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| | The phospholipid fatliquor PPC was prepared by compound method of natural phospholipid and synthetic phosphonate ester and sulphited oil. The properties of the product were discussed. | | 介绍了利用天然大豆磷脂、合成磷酸酯、亚硫酸化油等制备复合型磷脂加脂剂的方法及其性能。 | | 文摘来源 | | AIM: The study the methods and quality valuation for making thermosensitive liposomes with natural lipid instead of synthetic lipid. METHOD:Natural lipid, viz: soya phosphotidy1choline, cholesterol, with different proportion and temperature were used to prepare thermosensitive small unilamellar liposomes according to aequlis design principle for testing. Each factor include five level. By reverse phase evaporating method, the condition and technology for preparing thermosensitive liposomes were optimized. T... | | 目的:研究用天然磷脂替代合成磷脂制备热敏脂质体的方法及其质量评价。方法:以天然大豆磷脂为主要材料,胆固醇为附加剂,参照均匀设计原理选取影响脂质体热敏性的两个因素:磷脂与胆固醇的比例、制备温度和超声顺序(作为一个因素来考虑),每个因素选取五个水平进行实验。采用逆相蒸发法制备氟脲脱氧核苷热敏脂质体并对其药物释放量、粒径大小及水中稳定性进行测定。结果:42℃时,药物释放量达到了被包封药物量的88.28%。水中放置4个月基本稳定,渗透率4.5%。结论:天然磷脂能替代合成磷脂制备具有良好相变温度的热敏脂质体。 | | 文摘来源 | | Objective To observe the action of Agaricus blazei Murrill ω-6 polyunsaturated fatty acid (ω-6APFA) on inhibiting the formation of thrombus and relieving arteriosclerosis. Methods Sixty rats were randomly divided into control group, natural soybean phospholipids capsule (NSPC) 0.70 g·kg~ -1 ·d~ -1 group,ω-6APFA 0.07, 0.14 and 0.28 g·kg~ -1 ·d~ -1 groups (n=12). Rats in each group were exhibited once a day for 7 d,1 h after the last exhibition ,all rats were injected chloral hydrate 300 mg·kg~ -1 in abdomina... | | 目的:观察姬松茸ω-6多不饱和脂肪酸(ω-6APFA)抑制血栓形成及活血化瘀作用。方法:60只大鼠随机分为空白对照组(n=12)、天然大豆磷脂胶囊(NSPC)0·70g·kg-1·d-1剂量组(n=12)和ω-6APFA0·07、0·14及0·28g·kg-1·d-13个剂量(n=12)组,各组均连续灌胃给药7d,末次给药后1h于动物腹腔注射300mg·kg-1水合氯醛麻醉,分离右侧颈总动脉,应用实验性体内血栓形成测定仪检测血栓形成时间。另取60只小鼠,随机分为空白对照组(n=12)、NSPC1·0g·kg-1·d-1剂量组(n=12)和ω-6APFA0·1、0·2、0·4g·kg-1·d-13个剂量组(n=12),各组均连续灌胃给药7d,于末次给药后1h小鼠眶静脉采血,采用玻片法测定凝血时间。结果:NSPC0·70g·kg-1·d-1剂量组及ω-6APFA0·14及0·28g·kg-1·d-1剂量组均对大鼠体内血栓形成有明显抑制作用,与对照组比较差异均有显著性(P<0·05),且ω-6APFA0·14及0·28g·kg-1·d-1剂量组优于NSPC0·70g·kg-1·d-1剂量组。NSPC1·... | | 文摘来源 | |   | | << 更多相关文摘 |
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