In order to study the role of nitric oxide in the schistosomiasis hepatic damage, the rabbits ( n =40) were infected with cercariae of schistosoma japonicum percutaneously. Using S P immunohistochemical technique, the expression and localization of iNOS and CD 68 in rabbit liver 8, 12, 16, 20, 24 weeks after infection were observed.
Changes in sphingomyelinase activity, tumor necrosis factor α expression, and level of lipid peroxidation products in the course of development of cholestatic liver injury have been studied.
In conclusion, induction of HO-1 provides protection against liver injury during cold ischemia preservation and improves the preservation of liver graft.
Effectiveness of pectin extracted from the eelgrass Zostera marina for alleviating lead-induced liver injury
The effects of pectin from the eelgrass Zostera marina on toxic liver injury induced by enteral administration of lead acetate are examined in experiments on rats.
The hepatoprotective potential of earthworm extract (EE) (Lampito mauritii, Kinberg) was evaluated against paracetamol-induced liver injury in Wistar albino rat, in comparison with silymarin, the standard hepatoprotective drug.
Alcohol abuse is thought to be a risk factor for the cause of liver damage, hyperlipidemia and insulin resistance.
Since leukocytes are much more available than hepatocytes or neuronal cells in humans, we assume that CE in peripheral blood leukocytes (neutrophils and monocytes) can be used as markers for indication of pending liver damage by CPZ.
In this study, we examined the effects of its ethanolic root extract on experimental liver damage in order to evaluate its hepatoprotective effects against hepatotoxicity induced in rats by ethanol at a dosage of 5 g/kg body weight for 60 days.
The degree of liver damage was analysed using serum marker enzyme activities, the total protein, albumin, globulin, ceruloplasmin and liver glycogen contents, and the A/G ratio.
The correlation of serum arylesterase (PON1) activity on phenylacetate determined by an integrated method to classical biochemical indexes of liver damage was investigated for the use of PON1 activity to evaluate liver damage.
It is suggested that increased synthesis of AFP corresponds to liver cell regeneration secondary to hepatic damage.
This amounts to no more than 22 % of the levels known from galactosemic children to be safe, concerning ocular, neural or hepatic damage.
A case of serious acute hepatic damage probably induced by carbamazepine (CBZ) is described.
The type of hepatic damage revealed by the laboratory tests and the early appearance of the clinical symptoms with non-toxic serum CBZ levels support the hypothesis of an idiosyncratic reaction to CBZ.
It is well known that hepatitis C virus (HCV) can be associated with cryoglobulinemia- induced central and peripheral nervous system disorders, even without significant hepatic damage.