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心脏毒
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  cardiotoxin
     Effects of Ca ̄(2+) entry blockers on the increase of cytoplasmic free Ca ̄(2+) by cardiotoxin in rat heart cells
     钙流拮抗药对眼镜蛇心脏毒升高大鼠心肌胞浆Ca~(2+)作用的影响
短句来源
     In this study, the fura-2 fluorescent technique was used to determine the effects of Ca2+ entry blockers on the increase of cytoplasmic free Ca2+ concentration induced by cardiotoxin(CTX) in freshly isolated rat heart cells.
     Fura-2荧光测定实验显示,眼镜蛇心脏毒(CTX)能明显升高新鲜分离的大鼠心肌细胞的胞浆Ca2+浓度。
短句来源
     In the present study, the effects of cardiotoxin ( CTX ) on the cy? toplasmic calcium ion concentration of Jacrimal acinar cell were deter- mined by continuaous monitoring of changes of cytoplasmic calcium with Fura-2 fluorescene technique.
     用Fura—2荧光技术直接测定眼镜蛇心脏毒(CTX)对大鼠泪腺细胞胞浆Ca~(2+)浓度的影响。
短句来源
     The relationship between the primary structure and 50% mice lethal dosage of 24 samples of cardiotoxin from cobra venom as well as the relationship between the primary structure and the 63% depolarization dosage of 19 samples of cardiotoxin for cultured rat myoball were analysed.
     对24种眼镜蛇心脏毒的一级结构和半数致死量关系和19种眼镜蛇心脏毒一级结构和大鼠培养骨骼肌细胞膜去极化剂量关系的分析结果表明,眼镜蛇心脏毒的第4、10、16、29和60位对其生物活性具有重要意义;
短句来源
     OBJECTIVE:To study the Inhibitory effects of cardiotoxin of bungarus fasciatus venoms on sarcoma 180 and ehrilich asciters careenoma.
     目的 :探讨金环蛇毒心脏毒对 S180 ,EAC腹水癌细胞的细胞毒作用。
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  “心脏毒”译为未确定词的双语例句
     Not a caseshowed side effect of heart, but hair losing was 100%, decrease of white blood cellwas often (Ⅱ°45.3%, Ⅲ°31.4%) with the lowest level reached at 13.4 days afterchemotherapy and recovered at 19.6 days in average.
     86例用阿霉素联合方案,无1例出现心脏毒副反应,脱发副反应最多,为100%,白细胞下降也较多见,45.3%为Ⅱ°,31.4%为Ⅲ°,下降最低时间为化疗后平均13.4天(6—22天),平均19.6天恢复(14—26天)。
短句来源
     QUANTITATIVE ANALYSIS OF THE PRIMARY STRUCTURE-FUNCTION RELATION OF CARDIOTOXIN FROM COBRA VENOM
     眼镜蛇心脏毒一级结构和功能关系的定量分析
短句来源
     Gastrointestinal disorders were significantly different between two groups ( P < 0.01) .
     不良反应中白细胞下降率,两组差异无显著性(P>0.05),胃肠道反应发生率两组差异有显著性(P<0.05),脱发及心脏毒副反应发生率两组差异有显著性(P<0.01)。
短句来源
     Fractions Ⅺ, Ⅻ and ⅩⅤ were shown to be cardiotoxic principles similar :to cobra card iotoxinand fraction ⅩⅢ and ⅩⅣ were neurotoxic principles which acted on the p ostsynaptics N-cholinergic receptors of the motor endplate.
     在这5个组分中,Ⅺ、Ⅻ、ⅩⅤ是心脏毒,ⅩⅢ、ⅩⅣ是神经毒。 心脏毒组分Ⅺ、ⅫⅩⅤ使离体大鼠心脏挛缩,心跳停止于收缩期;
短句来源
     Conclusions:The effect of mitoxantrone combined chemotherapy is satisfactory in treatment of advanced breast cancer and the toxicity is low.
     结论 :米托蒽醌联合化疗治疗晚期乳腺癌与阿霉素联合方案比较疗效相当 ,但心脏毒副作用轻
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  相似匹配句对
     Clinical Manifestations of Cardiac Involvement in Patients with Mushroom Poisoning
     蕈中心脏损害
短句来源
     An Analysis of the Cardiac Side Effects and Cardiotoxicity Associated with Clozapine and the Involved Risk Factors
     氯氮平所致心脏副反应及危险因素分析
短句来源
     The Heart of a Family
     家之心脏
短句来源
     CARDIAC AMYLOID OSIS
     心脏淀粉样变性病
短句来源
     Cytochalasin B
     细胞B
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  cardiotoxin
Interaction of Cardiotoxin A5 with Membrane: Role of Conformational Heterogeneity and Hydrophobic Properties
      
über die herzwirksame Komponente des Kobragiftes (?Cardiotoxin")
      
Pharmacological properties of cardiotoxin isolated from Formosan cobra venom
      
The latter, named cardiotoxin, caused contracture followed by paralysis of the chick biventer cervicis muscle, the frog sartorius muscle and the rat diaphragm, in consequence of irreversible depolarization of the cell membrane.
      
Cardiotoxin caused systolic arrest of the isolated frog heart and the rat atrium, probably by the same mechanism.
      
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The venom of Bungarus fasciatus was separated into seventeen fractions in a CM-cellulose column with ammonium acetate buffer by linear pH and ionic strength gradient elution. Fractions Ⅺ, Ⅻ and ⅩⅤ were shown to be cardiotoxic principles similar :to cobra card iotoxinand fraction ⅩⅢ and ⅩⅣ were neurotoxic principles which acted on the p ostsynaptics N-cholinergic receptors of the motor endplate.The cardiotoxic fractions were shown to produce systolic standstill ofthe isolated rat heart, to induce contracture...

The venom of Bungarus fasciatus was separated into seventeen fractions in a CM-cellulose column with ammonium acetate buffer by linear pH and ionic strength gradient elution. Fractions Ⅺ, Ⅻ and ⅩⅤ were shown to be cardiotoxic principles similar :to cobra card iotoxinand fraction ⅩⅢ and ⅩⅣ were neurotoxic principles which acted on the p ostsynaptics N-cholinergic receptors of the motor endplate.The cardiotoxic fractions were shown to produce systolic standstill ofthe isolated rat heart, to induce contracture of the baby chick biventer cervicis muscle and to produce local irritation on rabbit eyes. Fraction ⅩⅤ exhibited direct hemolytic activity on washed guinea pig erythrocytes.Fraction ⅩⅢ was shown, to be a neurotoxin on neuromuscular preparations. The twitch response of the skeletal muscle to indirect stimulation were progressively abolished in the baby chick biventer ceryicis muscle, the rat phrenic nerve diaphragm and the frog sartorium, muscle, while the responses to direct stimulation or to high K~+ were not appreciably affected. The Ach release of the rat phrenic nerve ending was also unaffected. The response to Ach (even 10 times the initial) was completely abolished inthe chick biventer cervicis muscle. The Ach dose-response curve was shifted to the right and was antagonized by neostigmine. The blocking actions were partially reversible in frog sartorium muscle and rat phrenic nerve diaphragm after repeated washings with physiological solution. It is concluded that fraction ⅩⅢ is a neurotoxin which acts on postsynaptic cholinergic receptors of motor endplate to produce nondepolarization type neuromuscular block.

金环蛇毒用羧甲基纤维素柱层析分离出17个蛋白组分,其中5个组分是毒性较大的致死成分。在这5个组分中,Ⅺ、Ⅻ、ⅩⅤ是心脏毒,ⅩⅢ、ⅩⅣ是神经毒。心脏毒组分Ⅺ、ⅫⅩⅤ使离体大鼠心脏挛缩,心跳停止于收缩期;使小鸡离体颈二腹肌挛缩,最后致痉挛性麻痹;对兔眼结合膜有局部刺激作用,使结合膜充血水肿。组分ⅩⅤ还具有直接溶血作用。 神经毒组分ⅩⅢ阻断大鼠、小鸡、青蛙神经肌肉标本的突触传递,标本对乙酰胆碱的反应消失,对直接刺激以及对高浓度氯化钾的反应无减少,神经末梢乙酰胆碱的释放最无显著改变;使蛙腹直肌乙酰胆碱量效曲线平行右移,新斯的明可以对抗这个作用。组分ⅩⅣ的作用与组分ⅩⅢ相似。实验提示,组分ⅩⅢ、ⅩⅣ是作用于终板后膜的神经毒。

Fifteen fractions were separated from the crude venom of Ophiophagus hannah on CM-cellulose 11 column chromatography with ammonium acetate buffer by 2-stage gradient elution and purified on Sephadex G-50 column. Among them, four fractions (Ⅷ. Ⅸ, Ⅻ and ⅩⅢ) showed high lethality. These four fractions were tested in experiments, unlike cobra venom and some other elapid venoms, and exhibited no cardiotoxic and presynaptic activities. They blocked the neuromuscular transmission of the isolated chick biventer cervicis...

Fifteen fractions were separated from the crude venom of Ophiophagus hannah on CM-cellulose 11 column chromatography with ammonium acetate buffer by 2-stage gradient elution and purified on Sephadex G-50 column. Among them, four fractions (Ⅷ. Ⅸ, Ⅻ and ⅩⅢ) showed high lethality. These four fractions were tested in experiments, unlike cobra venom and some other elapid venoms, and exhibited no cardiotoxic and presynaptic activities. They blocked the neuromuscular transmission of the isolated chick biventer cervicis muscle and inhibited its response to Ach, but not the response to KC1. The neuromuscular block produced by fractions Ⅻ, ⅩⅢ and Ⅸ was reversible and that by fraction Ⅷ was irreversible. The Ach release on the nerve terminal was not affected and Ach dose-response curve was shifted parallelly to the right by fractions Ⅷ and Ⅸ. It is concluded that these four fractions may be regarded as postsynaptic neurotoxins.

眼镜王蛇毒用CM-C11柱层析,醋酸铵缓冲液洗脱,分出15个蛋白组分,其中组分Ⅷ、Ⅸ、Ⅻ和ⅩⅢ为毒性较大的致死组分。实验证明眼镜王蛇全毒及四个毒性组分都不具有心脏毒及突触前神经毒活性。它们阻断小鸡颈二腹肌神经肌标本对间接刺激及对外源性乙酰胆碱的反应;神经肌传递阻滞后,标本对直接刺激及对氯化钾的反应不受影响。组分Ⅸ、Ⅻ和ⅩⅢ对神经肌传递的阻滞容易逆转,组分Ⅷ则较难逆转。这四个毒性组分均为突触后神经毒,其毒力依次为Ⅷ>Ⅸ>Ⅻ>ⅩⅢ,眼镜王蛇毒的主要毒性成分是突触后神经毒。

0,75% Bupivacaine had been applied 327 times in epidural block, among them 122 times were simple while the rest continuous. In those received continuous epidural block, 78 times had bupivacaine served as supplement and 87 times had a testing dose with lidocaine. For Cesarean section, epidural block with 2% lidocaine would be enough, and only a few with 0.75% bupivacaine had nothing particupar under careful mange ment. According to the experience obtained from ESWL 103 times, preventive measure with ephedrine...

0,75% Bupivacaine had been applied 327 times in epidural block, among them 122 times were simple while the rest continuous. In those received continuous epidural block, 78 times had bupivacaine served as supplement and 87 times had a testing dose with lidocaine. For Cesarean section, epidural block with 2% lidocaine would be enough, and only a few with 0.75% bupivacaine had nothing particupar under careful mange ment. According to the experience obtained from ESWL 103 times, preventive measure with ephedrine and/or atropine were not absolutely necessary. By the same way the adjuvants pethidine and fentanyl could be reduced to minimal without harm For the safty application of 0.75% bupi-vacaine in epidural block, the following factors are seriously considered and discussed, namely: (1)Indications should be definite and sure. (2) Pay special attention to the early signs of neural and cardiovascular toxicities together with their prevention and proper treatment. (3)Hypoxemia and hypercarpnia are prohibited to beexisting.(4)Over dose should be given with special caution while toxic dose avoided.(5)0.75% bupivacaine itself can be used as testing dose with advantage. (6) Addition of epinephrine into 0.75% bupivacaine has no benefit for prolonging of the analgesic effect, but for the safety sake one would not be against to have it.

0.75%丁哌卡因应用于硬外327次,内122次为单硬,余为连硬。连硬中有78次,系在2%利多卡因后肌松不够的情况下加用,87次先用2%利多卡因作试探而后注入适量。剖腹产硬外一般不妨采用2%利多卡因,用0.75%丁哌卡因者不多,但慎用之亦无碍。需要肌松的腹腔内手术,硬外应选用0.75%丁哌卡因;硬外预防性用药,按ESWL单硬103次的经过,有41次作证,可以省却,不妨仍按需给予。由于丁哌卡因的镇痛效应显著,辅佐用药尤其是哌替啶或芬太尼等使用的机会少于利多卡因和丁卡因合剂,ERWL硬外中有31次未用。0.75%丁哌卡因的合理应用,除明确适应证外,要注意神经毒和心脏毒的早兆,无低氧血症和酸血症的存在,忌用超剂量和中毒量。硬外的试探性用药可迳用小剂量的0.75%丁哌卡因。单硬可用0.75%丁哌卡因,但应慎重。

 
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