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间质效应细胞
相关语句
  interstitial effective cell
     SMC was the interstitial effective cell of IH.
     结论 移植静脉内膜增生中的胶原是由SMC合成及分泌的 ,SMC是ECM堆积的间质效应细胞
短句来源
  interstitial effective cells
     Objective To understand the interstitial effective cells secreting extracellular matrix (ECM) in intimal hyperplasia (IH) after venous implantation.
     目的 明确静脉移植后内膜增生 (IH)过程中分泌细胞外基质 (ECM )的间质效应细胞
短句来源
  “间质效应细胞”译为未确定词的双语例句
     In recent years, bioresearch about ECM indicated that there some kinds of matrix effector cells play key roles in the formation of organic fibrosis and the activation of them is the main source of collagenation cells.
     近年来关于ECM的生物学研究表明,在器官纤维化的形成过程中,往往有一些间质效应细胞发挥关键作用,它们的激活已成为胶原生成细胞的主要来源。
短句来源
     Whether there is a kind of matrix effector cells just like hepatic stellate cells, Mesangial cells, and pancreatic stellate cells in myocardial interstitial cells is not sure.
     心肌间质细胞中是否有像肝星状细胞、肾小球系膜细胞、胰腺星状细胞等那样的间质效应细胞至今还未确定。
短句来源
     METHODS:Isoproterenol (ISP) was injected into Wistar rats to make a myocardial ischemia and necrotic model. The activities of GOT,CK,LDH and hydroxybutyrate dehydrogenase in serum and contents of local angiotensin-converting enzyme (ACE)content,angiotensin-Ⅱ(Ang-Ⅱ),and collagen in injured myocardium were determined,the fibroblasts in myocardium were observed by immunohistochemical method 3,7,14 and 21 days after injected ISP, respectively.
     方法:用异丙基肾上腺素(ISP)注射大鼠,造成心肌缺血缺氧和心肌坏死模型,检测血清内GOT、CK、LDH、HBDH(羟丁酸脱氢酶)的活性,并检测心肌组织内血管紧张素-Ⅰ转换酶(ACE)、血管紧张素-Ⅱ(Ang-Ⅱ)和心肌胶原含量变化,观察细胞外间质效应细胞增殖情况。
短句来源
  相似匹配句对
     the effector cell of RTE is T cells.
     RTE的效应细胞是T细胞 ;
短句来源
     Effect of Single α-Particle on Cells
     单个α-粒子的细胞效应
短句来源
     Ultrasttructure of Interstitial cell and Lymphatics in the Testis
     睾丸间质细胞及淋巴管的超微结构
短句来源
     A second cell type is the endometrial stromal cells.
     第二种为子宫内膜间质细胞
短句来源
     The T lymphocytes characterized by alpha naphthyl acetate (ANAE) staining were major cells in the stroma of ovarian malignancies.
     α-醋酸萘酯酶染色显示T淋巴细胞是肿瘤间质中的主要效应细胞
短句来源
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The autogenous jugular vein was grafted into the carotid artery in a rat. The grafts were haversted at 1,2,4,7 days and 2,4,6.12,18,24 weeks after implantation. The histological cross section of each specimen was stained with van gieson and weigert stain for morphometric evaluation. The smooth muscle cell (SMC) phenotypic modulation and collagen I (col I) and collagen III (col III) expression in the neointima of vein graft were detected by immunohis-tochemical methods with monospecific antibodies a-gainst Desmin...

The autogenous jugular vein was grafted into the carotid artery in a rat. The grafts were haversted at 1,2,4,7 days and 2,4,6.12,18,24 weeks after implantation. The histological cross section of each specimen was stained with van gieson and weigert stain for morphometric evaluation. The smooth muscle cell (SMC) phenotypic modulation and collagen I (col I) and collagen III (col III) expression in the neointima of vein graft were detected by immunohis-tochemical methods with monospecific antibodies a-gainst Desmin (Dm), col I , col III . The experimental results showed: 1) The phenotype of SMC in the neointima revealed a transformation from the contractile into the synthetic 2 weeks after grafting. Synthetic phenotype SMC were highest at 6 weeks after grafting. 2) Col I appeared in the neointima 2 weeks and reached peak 12 weeks after grafting. Then it remained steady. 3) col I in the neointima appeared earlier and increased more quickly than col III .

目的:研究静脉移植术后内膜增生(IH)中细胞基质(ECM)堆积的发生、发展及与平滑肌细胞(SMC)增殖的关系.方法:将大鼠一段颈外静脉桥接移植入颈总动脉,运用组织切片的特殊染色及免疫组化方法,观察术后1天至24周移植静脉的IH中,Ⅰ型胶原(ColⅠ)、Ⅱ型胶原(ColⅢ型)及SMC结蛋白(D_m)的变化.结果及结论:术后2周,IH中开始出现胶原的堆积,术后12周,IH中胶原含量达最大值并自此保持稳定不变,术后24周IH主要由细胞外基质组成;术后2周,IH中SMC的D_m开始表达,表明SMC的表型开始由收缩型向分泌型改变,术后6周,D_m达最大值,表明此时分泌型SMC最多,SMC可能是分泌细胞外基质的间质效应细胞.

AIM:To investigate the relationship between collagen metabolism and local renin angiotensin systems in injured myocardium. METHODS:Isoproterenol (ISP) was injected into Wistar rats to make a myocardial ischemia and necrotic model.The activities of GOT,CK,LDH and hydroxybutyrate dehydrogenase in serum and contents of local angiotensin-converting enzyme (ACE)content,angiotensin-Ⅱ(Ang-Ⅱ),and collagen in injured myocardium were determined,the fibroblasts in myocardium were observed by immunohistochemical method...

AIM:To investigate the relationship between collagen metabolism and local renin angiotensin systems in injured myocardium. METHODS:Isoproterenol (ISP) was injected into Wistar rats to make a myocardial ischemia and necrotic model.The activities of GOT,CK,LDH and hydroxybutyrate dehydrogenase in serum and contents of local angiotensin-converting enzyme (ACE)content,angiotensin-Ⅱ(Ang-Ⅱ),and collagen in injured myocardium were determined,the fibroblasts in myocardium were observed by immunohistochemical method 3,7,14 and 21 days after injected ISP, respectively.RESULTS:Local ACE and Ang-Ⅱ contents were significantly increased with proliferation of the fibroblasts and increase of collagen content after ISP injection.CONCLUSION:Accumulation of collagen in injured myocardium is all related to the release of ACE and Ang-Ⅱ.Ang-Ⅱ might be a signal molecule for collagen accumulation in relatively high concentration in injured myocardium.

目的:探讨缺血缺氧性心肌损伤过程中血管紧张素-Ⅱ(Ang-Ⅱ)与心肌胶原代谢的关系。方法:用异丙基肾上腺素(ISP)注射大鼠,造成心肌缺血缺氧和心肌坏死模型,检测血清内GOT、CK、LDH、HBDH(羟丁酸脱氢酶)的活性,并检测心肌组织内血管紧张素-Ⅰ转换酶(ACE)、血管紧张素-Ⅱ(Ang-Ⅱ)和心肌胶原含量变化,观察细胞外间质效应细胞增殖情况。结果:注射ISP后,血清GOT、CK、LDH、HBDH活性增加,心肌匀浆内ACE、Ang-Ⅱ含量上升,并发现在ACE、Ang-Ⅱ升高的同时有成纤维细胞的增生,以后心肌胶原含量明显升高。结论:心肌缺血缺氧后,心肌局部合成释放ACE、Ang-Ⅱ增加,使心肌成纤维细胞增殖和合成胶原能力增强,出现心肌胶原含量的增加。说明Ang-Ⅱ是心肌间质胶原反应的一个信号分子

Objective To understand the interstitial effective cells secreting extracellular matrix (ECM) in intimal hyperplasia (IH) after venous implantation. Methods After establishing a animal model of IH following venous grafting, the location of medial smooth muscle cells (SMC) was determined by using Desmin immunohistological method and special straining (VG straining). Using in situ hybridization the expression of α1(Ⅰ) and α1(Ⅲ) precollagen mRNA of collagenⅠand collagen Ⅲ was located 1, 2, 4, 6 and 8 weeks after...

Objective To understand the interstitial effective cells secreting extracellular matrix (ECM) in intimal hyperplasia (IH) after venous implantation. Methods After establishing a animal model of IH following venous grafting, the location of medial smooth muscle cells (SMC) was determined by using Desmin immunohistological method and special straining (VG straining). Using in situ hybridization the expression of α1(Ⅰ) and α1(Ⅲ) precollagen mRNA of collagenⅠand collagen Ⅲ was located 1, 2, 4, 6 and 8 weeks after venous transplantation. Results The expression of α1(Ⅰ), α1(Ⅲ) precollagen mRNA was detectale in SMCs of thickened neointimal at 1, 2, 4, 6, 8 weeks after venous implantation. Conclusion ECM in IH of venous grafts was secreted by SMC after venous implantation. SMC was the interstitial effective cell of IH.

目的 明确静脉移植后内膜增生 (IH)过程中分泌细胞外基质 (ECM )的间质效应细胞。方法 建立静脉移植后内膜增生动物模型 ,采用Desmin免疫组织化学及特殊染色明确平滑肌细胞 (SMC)的位置 ,用原位杂交检测细胞外基质的重要成分———Ⅰ、Ⅲ型胶原α1(Ⅰ )、α1(Ⅲ )前胶原mRNA在静脉移植术后 1、2、4、6、8周的定位表达。结果 术后早期 ,移植静脉增生内膜的SMC中有α1(Ⅰ )、α1(Ⅲ )前胶原mRNA的表达。术后远期 ,α1(Ⅰ )、α1(Ⅲ )前胶原mRNA也在增生内膜的SMC中表达。结论 移植静脉内膜增生中的胶原是由SMC合成及分泌的 ,SMC是ECM堆积的间质效应细胞

 
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