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   负性信号 的翻译结果: 查询用时:0.533秒
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负性信号
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  “负性信号”译为未确定词的双语例句
     We detected the level of CD3+CD28+ and CD3+CTLA-4+ on PBMCs and SFMCs of 32 RA patients and 12 controls by two-color flow cytometric analysis and found there are some differences between them.
     对18例服用SN治疗2月的RA病人研究发现,服用SN后,RA-PBMC上CD3+CTLA-4+的表达增高,CD3+CD28+则无显著改变,提示更多的负性信号抑制了T细胞活化或诱导了T细胞的失能(Anergy),从而产生了抑制RA体内T细胞反应的效应。
短句来源
     Conclusion:①P27 plays an important role in transmitting celluar negative signals.
     结论 :①P2 7在介导胞外信号尤其是负性信号的传导中起着极其重要的作用。
短句来源
     T-cell responses are regulated by activating and inhibitingsignals.
     CTLA-4与CD28的共同配体是APC细胞表面的B7分子,其与CD28竞争B7配体,向T细胞传递负性信号,影响T细胞的增殖,细胞因子的产生和免疫反应。
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  相似匹配句对
     New method to realize remote signal measure
     信号遥测方法
短句来源
     Signal transduction of ataxia-telangiectasia
     AT的信号传导
短句来源
     Blind separation with unknown signs of the kurtoses of sources
     未知源信号峭度正负性的盲分离
短句来源
     The Research of SOCS1 Negative Regulating Lipopolysaccharide Signalling of Kupffer Cells
     SOCS1负性调节Kupffer细胞内毒素信号传导的研究
短句来源
     ③negative mood;
     3负性情绪 ;
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  negative signaling
Induction of the latter has been termed "negative signaling" and can be triggered by receptors on immune cells that are distinct from activating receptors while other growth-promoting receptors induce both positive and negative signaling events.
      
Furthermore, recent experimental evidence is reviewed that indicates an important contribution of negative signaling to the intracellular survival of infectious pathogens.
      
Recent studies in gene knockout mice have demonstrated that the negative signaling by CD32B plays a critical role in preventing immune complex (IC)-mediated autoimmune diseases by regulating the activation signal delivered by CD16A.
      
However, recent work have revealed that Src family PTKs and FcεRI β-subunit transduce both positive and negative signaling with unexpectedly complex mechanisms.
      
It therefore functions as a negative signaling regulator.
      
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Objective:To investigate the expression of CyclinE?P27 in primary gallbladder carcinoma and its relation to development of the carcinoma.Methods:The expression of CyclinE?P27 in primary gallbladder carcinoma were detected by S P immunohistochemical staining,20 cases of chronic cholecystitis were collected as contrast.Results:①The positive rate of CyclinE(47.22%) in gallbladder carcinoma increased significantly,while that of P27(47.22%) decreased remarkably.②In metastasis or low differentiation there was higher...

Objective:To investigate the expression of CyclinE?P27 in primary gallbladder carcinoma and its relation to development of the carcinoma.Methods:The expression of CyclinE?P27 in primary gallbladder carcinoma were detected by S P immunohistochemical staining,20 cases of chronic cholecystitis were collected as contrast.Results:①The positive rate of CyclinE(47.22%) in gallbladder carcinoma increased significantly,while that of P27(47.22%) decreased remarkably.②In metastasis or low differentiation there was higher expression of CyclinE. The positive rate of P27 was inversely proportional to the middle and higher differentiation group or non metastasis group.③The expression of CyclinE was inversely correlated with the expression of P27.④There was significant difference in survival time between patients with P27(+) and P27(-) or CyclinE(+) and CyclinE(-). There were statistically correlations between the first group and the second group.Conclusion:①P27 plays an important role in transmitting celluar negative signals. Once cells were stimulated by malignant signals. The expression of P27 is down regulated. There is a significant in over expression in CyclinE decreasing of P27 in development and metastasis of gallbladder carcinoma.②The detection of CyclinE?P27 may be useful in assessing the development of the cancer,judging prognosis and eventually renders a possible target for novel therapeutic strategies.

目的 :研究CyclinE、P2 7的蛋白产物在原发性胆囊癌发生、发展过程中的表达特点及相互关系。方法 :应用免疫组化S P法检测 36例原发性胆囊癌中CyclinE、P2 7的表达 ,并以同期 2 0例慢性胆囊炎作对照。结果 :①CyclinE基因蛋白产物阳性表达率为 4 7.2 % (1 7/36 ) ,显著高于其相应良性对照组的 1 0 .0 % (2 /2 0 )。P2 7蛋白表达率为 4 7.2 % (1 7/36 ) ,显著低于相应良性对照组 1 0 0 % (2 0 /2 0 )。②CyclinE在低分化、有淋巴结或远处转移表达率 (84 .6 %、6 2 .5 % )明显高于高中分化、无转移 (2 6 .1 %、1 6 .7% )。P2 7在高中分化、无淋巴结或远处转移、NevinⅠ~Ⅲ期的患者中阳性表达率 (分别为 6 0 .9%和 75 .0 % )明显高于低分化、有转移、NevinⅣ~Ⅴ期患者 (2 3.1 %、33.3% )。③P2 7与CyclinE两者呈负相关。④P2 7阳性患者生存率高于P2 7阴性患者 (P <0 .0 5 )。CyclinE阳性患者生存率低于CyclinE阴性...

目的 :研究CyclinE、P2 7的蛋白产物在原发性胆囊癌发生、发展过程中的表达特点及相互关系。方法 :应用免疫组化S P法检测 36例原发性胆囊癌中CyclinE、P2 7的表达 ,并以同期 2 0例慢性胆囊炎作对照。结果 :①CyclinE基因蛋白产物阳性表达率为 4 7.2 % (1 7/36 ) ,显著高于其相应良性对照组的 1 0 .0 % (2 /2 0 )。P2 7蛋白表达率为 4 7.2 % (1 7/36 ) ,显著低于相应良性对照组 1 0 0 % (2 0 /2 0 )。②CyclinE在低分化、有淋巴结或远处转移表达率 (84 .6 %、6 2 .5 % )明显高于高中分化、无转移 (2 6 .1 %、1 6 .7% )。P2 7在高中分化、无淋巴结或远处转移、NevinⅠ~Ⅲ期的患者中阳性表达率 (分别为 6 0 .9%和 75 .0 % )明显高于低分化、有转移、NevinⅣ~Ⅴ期患者 (2 3.1 %、33.3% )。③P2 7与CyclinE两者呈负相关。④P2 7阳性患者生存率高于P2 7阴性患者 (P <0 .0 5 )。CyclinE阳性患者生存率低于CyclinE阴性患者 (P <0 .0 5 )。结论 :①P2 7在介导胞外信号尤其是负性信号的传导中起着极其重要的作用。在原发性胆囊癌细胞中CyclinE表达上调 ,P2 7表达下调 ,且在有淋巴结或远处转移、NevinⅣ~Ⅴ期患者中更为明显。CyclinE过度表达和P2 7表达下降 ,在胆囊癌的发生、发展、转移中起重要作用。②联合检

Neurotrophins are essential factors during neuronal development. They promote survival, differen- tiation and myelination of neurons via Trk receptor tyrosine kinases and the p75 neurotrophin receptor. Paradoxically, compare to these “positive” roles, the p75 neurotrophin receptor also ensures some “negative” roles such as apoptosis of neonatal and injured neurons. Until recently, the mechanisms by which the p75 neurotrophin receptor governs these opposing functions have remained elusive. By the identification...

Neurotrophins are essential factors during neuronal development. They promote survival, differen- tiation and myelination of neurons via Trk receptor tyrosine kinases and the p75 neurotrophin receptor. Paradoxically, compare to these “positive” roles, the p75 neurotrophin receptor also ensures some “negative” roles such as apoptosis of neonatal and injured neurons. Until recently, the mechanisms by which the p75 neurotrophin receptor governs these opposing functions have remained elusive. By the identification of new ligands and cytosolic interacting partners, receptor cleavage products and coreceptors such as: s-p75NTR, proNGF and sortilin, some of these mechanisms are now being unraveled. Here, we review recent progress in delineating the molecular networks that enable p75NTR to dictate neuroal apoptosis.

在神经发育过程中,神经营养因子通过其低亲和力受体p75NTR与高亲和力受体Trk的介导,在神经元的存活、分化与髓鞘形成中发挥着重要的作用;与存活、生长这些“正性”信号相反,p75NTR也介导受损后及新生神经元凋亡这一“负性”信号。一直以来,p75NTR是如何介导这些截然相反的功能仍不清楚,尤其是何时引起凋亡,其机制如何更是所知甚少。近来,随着s-p75NTR、proNGF、sortilin复合受体等的发现,其中的一些机制开始有所明朗。本文就p75NTR介导神经元凋亡的研究进展做一综述。

 
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