individual of both IFNα_(2a) and THYα_1 medicines during treating human cancers and some virus infection diseases,and we considered to construct a fusion protein molecule containing both IFNα_(2a) and THYα_1 by DNA recombination.
     人干扰素α2a(IFNα2a)和胸腺肽α1(THYα1)联合使用效果远大于各自单独使用的效果,本文通过DNA重组技术将两者构建成一个融合蛋白药物
短句来源
     CONCLUSION chitosan-PLA-NP demonstrated its potential on improving the efficacy of the direct nose-brain transport for drugs.
     结论chitosan-PLA-NP能促进药物由鼻直接转运入脑,有望作为多肽蛋白药物鼻腔给药的载体。
     The phage surface display technology is widely used in disease diagnosis, specific antibody, and protein medicine production.
     噬菌体表面展示技术广泛应用于疾病诊断、特异性抗体及蛋白药物生产等。
短句来源
     Protein Release from Implantable Collagen Carrier and Pharcodynamics Study
     以胶原为载体的蛋白药物体内释放和药代动力学的研究
短句来源
     Market Analysis and the R&D Trend for Recombinant Protein Therapeutics
     国际重组蛋白药物市场和研发趋势的分析
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  protein drug
The results of static light scattering have suggested that at pH 7.4, 5.8, 4.9, the molecular weight of the protein/drug complexes is 210,000 g·mol-1, 418,000 g·mol-1, 448,000 g·mol-1, respectively.
      
Dynamic light scattering provides information on diffusion coefficient and particle distributions of protein/drug complexes under different conditions, which suggests a broad hydrodynamic diameter range of scatters.
      
Method of fabrication of submicron composite microparticles of hydroxyapatite and ferromagnetic nanoparticles for a protein drug
      
Lysozyme, a cationic antibacterial enzyme, which has important applications in the reduction of prosthetic valve endocarditis, was chosen as a model protein drug.
      
Insulin, which is commonly used to assess protein drug delivery, was retained in the CS gel beads.
      
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  protein drugs
Effect of ionic strength on the loading efficiency of model polypeptide/protein drugs in pH-/temperature-sensitive polymers
      
Chitosan (CS) gel beads were prepared in a 10% (w/v) aqueous amino acid solution (pH 9.0) as a vehicle for delivering peptide and protein drugs.
      
Vitamin E succinate (VES), an anti-inflammatory drug, and bovine serum albumin (BSA), a model of anti-inflammatory protein drugs, were loaded into the gels and their release kinetics were measured in vitro.
      
Semi-interpenetrating network of poly(ethylene glycol) and poly(D, L-lactide) for the controlled delivery of protein drugs
      
These IPNs were developed for the controlled delivery of protein drugs such as growth factors.
      
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The influence of different route of injection and combined use of dexamethasone on human immune response to Trichosanthin was studied.Serum specific antibody production in patients injected with.Trichosanthin into amniotic sac was less than that in patients injectid intramuscularly(P<0.05),while the intensity of skin reaction and HBDI(human basophil degranulation index)were found to be about the same(P>0.05).Skin reaction,HBDI and IgE antibody production could be suppressed significantly by combined use of dexamethason(P<0.05),especially...

The influence of different route of injection and combined use of dexamethasone on human immune response to Trichosanthin was studied.Serum specific antibody production in patients injected with.Trichosanthin into amniotic sac was less than that in patients injectid intramuscularly(P<0.05),while the intensity of skin reaction and HBDI(human basophil degranulation index)were found to be about the same(P>0.05).Skin reaction,HBDI and IgE antibody production could be suppressed significantly by combined use of dexamethason(P<0.05),especially in cases with amniotic sac injection.

本文研究了不同用药途径和地塞米松对天花粉蛋白所致人体免疫应答的影响。从4例羊膜腔注射结晶天花粉蛋白和13例天花粉蛋白药物流产,联合应用地塞米松者的皮试反应,嗜碱性细胞脱颗粒试验及血清抗天花粉蛋白IgE和IgG抗体测定(各81人次)的动态观察中发现,经羊膜腔途径给药可降低血清中抗天花粉蛋白的抗体水平;应用地塞米松能抑制机体对天花粉蛋白的致敏状态,该抑制效应以羊膜腔注射联合应用地塞米松时尤为显著。

Verapamil,a calcium channel antagonist,was used as the reversal reagent for drug resistance in bladder tumor.The result denoted that verapamil could reverse effectively the drug resistance of bladder tumor and would inhibit the drug efflux pump effect of P-GP glycoprotein, increasing vincristine accumulation in cells.It was suggested that verapamil combined with intravesical instillation of chemotherapeutic agents might be an effective means of preventing drug resistance and recurrence of bladder tumor.

采用MTT、HPLC等方法对膀胱癌耐药细胞耐药性逆转进行实验研究,以钙通道阻断剂异搏定为逆转剂。结果表明:异搏定能有效地逆转膀胱癌细胞的抗药性,主要通过抑制P-GP糖蛋白的药物外流“泵”作用,增加了细胞内长春新碱(VCR)的蓄积。抗药逆转剂(异搏定)与化疗药物联合应用进行膀胱腔内灌注可能是治疗和预防膀胱肿瘤抗药及复发的有效手段。

OBJECTIVE:Specific drug efflux from the endothelial cells of capillary blood vessels of brain mediated by p-glycoprotein(P-gp) is described.METHODS:The conclusion that the relationship between p-glycoptein and drug delivery was drawn from datum analysis induce and summary.RESULTS:P-glycoprotein at the blood-brain was found to function as ATP-depended efflux pump transporting various drugs out of cells and decreasing the apparent permeability of brain.CONCLUSION:The utilization of multidrug resistance reverses...

OBJECTIVE:Specific drug efflux from the endothelial cells of capillary blood vessels of brain mediated by p-glycoprotein(P-gp) is described.METHODS:The conclusion that the relationship between p-glycoptein and drug delivery was drawn from datum analysis induce and summary.RESULTS:P-glycoprotein at the blood-brain was found to function as ATP-depended efflux pump transporting various drugs out of cells and decreasing the apparent permeability of brain.CONCLUSION:The utilization of multidrug resistance reverses may make it possible to inhance delivery of drugs into the brain or decrease the apparent permeability in order to prevent undesirable side effects in the central neural system.

目的 :综述脑毛细血管内皮细胞上的P -糖蛋白药物外排功能。方法 :根据对有关的资料的分析、归纳、总结得出P -糖蛋白与脑内药物转运的关系。结果 :血脑屏障上的P -糖蛋白具有ATP依赖性的药物外排泵的功能 ,能降低脑内药物的浓度。结论 :利用多药耐药性逆转剂有可能提高脑内的药物转运或者降低药物的通透性减少中枢神经系统的不良反应

 
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