The effects of determination of methods, main excipients and accelerated stability test on the sustained-release character were studied. The correlation of in vitro drug dissolution and in vivo absorption was tested.

An accelerated stability test was carried out to study the stability of the inclusion compounds in water by isothermal heating method(at 40,50,60,70,80 ℃). Data obtained in the kinetic information were applied to predict shelf-lives at room temperature. UV difference spectrophotometry was used for phenobarbital sodium determination.

The effects of determination of methods, main excipients and accelerated stability test on the sustained-release character were studied. The correlation of in vitro drug dissolution and in vivo absorption was tested.

An accelerated stability test was carried out to study the stability of the inclusion compounds in water by isothermal heating method(at 40,50,60,70,80 ℃). Data obtained in the kinetic information were applied to predict shelf-lives at room temperature. UV difference spectrophotometry was used for phenobarbital sodium determination.

The stability of lyophilized thrombin was estimated with accelerated storage test, and the activity of thrombin would lose 10% after 161.8 days, 4.1 years, 6.2 years and lose 50% after 2.9 years, 26.7 years, 40.7 years kept at 25 ℃, 4℃ and 0℃ respectively.

METHODS Using infrared technique, accelerating test method and thermogravimetry to investigate the thermal decomposition processes and using Coast Redfern method, MKN method and Ozawa method to deal with the data to get kinetic functions.

METHODS: The stability of glipizide capsules was studied under strong light of 4 000 lux,high temperature of 40℃,60℃,80℃, high humidity of RH75%,RH92.5%,exposure in air,and after three months stability test continuously under the condition of 40℃ and RH75%.

Accelerated stability studies have been carried out on each drug by exposure to acid, base, H2O2, and heat for different time periods.

In addition, this method was well suited to monitor the consistency of sialic acid distribution and to detect deamidation events occurring in accelerated stability studies.

In accelerated stability tests, the clopidogrel resinate tablet (Pregrel?) showed less brown discoloration and fewer impurities than the clopidogrel bisulfate tablets under open and closed conditions.

Shelf lives are estimated using addition of an uncertainty component based on real-temperature stability studies rather than by accelerated stability studies.

Their normal shelf-life and accelerated stability studies were also examined.

An accelerated stability test using the peroxide value as an index

A variety of compounds were evaluated as antioxidants for carotene in mineral oil solution by an accelerated stability test.

Accelerated stability test for vitamin A in oils and fats by means of surface-enlarging at room temperature

Also, in an accelerated stability test conducted on potato lipid, olive oil and Swift's Triple X Vream at 148°F (64.5°C), the curve for the potato fat was almost superimposed upon the curve for olive oil which is regarded as an unstable oil.

Based on the results of the stability testing programme, an accelerated stability test should be applied to each new batch of vaccine.

The Stability Study of Piperacillin(I)was discussed in this paper.

The initial average rate method for predicting the shelflife of pharmaceuticals is established by using the logarithm of the average rate of the initial stage of reaction (lg V0) instead of the logarithm of the rate constant (lg k) in the Arrhenius equation. It was found that the regression curve of lg V0 by plotting against the reciprocal of Kelvin temperature (1/T)is a contended well straight line. The linear equation so obtained is in accordance with Arrhenius' exponential equation and can be used to calculate...

The initial average rate method for predicting the shelflife of pharmaceuticals is established by using the logarithm of the average rate of the initial stage of reaction (lg V0) instead of the logarithm of the rate constant (lg k) in the Arrhenius equation. It was found that the regression curve of lg V0 by plotting against the reciprocal of Kelvin temperature (1/T)is a contended well straight line. The linear equation so obtained is in accordance with Arrhenius' exponential equation and can be used to calculate the activation energy and shelflife at room temperature. Since k is not needed here, the calculation can be made without knowledge of the order of reaction. Thus this method is simple and convenient. Under each testing temperature only one analysis of initial stage sample is needed, so laboratory work and data treatment are greatly reduced.We applied this initial average rate method and also classical isothermal kinetic method to determine the stability of ascorbic acid solution, the activation energies of oxidation of ascorbic acid obtained were 18.60 and 18.50 kcal mol~(-1) respectively; the shelflives at 20℃ were 125 and 111 days. The results agreed satisfactorily.This method was also used to determine the stabilities of solutions of arabinosylcytosine and streptomycin sulfate. The activation energies obtained were comparable to published values.

Freeze dried human leucocyte γ-IFN was studied on its heat stability at four different temperatures. The result showed that the residual activity was more than 50% after the preparation had been heated at 66℃ for 11 days, or 56℃ for 35 days or 37℃ for 5 months. The losses of activi ty were less than 10% and 15% after the preparation had been stored at 5℃ for one year and two years, respectively. The calculation results obtained from the formula associated with accelerated degradation tallyed with that obtained...

Freeze dried human leucocyte γ-IFN was studied on its heat stability at four different temperatures. The result showed that the residual activity was more than 50% after the preparation had been heated at 66℃ for 11 days, or 56℃ for 35 days or 37℃ for 5 months. The losses of activi ty were less than 10% and 15% after the preparation had been stored at 5℃ for one year and two years, respectively. The calculation results obtained from the formula associated with accelerated degradation tallyed with that obtained from the tests above. Thus, the heat stability of the preparation was good.