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| | Objective: To evaluate the thermal effect, bioeffect and safety of FEP. Methods: Studies on pig's kidney, liver, bladder, colon, ovary and large vessels in vivo , the thermal effect of FEP, distribution of temperature and pathologic changes after FEP were observed. Results: Local high temperatures(>70℃)were observed in pig's kidney, liver in vivo . The pathologic changes of target tissues after FEP were necrosis, liquidizatin and fibrosis. Conclusion: FEP can be used to treat solid tumors d... | | 目的:了解高能聚焦超声热疗的升温效应和生物效应及安全性。方法:分别以活体猪肾及肝、膀胱、结肠壁、卵巢、大血管作为靶组织进行体外聚焦热疗(focused extracorporealpyrotherapy,FEP) 实验,观察靶区温度升高、温度分布和靶组织热疗后的病理改变。结果:FEP可在活体猪肾、肝等组织内形成一大于70 ℃的局限性高温区,FEP后靶组织的病理过程为坏死、液化、纤维化。结论:高能聚焦超声热疗可用于机载B超可探及的腹、盆腔实体肿瘤的治疗。 | | 文摘来源 | | Objective: To evaluate the clinical effect and clinical benefit(%) of Octreotide & high-intensity focused ultrasound(HIFU) thermotherapy in the treatment of late period primary pancreatic carcinoma. Methods: 1 thermotherapy on tumor was repeated in HIFU therapy machine with output power 200 -300 W every 48. Meanwhile, subcutaneous injection octreotide 100 ug q8 h, 1 week pause every 3 weeks. until progress. Results: 1 case was CR, 3 cases PR, 1 case SD, and 1 case PD in total 6 cases primary pancreatic carc... | | 目的 试用奥曲肽合并高能聚焦超声热疗治疗晚期原发性胰腺癌,评价其疗效和临床受率情况。方法 使用高能聚焦超声肿瘤治疗机用输出功率200~300 W对肿瘤进行热疗,每次治疗时间约为1 h,间隔48 h重复治疗。同时给予善宁(Octreotide)100 μg皮下注射,3次/d,使用3周,停1周。用至疗效有进展证据时停药。结果 6例晚期原发性胰腺癌,1例完全缓解,3例部分缓解,1例微效,1例稳定,临床受益疗效6例患者中,有2例Ⅰ、Ⅱ级疼痛消失,2例Ⅲ级疼痛减轻至Ⅱ级,1例Ⅳ级疼痛减至Ⅱ级,1例疼痛无明显减轻。结论 奥曲肽合并高能聚焦超声热疗,初步疗效非常显著,不失为一种有意义的探索。 | | 文摘来源 | | Objective To explore the therapeutic efficacy of high intensity focused ultrasound (HIFU) in advanced malignant tumors of urinary tract. Methods From October 2002, thirteen urinary cancer patients were treated by HIFU, including 5 renal cell carcinoma, 4 bladder cancer, 2 non hormone dependent prostatic cancer, 1 small cell prostatic carcinoma, 1 prostatic sarcoma. HIFU technique was used to treat the target tumors. All cases were preoperatively examed and postoperatively followed up by symptom ... | | 目的 探索高能聚焦超声热疗 (HIFU )治疗泌尿系统恶性肿瘤的疗效及其安全性。方法 2 0 0 2年 10月起 ,应用我院与上海交通大学联合研制的HIFU 2 0 0 1型高能聚焦超声治疗系统治疗泌尿系统晚期恶性肿瘤 13例 ,包括 5例晚期肾癌、4例浸润性膀胱癌、2例激素非依赖型前列腺癌、1例前列腺小细胞癌和 1例晚期前列腺肉瘤。对肿瘤靶组织进行HIFU治疗 ,并分别于治疗前、后行病变区B超、CT和 (或 )膀胱镜检查 ,随时记录症状变化、检查结果及并发症情况。结果 随访时间为 2~ 9个月。与治疗前相比 ,除 1例肾癌和 1例激素非依赖型前列腺癌的疗效不明显外 ,11例于治疗后 2周左右起B超示肿瘤组织内液化、坏死 ,回声明显增强 ,质地不均 ;CT示囊性改变 ,膀胱镜检查发现肿瘤乳头有坏死、脱落。 3例膀胱外浸润性包块萎缩 ,4例前列腺癌患者血清前列腺特异性抗原水平降低。治疗总有效率为 84 .6 % (11/ 13例 )。治疗过程中 ,所有患者的局部不适能耐受 ,无需特殊处理 ,治疗结束后无明显疼痛等不适。均无皮肤灼伤、穿孔、大出血等并发症。结论 HIFU可作为... | | 文摘来源 | |   | | << 更多相关文摘 |
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