Objective To study the differential expression of transforming growth factor β 1 (TGFβ 1) in oral carcinoma and stroma lymphocytes by induction chemotherapy and inquire into the mechanism of TGFβ 1 information transmission.
Results Significantly higher proportion of patients with oral carcinoma (16/16) had IgG antibody to HHV-6 in sera compared with those (12/16) in control subjects, and geometric mean titer of these two groups was 1:118 and 1:64 respectively ( P < 0.05) .
Objective:To investigate survivin expression and HPV infection in oral leukoplakia(OLK) and oral squamous cell carcinoma(OSCC) and to further explore the mechanism of HPV's carcinogenesis in oral carcinoma .
The clinical and biologic importance of these immune biomarkers is revealed by the finding that they appear to independently predict 5-year survival in patients with oral carcinoma.
Because the oral cavity is easy to examine and risk factors for oral cancer are known, there is great opportunity to improve patient outcomes through diagnosis and treatment of premalignant lesions before the development of invasive oral carcinoma.
We found that relative to non-specific chronic mucositis, oral carcinoma-in-situ/superficially-invasive OSCC contained more monocyte-lineage cells.
The results were compared with those obtained in a group of five patients who underwent composite resection for oral carcinoma without mandibular reconstruction.
These results indicate a successive increase of the detection rate of HPV 16 and 18 from low level in non or questionably preneoplastic lesions (lichen planus) to preneoplastic lesions (leukoplakia and cheilitis) and to oral carcinoma.