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血浆稳定性
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  plasma stability
     Objective:To study the in vitro release,plasma stability and in vivo pharmacokinetics of monoammonium glycyrrhizinate liposome.
     目的:研究甘草酸单铵脂质体体外释放、血浆稳定性及体内药动学性质。
短句来源
  “血浆稳定性”译为未确定词的双语例句
     Stability of Synthetic Exendin-4 in Human Plasma in Vitro
     合成Exendin-4的体外人血浆稳定性研究
短句来源
     Conclusion: The analytical method has a relatively good sensitivity and reproducibility and it can provide important reference to the preclinical and clinical pharmacokinetic studies.
     结论:本方法准确,灵敏度较高,重复性好,适于对阿德福韦酯结构类似物进行体外血浆稳定性评估筛选,并可为临床前/临床药代研究提供重要的方法学参考。
短句来源
     Methods: Permeable membrane method was adopted to study the in vitro release, RP-HPLC method was adopted to study the in vivo pharmacokinetics of monoammonium glycyrrhizinate and its liposome using progesterone as internal standard. The pharma-cokinetic parameters were calculated by 3P87 program.
     方法:采用透析膜扩散法考察甘草酸单铵脂质体体外释放和血浆稳定性,应用RP-HPLC法,以黄体酮为内标,考察甘草酸单铵及其脂质体静脉注射后的药动学行为,应用3P87软件计算药动学参数。
短句来源
     In recent years, great progress has been made through the development of novel chemically modified nucleotides with improved properties, such as enhanced serum stability, higher target affinity and low toxicity, in the research of antisense oligonucleotides and nucleic acid catalysts.
     近年核苷酸化学修饰方面取得了很大进展。 经恰当修饰的反义寡核苷酸和核酸催化剂可以提高其血浆稳定性和靶向亲和性,并且降低其细胞毒性。
短句来源
     METHODS The particles size, Zeta potential, haemolyticus, and sedimentation stability were evaluated. Entrapment efficiency and the stability of liposomes in human plasma were determined by reverse dialysis method, and the shape of these nanoliposomes was observed by transmission electron microscopy.
     方法 考察处方的粒径分布、Zeta电位、溶血性、沉降稳定性,用反透析法测其包封率、脂质体的血浆稳定性,观察其基本形态。
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  相似匹配句对
     C kstability ;
     C k稳定性;
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     Plasma level of myeloperoxidase is not elevated in patients with stable angina pectoris
     冠心病稳定性心绞痛患者血浆髓过氧化物酶的变化
短句来源
     Study on Stability of Hepatitis C Virus RNA in Plasma
     血浆丙型肝炎病毒核酸稳定性的研究
短句来源
     3. the stability.
     3.稳定性
短句来源
     plasma;
     血浆游离DNA ;
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  plasma stability
Variational approaches to the problems of plasma stability and of nonlinear plasma dynamics
      
Effect of helical magnetic fields on plasma stability in tokamaks
      
The model is used to predict how the stray magnetic fields will influence plasma stability in a tokamak reactor (ITER).
      
The effect of the vacuum chamber's shape on the plasma stability is studied.
      
MHD plasma stability in alternative toroidal systems and the local dispersion relation
      
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  stability in plasma
Frequency stability in plasma relativistic microwave oscillators
      
The ICP-MS method, which measured total Gd, was used in conjunction with LC methods to assess MGd stability in plasma.
      
In conclusion, HMPAO produces higher labelling efficiency and the label shows greater in vitro stability in plasma.
      
The specific enzyme activities of agalsidase alfa and agalsidase beta were 1.70 and 3.24?mmol?h-1?mg protein-1, respectively, and there was no difference in stability in plasma between them.
      
N3S-RGDS-derivative peptide (SMA1) showed more stable coordination binding with 99mTc and a higher stability in plasma with regard to N4-RGDS-derivative peptide (F22).
      
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  stability in human plasma
The in vitro stability in human plasma of two different technetium-99m-fibrinogen compounds
      


Objective:To study the in vitro release,plasma stability and in vivo pharmacokinetics of monoammonium glycyrrhizinate liposome. Methods: Permeable membrane method was adopted to study the in vitro release, RP-HPLC method was adopted to study the in vivo pharmacokinetics of monoammonium glycyrrhizinate and its liposome using progesterone as internal standard. The pharma-cokinetic parameters were calculated by 3P87 program. Results: The in vitro release of the liposome was conformed to Higuchi equation and human...

Objective:To study the in vitro release,plasma stability and in vivo pharmacokinetics of monoammonium glycyrrhizinate liposome. Methods: Permeable membrane method was adopted to study the in vitro release, RP-HPLC method was adopted to study the in vivo pharmacokinetics of monoammonium glycyrrhizinate and its liposome using progesterone as internal standard. The pharma-cokinetic parameters were calculated by 3P87 program. Results: The in vitro release of the liposome was conformed to Higuchi equation and human plasma had obvious effect on its leakage. The pharma-cokinetic behavior of monoammonium glycyrrhizinate and its liposome were conformed to two compartment open model. In comparison with monoammonium glycyrrhizinate, the liposome's AUC was increased by 25.1 % and the liposome's Cl (clearance rate) decreased by 20.6% . Conclusion: Although monoammonium glycyrrhizinate liposome is instable in human plasma but after intravenous administration its phamarcokinetic behavior is improved in comparison with monoammonium glycyrrhizinate.

目的:研究甘草酸单铵脂质体体外释放、血浆稳定性及体内药动学性质。方法:采用透析膜扩散法考察甘草酸单铵脂质体体外释放和血浆稳定性,应用RP-HPLC法,以黄体酮为内标,考察甘草酸单铵及其脂质体静脉注射后的药动学行为,应用3P87软件计算药动学参数。结果:甘草酸单铵脂质体体外释放符合Higuchi方程,与人空白血浆混合后脂质体发生明显泄漏。静注给药后,甘草酸单铵及其脂质体的药动学行为均符合二房室开放模型,与甘草酸单铵相比,其脂质体的AUC上升了25.1%,清除率下降了20.6%。结论:甘草酸单铵脂质体在人空白血浆中泄漏增加,其静注给药后的药动学性质与甘草酸单铵相比有所改善。

In recent years, great progress has been made through the development of novel chemically modified nucleotides with improved properties, such as enhanced serum stability, higher target affinity and low toxicity, in the research of antisense oligonucleotides and nucleic acid catalysts. Nucleic acid catalysts are a novel tool in molecular biology, but its stability and activity in vivo need to be further improved. In this article, we review the latest advances in researches of the effects of chemically modified...

In recent years, great progress has been made through the development of novel chemically modified nucleotides with improved properties, such as enhanced serum stability, higher target affinity and low toxicity, in the research of antisense oligonucleotides and nucleic acid catalysts. Nucleic acid catalysts are a novel tool in molecular biology, but its stability and activity in vivo need to be further improved. In this article, we review the latest advances in researches of the effects of chemically modified nucleotides on antisense oligonucleotides and nucleic acid catalysts.

近年核苷酸化学修饰方面取得了很大进展。经恰当修饰的反义寡核苷酸和核酸催化剂可以提高其血浆稳定性和靶向亲和性,并且降低其细胞毒性。核酸催化剂是一类崭新的分子生物学工具,其生物学活性及体内稳定性有待于进一步提高。文章对近年最有应用前景的核苷酸化学修饰在反义寡核苷酸及核酸催化剂中的研究进展进行综述。

OBJECTIVE To study the properties of nimodipine nanoliposomes and to establish the quality evaluation methods. METHODS The particles size, Zeta potential, haemolyticus, and sedimentation stability were evaluated. Entrapment efficiency and the stability of liposomes in human plasma were determined by reverse dialysis method, and the shape of these nanoliposomes was observed by transmission electron microscopy. RESULTS The mean particle size of these nanoliposomes was 24.8 nm with the polydispersity index of 0.326....

OBJECTIVE To study the properties of nimodipine nanoliposomes and to establish the quality evaluation methods. METHODS The particles size, Zeta potential, haemolyticus, and sedimentation stability were evaluated. Entrapment efficiency and the stability of liposomes in human plasma were determined by reverse dialysis method, and the shape of these nanoliposomes was observed by transmission electron microscopy. RESULTS The mean particle size of these nanoliposomes was 24.8 nm with the polydispersity index of 0.326. The entrapment efficiency reached 86.1% . The liposomes were stable for 1 hour in human plasma. CONCLUSION The methods above were suitable for the quality evaluation of nimodipine nanoliposomes freeze-dried powder, and can effectively demonstrate its properties.

目的 研究尼莫地平纳米脂质体冻干粉的性质,建立其质量评价方法。方法 考察处方的粒径分布、Zeta电位、溶血性、沉降稳定性,用反透析法测其包封率、脂质体的血浆稳定性,观察其基本形态。结果 尼莫地平纳米脂质体的平均粒径为24.8 m,多分散系数为0.326,包封率为86.1%,体外稳定性好,人血浆稳定期约为1 h。结论 上述方法适用于尼莫地平纳米脂质体冻干粉的质量评价,可有效地反映其各方面的性质。

 
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