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精子抗原
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  sperm antigen
     Cloning and Expression of the Fusion Protein of Murine Sperm Antigen Sp17 and Interleukin-5 and Its Immunological Contraceptive Effects
     鼠精子抗原Sp17与IL-5融合蛋白的克隆表达及其免疫性避孕效研究
短句来源
     Positive cell-mediate immunological reaction to sperm antigen appeared at 3rd day after operation and anti-sperm antibody appeared at 15th day after operation,with an incidence of 60-80 % .
     术后3天开始出现精子抗原的细胞免疫阳性反应,术后15天后相继出现凝集抗体、制动抗体阳性反应,发生率为60~80%。
短句来源
     Positive agglutination reactions between the above anti-Samollena sera such as(O2, O4, O8, O10, O27, Vi sera and Hc, Hd, Hs, Hw, Hy, H7 sera) and human sperm antigen were found as well as a possitive immobilization reaction Vi antisera and human sperm antigen. Also cross agglutination reaction between rabbit anti-human sperm serum and Vi strain was demonstrated.
     结果沙门氏O_2、O_4、O_8、O_(10)、O_(27)、Vi以及Hc、Hd、Hs、Hw、Hy、H_7抗血清与人精子抗原呈凝集阳性反应,Vi抗血清与人精子呈制动阳性反应,也发现兔抗人精子血清与Vi菌株呈现凝集阳性反应。
短句来源
     Conclusion: Sp17 is an important sperm antigen. Anti-Sp17 antibodies in the serum can be taken as auxiliary diagnostic index of infertility,and Sp17 is shown to be a potential candidate immunocontraception vaccine.
     结论:Sp17是重要的精子抗原组分,血清中Sp17抗体的检测可作为不育患者辅助诊断指标,同时也提示Sp17可能是一种免疫避孕候选抗原疫苗。
短句来源
     Conclusions Recombinant strains X4632(pFEC) and X4550(pFEC) are worthy to be studied to serve as live vaccine delivery vehicle for sperm antigen.
     结论 X463 2 (pFEC)、X45 5 0 (pFEC)疫苗株可作为递呈精子抗原的活菌载体。
短句来源
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  sperm antigens
     Extraction and purification of protein M r 36 000 from Escherichia coli 506 strain that cross reacts with human sperm antigens
     与人精子抗原交叉的大肠埃希菌506株M_r36000蛋白的提取与纯化
短句来源
     The sperm antigens were examined using the method of ELISA and specific monoclonal antiboby against human sperm.
     本实验应用单克隆抗人精子抗体和酶标记羊抗人精子抗体,采用ELISA方法确定精子抗原成份的存在。
短句来源
     The inbred Balb/c and C 57 mice, and the outbred Swiss Webster mice were intragastrointestinally immunized with human sperm antigens. The lymphocytes from the spleen, mesenteric lymph node (MLN), Peyer's patch (PP) and uterus or epididymis were isolated and cultured.
     在Balb/c、C57和昆明鼠的消化道不同部位以人精子抗原免疫后,取其脾、肠系膜淋巴结、Peyer氏淋巴小结及子宫或附睾中的淋巴细胞进行培养。
短句来源
     135 sterilized men whose vas deferenses were injected with drug 4 months to 10 yearspreviously,and another 35 men vasectomized 10-20 years previously were examined fordetecting immune responses to human sperm antigens in the peripheral blood,by using theKibrick test,the Franklin-Dukes test,the Isojima test and the leucocyte adherence inhibitiontest(LAI test); while 29 normal fertile men were used as controls.
     本文用明胶凝集试验、试管—玻片凝集试验、精子制动试验和白细胞粘附抑制试验(LAI 试验)作为指标,对29名有生育力、135名输精管注射绝育后4个月—10年及35名输精管结扎后10—20年的男子,进行外周血精子抗原的免疫反应观察。
短句来源
     CELLULAR IMMUNITY OF SPERM ANTIGENS AS DETERMINED BY LEUCOCYTE ADHERENCE INHIBITION TEST (LAIT): AN ANALYSIS OF 335 CASES
     白细胞粘附抑制试验测定人精子抗原的细胞免疫反应(附335例报告)
短句来源
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  “精子抗原”译为未确定词的双语例句
     Design of an epitope peptide from sperm specific antigen and its immune effect
     多价精子抗原表位肽的设计与免疫效应研究
短句来源
     LEUCOCYTE MIGRATION INHIBITION TEST TO HUMAN SPERMATOZOAL ANTIGEN
     人精子抗原的白细胞移动抑制试验
短句来源
     Effect of the anti-sperm 51kD Antibody on Spermatozoa
     51kD精子抗原的抗体对精子的影响
短句来源
     Anti-spermatozoa Abs appeared earlier and the titer was higher when heterogenous animals were immunized.
     用精子抗原免疫异种动物,抗精子抗体产生早,效价高,而免疫同种动物则抗原性极弱;
短句来源
     Conclusions The live vaccine strains X4632(pCFL)and X4550(pCFL)are worthy to be studied as a contraceptive vaccine.
     结论 X4 6 32 (pCFL)、X4 5 5 0(pCFL)疫苗株的构建 ,为研究以cyritestin为靶抗原的精子抗原避孕疫苗打下了基础
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  sperm antigen
As a candidate protein for sperm-egg membrane fusion, the sperm antigen was investigated in the process of post-testicular maturation (PTM).
      
Sperm antigen expression during epididymal transit was examined in 4- to 16-week-old intact and castrated ICR mice, using the avidin-biotin complex (ABC) immunohistochemical method with monoclonal antibody T21 against a flagellar surface antigen.
      
We have detected an acrosomal sperm antigen, SAA-1, by monoclonal antibodies directed against SAA-1, that appears to be critically involved in the regulation of the acrosome reaction.
      
A second assay was developed to test the ability of sperm antigen to prevent the interaction between Abl and Ab2.
      
A second assay was developed to test the ability of soluble sperm antigen to prevent the interaction between Abi and Ab2.
      
更多          
  sperm antigens
Serological identification of sperm antigens specified by lethalt-alleles in the mouse
      
There is a strong body of evidence that in humans and in other species at least some antibodies that bind to sperm antigens can cause infertility.
      
Eight of the MAbs bind sperm antigens not common to eggs, though FS2, FS4, FS5 and FS9 bind antigens present on both sperm and eggs.
      
Cyto-immunological studies of guinea pig sperm antigens
      
In a survey of sperm antigens in the rat, a new intra-acrosomal antigen was found using a monoclonal antibody MC41 raised against rat epididymal spermatozoa.
      
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In a group of 20 males takiug Gossypol,the blood immunity to sperm antigen wasexamined by means of Kibrick test,Franklin-Duke test,Isojima test and Leucocyte adher-ence inhibiting test(LAIT)coutrasted with 31 male controls with normal fertility.Inthe normal male group,the first three humoral immunity tests gave no positive results,but LAIT showed a positive result of 9.7%.In the Gossypol-treated group,Kibrick testshowed a positive result of 5.2%, but both the Franklin-Duke test and Isojima test werenegative;LAIT...

In a group of 20 males takiug Gossypol,the blood immunity to sperm antigen wasexamined by means of Kibrick test,Franklin-Duke test,Isojima test and Leucocyte adher-ence inhibiting test(LAIT)coutrasted with 31 male controls with normal fertility.Inthe normal male group,the first three humoral immunity tests gave no positive results,but LAIT showed a positive result of 9.7%.In the Gossypol-treated group,Kibrick testshowed a positive result of 5.2%, but both the Franklin-Duke test and Isojima test werenegative;LAIT was positive in 10% of cases.From the above results,it is concluded that oral Gossypol is ineffective in inducing auto-immunity reaction to sperm antigen.

用明胶凝集试验、微量凝集试验、制动试验和白细胞粘附抑制试验对20例服用棉酚后的男性,进行精子抗原的血液免疫学检测,并与31例正常生育力男性对照。发现正常男子组三项体液免疫试验为阴性,而白细胞粘附抑制试验有9.7%阳性率。服棉酚组明胶凝集试验阳性率为5.2%,微量凝集试验和制动试验为阳性,白细胞粘附抑制试验的阳性率10%。本文认为服用棉酚后并不引起机体对精子抗原的自身免疫反应。

Cell-mediated immunity (CMI) to spermatoal antigen was studied in 79 men and women. The leukocyte adherence inhibition test (LAIT) in the presence of spermatozoal antigen (2×10~5ml) was taken as an index of CMI. The results were as follows: in a group of 15 unexplained infertile men, 11 showed a positive LAIT reaction; on the other hand, among 44 normal fertile men only 7 gave a positive reaction. Among female testees, 2 of the 10 virgins and all of the ten married women showed a positive reaction. It was found...

Cell-mediated immunity (CMI) to spermatoal antigen was studied in 79 men and women. The leukocyte adherence inhibition test (LAIT) in the presence of spermatozoal antigen (2×10~5ml) was taken as an index of CMI. The results were as follows: in a group of 15 unexplained infertile men, 11 showed a positive LAIT reaction; on the other hand, among 44 normal fertile men only 7 gave a positive reaction. Among female testees, 2 of the 10 virgins and all of the ten married women showed a positive reaction. It was found that the LAIT may be used as a method for the detection of CMI to spermatozoal antigen in the infertile men and for the evaluation of CMI of antifertile vaccines.

本文用白细胞粘附抑制试验(LAIT)对79名男女受试者作精子抗原(2×10~5/ml)的细胞免疫研究,发现15名不明原因的不育男子中,LAIT有11名阳性;44名正常有生育力的男子中7名阳性;10名处女中2名阳性;10已婚妇女全部阳性,通过上述情况的观察说明LAIT可用来测定不育男子对精子抗原的细胞免疫以及评价抗生育疫苗的细胞免疫。

135 sterilized men whose vas deferenses were injected with drug 4 months to 10 yearspreviously,and another 35 men vasectomized 10-20 years previously were examined fordetecting immune responses to human sperm antigens in the peripheral blood,by using theKibrick test,the Franklin-Dukes test,the Isojima test and the leucocyte adherence inhibitiontest(LAI test);while 29 normal fertile men were used as controls.The results were as fol-lows:In the normal fertile men,positivity was zero by all the three humoral immunologicaltest,but...

135 sterilized men whose vas deferenses were injected with drug 4 months to 10 yearspreviously,and another 35 men vasectomized 10-20 years previously were examined fordetecting immune responses to human sperm antigens in the peripheral blood,by using theKibrick test,the Franklin-Dukes test,the Isojima test and the leucocyte adherence inhibitiontest(LAI test);while 29 normal fertile men were used as controls.The results were as fol-lows:In the normal fertile men,positivity was zero by all the three humoral immunologicaltest,but 10.7% by the LAI test.During various periods after intravasal injection of the drug a considerable proportionof the sterilized men showed positive reaction in different degrees by all the four tests;incomparison with the normal fertile group,there were significant differences statistically.The peak incidences of sperm agglutinating and immobilizing antibodies occurred duringthe period from 6 months to 2 years after injection.Although the positive incidence bythe LAI test was also highest in this period,it was not significantly different from that ofother periods.The immobilizing antibody generally occurred together with the agglutin-in,and the incidences of sperm antibodies were correlated with the positive incidence bythe LAI test.In the post-vasectomy group,there also existed humoral and cellular immune responsesto sperm antigens,but the incidences of antibodies,especially immobilizing antibodies(2.9%),were lower than those of the post-injection group.There was no significant decline in posi-tive incidence by the LAI test.

本文用明胶凝集试验、试管—玻片凝集试验、精子制动试验和白细胞粘附抑制试验(LAI 试验)作为指标,对29名有生育力、135名输精管注射绝育后4个月—10年及35名输精管结扎后10—20年的男子,进行外周血精子抗原的免疫反应观察。结果:具有正常生育力的男子,三个体液免疫试验均为阴性,LAI 试验阳性率为10.7%。输精管注射绝育者,在绝育后不同时期,四个试验均有不同程度的阳性率,其中精子凝集抗体和制动抗体发生率的高峰在绝育后6个月—2年,LAI 试验的阳性率也在6个月—2年最高(但与其他各时期的阳性率差别不显著);制动抗体一般伴凝集抗体而产生。输精管结扎者,在结扎后10—20年,精子凝集抗体和制动抗体的检出率低于注射绝育后6~10年组,特别是制动抗体的发生率已相当低(2.9%);LAI 试验阳性率降低不显著。

 
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