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前列腺癌
相关语句
  prostate cancer
    Pharmacological Profile of LXT-101, a Novel GnRH Antagonist, in Treatig Prostate Cancer
    新结构GnRH拮抗类似物LXT-101抗前列腺癌药理作用及作用机理的研究
短句来源
    SPOM-1 and SPOM-2 were shown to inhibit prostate cancer cell PC-3M significantly, and there was a certain dose-effect relationship.
    研究发现,SPOM-1,SPOM-2在体外能明显抑制前列腺癌PC-3M细胞,并呈一定的量效关系,EC50分别为38,11g·mL-1;
短句来源
    It was concluded from the test that the activity of SPOM-2 inhibiting prostate cancer cell PC-3M was superior to that of SPOM-1.
    SPOM-2的抗前列腺癌PC-3M细胞活性大于SPOM-1.
短句来源
    Progress in Researches on Drugs for Prostate Cancer
    治疗前列腺癌药物的研究进展
短句来源
    Prostate cancer (Pca) is one of the most common cancers and the second leading cause of cancer deaths in males in the United States.
    前列腺癌是西方男性常见的恶性肿瘤,在美国其发病率位居男性恶性肿瘤的第一位,死亡率仅次于肺癌位居第二位。
短句来源
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  prostatic cancer
    Both the cytoplasmic and nuclear AR content in prostatic cancer are higher than that in normal prostate and benign prostatic hypertrophy (P<0.05).
    人前列腺癌的胞浆胞核AR含量均高于正常前列腺及前列腺肥大的(P<0.05)。
短句来源
  prostatic carcinoma
    Three patients with prostatic carcinoma who experienced bilateral orchidectomy 2 to 12 weeks ago were examined, and each patient accepted intramuscular injection of estradiol benzoate (E2B) in dose of 1 mg daily for 7 days.
    3例前列腺癌施行双侧睾丸切除术后2~12周的患者,每天肌注苯甲酸雌二醇1mg,连续7d。
短句来源
    The inhibition of melatonin(MT) on growth of human prostatic carcinoma cell lines ofPC-3m was studied by examining the influence of MT in a different concentrations andvarious time on cell culture in vitro with MTT and board clone assays.
    本文采用前列腺癌PC-3m细胞分别和不同浓度的褪黑素(MT)进行不同时间的培养,选用MTT法和平板克隆法进行检测。
短句来源
    Background: Prostatic carcinoma (PCa) is one of the frequent malignant tumors in western countries and accounts for the second place of the male death in USA.
    背景: 前列腺癌(PCa)是西方国家最常见的恶性肿瘤之一,是美国男性癌症死亡的第二大原因。
短句来源
  “前列腺癌”译为未确定词的双语例句
    THE INHIBITORY ACTION OF THE PULSATILE LH SECRETION IN CASTRATED MEN WITH PROSTATIC CARCINOMA
    雌二醇对去势前列腺癌患者LH脉冲分泌的抑制作用
短句来源
    Preparation of Prostatic Carcinoma-targeted Ultrasound Contrast Agent and Its Experimental Study
    人前列腺癌靶向超声造影剂的制备及实验研究
短句来源
    Orchiectomy was the most usual management, which was based on Huggins' important findings in 1941 that about 70 percent of Pca is hormone-dependent.
    1941年,芝加哥大学的Huggins和Hodges发现约70%的前列腺癌具有雄激素依赖性,其后前列腺癌的内分泌治疗的研究广泛开展起来。
短句来源
    Our results indicate that MT could inhibit PC-3m cell proliferation, and strengthen orally to the chemotherapeutic action of 5-Eu, so it maybe decrease the chemotherapeuticdose and adverse drug reaction of 5-Eu in clinical.
    研究提示,MT能够抑制前列腺癌PC-3m细胞的增殖,并可相加或协同5-Fu的作用,减少5-Fu的用量,并可能降低5-Fu的不良反应。
短句来源
    The attack rate in our country has been increasing sharply for the past few years.
    近年来,我国前列腺癌的发病率也急剧上升。
短句来源
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  prostate cancer
The possibility of using AGR2 as a diagnostic marker of prostate cancer is discussed.
      
Calcitriol induces transcription of the placental transforming growth factor β gene in prostate cancer cells via an androgen-ind
      
Calcitriol (1α,25-dihydroxycholecalciferol) suppresses the growth of prostate cancer cells.
      
Growth suppression of hormone-sensitive LNCaP prostate cancer cells by calcitriol is believed to depend on androgens, but the mechanisms of the interactions between the calcitriol-and androgen-dependent signaling pathways is unclear.
      
It was assumed that calcitriol stimulates production of PTGF-β independently of 5α-dihydrotestosterone and that its effect on prostate cancer cell growth is partly mediated by an androgen-independent mechanism.
      
更多          
  prostatic cancer
As far as prostatic cancer was concerned, milk was most closely correlated (r=0.711) with its incidence, followed by meat and coffee.
      
Stepwise-multiple-regression analysis identified milk, meat, butter and coffee as significant factors contributing to the incidence of prostatic cancer (R=0.993).
      
Objective: To diagnose prostatic cancer (CaP) with cDNA macroarray.
      
The significance of PSA modified parameters (F/T)/PSAD for diagnosing prostatic cancer in the grey zone of 4~10 ng/ml
      
The objective of this study was to test the hypothesis that prostatic cancer is associated with the changes of zinc (Zn) and cadmium (Cd) concentration.
      
更多          
  prostatic carcinoma
We investigated the effect of the soy isoflavone genistein on the proliferation and contact-stimulated migration of rat prostatic carcinoma MAT-LyLu and AT-2 cell lines.
      
Normal prostate, benign prostatic hyperplasia (BPH), and prostatic carcinoma (PCA) were analyzed for Zn and Cd by atomic absorption spectrometry.
      
Response and palliation in a phase II trial of gemcitabine in hormone-refractory metastatic prostatic carcinoma
      
Neuroendocrine differentiation in prostatic carcinoma: An?update?on?recent?developments
      
However, it has been proposed that various neuroendocrine (NE) hormones and growth factors may be involved in the pathogenesis of prostatic carcinoma (CaP).
      
更多          


The result of radioligand binding assay study demonstrated that in the prostate both cytoplasmic and nuclear AR can be saturated by 5 nmol/1 dihydrotestosterone (DHT). The values of Bmax and KD are 129.4 fmol/mg protein and 0.88 nmol/1 in cytoplasm; 176.2 fmol/mg protein and 3.2 nmol/1 in nucleus. Both the cytoplasmic and nuclear AR content in prostatic cancer are higher than that in normal prostate and benign prostatic hypertrophy (P<0.05). It is useful in selecting suitable therapy for PC patients. Thaw-mount...

The result of radioligand binding assay study demonstrated that in the prostate both cytoplasmic and nuclear AR can be saturated by 5 nmol/1 dihydrotestosterone (DHT). The values of Bmax and KD are 129.4 fmol/mg protein and 0.88 nmol/1 in cytoplasm; 176.2 fmol/mg protein and 3.2 nmol/1 in nucleus. Both the cytoplasmic and nuclear AR content in prostatic cancer are higher than that in normal prostate and benign prostatic hypertrophy (P<0.05). It is useful in selecting suitable therapy for PC patients. Thaw-mount autoradiography demonstrated that AR are mainly located in the epithelial cells of the glandular tissue of prostate.

本室建立了雄激素受体(AR)测定的放射配基结合分析(RBA)法。测得人前列腺组织中胞浆、胞核的AR均可被约5nmol/l的双氢睾酮饱和,其最大结合容量分别为129.4fmol/mg胞浆蛋白和176.2fmol/mg胞核蛋白;平衡解离常数分别为0.88nmol/l和3.2nmol/l。人前列腺癌的胞浆胞核AR含量均高于正常前列腺及前列腺肥大的(P<0.05)。为前列腺癌病人选择治疗方案提供了理论依据。同时用融裱法放射自显影证实了AR主要分布在前列腺组织的腺区,尤其是腺上皮细胞核。

Three patients with prostatic carcinoma who experienced bilateral orchidectomy 2 to 12 weeks ago were examined, and each patient accepted intramuscular injection of estradiol benzoate (E2B) in dose of 1 mg daily for 7 days. Blood sampe was drawn in an interval of 10 min was done for LH pulse analysis before and after the injection for a period of 7h. The results showed that the mean serum LH level decreased significantly from 177,58±3.20 to 174.70±7.60, 138.30±5.83 to 132.02± 5.77 and 145.88± 3.82 to 142.80±...

Three patients with prostatic carcinoma who experienced bilateral orchidectomy 2 to 12 weeks ago were examined, and each patient accepted intramuscular injection of estradiol benzoate (E2B) in dose of 1 mg daily for 7 days. Blood sampe was drawn in an interval of 10 min was done for LH pulse analysis before and after the injection for a period of 7h. The results showed that the mean serum LH level decreased significantly from 177,58±3.20 to 174.70±7.60, 138.30±5.83 to 132.02± 5.77 and 145.88± 3.82 to 142.80± 3.65U / L, respectively (P<0.01 in all), whereas the LH pulse amplitude and pulse frequency were not (P<0.05 in all). Two of three patients continued to take diaethyst ilestrol 2 mg daily for about one year, and the mean serum LH level (all <5 U / L) was significantly suppressed and LH pulses completely disappeared. It was concluted that (1) E2 was not only able to suppress the LH pulse amplitude but also pulse frequency in men, suggesting a feedback effect of E2 on both hypothalamus and pituitary; (2) the inhibiting action of E-, on LH pulsatile secretion is dependent on a prolonged use of E2.

3例前列腺癌施行双侧睾丸切除术后2~12周的患者,每天肌注苯甲酸雌二醇1mg,连续7d。治疗前后分别每10min采血一次,作7h LH脉冲分析。结果表明,3例患者平均血清LH水平分别由177.58±3.20、138.30±5.83和145.88±3.82IU/L下降到174.90±7.60、132.02±5.77和142.80±3.65IU/L(P均<0.01),但LH脉冲幅度和频率无明显变化(P均>0.05)。其中,2例患者连续口服已烯雌酚2mg/日约1年后,平均血清LH明显被抑制(均≤5IU/L),LH脉冲消失。结论:(1)E_2不仅能抑制LH脉冲幅度,而且能抑制脉冲频率。表明E_2对下丘脑和垂体均有反馈作用;(2)E_2对LH脉冲的抑制作用有赖于长期的E_2用药。

The preparation

氟他胺邻位硝基异构体的研究杨征宇,夏奕,郑筠青,夏鹏(上海医科大学药学院有机化学教研室上海200032;中国科学院上海有机化学研究所上海200032)氟他胺(flutamide,I)是美国先灵药厂生产的一种非甾体抗雄激素药物,临床上用于治疗前列腺癌。...

 
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