Experimental Study on Expression, Induced Differentiation and Neuronal Protective Effects to Glial Cells of Rat Bone Marrow Stromal Stem Cells after NGF、BDNF Gene Transfection
An Experimental Study on Mouse Embryonic Stem Cells Differentiation into Hepatic Progenitor Cells and Effects of Hepatic Progenitor Cells Transplantation into Mice with Acute Liver Failure
Establishment of the Model of Marrow Mesenchymal Stem Cells Differentiation in Vitro and Its Application to Mechanism Investigation on Bone Damage Caused by Environmental Chemicals
Experimental Study on Expression, Induced Differentiation and Neuronal Protective Effects to Glial Cells of Rat Bone Marrow Stromal Stem Cells after NGF、BDNF Gene Transfection
The Research of Induced Differentiation of Bone Marrow Stromal Cells and Improving Functional Outcome Following Bone Marrow Stromal Cells Transplantation in Injured Spinal Cord in Rats
This study suggests, at the first time, that the induced differentiation of MG-63 cells is companied with the expression differentia of nuclear matrix proteins, and confirms the presence of special nuclear matrix proteins related to the cellular proliferation and differentiation.
Experimental Study on Repair of Rhesus Monkey Cranial Defects with Three-Dimensional Porous Poly (D,L-lactide)/PLA-PEG-PLA Triblock Copolymers/Osteoblasts (Differentiate from MSCs)
Experimental Study in the Treatment of Acute Liver Failure from Hepatectomy in Rats by Transplantation of Liver Cells Derived from Bone Marrow Stem Cells
Induced cells and Pluronic group: The best induced MSCs compounded with 25% Pluronic F-127 were mixed at 4℃ and suspended, until the final concentration of MSCs was 5×1010 L-1, which poured into the articular cartilage defects.
Of special interest are the Mellin operators of differentiation and integration, more correctly of anti-differentiation, enabling one to establish the fundamental theorem of the differential and integral calculus in the Mellin frame.
There are reverse inequalities for square functions of differences arising in ergodic theory and differentiation of functions.
Prolate Spheroidal Wavelets: Translation, Convolution, and Differentiation Made Easy
We extend the results by Jones and Rosenblatt about the series of the differences of differentiation operators along lacunary sequences to BMO and to the setting of weighted Lp spaces.
A nonlinear proportion integration differentiation (PID) controller is proposed on the basis of recurrent neural networks, due to the difficulty of tuning the parameters of conventional PID controller.
The effect of hexapeptide HLDF-6, the granulocytic differentiation inducer, on the tumor necrosis factor α (TNF-α)-induced differentiation and apoptosis of human promyelocytic leukemia HL-60 cells has been investigated.
Chemically Induced Differentiation of the Cells of Tumor Lines
The stimulating effect of the hormone on the epithelium-induced differentiation of thymocytes is mediated by the humoral factors of epithelial cells.
1.0 μmol / L As2O3 showed little influence on cortical neuron but effectively promoted apoptosis and induced differentiation of NB4.
This indicated that DADS induced differentiation in MGC803 cells.
In this study, we established an in vitro model of osteogenic-inductive differentiation of rat bone marrow mesenchymal stem cells (BMSCs) to determine the mechanisms and relative gene function underlying BMSCs osteogenesis.
Objective To investigate the relationship between induced differentiation and regulation of telomerase activity in cultured osteosarcoma cells. Methods Osteosarcoma cells were treated by different doses of retinoic acid (RA) and dexamethasone (DEX). Telomerase activity and human telomerase RNA (hTR) of treated cells were detected by telomere repeat amplification protocol (TRAP) and by Northern blotting analysis. Results After treatment with RA or DEX, the growth of HOS cells was inhibited. Alkaline...
Objective To investigate the relationship between induced differentiation and regulation of telomerase activity in cultured osteosarcoma cells. Methods Osteosarcoma cells were treated by different doses of retinoic acid (RA) and dexamethasone (DEX). Telomerase activity and human telomerase RNA (hTR) of treated cells were detected by telomere repeat amplification protocol (TRAP) and by Northern blotting analysis. Results After treatment with RA or DEX, the growth of HOS cells was inhibited. Alkaline phosphatase activity (differentiation marker of osteogenetic cells) of the cells increased significantly. Telomerase activity decreased with increasing treatment doses and times, but the expression level of hTR did not change obviously. Conclusions Both RA and DEX could inhibit cell growth and induce differentiation of HOS cells. Decreasing of telomerase activity could be considered as a marker of differentiation of HOS cells, but it does not correlate with the expression level of hTR.
Objective To study the influence of anordrin (ANO),α-ANO, tamoxifen (TAM),cisplatin (CDDP) and all trans retinoic acid(ATRA) on the growth of Swarm rat chondrosarcoma (SRCS). Methods Effects of drugs on the growth of SRCS implanted into subrenal capsules of mice were studied in vivo. Calcium deposits in SRCS were revealed by von Kossa staining. Trypan blue exclusion method was used for examining the growth condition of SRCS cells cultured in vitro . The alterations of alkaline phosphatase (ALPase)...
Objective To study the influence of anordrin (ANO),α-ANO, tamoxifen (TAM),cisplatin (CDDP) and all trans retinoic acid(ATRA) on the growth of Swarm rat chondrosarcoma (SRCS). Methods Effects of drugs on the growth of SRCS implanted into subrenal capsules of mice were studied in vivo. Calcium deposits in SRCS were revealed by von Kossa staining. Trypan blue exclusion method was used for examining the growth condition of SRCS cells cultured in vitro . The alterations of alkaline phosphatase (ALPase) activity of SRCS cells were observed with p nitrophenyl phosphate as substrate. o Cresolphthalein complexone colorimetry was employed to study the calcium content of SRCS cells. Results The tested drugs could inhibit the growth of SRCS implanted into subrenal capsules of mice at different degrees, and α-ANO caused 79.4% inhibition at the dosage 20 mg/kg. The IC 50 of CDDP,ATRA,TAM, α-ANO and ANO for SRCS cells after 96 h treatment wree 0 45, 1 47, 115 2, 161 7 and 241 5 μmol/L respectively. Calcium deposits were observed in SRCS treated by α-ANO and ATRA in vivo . α-ANO and ATRA also induced a significant elevation of ALPase activity and calcium content in SRCS cells in vitro for 96 h treatment. These phenomena were not observed in SRCS treated by CDDP and TAM. Conclusion Inducing SRCS toward differentiation and ossification was involved in the growth inhibition of SRCS caused by α-ANO and ATRA, but not by CDDP and TAM. The differentiation induction may be a new approach for clinical therapy of chondrosarcoma.$
Objective A rare huge desmoplastic fibroma on thoracic wall in 1 female case of 25 years old was resected, and the accompanying huge thoracic wall defect, ribs and soft tissues were repaired by tissue engineered bone and pedicled flap. The paper aims to explore the clinical results of early stage after operation. Methods Autogeneic bone marrow stromal cells (MSC) were obtained from bone marrow puncture of iliac bone and isolated and cultured according to the Houghton's methods, MSC were directively induced...
Objective A rare huge desmoplastic fibroma on thoracic wall in 1 female case of 25 years old was resected, and the accompanying huge thoracic wall defect, ribs and soft tissues were repaired by tissue engineered bone and pedicled flap. The paper aims to explore the clinical results of early stage after operation. Methods Autogeneic bone marrow stromal cells (MSC) were obtained from bone marrow puncture of iliac bone and isolated and cultured according to the Houghton's methods, MSC were directively induced and differentiated to osteoblasts. Allogeneic ribs were made to the bio-derived bone scaffold materials after treatment of decell, deantigen, decalcification and dry freezing. 5×10 6/ml MSC were cocultured with the bio-derived bone for 6 days in vitro. After intact resection of tumor, the diaphragm flap was applied to repair pleural cavity, the three defect ribs were repaired by tissue engineered bone and the soft tissue defect was repaired by transfer of pedicled ipsilateral abdominal flaps. Results The patient recovered well with first intention. Followed up for 3 months, tissue engineered ribs were matured in vitro and the heart and pulmonary functions were improved markedly. Conclusion The tissue engineered bone constructed by autogeneic MSC is advantageous in individual treatment.
诱导分化
differentiation 
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