The Clinical & Experimental Research on the K-ras Gene Point Mutations and Monoclonal Antibodies of the Gene Expression Products P21 Protein in Pancreatic Adenocarcinoma
Characterization and Application of Two Novel Monoclonal Antibodies Against CD154: Epitope and Functional Studies on Cell Membrane CD154 and Studies on the Origin of Soluble Serum CD154
EffectofCo-expressingChickenIL-2,IL-18,IFN-γ or Built CpG DNA in the Plasmid Backbone as Adjuvants on DNA Vaccines Against H5 Subtype Avian Influenza Delivered by Attenuated Salmonella and Production of Anti-chicken CD4 and CD8 Monoclonal Antibodies
Free peptide 13a could inhibit the binding of anti-LPS monoclonal antibody (mAb) to LPS (IC_ 50 = 125 μg/mL) and the binding of phage clone K1 to anti-LPS mAb (IC_ 50 = 15.6 μg/mL).
Free peptide P12 could inhibit the binding of anti-LPS mAb to LPS (IC_ 50 = 550 μg/mL) and the binding of phage clone P1 to anti-LPS mAb (IC_ 50 = 375 μg/mL).
Two hybridomas designatedas F7B7 and F7B9 secreting monoclonalanti-idiotypic antibodies against terminaltrisaccharide of PGL-I were developed byfusion of SP2/0 cells and spleen cells ofBALB/c mouse immunized with mousemonoclonal anti-trisaccharide of PGL-I(MAb_1-E_(10)F_1).
Aim To express and purify the fusion protein of the extracellular region of 9.1C3/LAIR 1 molecule with Fc fragment of human IgG1 and to prepare the monoclonal antibody (mAb) against the cxcellular region of 9.1C3/LAIR 1 expressed in the eukaryotic cells.
A mouse-human 6C6 chimeric antibody gene, which is a linkage of variable region gene of mouse 6C6 monoclone antibody and constant region gene of human antibody, has been cloned and effectively expressed in CHO cells.
The lymphocyte subsets,the LAK cell phenotypes and its cytotoxic ability of cord blood were determined by monoclone antibody,indirect immune fluorescent technique and LDH release methods. The results show that the expression of CD 3,CD 2 and HLA DR on cord blood was lower than adult peripheral blood ,but the expression of CD 4,CD 8,CD 4/CD 8,CD 16 ,CD 25 and CD 56 on cord blood was similar to adult peripheral blood.
Western blotting showed that the protein had a high specificity against mouse-anti-Sj14-3-3 monoclonal antibody and rSj14-3-3 had a promising immune reactivity.
Several indirect plasminogen (Pg) activators are known including streptokinase and the monoclonal antibody IV-Ic, whose mechanism of activation is well studied.
To characterize thermodynamically the activation of Pg by streptokinase (SK) and the monoclonal antibody (mAB) IV-Ic, the activation energies were calculated for various reaction stages.
The sensitivity of enzyme immunoassay based on all monoclonal antibodies was higher compared to analysis based on polyclonal rabbit antibodies (0.1 and 0.4 ng/ml, respectively).
The binding site of MAB F8 is in the immunodominant region of the TPO molecule, in the vicinity of the autoantigenic determinants, whereas the epitope specific for MAB A1 lies outside this location.
Five types of interaction of the AFP-MAB complex with the MAB fixed on NCM were found: 1) complete neutralization; 2) partial neutralization; 3) unidirectional neutralization; 4) enhanced binding; 5) lack of interaction.
Among the resulting monoclonal antibodies, two Ca2+-dependent clones (mAb3 and mAb19) recognizing recoverin were detected by solid-phase immunoenzyme assay.
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monoclonal antibody
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