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   细胞毒效应细胞 的翻译结果: 查询用时:0.752秒
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心血管系统疾病
肿瘤学
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细胞毒效应细胞
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  cytotoxic effector cells
     Multiple Myeloma Cell Line XG-7 Can Induce CD8 +TCRαβ-bearing T Cell to Proliferate and Differentiate into Cytotoxic Effector Cells
     多发性骨髓瘤细胞XG-7诱导CD8和TCRαβ阳性的T细胞增殖分化成为细胞毒效应细胞
短句来源
     The in vitro experimental results showed that IL-2-PE40 was able to selectively inhibit alloresponsive cells in allogeneic mixed lymphocyte culture(MLC),eliminate cytotoxic effector cells generated in MLC,and maintain the ConA inducing mitogenic response of the nonactivated cells.
     实验结果表明体外应用IL-2-PE40能够选择性抑制混合淋巴细胞培养(MLC)中的异基因反应细胞,清除MLC诱导产生的细胞毒效应细胞,保留未活化细胞对ConA诱导的丝裂原反应;
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  “细胞毒效应细胞”译为未确定词的双语例句
     Results: After stimulation by Bel-7402 cells PBMCs could proliferate and be cultured a long time. The CD4 V CD8 + ratio was skewed and the proportion of CD8 + T cells increased and accounted for more than 90 percent of total cells.
     结果:经肝癌细胞Bel-7402刺激的外周血单个核细胞可增殖分化为抗肿瘤的细胞毒效应细胞,CD4+/CD8+细胞比例偏移,CD8+T淋巴细胞增加,比例可以占到90%以上。
短句来源
  相似匹配句对
     Cytochalasin B
     细胞B
短句来源
     Cytotoxic T Cell
     细胞T细胞
短句来源
     The inhibition required the interaction of leukemic cells and rTNF-a lasting for more than 4 hours, and the cytotoxic effect might be the main mechanism.
     细胞效应可能是其主要的作用机制。
短句来源
     STUDY OF CYTOGENETIC TOXIN EFFECT IN EXPERIMENTAL RABBIT BRUCELLOSIS
     实验性家兔布氏菌病的细胞遗传效应的研究
短句来源
     CONCLUSION: NO is an effector molecule in cytotoxicity of activated macrophages.
     结论:NO是巨噬细胞细胞作用的一个效应分子。
短句来源
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  cytotoxic effector cell
IgA antibodies Human IgG1 antibodies do not effectively activate PMN, which are the most numerous cytotoxic effector cell population in humans.
      
Redirected target-cell lysis by a cytotoxic effector cell, mediated by a bispecific antibody.
      
These results identify LTB4-BLT1 as a potent nonchemokine pathway for cytotoxic effector cell traffic.
      
These results strongly indicate that the LTB4-BLT1 pathway is essential for cytotoxic effector cell movement to sites of acute inflammation.
      
These results need further investigations to determine the type of cytotoxic effector cell populations inthe IL-2-activated cells from collection 3.
      
  cytotoxic effector cells
On the other hand, CD4-CD8 T cells may be required for the proliferation of PBLs and generation of cytotoxic effector cells.
      
In cooperation with a subpopulation of T-lymphocytes, the T-helper cells, cytotoxic effector cells are generated from a further subpopulation of T-lymphocytes.
      
The generation of cytotoxic effector cells in vitro was lower for spleen cells from 22-day streptozotocin mice, although blastogenic responses in MLC were not depressed.
      
The generation of cytotoxic effector cells in vitro, however, was depressed for spleen cells obtained from 22- and 48-day Streptozotocin mice.
      
In this model of spontaneous autoimmunity, natural killer cells are candidate cytotoxic effector cells, believed to be the mediators of beta-cell cytolysis in vivo.
      
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We used MTT assay to test the cellular cytotoxicity ( NK, LAK, CTL, Macrophage), cytokine activities ( 1L-1, 1L-2, 1L-6, TNF), proliferation of lymphocytes and chemosensitivity of tumor cells, and compared it with radioactive isotope assay. The results showed that the MTT assay may be used to test the cellular cytotoxicity, cytokine ac-tivity, proliferation of lymphocytes and chemosensitivity of tumor cells. We think it is a simple, rapid, economic and safety method.

抗癌效应细胞(NK、LAK、CTL、Mφ)细胞毒效应、细胞因子和肿瘤化疗药敏检测目前多采用同位素法,但存在着使用同位素而引起的弊端。寻找一种简便,敏感及安全的检测手段已成为当务之急。我们将MTT比色法用于抗癌效应细胞功能、细胞因子及化疗药敏测定,并与同位素方法进行了对比,结果表明两种方法具有良好的相关性,MTT法与后者相比更为简便、经济、安全和实用。

IL-2-PE40 is a recombinant chimeric toxin designed to kill cells with IL-2 receptors.The in vitro experimental results showed that IL-2-PE40 was able to selectively inhibit alloresponsive cells in allogeneic mixed lymphocyte culture(MLC),eliminate cytotoxic effector cells generated in MLC,and maintain the ConA inducing mitogenic response of the nonactivated cells.The growth of CFU-GM did not inhibited by IL-2-PE40.Administration of IL-2-PE40 to mice underwent allogeneic bone marrow transplantation could prolong...

IL-2-PE40 is a recombinant chimeric toxin designed to kill cells with IL-2 receptors.The in vitro experimental results showed that IL-2-PE40 was able to selectively inhibit alloresponsive cells in allogeneic mixed lymphocyte culture(MLC),eliminate cytotoxic effector cells generated in MLC,and maintain the ConA inducing mitogenic response of the nonactivated cells.The growth of CFU-GM did not inhibited by IL-2-PE40.Administration of IL-2-PE40 to mice underwent allogeneic bone marrow transplantation could prolong their survival.

探讨白细胞介素2(IL-2)与绿脓杆菌外毒素组成的融合蛋白──IL-2-PE40对小鼠异基因骨髓移植的影响。实验结果表明体外应用IL-2-PE40能够选择性抑制混合淋巴细胞培养(MLC)中的异基因反应细胞,清除MLC诱导产生的细胞毒效应细胞,保留未活化细胞对ConA诱导的丝裂原反应;体内应用IL-2-PE40能延长异基因骨髓移植小鼠的存活期,而对CFU-GM产率无明显影响。

In the present study,the peripheral blood lymphocytes (PBL) from healthy donors were obtained after Ficoll Hypaque centrifugation and co cultured with the multiple myeloma cell line XG 7 An 3 H TdR incorporation assay demonstrated that PBL proliferated well in response to XG 7 stimulation An immunofluorescence assay showed that the CD4 +/CD8 + ratio was skewed and the proportion of CD8 + T cells increased The activated CD8 + T cell population could be rapidly amplified in the IL 2 containing...

In the present study,the peripheral blood lymphocytes (PBL) from healthy donors were obtained after Ficoll Hypaque centrifugation and co cultured with the multiple myeloma cell line XG 7 An 3 H TdR incorporation assay demonstrated that PBL proliferated well in response to XG 7 stimulation An immunofluorescence assay showed that the CD4 +/CD8 + ratio was skewed and the proportion of CD8 + T cells increased The activated CD8 + T cell population could be rapidly amplified in the IL 2 containing culture system and accounted for more than 96 percent of total cells Cytometry was used to assess the phenotype of the amplified T cells and the results revealed that the molecules CD3,CD8 and TCRαβ,were detectable,but not for CD4,CD16 and CD56 Cytotoxicity experiments perfomed with amplified CD8 + T cells showed that they could lyse not only the original stimulator XG 7 cells,but also other tumor cells such as RPMI8226,U266 and Daudi In summary,the above results indicate that CD8 + T cells in PBL after stimulation by XG 7 cells can proliferate and differentiate into cytotoxic effector cells against tumor cells This may potentially be useful in clinic for treatment of tumor patients

采用经密度梯度离心获得的正常健康人外周血淋巴细胞 (PBL )与多发性骨髓瘤细胞XG 7进行混合肿瘤淋巴细胞培养。3 H TdR掺入实验证实XG 7细胞可刺激PBL增殖 ;间接免疫荧光检测显示增殖的PBL中 ,CD4+ /CD8+ 细胞比例偏移 ,CD8+ T细胞增加。激活的CD8+ T细胞在含IL 2的培养体系中得到迅速扩增 ,占细胞总数的 96 %以上。流式细胞仪检测显示 ,扩增的T细胞表达CD3,CD8和TCRαβ ,而不表达CD4,CD16和CD5 6。细胞毒实验结果表明 ,扩增的CD8+ T细胞不仅杀伤原刺激细胞XG 7,也可杀伤其它肿瘤细胞如RPMI82 2 6 ,U2 6 6和Daudi。上述结果说明了经XG 7细胞所刺激PBL中的CD8+ T细胞可增殖分化成为抗肿瘤细胞的细胞毒效应细胞 ,这使得它们有可能在临床上用于肿瘤病人的治疗。

 
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