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尿中代谢物
相关语句
  urinary metabolites
     Most of the urinary metabolites of benzene and unmetabolized benzene in urine have been extensively investigated as biological markers of exposure to benzene.
     苯大部分尿中代谢物和尿中原形苯被作为苯暴露的生物标志物而被广泛研究。
短句来源
     The biomarkers of recent exposure were urinary metabolites (measuring responses up to hours after exposure), Including phenol, catechol, hydroquinone, benzenetriol, S-phenylmercapturic acid , trans,trans-Muconic Acid and adducts of blood proteins(days to weeks after exposure) which including benzene axide and benzoquinone adducts of albumin.
     短期苯暴露的生物标志物主要是苯尿中代谢物(暴露几小时后),包括苯酚、儿茶酚、氢醌、苯三酚、苯巯基尿酸和反反式粘糠酸; 血蛋白加合物(暴露几天或几周后),包括氧化苯和血白蛋白内加合物苯醌。
短句来源
  metabolite in urine
     Study on Correlation between Chromosome Aberration and Metabolite in Urine of Styrene Exposed Workers
     苯乙烯作业工人染色体畸变率与尿中代谢物相关性研究
短句来源
  “尿中代谢物”译为未确定词的双语例句
     The metabolites were analyzed by HPTLC and GC-MS.
     采用高效薄层色谱法(HPTLC)及气相色谱-质谱法(GC-MS)分析大鼠尿中代谢物
短句来源
     METHODS The metabolite of cetirizine in human urine after an oral dose of 20 mg cetirizine dihydrochloride to two healthy subjects were separated and identified with high-performance liquid chromatography/electrospray ion trap mass spectrometry (HPLC-ESI/MS~ n ).
     方法:本试验采用高效液相色谱-电喷雾离子阱质谱(ESI/MSn,electro-spray ion trap mass spectrometry)联用技术对2名中国健康志愿受试者口服20mg盐酸西替利嗪胶囊后尿中代谢物进行了初步鉴定。
短句来源
     Study on the Metabolites of Urine in Workers Exposed to Mixed Benzene
     混苯接触工人尿中代谢物的实验研究
短句来源
     Study on Mass Spectrometry of Griseofulvin and Its Metabolit in Rabbit Urine
     灰黄霉素及其在兔尿中代谢物的质谱研究
短句来源
     STUDY ON THE METABOLITES OF GUANFU BASE A HYDROCHLORIDE IN RAT URINE BY HIGH PERFORMANCE LIQUID CHROMATOGRAPH-MASS SPECTRUM
     高效液相-质谱联用法对盐酸关附甲素在大鼠尿中代谢物的研究
短句来源
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  相似匹配句对
     Detection of Methadone and Its Main Metabolite in Urine
     尿美沙酮及代谢物的检测
     Determination of the Metabolite of Heroin in Urine
     尿海洛因代谢物的检验
短句来源
     study on Metabolite of Dihydrotestosteron by GC/MSD
     尿双氢睾酮代谢物的质谱研究
短句来源
     Three metabolites were found in urine.
     在尿发现有3种代谢物
短句来源
     ANALYSIS OF TRAMADOL AND ITS METABOLITES IN HUMAN URINE
     人尿曲马多及其代谢物的分析
短句来源
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  urinary metabolite
Four recent studies with simultaneous application of trideutero-RRR and hexadeutero-all-rac resulted in ratios of up to 2 for plasma, and of ≈ 2.7 and ≈ 3.4 for α-CEHC (a urinary metabolite) and umbilical cord plasma, respectively.
      
Morphine-3-glucuronide (M3G), the major urinary metabolite of heroin and morphine, competed effectively with FL-MOR in a concentration-dependent manner for binding to the antimorphine MAb and was therefore used to construct the calibration curve.
      
In conscious PB-induced rats receiving nicotine orally or intravenously, 3'-hydroxycotinine was found as the main urinary metabolite of nicotine while only a small fraction was excreted as cotinine-N-oxide.
      
The metabolism of 4-aminobiphenyl by isolated hepatocytes from various species was compared with urinary metabolite profiles in the same species.
      
N-ccetyl-S-(1-cyano-2-hydroxyethyl)-l-cysteine, a new urinary metabolite of acrylonitrile and oxiranecarbonitrile
      
更多          
  urinary metabolites
However, most of NMR resonances for urinary metabolites remain to be fully assigned.
      
The novel approach proved to be quite suitable for screening urinary metabolites, without a necessity to preisolate the compounds and to evaporate to dryness.
      
Detection and Identification of Dizocilpine and its Major Urinary Metabolites in the Horse: A Preliminary Report
      
We now report development of a sensitive method for the detection of dizocilpine and preliminary characterization of its urinary metabolites in the horse.
      
The results show that Blue Chitin columns provide a straightforward and rapid means of extracting heterocyclic amines from urine samples, and that Blue Chitin column are also useful in the purification of urinary metabolites.
      
更多          
  metabolite in urine
Although the hLHβcf used to develop specific antibodies was purified from pituitaries, the assays developed recognize this metabolite in urine.
      
The new measuring systems allow the precise quantitation of this hLH metabolite in urine.
      
Using gas chromatography-mass spectrometry the occurrence of 4,5-dihydroxy-2-hexanone as ann-hexane metabolite in urine of man was confirmed after exposure of a male volunteer to a mean of 217 ppmn-hexane for 4 h (laboratory exposure).
      
While the major metabolite in serum was MEHP, the major metabolite in urine was 5OH-MEHP, followed by 5oxo-MEHP and MEHP.
      
Trans-3'-hydroxycotinine as a main metabolite in urine of smokers
      
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In a previous communication,we have reported the physiological disposition of N-C~(14)-formylsarcolysine.In as much as the tracer technic does not distinguish the unchanged drug from its metabolite(s),a highly specific method is developed for the determination of N-formylsarcolysine in biological samples. One ml of sample (whole blood,tissue homogenate (1:5),urine (1:1),bile and feces (1:10)) was pipetted into a centrifuge tube containing 20-40 mg of sodium bicarbonate and well shaken until dissolved.To the...

In a previous communication,we have reported the physiological disposition of N-C~(14)-formylsarcolysine.In as much as the tracer technic does not distinguish the unchanged drug from its metabolite(s),a highly specific method is developed for the determination of N-formylsarcolysine in biological samples. One ml of sample (whole blood,tissue homogenate (1:5),urine (1:1),bile and feces (1:10)) was pipetted into a centrifuge tube containing 20-40 mg of sodium bicarbonate and well shaken until dissolved.To the alkaline sample,10 ml of absolute alcohol was added to precipitate protein.The protein-free supernatant was evaporated to dryness under reduced pressure.The residue was dissolved in 5 ml of 0.1 M acetate buffer (pH 3.6) and extracted three times with 5 ml volumes of ethyl acetate.The pooled extract was again evaporated to dryness.The residue was dissolved in 5 ml of absolute alcohol and the light absorptions measured at 240,258 and 280 mμ.Since the absorption curve obtained from biological specimens is the additive effect of the absorption due to the blank specimen (which is essentially a straight line between 240 and 280 mμ,fig.1,Ⅲ) plus the actual N-formylsarcolysine curve,it is evident that the peak absorption at 258 mμ cannot be used as a measurement of drug concentra- tion without subtracting an unknown fraction contributed by the blank specimen.Based on the absorption spectrum of N-formylsarcolysine (fig.1,I),points A,B and C represent the optical densities at 258 (maximum absorption),240 and 280 mμ res- pectively.When a line was drawn from A perpendicular to the abscissa and crosses BC at D,the distance between A and D was found to be proportional to the quantity of N-formylsarcolysine in the sample.Interference by blank materials may thus be elimi- nated.The magnitude of D may also be calculated according to the equation: D=0.55B+0.45C. This method was shown to be very sensitive and highly specific. Five hours after an oral dose of N-formylsarcolysine (200 mg/kg) to normal rats, about 7.9% of the dose could be recovered from the gastrointestinal tract as unchanged drug.Since in vitro experiments showed that N-formylsarcolysine was rapidly meta- bolized to compounds not determined by this method,the disappearance of N-formyl- sarcolysine from the gastrointestinal tract does not reflect the actual absorption of the drug. When injected intravenously to rats and rabbits,N-formylsarcolysine disappeared rapidly from the blood with a biological half life of 12-15 minutes.In normal rats, about 23.8% of the administered dose was excreted in the urine in five hours.During the same period,the urinary excretion by rabbits was about 12.5%.In rats with a biliary cannula,as much as 12.4% of an intravenously injected dose could be reco- vered from the bile in five hours. One hour after N-formylsarcolysine (100 mg/kg) was given intravenously to normal rats or rats bearing Yoshida solid carcinoma,appreciable concentration was found in the kidneys,relatively low concentrations were present in the liver,while only trace amounts were present in the tumour and other tissues examined. When a dose of 300 mg of N-formylsarcolysine was given orally to patients suffer- ing from seminoma of the testis,very low concentrations of unchanged drug were found in the blood.About 7.1% of the administered dose was excreted in the urine. The hydroxy form of N-formylsarcolysine was shown to be the main metabolite in rats as well as in patients.

本文报告用分光光度计,采用三波长法在生物样品(血、尿、组织、胆汁及粪等)中测定N-甲酰溶肉瘤素(简称 N-甲)的方法;并用此法观察了 N-甲在动物及人体内的吸收、分布及排泄。本法特异性高,灵敏度为0.10 O.D.相当于样品中含 N-甲11.5微克。大鼠口服 N-甲200毫克/公斤后5小时,由胃肠道内容物可回收剂量的7.9%,而在所排出的粪中并无可测定的药物存在。体外实验证明 N-甲在胃肠道内容物的代谢很快。可见,药物由胃肠道消失的速度并不能反映其自胃肠道吸收的情况。静脉注射后,N-甲在大鼠及家兔的血中消失很快。其在血中的生物半衰期大鼠为12分钟,家兔为15分钟。给正常或肿瘤大鼠静脉注射 N-甲100毫克/公斤后1小时,药物含量以肾脏最高,肝次之,脾、肺、心等组织仅含痕迹量。肿瘤组织的药物含量亦很低。大鼠静脉注射 N-甲100毫克/公斤后5小时,由尿可回收剂量的23.8%,其中96.3%为前两小时所排出。由胆汁亦可回收剂量的12.4%。家兔静脉注射 N-甲50毫克/公斤后,12小时内可自尿排出剂量的12.5%,其中92.6%为前两小时所排出。成年男性肿瘤患者一次口服 N-甲300毫克后5小时内,血中的药物浓度...

本文报告用分光光度计,采用三波长法在生物样品(血、尿、组织、胆汁及粪等)中测定N-甲酰溶肉瘤素(简称 N-甲)的方法;并用此法观察了 N-甲在动物及人体内的吸收、分布及排泄。本法特异性高,灵敏度为0.10 O.D.相当于样品中含 N-甲11.5微克。大鼠口服 N-甲200毫克/公斤后5小时,由胃肠道内容物可回收剂量的7.9%,而在所排出的粪中并无可测定的药物存在。体外实验证明 N-甲在胃肠道内容物的代谢很快。可见,药物由胃肠道消失的速度并不能反映其自胃肠道吸收的情况。静脉注射后,N-甲在大鼠及家兔的血中消失很快。其在血中的生物半衰期大鼠为12分钟,家兔为15分钟。给正常或肿瘤大鼠静脉注射 N-甲100毫克/公斤后1小时,药物含量以肾脏最高,肝次之,脾、肺、心等组织仅含痕迹量。肿瘤组织的药物含量亦很低。大鼠静脉注射 N-甲100毫克/公斤后5小时,由尿可回收剂量的23.8%,其中96.3%为前两小时所排出。由胆汁亦可回收剂量的12.4%。家兔静脉注射 N-甲50毫克/公斤后,12小时内可自尿排出剂量的12.5%,其中92.6%为前两小时所排出。成年男性肿瘤患者一次口服 N-甲300毫克后5小时内,血中的药物浓度很低,但给药后12小时内可自尿排出剂量的7.1%,其中82.6%为前两小时所排出。用纸层离法证明,大鼠及肿瘤病人口服 N-甲后尿中的代谢物主要为羟基水解产物

Effects of exposure to pyrethroids combi-ned with methamidophos were studied in 524spraymen and compared with that of 1480 far-mers spraying only pyrethroids. The resultsshowed neither significant difference in theprevalence of adverse effects and acute intoxi-cation between two groups, nor inhibition ofblood cholinesterase in spraymen with combi-ned exposures. However, there was a tenden-cy of increase of urinary deltamethrin or fen-valerate in the combined exposedegroups wi-thout an increase of deltamethrin...

Effects of exposure to pyrethroids combi-ned with methamidophos were studied in 524spraymen and compared with that of 1480 far-mers spraying only pyrethroids. The resultsshowed neither significant difference in theprevalence of adverse effects and acute intoxi-cation between two groups, nor inhibition ofblood cholinesterase in spraymen with combi-ned exposures. However, there was a tenden-cy of increase of urinary deltamethrin or fen-valerate in the combined exposedegroups wi-thout an increase of deltamethrin metaboliteBr_2A in the urine. This might indicate aninhibilory effect of organophosphate on themetabolism of pyrethroids in man which issimilar to that found in animals.

为探讨混合喷洒拟菊酯与有机磷对施药员健康的影响,作者等在河北产棉区进行了流行病学调查和生物监测研究。混合喷洒拟菊酯与有机磷和单纯喷洒拟菊酯两组人群在不良反应率和中毒率上未见明显差别。混喷组施药员全血胆碱酯酶活性也未见明显变化。混喷组施药员尿中拟菊酯原型的排泄有高于单纯喷洒组的趋势,尿中代谢物Br_2A未见增加。结果表明,在本文观察的接触水平下,混合喷洒拟菊酯与有机磷杀虫剂对施药员健康的影响未超过单纯喷洒拟菊酯者。

In order to explian the mechanism of liver damage by TNT, it is of important significance to identify the structure of metabolites and to determine their concentrations in urine. Urine samples of workers were hydrolysed in acidic condition to set free the metabolites. Benzene extracts were analyzed by GC/MS. Two amino-dinitrotoluene(4-A,2-A)and two diamino - nitro-toluene (2,4-DA, 2,6-DA) were identified. Hydroxyamino - dinitrotoluene (4-HA) would decomposed in inlector of GC, it was identified by MS/CI. Nine...

In order to explian the mechanism of liver damage by TNT, it is of important significance to identify the structure of metabolites and to determine their concentrations in urine. Urine samples of workers were hydrolysed in acidic condition to set free the metabolites. Benzene extracts were analyzed by GC/MS. Two amino-dinitrotoluene(4-A,2-A)and two diamino - nitro-toluene (2,4-DA, 2,6-DA) were identified. Hydroxyamino - dinitrotoluene (4-HA) would decomposed in inlector of GC, it was identified by MS/CI. Nine urine samples of exposed workers were analyzed by HPLC. The sequence of concentrations were: 4A, 4-HA, 2-A, 2, 4-DA and 2, 6-DA. Original form TNT was not detected in most samples. Maximum concentration of 4-A was 7.7 mg/L. Still lower than BEL of ILO.

为阐明TNT对肝脏损伤的机理,搞清尿中代谢物的种类,结构及含量有着十分重要的意义。将工人尿样加酸水解使代谢物游离,用苯提取液做色谱/质谱分析。鉴定出两个-氨基二硝基甲苯(4-A,2-A);两个二氨基-硝基甲苯(2,4-DA,2,6-DA)。又用化学电离源质谱/质谱法鉴定出易分解的羟氨基二硝基甲苯(4-HA)。用高效液相色谱法测定了某化工厂9名工人尿样。其含量顺序为4-A,4-HA,2-A,2,4-DA,2,6-DA。大多数尿样未检出TNT原形。4-A浓度最大值7.7mg/L,仍低于ILO规定的生物阈限值。

 
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