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     Explore the Role of the Administration Manner Based on Pharmacokinetics Evidence in New TCM Drug Discovery
     中药新药前列栓给药途径选择的药动学依据
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     Objective:To create a quantitative analysis method of RP-HPLC to determine the serum concentration of berberine from QLS in rabbits.
     目的 :建立前列栓中小檗碱兔血清药物浓度的反相高效液相色谱定量分析方法。
短句来源
     (2) The pharmacokinetics evidence to establish the rectal administration and certain suppository for QLS.
     研究为前列栓的经肛门途径给药和栓剂剂型的确立 ,提供了药代动力学依据
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     Conclusion The combined use of Shulie granule and Qianlie Anshuan can effectively improve the clinical effects in the treatment of chroni prostatitis.
     结论舒列颗粒联合前列栓能提高慢性前列腺炎的临床疗效。
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  相似匹配句对
     Preparation and quality control of hollow suppository used for treating prostatitis
     前列中空的制备及质量控制
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     Study on the quality standard for Niuhuang Qianlieqing suppositories
     牛黄前列质量标准的研究
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     Chemoprevention of Prostate Cancer
     前列腺癌的化学预防
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     Radiotherapy for Prostate Cancer
     前列腺癌放射治疗
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     Preparation of dipyridamole suppository
     双嘧达莫的研制
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Objective:To create a quantitative analysis method of RP-HPLC to determine the serum concentration of berberine from QLS in rabbits.Methods:The conditions of chromatography:stationary phase:Platinum EPS column (C8 100A 3μ,150mm×4.6mm),mobile phase:acetonitrile~1/12N phosphate buffer solution(70∶30,v/v),flow rate:0.8ml·min -1,detection wavelength was 345 nm,temperature of column was 40℃,external standard method was quantitative analysis method.Results:The linear relationship of serum concentration of berberine...

Objective:To create a quantitative analysis method of RP-HPLC to determine the serum concentration of berberine from QLS in rabbits.Methods:The conditions of chromatography:stationary phase:Platinum EPS column (C8 100A 3μ,150mm×4.6mm),mobile phase:acetonitrile~1/12N phosphate buffer solution(70∶30,v/v),flow rate:0.8ml·min -1,detection wavelength was 345 nm,temperature of column was 40℃,external standard method was quantitative analysis method.Results:The linear relationship of serum concentration of berberine was shown well in the range of 0.72μg·L -1~578.98μg·L -1,the detectability was 0.36μg·L -1,recovery ratio was(96.06±4.74)%,degree of precision of within the day and among the day were 1.16%~2.18%、0.99%~3.04% respectively.Conclusion:This method was shown with good accuracy、good sensitivity and good specificity,can provide a valuable method for serum concentration detection of berberine.

目的 :建立前列栓中小檗碱兔血清药物浓度的反相高效液相色谱定量分析方法。方法 :色谱条件为 :固定相 :PlatinumEPS柱 (C810 0A 3μ ,15 0mm× 4 6mm) ,流动相 :乙腈~ 1 12N磷酸盐缓冲液 ( 70∶30 ,v v) ,流速 :0 8ml·min- 1 ,检测波长 345nm ,柱温40℃ ,外标法为定量测定法。结果 :血清小檗碱浓度在 0 72 μg·L- 1 ~ 5 78 98μg·L- 1 的范围内线性关系良好 ,检测限 0 36 μg·L- 1 ,回收率 ( 96 0 6± 4 74) % ,日内、日间精密度为 1 16 %~ 2 18%、0 99%~ 3 0 4%。结论 :本法准确性、灵敏度、专一性高 ,可为小檗碱的体内血清药物浓度分析提供有意义的方法学参考。

In order to explore the role of the route of administration based on pharmacokinetics evidence in new TCM drug Qianlieshuan (QLS) discovery. The authors use the methods as follow: the main component berberine containing in QLS in serum was detected by RP HPLC with UV detector, and the pharmacokinetics apparent parameters were compared between oral and rectal administration and were calculated by the 3P97 Pharmacokinetics Software.The results were: (1) In rectal administration, the models of pharmacokinetics...

In order to explore the role of the route of administration based on pharmacokinetics evidence in new TCM drug Qianlieshuan (QLS) discovery. The authors use the methods as follow: the main component berberine containing in QLS in serum was detected by RP HPLC with UV detector, and the pharmacokinetics apparent parameters were compared between oral and rectal administration and were calculated by the 3P97 Pharmacokinetics Software.The results were: (1) In rectal administration, the models of pharmacokinetics of berberine were one compartment open model in most rabbits, two compartments model in few rabbits, exceptional one can only fitted with statistics moment. One compartment model parameters: t 1/2 K e =(96 2±37 8)?min, c max =(178 9±88 9)?μg·L -1 , AUC=(47?917 4±23?255 6)?μg·L -1 ·min. (2) In oral administration, the plasma concentrations of berberine in most of the rabbits were under the detectability, only in two rabbits were detected and composed entire concentration time curves and could be fitted with one compartment model, the parameters were as follow: t 1/2 K e =(573 4±212 2)?min, c max =(7 0±2 5)?μg·L -1 , AUC=(7?725 2±4?764 6)?μg·L -1 ·min. The relative bioavailability of powder form by oral administration when compared with suppository by rectal administration was only 26 07% and 6.18%, respectively. (3) Prostatic tissue concentration of berberine could be detected in 1 2?h administered by rectal in some rabbits, but couldn't be detected when given by oral. There was significant difference between the two groups. Above mentioned results were shown that: (1) More advantages by rectal administration than administration by oral: rapid absorption, higher plasma concentration, longer efficient plasma concentration steady state, higher concentration of berberine in target organ which is prostate.(2) The pharmacokinetics evidence to establish the rectal administration and certain suppository for QLS.

采用RP HPLC法 ,比较研究前列栓经口和经肛门给药的药动学差异。结果表明 :(1 )经肛门途径用药 ,小檗碱在多数兔体内为一室开放模型 ,少数呈现为二房室模型 ,个别只能用统计矩拟合 ,其中一房室模型药代参数为t1 2 Ke=(96 2± 37 8)min ,cmax=(1 78 9± 88 9) μg·L-1 ,AUC =(4 791 7 4± 2 32 5 5 6 ) μg·L-1 ·min ;(2 )经灌胃途径给药 ,多数兔血药浓度在检测限以下 ,仅有 2只能测到完整曲线 ,可用一房室模型拟合 ,药代参数为t1 2 Ke=(5 73 4± 2 1 2 2 )min ,cmax=(7 0± 2 5 )μg·L-1 ,AUC =(772 5 2± 4 76 4 6 ) μg·L-1 ·min ,灌胃与肛塞相比的相对生物利用度仅为 2 6 0 7%和6 1 8% ;(3)前列腺组织药物浓度 ,经肛塞途径能测到部分 1~ 2h时间点的小檗碱浓度 ,但不足以构成可分析的浓度 时间曲线 ,而灌胃途径则根本无法测到小檗碱浓度 ,两组间差异极显著。经肛塞给药有以下优点 :吸收速度快、...

采用RP HPLC法 ,比较研究前列栓经口和经肛门给药的药动学差异。结果表明 :(1 )经肛门途径用药 ,小檗碱在多数兔体内为一室开放模型 ,少数呈现为二房室模型 ,个别只能用统计矩拟合 ,其中一房室模型药代参数为t1 2 Ke=(96 2± 37 8)min ,cmax=(1 78 9± 88 9) μg·L-1 ,AUC =(4 791 7 4± 2 32 5 5 6 ) μg·L-1 ·min ;(2 )经灌胃途径给药 ,多数兔血药浓度在检测限以下 ,仅有 2只能测到完整曲线 ,可用一房室模型拟合 ,药代参数为t1 2 Ke=(5 73 4± 2 1 2 2 )min ,cmax=(7 0± 2 5 )μg·L-1 ,AUC =(772 5 2± 4 76 4 6 ) μg·L-1 ·min ,灌胃与肛塞相比的相对生物利用度仅为 2 6 0 7%和6 1 8% ;(3)前列腺组织药物浓度 ,经肛塞途径能测到部分 1~ 2h时间点的小檗碱浓度 ,但不足以构成可分析的浓度 时间曲线 ,而灌胃途径则根本无法测到小檗碱浓度 ,两组间差异极显著。经肛塞给药有以下优点 :吸收速度快、血药浓度高、血药有效浓度维持时间长、靶器官前列腺组织内药物浓度相对较高 ,且药动学参数随兔不同而有较大的差异。研究为前列栓的经肛门途径给药和栓剂剂型的确立 ,提供了药代动力学依据

Objective To observe the clinical effects of Shulie granule combined with Qianlie Anshuan in the treatment of chronic prostatitis.Method 71 patient in the treatment group are treated with Shulie granule combined with Qianlie Anshuan,and 35 patients in the control group are treated with Qianlie Anshuan only.The clinical manifestations score and EPS-WBC are studied before and after treatment.Result The group treated by combine use of Shulie granule and Qianlie Anshuan is obviously better than the group treated...

Objective To observe the clinical effects of Shulie granule combined with Qianlie Anshuan in the treatment of chronic prostatitis.Method 71 patient in the treatment group are treated with Shulie granule combined with Qianlie Anshuan,and 35 patients in the control group are treated with Qianlie Anshuan only.The clinical manifestations score and EPS-WBC are studied before and after treatment.Result The group treated by combine use of Shulie granule and Qianlie Anshuan is obviously better than the group treated soely by Qianlie Anshuan in curative effects,manifestations score and EPS-WBC.Conclusion The combined use of Shulie granule and Qianlie Anshuan can effectively improve the clinical effects in the treatment of chroni prostatitis.

目的观察舒列颗粒冲服联合前列安栓局部纳肛治疗慢性前列腺炎的临床疗效。方法治疗组71例用舒列颗粒冲服联合前列安栓局部纳肛治疗,对照组35例单纯应用前列安栓局部纳肛治疗,观察2组治疗前后临床症状评分及前列腺按摩液白细胞计数(EPSWBC)评价疗效。结果治疗组总有效率87.86%,对照组为67.65%,2组比较有显著性差异(P<0.05)。EPSWBC恢复正常率优于对照组,且能明显改善症状。结论舒列颗粒联合前列栓能提高慢性前列腺炎的临床疗效。

 
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