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诱导分化
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  differentiation
    Experimental Study on Induction of Differentiation of Breast Cancer Cells by CDA-Ⅱ
    CDA-Ⅱ诱导分化乳腺癌细胞的实验研究
短句来源
    Study on the Differentiation of MSCs and Effect of MSCs with rAAV-GDNF on the Function Recovery of Spinal Cord after SCI in Rats
    骨髓间充质干细胞的诱导分化及GDNF基因修饰后对大鼠脊髓损伤修复的研究
短句来源
    Experimental Study on Expression, Induced Differentiation and Neuronal Protective Effects to Glial Cells of Rat Bone Marrow Stromal Stem Cells after NGF、BDNF Gene Transfection
    NGF、BDNF基因转染大鼠骨髓基质干细胞后的表达和诱导分化以及对神经胶质细胞保护作用的实验研究
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    An Experimental Study on Mouse Embryonic Stem Cells Differentiation into Hepatic Progenitor Cells and Effects of Hepatic Progenitor Cells Transplantation into Mice with Acute Liver Failure
    小鼠胚胎干细胞向肝前体细胞诱导分化及其对实验性急性肝衰竭的移植治疗研究
短句来源
    Establishment of the Model of Marrow Mesenchymal Stem Cells Differentiation in Vitro and Its Application to Mechanism Investigation on Bone Damage Caused by Environmental Chemicals
    骨髓间充质干细胞诱导分化模型的建立及其在环境化学物骨质损伤机制研究中的应用
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  induced differentiation
    Experimental Study on Expression, Induced Differentiation and Neuronal Protective Effects to Glial Cells of Rat Bone Marrow Stromal Stem Cells after NGF、BDNF Gene Transfection
    NGF、BDNF基因转染大鼠骨髓基质干细胞后的表达和诱导分化以及对神经胶质细胞保护作用的实验研究
短句来源
    Induced differentiation of bone marrow stem cells in transplanted rat liver
    骨髓干细胞在大鼠移植肝中的诱导分化
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    Isolation of the Spinal Cord Stem Cells and Its Induced Differentiation by BMP in Vitro
    脊髓神经干细胞的分离及BMP体外诱导分化的研究
短句来源
    The Research of Induced Differentiation of Bone Marrow Stromal Cells and Improving Functional Outcome Following Bone Marrow Stromal Cells Transplantation in Injured Spinal Cord in Rats
    骨髓基质干细胞定向诱导分化及其对急性脊髓损伤神经功能恢复的实验研究
短句来源
    This study suggests, at the first time, that the induced differentiation of MG-63 cells is companied with the expression differentia of nuclear matrix proteins, and confirms the presence of special nuclear matrix proteins related to the cellular proliferation and differentiation.
    首次表明在人成骨肉瘤MG 63细胞诱导分化过程中伴有核基质蛋白表达的差异,证实了与肿瘤细胞增殖分化相关的特异核基质蛋白的存在.
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  “诱导分化”译为未确定词的双语例句
    Experimental Study on Repair of Rhesus Monkey Cranial Defects with Three-Dimensional Porous Poly (D,L-lactide)/PLA-PEG-PLA Triblock Copolymers/Osteoblasts (Differentiate from MSCs)
    恒河猴间充质干细胞诱导分化成骨细胞复合PDLLA/PLA-PEG-PLA嵌段共聚物支架修复颅骨缺损
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    Experimental Study in the Treatment of Acute Liver Failure from Hepatectomy in Rats by Transplantation of Liver Cells Derived from Bone Marrow Stem Cells
    骨髓干细胞诱导分化的肝细胞移植对大鼠肝切除术后肝衰治疗作用的实验研究
短句来源
    Induced cells and Pluronic group: The best induced MSCs compounded with 25% Pluronic F-127 were mixed at 4℃ and suspended, until the final concentration of MSCs was 5×1010 L-1, which poured into the articular cartilage defects.
    诱导细胞复合支架组选取诱导分化最佳的骨髓间充质干细胞与25%可注射型支架材料Pluronic F-127在低温下混匀,重悬,细胞终浓度为5×1010L-1,注入股骨内髁软骨缺损区。
短句来源
    Rat Mesenchymal Stem Cells Can be Induced into Cardiomyocytes in Vitro
    大鼠骨髓间充质干细胞向心肌样细胞的体外诱导分化研究
短句来源
    The Investigation of Neural Stem Cells Derived From Bone Marrow Stromal Cells and Auto-transplantation for Treatment of Rabbit's Spinal Cord Injury
    兔骨髓基质细胞源性神经干细胞诱导分化及移植修复脊髓损伤实验研究
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  differentiation
Of special interest are the Mellin operators of differentiation and integration, more correctly of anti-differentiation, enabling one to establish the fundamental theorem of the differential and integral calculus in the Mellin frame.
      
There are reverse inequalities for square functions of differences arising in ergodic theory and differentiation of functions.
      
Prolate Spheroidal Wavelets: Translation, Convolution, and Differentiation Made Easy
      
We extend the results by Jones and Rosenblatt about the series of the differences of differentiation operators along lacunary sequences to BMO and to the setting of weighted Lp spaces.
      
A nonlinear proportion integration differentiation (PID) controller is proposed on the basis of recurrent neural networks, due to the difficulty of tuning the parameters of conventional PID controller.
      
更多          
  induced differentiation
The effect of hexapeptide HLDF-6, the granulocytic differentiation inducer, on the tumor necrosis factor α (TNF-α)-induced differentiation and apoptosis of human promyelocytic leukemia HL-60 cells has been investigated.
      
Chemically Induced Differentiation of the Cells of Tumor Lines
      
The stimulating effect of the hormone on the epithelium-induced differentiation of thymocytes is mediated by the humoral factors of epithelial cells.
      
1.0 μmol / L As2O3 showed little influence on cortical neuron but effectively promoted apoptosis and induced differentiation of NB4.
      
This indicated that DADS induced differentiation in MGC803 cells.
      
更多          
  inductive differentiation
In this study, we established an in vitro model of osteogenic-inductive differentiation of rat bone marrow mesenchymal stem cells (BMSCs) to determine the mechanisms and relative gene function underlying BMSCs osteogenesis.
      


Objective To investigate the relationship between induced differentiation and regulation of telomerase activity in cultured osteosarcoma cells. Methods Osteosarcoma cells were treated by different doses of retinoic acid (RA) and dexamethasone (DEX). Telomerase activity and human telomerase RNA (hTR) of treated cells were detected by telomere repeat amplification protocol (TRAP) and by Northern blotting analysis. Results After treatment with RA or DEX, the growth of HOS cells was inhibited. Alkaline...

Objective To investigate the relationship between induced differentiation and regulation of telomerase activity in cultured osteosarcoma cells. Methods Osteosarcoma cells were treated by different doses of retinoic acid (RA) and dexamethasone (DEX). Telomerase activity and human telomerase RNA (hTR) of treated cells were detected by telomere repeat amplification protocol (TRAP) and by Northern blotting analysis. Results After treatment with RA or DEX, the growth of HOS cells was inhibited. Alkaline phosphatase activity (differentiation marker of osteogenetic cells) of the cells increased significantly. Telomerase activity decreased with increasing treatment doses and times, but the expression level of hTR did not change obviously. Conclusions Both RA and DEX could inhibit cell growth and induce differentiation of HOS cells. Decreasing of telomerase activity could be considered as a marker of differentiation of HOS cells, but it does not correlate with the expression level of hTR.

【目的】探讨人骨肉瘤细胞分化与端粒酶活性调节之间的关系。【方法】用维甲酸和地塞米松诱导人骨肉瘤细胞分化 ,用端粒重复序列扩增法 (TRAP)检测端粒酶活性及用Northern印迹法检测人端粒酶RNA(RNA ,hTR)表达水平的改变。【结果】经维甲酸和地塞米松处理后 ,骨肉瘤细胞生长受到抑制 ,碱性磷酸酶活性升高 ,端粒酶活性明显下降 ,且与剂量 作用时间成负相关 ,但hTR表达水平并无改变。【结论】维甲酸和地塞米松有抑制骨肉瘤细胞增殖和诱导分化的作用 ,端粒酶活性下调可作为细胞分化指标 ,但与hTR表达水平不平行。

Objective To study the influence of anordrin (ANO),α-ANO, tamoxifen (TAM),cisplatin (CDDP) and all trans retinoic acid(ATRA) on the growth of Swarm rat chondrosarcoma (SRCS). Methods Effects of drugs on the growth of SRCS implanted into subrenal capsules of mice were studied in vivo. Calcium deposits in SRCS were revealed by von Kossa staining. Trypan blue exclusion method was used for examining the growth condition of SRCS cells cultured in vitro . The alterations of alkaline phosphatase (ALPase)...

Objective To study the influence of anordrin (ANO),α-ANO, tamoxifen (TAM),cisplatin (CDDP) and all trans retinoic acid(ATRA) on the growth of Swarm rat chondrosarcoma (SRCS). Methods Effects of drugs on the growth of SRCS implanted into subrenal capsules of mice were studied in vivo. Calcium deposits in SRCS were revealed by von Kossa staining. Trypan blue exclusion method was used for examining the growth condition of SRCS cells cultured in vitro . The alterations of alkaline phosphatase (ALPase) activity of SRCS cells were observed with p nitrophenyl phosphate as substrate. o Cresolphthalein complexone colorimetry was employed to study the calcium content of SRCS cells. Results The tested drugs could inhibit the growth of SRCS implanted into subrenal capsules of mice at different degrees, and α-ANO caused 79.4% inhibition at the dosage 20 mg/kg. The IC 50 of CDDP,ATRA,TAM, α-ANO and ANO for SRCS cells after 96 h treatment wree 0 45, 1 47, 115 2, 161 7 and 241 5 μmol/L respectively. Calcium deposits were observed in SRCS treated by α-ANO and ATRA in vivo . α-ANO and ATRA also induced a significant elevation of ALPase activity and calcium content in SRCS cells in vitro for 96 h treatment. These phenomena were not observed in SRCS treated by CDDP and TAM. Conclusion Inducing SRCS toward differentiation and ossification was involved in the growth inhibition of SRCS caused by α-ANO and ATRA, but not by CDDP and TAM. The differentiation induction may be a new approach for clinical therapy of chondrosarcoma.$

目的 研究双炔失碳酯 (ANO)及其 α异构体 (α-ANO)、三苯氧胺 (TAM)、顺铂 (CDDP)、全反式维甲酸(ATRA )对 Swarm大鼠软骨肉瘤 (SRCS)体内外生长的影响和机制。方法 观察药物 SRCS在小鼠肾囊腺下体内生长的影响 ;von Kossa法观察药物治疗对 SRCS中钙盐沉积的作用 ;用台盼蓝排染法观察了药物对 SRCS细胞体外生长的影响 ;以对硝基苯酚磷酸酯为底物研究药物对 SRCS细胞中碱性磷酸酯酶 (AL Pase)活性的影响 ;用邻甲酚酞络合酮比色法测定 SRCS细胞中的钙含量。结果 几种药物对 SRCS在小鼠肾囊膜下体内生长均有程度不一的抑制作用 ,α- ANO在 2 0 m g/ kg剂量下的生长抑制率为 79.4% ;CDDP、ATRA、TAM、α- ANO和 ANO作用 96 h对 SRCS细胞体外生长的 IC5 0 分别为 0 .45、1.47、115 .2、16 1.7和 2 41.5μmol/L ;α- ANO和 ATRA在体内可引起 SRCS中出现钙盐沉积 ;在体外作用 96 h可使 SRCS细胞中 AL Pase活性和钙含量显著性升高 ;而 CDDP和 ...

目的 研究双炔失碳酯 (ANO)及其 α异构体 (α-ANO)、三苯氧胺 (TAM)、顺铂 (CDDP)、全反式维甲酸(ATRA )对 Swarm大鼠软骨肉瘤 (SRCS)体内外生长的影响和机制。方法 观察药物 SRCS在小鼠肾囊腺下体内生长的影响 ;von Kossa法观察药物治疗对 SRCS中钙盐沉积的作用 ;用台盼蓝排染法观察了药物对 SRCS细胞体外生长的影响 ;以对硝基苯酚磷酸酯为底物研究药物对 SRCS细胞中碱性磷酸酯酶 (AL Pase)活性的影响 ;用邻甲酚酞络合酮比色法测定 SRCS细胞中的钙含量。结果 几种药物对 SRCS在小鼠肾囊膜下体内生长均有程度不一的抑制作用 ,α- ANO在 2 0 m g/ kg剂量下的生长抑制率为 79.4% ;CDDP、ATRA、TAM、α- ANO和 ANO作用 96 h对 SRCS细胞体外生长的 IC5 0 分别为 0 .45、1.47、115 .2、16 1.7和 2 41.5μmol/L ;α- ANO和 ATRA在体内可引起 SRCS中出现钙盐沉积 ;在体外作用 96 h可使 SRCS细胞中 AL Pase活性和钙含量显著性升高 ;而 CDDP和 TAM无上述现象。结论  α- ANO和 ATRA抑制 SRCS生长与其诱导 SRCS向成骨化方向分化有关 ,提示诱导分化治疗可能为临床治疗软骨肉瘤的新的有效途径。

Objective A rare huge desmoplastic fibroma on thoracic wall in 1 female case of 25 years old was resected, and the accompanying huge thoracic wall defect, ribs and soft tissues were repaired by tissue engineered bone and pedicled flap. The paper aims to explore the clinical results of early stage after operation. Methods Autogeneic bone marrow stromal cells (MSC) were obtained from bone marrow puncture of iliac bone and isolated and cultured according to the Houghton's methods, MSC were directively induced...

Objective A rare huge desmoplastic fibroma on thoracic wall in 1 female case of 25 years old was resected, and the accompanying huge thoracic wall defect, ribs and soft tissues were repaired by tissue engineered bone and pedicled flap. The paper aims to explore the clinical results of early stage after operation. Methods Autogeneic bone marrow stromal cells (MSC) were obtained from bone marrow puncture of iliac bone and isolated and cultured according to the Houghton's methods, MSC were directively induced and differentiated to osteoblasts. Allogeneic ribs were made to the bio-derived bone scaffold materials after treatment of decell, deantigen, decalcification and dry freezing. 5×10 6/ml MSC were cocultured with the bio-derived bone for 6 days in vitro. After intact resection of tumor, the diaphragm flap was applied to repair pleural cavity, the three defect ribs were repaired by tissue engineered bone and the soft tissue defect was repaired by transfer of pedicled ipsilateral abdominal flaps. Results The patient recovered well with first intention. Followed up for 3 months, tissue engineered ribs were matured in vitro and the heart and pulmonary functions were improved markedly. Conclusion The tissue engineered bone constructed by autogeneic MSC is advantageous in individual treatment.

目的 应用组织工程技术构建的肋骨和带蒂皮瓣移位修复 1例 2 5岁女性患者胸壁巨大韧带样纤维瘤切除后 ,合并软组织、肋骨缺损的早期效果。方法 经髂骨穿刺抽取骨髓组织 ,按 Houghton法分离培养骨髓基质干细胞 ,经定向诱导分化为成骨样细胞 ;用同种异体肋骨经去细胞、去抗原、部分脱钙和冻干处理 ,制成保存天然框架的生物衍生骨支架 ,将 5× 10 6 /ml骨髓基质干细胞与骨支架材料联合培养 6天 ;待完整切除肿瘤后 ,用膈肌瓣修复胸膜腔 ,组织工程肋骨修复 3根肋骨 ,同侧带蒂侧腹壁皮瓣移位修复胸壁软组织缺损。结果 手术经过顺利 ,伤口 期愈合。术后 3个月随访 ,植入组织工程肋骨在体内逐渐发育成成熟肋骨 ,心肺功能显著改善。结论 应用自体骨髓基质干细胞构建的组织工程肋骨在个体化治疗中显示了优越性。

 
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