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前列腺间质增生
相关语句
  prostatic stromal hyperplasia
     Establishment of Rats Prostatic Stromal Hyperplasia Model
     大鼠前列腺间质增生模型的建立
短句来源
  相似匹配句对
     Evolution of stromal nodules in benign prostatic hyperplasia
     良性前列腺增生间质结节的演化
短句来源
     Establishment of Rats Prostatic Stromal Hyperplasia Model
     大鼠前列腺间质增生模型的建立
短句来源
     Interstital Laser Thermotherapy for the Treatment of Benign Prostatic Hyperplasia
     激光间质内凝固治疗前列腺增生
短句来源
     Madigan's prostatectomy for benign prostatic hyperplasia
     Madigan前列腺增生切除术
短句来源
     Drug Therapy of Benign Prostatic Hyperplasia
     前列腺增生症的药物治疗
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The histopathological and clinical data of 103 benign prostatic hyperplasia(BPH) cases were reviewed and evaluated. Among them, the weight of the prostate was over 200g (giant BPH) in 3 and the weight was under 26g in 5. It was noted that it was not the weight but the histopathological features that correlated with the obstructive symptoms, IPSS and the Qmax. Inflammatory changes of prostatic urethra were usually accompanied by the irritative symptoms and hyperplastic nodules, mostly stromal or (and) adenomuscular,...

The histopathological and clinical data of 103 benign prostatic hyperplasia(BPH) cases were reviewed and evaluated. Among them, the weight of the prostate was over 200g (giant BPH) in 3 and the weight was under 26g in 5. It was noted that it was not the weight but the histopathological features that correlated with the obstructive symptoms, IPSS and the Qmax. Inflammatory changes of prostatic urethra were usually accompanied by the irritative symptoms and hyperplastic nodules, mostly stromal or (and) adenomuscular, correlated closely with obstrutive symptoms. Cases with adenoma nodules might suffer a relatively mild obstructive symptoms, but sometimes accompanied by atypical hyperplasia.

对103例无选择性良性前列腺增生病例的临床资料和病理资料进行比较研究。前列腺重量低于26g者5例,200g以上的巨大前列腺3例。本研究结果显示患者排尿梗阻症状、国际前列腺症状评分、最大尿流率与前列腺重量无关,而与前列腺病理组织学病变密切相关。排尿刺激症状的病理基础为尿道炎性病变。尿道梗阻症状与前列腺间质增生密切相关,这类前列腺增生结节以基质结节、腺肌型结节为主。以腺体增生为主病例可表现排尿梗阻相对轻微,但常伴有不典型增生。

Purpose:To investigate the expressions of transforming growth factor β1 (TGFβ1) in benign prostatic hyperplasia (BPH) on the level of mRNA and protein.Method:To detect the expressions of TGFβ1 mRNA of BPH and protein in 22 cases of human BPH 10 cases of normal prostatic (NP) specimens by mRNA in situ hybridization and immunohistochemistry.Results:Obvious expression of TGFβ1 mRNA was found in the epithelial and mysenchymal of BPH and NP,no significant difference was found between BPH and NP (P> 0.05);the expression...

Purpose:To investigate the expressions of transforming growth factor β1 (TGFβ1) in benign prostatic hyperplasia (BPH) on the level of mRNA and protein.Method:To detect the expressions of TGFβ1 mRNA of BPH and protein in 22 cases of human BPH 10 cases of normal prostatic (NP) specimens by mRNA in situ hybridization and immunohistochemistry.Results:Obvious expression of TGFβ1 mRNA was found in the epithelial and mysenchymal of BPH and NP,no significant difference was found between BPH and NP (P> 0.05);the expression of TGFβ1 mRNA in stromal cells was significantly higher than that in epithelial cells in BPH or NP respectively (P< 0.01).Immunoreactivity for TGFβ1 protein was positive in mysenchymal of all prostatic tissue,however weakly positive or negative in epithelium.The level of immunostaining for TGFβ1 in mysenchymal of BPH was significantly higher than that in NP (P< 0.01),especially in the proliferative nodes containing mainly of stroma.Conclusion:TGFβ1 might be a causative factor in mysenchymal proliferation of BPH,the starting and promoting factor of BPH regulates the expression of TGFβ1 on the level of posttranscription.

目的 :在转录和翻译水平探讨转化生长因子 β1(TGFβ1 )在良性前列腺增生症 (BPH)前列腺组织中的表达及意义。方法 :应用原位杂交和免疫组织化学法对 2 2例 BPH和 10例正常前列腺 (NP)组织标本中 TGFβ1的表达进行定性、定位检测。结果 :BPH前列腺和 NP组织的上皮和间质都有明显的 TGFβ1 m RNA表达 ,其表达在 BPH和 NP间差异无显著性意义 (P >0 .0 5 ) ;在两组内 ,基质细胞 TGFβ1 m RNA表达明显高于上皮细胞 (P<0 .0 1)。 BPH前列腺和 NP的上皮组织中 TGFβ1 蛋白表达较弱 ,且两者之间差异无显著性意义 (P >0 .0 5 ) ;间质中 TGFβ1 表达均为阳性 ,BPH前列腺间质中阳性表达显著强于 NP的间质 (P <0 .0 1) ,以基质为主要成分的增生结节中表达更高。结论 :TGFβ1 是导致 BPH前列腺间质增生的重要物质 ,启动 BPH发生发展的因素在转录后水平调控 TGFβ1 的表达。

To establish the prostatic stromal hyperplasia model of rats,male Wistar rats were randomly distributed into eight groups: Normal group(group N),castrated group(group C),castrated and estradiol(E) or testosterone(T) treated group(group C+E or group C+T),and castrated groups treated with both E and T in different ratio(group C+E/T,E/T=1∶50,1∶100,1∶200 and 1∶300).The prostatic index(PI),hematoxylin-eosin stained pathological sections and immunohistochemical distribution of smooth muscle α-actin in experimental...

To establish the prostatic stromal hyperplasia model of rats,male Wistar rats were randomly distributed into eight groups: Normal group(group N),castrated group(group C),castrated and estradiol(E) or testosterone(T) treated group(group C+E or group C+T),and castrated groups treated with both E and T in different ratio(group C+E/T,E/T=1∶50,1∶100,1∶200 and 1∶300).The prostatic index(PI),hematoxylin-eosin stained pathological sections and immunohistochemical distribution of smooth muscle α-actin in experimental rats were investigated after treatment for 28 days.The highest PIs were found in groups C+E/T 1∶100 and 1∶200.The pathological and immunohistochemical analysis suggested group C+E/T 1∶100 had obvious prostatic stromal hyperplasia with an increased proportion of smooth muscle cells(SMCs).Therefore,1∶100 is the best ratio of estrodiol and testosterone for establish the prostatic stromal hyperplasia model in rats.

为建立前列腺间质增生的动物模型,将大鼠随机分为假手术组、去势组、去势+雄激素组、去势+雌激素组、去势+不同比例的雌/雄激素组(1∶50,1∶100,1∶200,1∶300),考察各实验组的前列腺指数、组织切片的形态学和平滑肌特异蛋白免疫组化染色的变化.结果表明与正常组比较,凡施用雌/雄激素组的前列腺指数均明显增高,以1∶100和1∶200组尤为明显.去势+不同比例雌/雄激素组较正常组的前列腺组织增生明显,而且间质中平滑肌细胞成分在雌/雄激素比例为1:100组明显增加.因此,用雌/雄激素协同作用诱导大鼠前列腺间质增生的最佳比例为1∶100.

 
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