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重组卵泡刺激素
相关语句
  recombinant follicle stimulating hormone
     Objective To compare the effects of menotropins(HMG) and recombinant follicle stimulating hormone(rFSH,Gonal-F) in vitro fertilization-embryonic transplantation(IVF-ET) and intracytoplasmic sperm injection(ICSI).
     目的比较在体外受精-胚胎移植(IVF-ET)及卵母细胞单精子显微注射(ICSI)中尿促性素(menotropins,HMG)和重组卵泡刺激素的作用。
短句来源
  recombinant follicle stimulating hormones
     Observing the ovulation-promotion effect of gene recombinant follicle stimulating hormones
     基因重组卵泡刺激素促排卵效果的观察
短句来源
  “重组卵泡刺激素”译为未确定词的双语例句
     Methods Comparative analysis of 1049 patients undergoing IVF and ICSI cycles,who receiving urinary FSH(uFSH),highly purified urinary FSH(hpFSH) or recombinant FSH(rFSH) in combination with different GnRH agonist(GnRHa) regimens.
     方法在促性腺激素释放激素激动剂(GnRHa)长或短方案下,分别应用尿卵泡刺激素(uFSH)、高纯度尿卵泡刺激素(hpFSH)和基因重组卵泡刺激素(rFSH)促排卵,回顾性分析1049例实施IVF和ICSI的治疗周期。
短句来源
     but in group B (n=59),Gonal-F was used for the first three days,then HMG was used instead of Gonal-F from the forth day;
     B组 5 9例 ,促排卵的第 1~ 3天采用基因重组卵泡刺激素 (rF SH ,商品名Gonal F) ,第 4天后改为国产HMG。
短句来源
     Methods: Mouse testicular cells at 7~8 d of age were obtained using combined enzyme digestion method and cultured in an exogenous hormone supplemented culture system with r-FSH and testosterone.
     方法采用7~8 d龄小鼠睾丸组织,以组合酶消化法制备睾丸细胞,在含重组卵泡刺激素(r-FSH)和睾酮的培养基中进行体外培养;
短句来源
     Objective To study prospectively the values of basal and dynamic measurement of inhibin B(INHB), estrodiol (E_2)following gonadotrophin therapy in vitro fertilization(IVF)cycles in predicting ovarian response to stimulation in young women.
     目的探讨以经重组卵泡刺激素(rFSH)刺激后体外受精(IVF)周期中不同时间血清抑制素B(INHB)、雌二醇(E2)的动态变化,预测不孕患者卵巢的反应性,为选择最佳的超促排卵方案提供理论依据。
短句来源
     Objective To analyze the clinical pregnancy rate of four tropic hyper ovulation programmes (THOP) in Vitro Fertilization and embryo transfer (IVF-ET),and investigate the applicable value of homemade HMG and imported Gonal-F.
     目的 分析 4种促超排卵方案 (tropichyperovulationprogramme ,THOP)在体外授精 -胚胎移植 (invitrofertilizationandembryotransfer,IVF ET)中的临床妊娠率 ,以探讨国产尿促性腺激素 (HMG)与进口基因重组卵泡刺激素 (Gonal F)的应用价值。
短句来源
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  相似匹配句对
     The recombinant plasmid expressed well in E.
     从重组E.
短句来源
     Observing the ovulation-promotion effect of gene recombinant follicle stimulating hormones
     基因重组卵泡刺激素促排卵效果的观察
短句来源
     EXPRESSION OF HUMAN FOLLICLE STIMULATING HORMONE IN INSECT CELLS
     重组卵泡刺激素在昆虫细胞中的表达
短句来源
     A recombinant E.
     重组大肠杆菌 E.
短句来源
     The study advance of follicle stimulating hormone
     卵泡刺激素研究进展
短句来源
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  recombinant follicle stimulating hormone
Our report concerns the death of a 31-year-old woman with primary infertility on recombinant follicle stimulating hormone therapy (Gonal-F) who developed a fatal adult respiratory distress syndrome.
      


The stimulatory effects of FSH on antral and preovulatory follicles are well known, but controversial results have been reported regarding the FSH dependency of preantral follicles. The role of epidermal growth factor (EGF) in the preantral folliculogenesis is still inconclusive. The aim of this study was to investigate whether rechFSH and EGF are involved in the growth of oocyte-granulosa cell complexes (OGCs) and oocyte. Ovaries were obtained from 12 day-old mice, and OGCs were harvested using Collagenase...

The stimulatory effects of FSH on antral and preovulatory follicles are well known, but controversial results have been reported regarding the FSH dependency of preantral follicles. The role of epidermal growth factor (EGF) in the preantral folliculogenesis is still inconclusive. The aim of this study was to investigate whether rechFSH and EGF are involved in the growth of oocyte-granulosa cell complexes (OGCs) and oocyte. Ovaries were obtained from 12 day-old mice, and OGCs were harvested using Collagenase digestion. 30~40 OGCs were cultured per well supplemented with fetal bovine sera (FBS), rechFSH, and EGF, respectively. The diameters of oocytes and OGCs were measured every 4 days and some explants were photographed every day. The results reveal that rechFSH can significantly promote the growth of preantral oocyte and OGC, which was augmented by the presence of EGF (p<0.05). However, at the end of culture, the diameter of oocytes was significantly smaller than that grew in vivo an the corresponding time (p<0.05). These results suggest that FSH and EGF play important roles in regulating OGCs development, and the full growth of OGCs also needs other substance(s) to join in.

卵泡刺激素(FSH)对有腔卵泡和排卵前卵泡的促生长作用已被普遍接受,但关于其对腔前卵泡发育的作用报道结果不尽相同。关于表皮生长因子(EGF)对腔前卵泡的作用尚不确切。本研究目的在于探讨人重组卵泡刺激素(rechFSH)和EGF对早期卵泡发育的作用。利用胶原酶消化法从12日龄的小鼠卵巢中分离得到卵母细胞-颗粒细胞复合体(OGCs)(Fig.1)。体外每孔30~40个培养物并分别添加胎牛血清(FBS)、rechFSH和EGF。培养物每4天测量卵母细胞和OGCs直径,并每天照相。结果显示rechFSH显著促进小鼠OGCs及其卵母细胞的体外发育,这一作用可被EGF进一步增强(p<0.05)(Fig.2)。但到第八天培养结束时,培养后的OGCs卵母细胞要显著小于体内同期生长对照组(p<0.05)(Fig.3)。说明FSH和EGF在卵泡早期发育中起重要作用。

Objective: To investigate the efficacy and safety of recombinant human FSH (rFSH, Gonal-F) and highly purified urinary human FSH (uFSH, Metrodin HP) in women undergoing controlled ovarian hyperstimulation for in-vitro fertilization(IVF)/intracytoplasmic sperm injection(ICSI). Methods: 100 and 102 infertile women were randomly assigned in the rFSH and FSH groups respectively. Following down regulation in a long gonadotrophin-releasing hormone (GnRH) agonist protocol, patients received rFSH or uFSH s.c., at...

Objective: To investigate the efficacy and safety of recombinant human FSH (rFSH, Gonal-F) and highly purified urinary human FSH (uFSH, Metrodin HP) in women undergoing controlled ovarian hyperstimulation for in-vitro fertilization(IVF)/intracytoplasmic sperm injection(ICSI). Methods: 100 and 102 infertile women were randomly assigned in the rFSH and FSH groups respectively. Following down regulation in a long gonadotrophin-releasing hormone (GnRH) agonist protocol, patients received rFSH or uFSH s.c., at a fixed dose of 150 IU, till an adequate developed follicle was achieved then received human chorionic gonadotrophin injection. Results: The duration of FSH treatment was significantly shorter in rFSH group than in uFSH (12.5±2.4 vs 14.6±1.7 days) (P<0.05) and significantly fewer ampoules of Gn were required in rFSH group(28.7±7.6 vs 32.6±4.9),( P<0.05). There were significantly more follicles≥10 mm in diameter with rFSH(15.6±8.2 vs 12.5±7.2)(P<0.05) and also more oocytes retrieved (13.2±5.7 vs 10.3±5.5)( P<0.05). Although there was no statistical difference in pregnancy rate between two groups, however patients in rFSH group had a slightly higher pregnancy rate per cycle than patients in uFSH groups (42% vs 37.3%). Moderate to severe ovarian hyperstimulation syndrome occurred in 3.0% and 2.0% of rFSH and uFSH groups respectively (not significant) Conclusion: There was no significant difference in the rates of implantation and pregnancy between two groups. However, rFSH seems more effective in inducing multifollicular development and resulting in achieving more good qualitative oocytes and embryos.

目的 比较重组卵泡刺激素 (rFSH)与高纯度尿提取卵泡刺激素 (uFSH)在促超排卵周期中的有效性和安全性。 方法  2 0 2例接受体外受精 胚胎移植 (IVF ET)的不育患者 ,随机分为rFSH组 1 0 0例及uFSH组 1 0 2例。两组均采用黄体期长方案促超排卵。卵泡监测、取卵、IVF、ET等均按本中心常规进行。观察两组用药时间、用药剂量、获卵数、妊娠率及重度卵巢过度刺激综合征 (OHSS)发生率等。 结果 rFSH组与uF SH组比较 ,使用FSH天数及安瓿数显著减少 (P <0 .0 5) ,分别为 ( 1 2 .5± 2 .4)及 ( 1 4 .6±1 .7)、( 2 8.7± 7.6)及 ( 3 2 .6± 4.9) ,hCG日直径 >1 0mm的卵泡数、获卵数、优质胚胎率及可冻存胚胎率显著增多 (P <0 .0 5)。临床妊娠率 (分别为 42 %及 3 7.3 % )、胚胎种植率、多胎率、重度OHSS发生率 (分别为 3 %及 2 % )无显著差异 (P >0 .0 5)。 结论 虽然两组种植率及妊娠率无差异 ,但rFSH能更有效地促卵泡生长从而获得更多数量的优质卵与胚胎

Objective To analyze the clinical pregnancy rate of four tropic hyper ovulation programmes (THOP) in Vitro Fertilization and embryo transfer (IVF-ET),and investigate the applicable value of homemade HMG and imported Gonal-F.Methods One hundred and sixty two infertile cases who need IVF-ET were divided into four groups randomly,and down regulation in a long gonadotrophin-releasing hormone agonist(GnRH-a)(commodity name:triptorelin) protocol was adopted in all cases from luteal phase of last menstrual cycle,and...

Objective To analyze the clinical pregnancy rate of four tropic hyper ovulation programmes (THOP) in Vitro Fertilization and embryo transfer (IVF-ET),and investigate the applicable value of homemade HMG and imported Gonal-F.Methods One hundred and sixty two infertile cases who need IVF-ET were divided into four groups randomly,and down regulation in a long gonadotrophin-releasing hormone agonist(GnRH-a)(commodity name:triptorelin) protocol was adopted in all cases from luteal phase of last menstrual cycle,and gonadotrophin hormone was used decreasingly from the 3rd day of menstruation.Only HMG was used in group A (n=37);but in group B (n=59),Gonal-F was used for the first three days,then HMG was used instead of Gonal-F from the forth day;Only Gonal-F was used from the beginning to the end in group C (n=31).In group D(n=35),Gonal-F was used from 1st to 3rd day during the tropic ovulation,HMG was used instead of Gonal-F from 4th to 6th day,and then from the 7th day,Gonal-F was used again.The number of ova obtained,fertilization rate,fertilized cleavage of oocytes,clinical pregnancy rate per ET cycle and the medicine cost of the patients of four groups were compared.Results There was no obvious difference in the aspects of the number of ova obtained,fertilization rate,fertilized cleavage of oocytes,and pregnancy rate among the four groups (P>0.05).Whereas,the medicine expenses were significantly different (P<0.01).Conclusion Depending on its privilege of price,homemade HMG is a kind of tropic ovulation medicine that is more suitable to the domestic conditions.

目的 分析 4种促超排卵方案 (tropichyperovulationprogramme ,THOP)在体外授精 -胚胎移植 (invitrofertilizationandembryotransfer,IVF ET)中的临床妊娠率 ,以探讨国产尿促性腺激素 (HMG)与进口基因重组卵泡刺激素 (Gonal F)的应用价值。方法 将需行IVF ET的 16 2例病人随机分为 4组 ,均于前一月经周期的黄体期应用促性腺激素释放激素激动剂 (GnRH a ,达必佳 )长方案降调节 ,从月经周期第 3天开始递减法给予促性腺激素 (Gn)促排卵。A组 37例 ,单用国产HMG促排卵 ;B组 5 9例 ,促排卵的第 1~ 3天采用基因重组卵泡刺激素 (rF SH ,商品名Gonal F) ,第 4天后改为国产HMG。C组 31例 ,全部采用Gonal F ;D组 35例 ,除促排卵的第 4~ 6天用药与A组相同外 ,其余同C组。比较 4组病人的取卵数、受精率、卵裂率、临床妊娠率及药费。结果  4组病人的取卵数、受精率、卵裂率及临床妊娠率差异均无显著性 (P >0 .0 5 ) ;4组病人的药费...

目的 分析 4种促超排卵方案 (tropichyperovulationprogramme ,THOP)在体外授精 -胚胎移植 (invitrofertilizationandembryotransfer,IVF ET)中的临床妊娠率 ,以探讨国产尿促性腺激素 (HMG)与进口基因重组卵泡刺激素 (Gonal F)的应用价值。方法 将需行IVF ET的 16 2例病人随机分为 4组 ,均于前一月经周期的黄体期应用促性腺激素释放激素激动剂 (GnRH a ,达必佳 )长方案降调节 ,从月经周期第 3天开始递减法给予促性腺激素 (Gn)促排卵。A组 37例 ,单用国产HMG促排卵 ;B组 5 9例 ,促排卵的第 1~ 3天采用基因重组卵泡刺激素 (rF SH ,商品名Gonal F) ,第 4天后改为国产HMG。C组 31例 ,全部采用Gonal F ;D组 35例 ,除促排卵的第 4~ 6天用药与A组相同外 ,其余同C组。比较 4组病人的取卵数、受精率、卵裂率、临床妊娠率及药费。结果  4组病人的取卵数、受精率、卵裂率及临床妊娠率差异均无显著性 (P >0 .0 5 ) ;4组病人的药费差异有显著性 (P <0 .0 1)。结论 国产HMG具有价格优势 ,是一种比较适合中国国情的促排卵药物。

 
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