助手标题  
全文文献 工具书 数字 学术定义 翻译助手 学术趋势 更多
查询帮助
意见反馈
   三维药效团 的翻译结果: 查询用时:0.016秒
图标索引 在分类学科中查询
所有学科
有机化工
更多类别查询

图标索引 历史查询
 

三维药效团
相关语句
  pharmacophore
     Pharmacophore Model Analysis of Medetomidine and its Analogs
     Medetomidine及其类似物的三维药效团模型研究
短句来源
     In this paper,the three dimensional pharmacophore model of two kinds of HCV NS3 serine protease inhibitors was obtained by using the CATALYST software.
     通过CATALYST软件包得到了两类HCVNS3丝氨酸蛋白酶抑制剂的三维药效团模型.
短句来源
     A common pharmacophore model was generated and regressed within the ensemble of 19 active compounds. The pharmacophore model shows great correlate coefficient (R = 0 958) and high forcast ability.
     本文对这一系列化合物进行了柔性的三维药效团分析 ,得到了一个预测能力很好的药效团模型 ,线性回归系数R =0 .958。
短句来源
     2)Established 3D pharmacophore model of NA inhibitors and searched con-formations in the target compound database;
     2)建立神经氨酸酶抑制剂三维药效团并对目标数据库进行构象搜索;
短句来源
     The three-dimensional pharmacophore construction method is one of the important subjects in the field of computer-aided drug design.
     三维药效团构建方法是信息技术在药物研究领域的重要内容之一。
短句来源
更多       
  three dimensional pharmacophore
     In this paper,the three dimensional pharmacophore model of two kinds of HCV NS3 serine protease inhibitors was obtained by using the CATALYST software.
     通过CATALYST软件包得到了两类HCVNS3丝氨酸蛋白酶抑制剂的三维药效团模型.
短句来源
  “三维药效团”译为未确定词的双语例句
     Study on the Methodology of Chinese Medicine Virtual Screening Based on Pharmacophores
     基于三维药效团的活血化瘀中药虚拟筛选方法学研究
短句来源
     The 3D Biophore Model of Sulfonylurea Herbicides Using APEX-3D Method
     磺酰脲类除草剂的三维药效团模型
短句来源
     Its study mainly aims to establish and improve TCM informatics database, develop knowledge discovery in database of Chinese medicine, examine TCM and complex system of human body using both linear and non-linear means, explore computerized simulation of TCM chemical information.
     基于中药信息学研究的要求,本论文主要开展了以下三个方面工作:1、中药化学成分数据库和三维药效团数据库的建立在原有数据库的基础上,用ChemOffice、ISIS/Base、Sybyl、Catalyst等系统或方法,对中药化学成分信息进行规范处理,用CatDB建立多构象数据,补充完善已有的《中药化学成分数据库》。
短句来源
     In this paper three-dimensional pharmcophore models of this series compound binding to α1 and α2 - adrenoceptor have been studied using Catalyst software. The correlate coefficient of the two modelds are 0.96 and 0.99 respectively and shows good predictive ability.
     本文用Catalyst软件包对这一系列的化合物进行了三维药效团模型研究,建立了与α1和α2-肾上腺素能受体结合的不同的药效团模型,2个模型的线性回归系数分别是0.96和0.99。
短句来源
     Conclusion This method can improve hit rate of lead compounds discovery and can be used to design novel EGFR inhibitors.
     结论 基于三维药效团模型进行药物分子的设计,可以减少后续工作的计算量,提高先导化合物的命中率,用于指导新型的酪氨酸激酶抑制剂的设计。
短句来源
查询“三维药效团”译词为用户自定义的双语例句

    我想查看译文中含有:的双语例句
例句
为了更好的帮助您理解掌握查询词或其译词在地道英语中的实际用法,我们为您准备了出自英文原文的大量英语例句,供您参考。
  pharmacophore
The 3D QSAR studies using Apex 3D expert system led to the identification of the pharmacophore in terms of common biophoric sites and secondary sites for interacting with PPARγ receptors.
      
The pharmacophore patterns of various drugs are identified.
      
Pharmacophore-based predictive model generation for potent antimalarials targeting haem detoxification pathway
      
Pharmacophore hypotheses were developed for molecules having antimalarial activities targeting the haem detoxification pathway of the malaria parasite.
      
In current work we are designing pharmacophore queries corresponding to loop domains 1 or 4 that incorporate features of the NGF crystal structure along with features derived from peptidomimetic structure-activity-relationships.
      
更多          


Receptor tyrosine kinases (RTKs) have been shown to play a crucial role in the cellular signal transduction pathways. The overexpress of RTKs caused cellular proliferation have close relationship with malignant tumor development. A novel molecule family selectively inhibit HER2 receptor, one of the PTKs, were found recently. Flexible pharmacophore research was performed on this group of tyrophostins in this study. A common pharmacophore model was generated and regressed within the ensemble of 19 active compounds....

Receptor tyrosine kinases (RTKs) have been shown to play a crucial role in the cellular signal transduction pathways. The overexpress of RTKs caused cellular proliferation have close relationship with malignant tumor development. A novel molecule family selectively inhibit HER2 receptor, one of the PTKs, were found recently. Flexible pharmacophore research was performed on this group of tyrophostins in this study. A common pharmacophore model was generated and regressed within the ensemble of 19 active compounds. The pharmacophore model shows great correlate coefficient (R = 0 958) and high forcast ability. The model proved to correctly represent the 3D factors affect the tyrphostins' biological activity.

对受体酪氨酸激酶 (RTK)的药物抑制对控制恶性肿瘤具有重要意义。最近发现的苄叉丙二腈化合物家族对RTK中的HER2受体具有较强的抑制作用。本文对这一系列化合物进行了柔性的三维药效团分析 ,得到了一个预测能力很好的药效团模型 ,线性回归系数R =0 .958。这个模型对于研究此类化合物的结构与活性关系 ,以及评估此类未知化合物活性具有重要作用。

In this paper,the three dimensional pharmacophore model of two kinds of HCV NS3 serine protease inhibitors was obtained by using the CATALYST software.Although these two kinds of inhibitors possess quite different structures,yet a common pharmacophore model with very good statistical results can be determined.The results uncover that these two kinds of molecules will take the similar pattern when they interact with the receptor.Based on the pharmacophore model,a 3D QSAR analysis was performed and the model...

In this paper,the three dimensional pharmacophore model of two kinds of HCV NS3 serine protease inhibitors was obtained by using the CATALYST software.Although these two kinds of inhibitors possess quite different structures,yet a common pharmacophore model with very good statistical results can be determined.The results uncover that these two kinds of molecules will take the similar pattern when they interact with the receptor.Based on the pharmacophore model,a 3D QSAR analysis was performed and the model showed good predictive ability (correlation coefficient R=0.89).

通过CATALYST软件包得到了两类HCVNS3丝氨酸蛋白酶抑制剂的三维药效团模型.尽管这两类抑制剂具有完全不同的骨架结构,但得到的药效团却具有共同的特性.这表明当这两类抑制剂和受体发生相互作用时,可能采用了相似的结合模式.根据药效团模型,进行了三维构效关系的研究.结果表明 ,得到的药效团模型具有很好的预测能力 (线性回归系数R=0.89).

Without the crystal structure of the target enzyme, a common pharmacophore model of five kinds of protoporphyrinogen oxidase (Ptotox) inhibitors which chemical structures are different was obtained by using constrained systematic search method. This model has important significance not only in researching the interrelation mechanism between varied Protox inhibitors and Protox on molecular level, but also in guiding to design and synthesize new and high-effective Ptotox inhibitors.

在靶酶三维结构未知的条件下,采用限制性系统搜索方法(Constrained Systematic Search),对5类典型的原叶琳原氧化酶(Protox)抑制剂的三维药效团进行了研究,发现这些抑制剂共同的活性部位可能是2个疏水中心和一个氢键接受体,得到的药效团模型对在分子和原子水平探讨不同结构类型的原卟啉原氧化酶抑制剂与靶酶相互作用的共同机制,指导新型抑制剂的设计与合成等方面具有重要的理论指导意义和潜在的实际应用价值。

 
<< 更多相关文摘    
图标索引 相关查询

 


 
CNKI小工具
在英文学术搜索中查有关三维药效团的内容
在知识搜索中查有关三维药效团的内容
在数字搜索中查有关三维药效团的内容
在概念知识元中查有关三维药效团的内容
在学术趋势中查有关三维药效团的内容
 
 

CNKI主页设CNKI翻译助手为主页 | 收藏CNKI翻译助手 | 广告服务 | 英文学术搜索
版权图标  2008 CNKI-中国知网
京ICP证040431号 互联网出版许可证 新出网证(京)字008号
北京市公安局海淀分局 备案号:110 1081725
版权图标 2008中国知网(cnki) 中国学术期刊(光盘版)电子杂志社