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生化代谢物
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     Objective To investigate the application of proton magnetic resonance spectroscopy (1H-MRS) in detecting the biochemical metabolism in children with febrile seizure(FS), and to evaluate the information of brain injury and study the clinical significance of 1H-MRS in FS.
     目的应用氢质子磁共振波谱(1H-MRS)检测热性惊厥(FS)患儿脑组织生化代谢物,了解FS发作后脑损伤情况,探讨1H-MRS在FS中应用的意义。
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     Objective To investigate the application of proton magnetic resonance spectroscopy (1H-MRS) combined with magenetic resonance imaging (MRI) in detecting biochemical metabolism in children with epilepsy.
     目的 探讨应用质子磁共振波谱 (protonmagneticresonancespectroscopy,1H MRS)对癫痫患儿进行脑组织生化代谢物检测的临床意义。 方法  1997年 9月至 1998年 2月对 2 0例癫痫患儿和8例正常儿童 (对照组 )进行常规头颅MRI和海马杏仁核区域 1H MRS检查。
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  相似匹配句对
     biochemical coupling;
     生化偶联 ;
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     S-Adenosyl-L-methionine takes part in many biochemical reactions,and is an important metabolite in vivo .
     S 腺苷甲硫氨酸 (SAM)参与多种生化反应 ,是生物体内重要的中间代谢物
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     Biochemical Application of Bagasse
     蔗渣的生化利用
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     Metabonomics can be directly understood the physiological and biochemical situation by its "metabolome profile" as a whole.
     它能用反映整体的代谢物图直接认识生理何生化状态。
     (2) secondary metabolite synthesis;
     (2)次生代谢物的合成;
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  biochemical substances
Although we cannot assess the clinical usefulness of biochemical substances merely on the basis of their in vitro effects, understanding these mechanisms is fundamental to the success of the new therapeutic approach which is currently under way.
      
The initiation of monokaryotic fruiting in the basidiomycetous fungus Schizophyllum commune has been observed to occur spontaneously, in response to biochemical substances, and following mechanical injury.
      
It can easily be incorporated into the determination of biochemical substances that produce hydrogen peroxide under catalytic oxidation in the presence of their oxidase.
      
Biomarkers as biochemical substances of collagen metabolism are produced during bone turnover and can be determined as parameters of bone metabolism not only in serum, but also in urine.
      
Biochemical substances were measured to reflect organ functions.
      
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Objective To investigate the application of proton magnetic resonance spectroscopy (1H-MRS) combined with magenetic resonance imaging (MRI) in detecting biochemical metabolism in children with epilepsy. Methods In 20 cases of epilepsy,6 were intractable epilepsy and 8 normal subjects exprienced MRI and single-voxel 1H-MRS exminations by locating in the amygdaloid-hippocampus The signal intensities of N-acetylaspartate(NAA),creatine+phosphocreatine(Cr),choline-containig compounds(Cho) and the ratios...

Objective To investigate the application of proton magnetic resonance spectroscopy (1H-MRS) combined with magenetic resonance imaging (MRI) in detecting biochemical metabolism in children with epilepsy. Methods In 20 cases of epilepsy,6 were intractable epilepsy and 8 normal subjects exprienced MRI and single-voxel 1H-MRS exminations by locating in the amygdaloid-hippocampus The signal intensities of N-acetylaspartate(NAA),creatine+phosphocreatine(Cr),choline-containig compounds(Cho) and the ratios of NAA/Cho+cr,NAA/Cho,and NAA/Cr were set into comparison bilaterally between the patients and controls. Results 15 patients were abnormal in 1H-MRS examination The signal intensity of NAA in MRI abnormal area was obviously lower than that in the contralaterals of focus and the controls,the Cho was higher than in the contralaterals and controls;NAA/Cho+Cr (0 59±0 11) and NAA/Cho (1 08±0 36) were lower than those in contralaterals (0 75±0 17,1 40±0 38)and controls (0 77±0 12,1 29±0 48) NAA,Cho,Cr and ratios of NAA/Cho+Cr,NAA/Cho,NAA/Cr of the left and the right side of controls were not significantly different There are decreases of bilateral NAA and ratio NAA/Cho+Cr in 5 out of the 6 children with intractable epilepsy. Conclusions Signal intensity of NAA and ratio NAA/Cho+Cr,NAA/Cho in children with epilepsy were decreased by 1H-MRS detection These spectral abnormalities may reflect neuronal loss or dysfunction,there are bilateral diffuse abnormalities in the intractable epilepsy 1H-MRS may help understand the underlying pathophysiology in children with epilepsy

目的 探讨应用质子磁共振波谱 (protonmagneticresonancespectroscopy,1H MRS)对癫痫患儿进行脑组织生化代谢物检测的临床意义。方法  1997年 9月至 1998年 2月对 2 0例癫痫患儿和8例正常儿童 (对照组 )进行常规头颅MRI和海马杏仁核区域 1H MRS检查。 2 0例癫痫患儿中 6例为难治性癫痫。检测指标 :N 乙酰天门冬氨酸 (N acetylaspartate ,NAA)、肌酸 (creatine ,Cr)和胆碱 (choline,Cho)的信号强度和计算NAA/Cho +Cr、NAA/Cho和NAA/Cr的比值 ,并进行比较。结果 病例组 1H MRS检查异常 15例 ,其病灶侧NAA信号强度明显低于病灶对侧及对照组 ,病灶侧Cho高于病灶对侧及对照组 ,病灶侧NAA/Cho+Cr比值为 0 5 9± 0 11,明显低于病灶对侧 (0 75± 0 17)及对照组 (0 77±0 12 ) ;NAA/Cho比值为 1 0 8± 0 36 ,也低于病灶对侧 (1 40± 0 38)及对照组 (1 2 9± 0 48) ;病灶侧...

目的 探讨应用质子磁共振波谱 (protonmagneticresonancespectroscopy,1H MRS)对癫痫患儿进行脑组织生化代谢物检测的临床意义。方法  1997年 9月至 1998年 2月对 2 0例癫痫患儿和8例正常儿童 (对照组 )进行常规头颅MRI和海马杏仁核区域 1H MRS检查。 2 0例癫痫患儿中 6例为难治性癫痫。检测指标 :N 乙酰天门冬氨酸 (N acetylaspartate ,NAA)、肌酸 (creatine ,Cr)和胆碱 (choline,Cho)的信号强度和计算NAA/Cho +Cr、NAA/Cho和NAA/Cr的比值 ,并进行比较。结果 病例组 1H MRS检查异常 15例 ,其病灶侧NAA信号强度明显低于病灶对侧及对照组 ,病灶侧Cho高于病灶对侧及对照组 ,病灶侧NAA/Cho+Cr比值为 0 5 9± 0 11,明显低于病灶对侧 (0 75± 0 17)及对照组 (0 77±0 12 ) ;NAA/Cho比值为 1 0 8± 0 36 ,也低于病灶对侧 (1 40± 0 38)及对照组 (1 2 9± 0 48) ;病灶侧Cr和NAA/Cr与病灶对侧及对照组比较 ,差异无显著意义。对照组左、右侧代谢物信号强度及代谢物比值无明显差异。 6例难治性癫痫患儿中 ,有 5例双侧NAA/Cho+Cr比值下降。结论  1H MRS检测结果显示 ,癫痫患儿脑组织中NAA信号强度下降 ,Cho信号强度升高 ,NAA/Cho+Cr比值下降 ,提示神经细胞受损 ,胶质细胞增生。难治性癫痫患儿有弥漫性

Objective: To investigate the effect of UU infection on azoospermia patients. Methods:UU culture and seminal plasma biochemistry analysis on 143 Azoospermia patients are performed.Results:The positive rate of detection of UU culture was 48.95%.Many abnormal metabolites were occured in seminal plasma from patients with azoospermia and the contents of the fructose,acid phosphatase and Ca2+ in seminal plasma had a significant differences between the positive and negative UU cultures. Conclusion:There are many...

Objective: To investigate the effect of UU infection on azoospermia patients. Methods:UU culture and seminal plasma biochemistry analysis on 143 Azoospermia patients are performed.Results:The positive rate of detection of UU culture was 48.95%.Many abnormal metabolites were occured in seminal plasma from patients with azoospermia and the contents of the fructose,acid phosphatase and Ca2+ in seminal plasma had a significant differences between the positive and negative UU cultures. Conclusion:There are many causes of azoospermia,but one of these important reasons is UU infection.

目的 :探讨解脲支原体 (UU)感染对无精子症发生的影响。方法 :对143例无精子症患者进行UU培养和精浆生化分析。结果 :解脲支原体培养阳性率48.95% ;无精子症患者精浆中有较多异常生化代谢物 ;UU感染 ( + )与 ( - )比较 ,果糖、酸性磷酸酶、钙含量有显著性差异 ,均P<0.05。结论 :无精子症病因多 ,UU感染是无精子症的重要病因之一

Objective To investigate the application of proton magnetic resonance spectroscopy (1H-MRS) in detecting the biochemical metabolism in children with febrile seizure(FS), and to evaluate the information of brain injury and study the clinical significance of 1H-MRS in FS.Methods Twenty-five cases of children with FS [15 cases with simple febrile seizure(SFS) and 10 cases with complex (CFS)] and 6 cases without nervous system disease exprienced magnetic resonance imaging(MRI) examinations of skull and single-voxel...

Objective To investigate the application of proton magnetic resonance spectroscopy (1H-MRS) in detecting the biochemical metabolism in children with febrile seizure(FS), and to evaluate the information of brain injury and study the clinical significance of 1H-MRS in FS.Methods Twenty-five cases of children with FS [15 cases with simple febrile seizure(SFS) and 10 cases with complex (CFS)] and 6 cases without nervous system disease exprienced magnetic resonance imaging(MRI) examinations of skull and single-voxel 1H-MRS examinations of the hippocampi-temporal lobe. The signal intensities of N-acetylaspartate(NAA),eatine+phosphocreatine(Cr),choline-containig compounds(Cho),lactate(Lac)and the ratios of NAA/(Cho+Cr) and Lac/Cr were set into comparison between the patients and controls.Results The study showed that all children investigated by MRI were normal. The ratio of NAA/(Cho+Cr) in SFS patients was 0.71±0.05,CFS patients was 0.65±0.04,control group was 0.73±0.05. The NAA/(Cho + Cr) ratio in CFS group was lower than that in SFS and control group (Pa<0.01), but no significant difference was found between SFS and control groups (P>0.05).The ratios of Lac/Cr in the patients of SFS group(0.32±0.21) and CFS group (0.65±0.30) were higher than that in control group(0.05±0.04) (Pa<0.05), and Lac/Cr ratio in patients of CFS group was higher than that in SFS group(P<0.01).Conclusion 1H-MRS can provide earlier information on brain injury sensitively and noninvasively in children with FS, and it may be used for therapy and prognosis in children with FS,especially CFS.

目的应用氢质子磁共振波谱(1H-MRS)检测热性惊厥(FS)患儿脑组织生化代谢物,了解FS发作后脑损伤情况,探讨1H-MRS在FS中应用的意义。方法对25例FS患儿和6例神经系统正常儿童进行常规头颅MRI和颞叶海马区的1H-MRS检查。25例FS患儿中,15例为单纯性热性惊厥(SFS),10例为复杂性热性惊厥(CFS)。检测指标为N-乙酰天门冬氨酸(NAA)、肌酸(Cr)、胆碱(Cho)、谷氨酸-谷氨酰胺复合物(Glx)和乳酸(Lac)的信号强度,计算并比较NAA/(Cho+Cr)和Lac/Cr的比值。结果头颅MRI检查结果为FS组及对照组均未显示异常。1H-MRS检测结果为NAA/(Cho+Cr)比值,SFS组为0.71±0.05,CFS组为0.65±0.04,对照组为0.73±0.05,CFS组明显低于SFS组及对照组(Pa<0.01),但后二者之间无明显差异(P>0.05)。Lac/Cr比值SFS组(0.32±0.21)和CFS组(0.63±0.30)高于对照组(0.05±0.04)(Pa<0.05),且CFS组高于SFS组(P<0.01)。结论1H-MRS作为一项无创检查,能更敏感地发现F...

目的应用氢质子磁共振波谱(1H-MRS)检测热性惊厥(FS)患儿脑组织生化代谢物,了解FS发作后脑损伤情况,探讨1H-MRS在FS中应用的意义。方法对25例FS患儿和6例神经系统正常儿童进行常规头颅MRI和颞叶海马区的1H-MRS检查。25例FS患儿中,15例为单纯性热性惊厥(SFS),10例为复杂性热性惊厥(CFS)。检测指标为N-乙酰天门冬氨酸(NAA)、肌酸(Cr)、胆碱(Cho)、谷氨酸-谷氨酰胺复合物(Glx)和乳酸(Lac)的信号强度,计算并比较NAA/(Cho+Cr)和Lac/Cr的比值。结果头颅MRI检查结果为FS组及对照组均未显示异常。1H-MRS检测结果为NAA/(Cho+Cr)比值,SFS组为0.71±0.05,CFS组为0.65±0.04,对照组为0.73±0.05,CFS组明显低于SFS组及对照组(Pa<0.01),但后二者之间无明显差异(P>0.05)。Lac/Cr比值SFS组(0.32±0.21)和CFS组(0.63±0.30)高于对照组(0.05±0.04)(Pa<0.05),且CFS组高于SFS组(P<0.01)。结论1H-MRS作为一项无创检查,能更敏感地发现FS患儿的早期脑损伤,为FS尤其是CFS患儿的治疗、评估预后提供客观依据。

 
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