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加速稳定性
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  accelerated stability
     Method suspension quantitative germicidal test and accelerated stability test were carried out.
     方法采用悬液定量杀灭试验、加速稳定性试验等方法进行实验研究。
     Methods:Suspension quantitative germicidal test and accelerated stability test were carried out.
     方法:采用悬液定量杀灭试验、加速稳定性试验等方法进行实验研究。
短句来源
     The effects of determination of methods, main excipients and accelerated stability test on the sustained-release character were studied. The correlation of in vitro drug dissolution and in vivo absorption was tested.
     进行体外释放度试验 ,研究体外释放度测定方法 ,辅料和加速稳定性试验对释放度的影响 ,并进行体外释放和体内吸收相关性检验。
短句来源
     An accelerated stability test was carried out to study the stability of the inclusion compounds in water by isothermal heating method(at 40,50,60,70,80 ℃). Data obtained in the kinetic information were applied to predict shelf-lives at room temperature. UV difference spectrophotometry was used for phenobarbital sodium determination.
     方法:采用β-环糊精作为包合剂制备苯巴比妥钠包合物,应用等温加热法,选择40,50,60,70,80℃进行加速稳定性试验考察其在水溶液中的稳定性,应用动力学数据估算有效期,以紫外分光光度法测定苯巴比妥钠含量。
短句来源
     accelerated stability test was performed according to experience.
     并采用经验法进行加速稳定性试验。
短句来源
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  accelerated stability test
     Method suspension quantitative germicidal test and accelerated stability test were carried out.
     方法采用悬液定量杀灭试验、加速稳定性试验等方法进行实验研究。
     Methods:Suspension quantitative germicidal test and accelerated stability test were carried out.
     方法:采用悬液定量杀灭试验、加速稳定性试验等方法进行实验研究。
短句来源
     The effects of determination of methods, main excipients and accelerated stability test on the sustained-release character were studied. The correlation of in vitro drug dissolution and in vivo absorption was tested.
     进行体外释放度试验 ,研究体外释放度测定方法 ,辅料和加速稳定性试验对释放度的影响 ,并进行体外释放和体内吸收相关性检验。
短句来源
     An accelerated stability test was carried out to study the stability of the inclusion compounds in water by isothermal heating method(at 40,50,60,70,80 ℃). Data obtained in the kinetic information were applied to predict shelf-lives at room temperature. UV difference spectrophotometry was used for phenobarbital sodium determination.
     方法:采用β-环糊精作为包合剂制备苯巴比妥钠包合物,应用等温加热法,选择40,50,60,70,80℃进行加速稳定性试验考察其在水溶液中的稳定性,应用动力学数据估算有效期,以紫外分光光度法测定苯巴比妥钠含量。
短句来源
     accelerated stability test was performed according to experience.
     并采用经验法进行加速稳定性试验。
短句来源
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  “加速稳定性”译为未确定词的双语例句
     The stability of lyophilized thrombin was estimated with accelerated storage test, and the activity of thrombin would lose 10% after 161.8 days, 4.1 years, 6.2 years and lose 50% after 2.9 years, 26.7 years, 40.7 years kept at 25 ℃, 4℃ and 0℃ respectively.
     加速稳定性实验估算出凝血酶冻干品具有较好的稳定性,25℃,4℃和0℃时,活性损失10%需要的时间分别为161.8d(天),4.1a(年),6.2a,活性损失50%需要的时间分别为2.9a,26.7a,40.7a。
短句来源
     METHODS Using infrared technique, accelerating test method and thermogravimetry to investigate the thermal decomposition processes and using Coast Redfern method, MKN method and Ozawa method to deal with the data to get kinetic functions.
     方法 用红外光谱技术、加速稳定性试验方法和热重仪分析方法测定分解过程 ,用Ozawa法以及Coast Redfern法和MKN法处理数据确定热分解函数。
短句来源
     No obvious change in the quality of the products was observed after the accelerated test ofstability.
     经加速稳定性试验后,产品的质量指标未有变化,制剂质量稳定,有效期可定为二年。
短句来源
     METHODS: The stability of glipizide capsules was studied under strong light of 4 000 lux,high temperature of 40℃,60℃,80℃, high humidity of RH75%,RH92.5%,exposure in air,and after three months stability test continuously under the condition of 40℃ and RH75%.
     方法 :进行强光、高温、高湿度及空气露置等影响因素试验 ,并在40℃、RH75 %的条件下进行三个月的加速稳定性试验。
短句来源
     Freeze dried human leucocyte γ-IFN was studied on its heat stability at four different temperatures.
     在三种温度下对冻干人白细胞γ干扰素进行了多等温加速稳定性试验和5℃保存的稳定性考察。
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  accelerated stability
Accelerated stability studies have been carried out on each drug by exposure to acid, base, H2O2, and heat for different time periods.
      
In addition, this method was well suited to monitor the consistency of sialic acid distribution and to detect deamidation events occurring in accelerated stability studies.
      
In accelerated stability tests, the clopidogrel resinate tablet (Pregrel?) showed less brown discoloration and fewer impurities than the clopidogrel bisulfate tablets under open and closed conditions.
      
Shelf lives are estimated using addition of an uncertainty component based on real-temperature stability studies rather than by accelerated stability studies.
      
Their normal shelf-life and accelerated stability studies were also examined.
      
更多          
  accelerated stability test
An accelerated stability test using the peroxide value as an index
      
A variety of compounds were evaluated as antioxidants for carotene in mineral oil solution by an accelerated stability test.
      
Accelerated stability test for vitamin A in oils and fats by means of surface-enlarging at room temperature
      
Also, in an accelerated stability test conducted on potato lipid, olive oil and Swift's Triple X Vream at 148°F (64.5°C), the curve for the potato fat was almost superimposed upon the curve for olive oil which is regarded as an unstable oil.
      
Based on the results of the stability testing programme, an accelerated stability test should be applied to each new batch of vaccine.
      


The Stability Study of Piperacillin(I)was discussed in this paper.

本文报道了氧哌嗪青霉素的稳定性研究。在水溶液和固体的状态下,本品的降解反应可视为酸性条件下的水解反应。0.5%的水溶液在室温可稳定18小时;15%及30%的水溶液在室温可稳定24小时。根据加速稳定性试验,推算出本品固体在室温的贮藏期为2.5年以上。

The initial average rate method for predicting the shelflife of pharmaceuticals is established by using the logarithm of the average rate of the initial stage of reaction (lg V0) instead of the logarithm of the rate constant (lg k) in the Arrhenius equation. It was found that the regression curve of lg V0 by plotting against the reciprocal of Kelvin temperature (1/T)is a contended well straight line. The linear equation so obtained is in accordance with Arrhenius' exponential equation and can be used to calculate...

The initial average rate method for predicting the shelflife of pharmaceuticals is established by using the logarithm of the average rate of the initial stage of reaction (lg V0) instead of the logarithm of the rate constant (lg k) in the Arrhenius equation. It was found that the regression curve of lg V0 by plotting against the reciprocal of Kelvin temperature (1/T)is a contended well straight line. The linear equation so obtained is in accordance with Arrhenius' exponential equation and can be used to calculate the activation energy and shelflife at room temperature. Since k is not needed here, the calculation can be made without knowledge of the order of reaction. Thus this method is simple and convenient. Under each testing temperature only one analysis of initial stage sample is needed, so laboratory work and data treatment are greatly reduced.We applied this initial average rate method and also classical isothermal kinetic method to determine the stability of ascorbic acid solution, the activation energies of oxidation of ascorbic acid obtained were 18.60 and 18.50 kcal mol~(-1) respectively; the shelflives at 20℃ were 125 and 111 days. The results agreed satisfactorily.This method was also used to determine the stabilities of solutions of arabinosylcytosine and streptomycin sulfate. The activation energies obtained were comparable to published values.

初均速法预测药物贮存期系以药物分解初阶段的平均速度Ⅴ_0的对数,代替反应速度常数k的对数对开尔文温度(Kelvin T)的倒数回归,得到符合Arrhenius指数规律的直线方程,由此计算活化能及室温贮存期。因为不必求k,所以不必知道反应级数。此法简便,在每个加速稳定性试验温度下,只需在反应初阶段取样分析一次,实验工作量及数据处理工作量均大大减少。 本文分别用初均速法与经典法测定了抗坏血酸溶液的稳定性,得到抗坏血酸氧化的活化能分别为18.32及18.49 kcal·mol~(-1)。20℃贮存期分别为119天及110天,结果符合很好。本文并应用初均速法测定了阿糖胞苷溶液及硫酸链霉素溶液的稳定性,得到活化能数值与文献值符合。

Freeze dried human leucocyte γ-IFN was studied on its heat stability at four different temperatures. The result showed that the residual activity was more than 50% after the preparation had been heated at 66℃ for 11 days, or 56℃ for 35 days or 37℃ for 5 months. The losses of activi ty were less than 10% and 15% after the preparation had been stored at 5℃ for one year and two years, respectively. The calculation results obtained from the formula associated with accelerated degradation tallyed with that obtained...

Freeze dried human leucocyte γ-IFN was studied on its heat stability at four different temperatures. The result showed that the residual activity was more than 50% after the preparation had been heated at 66℃ for 11 days, or 56℃ for 35 days or 37℃ for 5 months. The losses of activi ty were less than 10% and 15% after the preparation had been stored at 5℃ for one year and two years, respectively. The calculation results obtained from the formula associated with accelerated degradation tallyed with that obtained from the tests above. Thus, the heat stability of the preparation was good.

在三种温度下对冻干人白细胞γ干扰素进行了多等温加速稳定性试验和5℃保存的稳定性考察。结果表明,样品在66℃加温11天,或56℃加温35天,或37℃加温5个月,能保持50%以上的活力;在5℃保存一年后,效价损失不超过10%,保存两年损失不超过15%。用加速降解有关公式推算的结果与实验值较为吻合。产品稳定性良好。

 
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