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rb磷酸化
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  rb phosphorylation
    The aberrant Rb phosphorylation might contribute to the decreased transcription of E2F downstream genes.
    这种ERK不依赖的Rb磷酸化可能是导致E2F调控的基因转录下调的原因之一。
短句来源
    Studies on the state of Rb phosphorylation revealed there were two types of Rb phosphorylation in cell cycle: ERK-dependent and ERK-independent phosphorylation.
    对Rb磷酸化状态的研究显示细胞中可能存在两种不同性质的Rb磷酸化:ERK依赖的和ERK不依赖的磷酸化。
短句来源
    In normal cells, the ERK-dependent Rb phosphorylation was predominant, while in early-G1 treated CHO cells the ERK-independent Rb phosphorylation prevailed.
    正常细胞中前者占主导作用,而早G1期TC处理的细胞中后者成为Rb磷酸化的主要形式。
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  rb phosphorylation
Rb phosphorylation is mediated by cyclin-dependent kinases (CDKs), whose activity is enhanced by cyclins and inhibited by CDK inhibitors.
      
Although one mechanism for its tumor suppression may be prevention of Rb phosphorylation, thereby causing G1 arrest, many normal cell types express p16INK4A, and are still able to traverse the cell cycle.
      
The INK4a/ARF locus on chromosome 9p21 encodes two gene products that are involved in cell cycle regulation through inhibition of CDK4-mediated RB phosphorylation (p16INK4a) and binding to MDM2 leading to p53 stabilization (p14ARF).
      
Rb phosphorylation was more rapid in MCF-7 cells than in MCF10A cells, whereas Rb dephosphorylation appeared deregulated in MDA-MB-231 cells.
      
Antineoplaston caused the down-regulation of PKCα protein expression, resulting in inhibition of ERK MAPK phosphorylation, with resultant inhibition of Rb phosphorylation leading to G1 arrest.
      
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D-type cyclin (cyclinD, CycD) regulates the G1/S transition. Under the stimulation of the exogenous signals, CycD accumulates and binds to cyclin dependent kinase (CDK) to form active complexes, which phosphorylate the retinoblastoma (Rb) protein. Rb phosphorylation results in releasing the transcription fac- tor E2F and thereby drives the G1/S transition. The control pathway is conserved in all higher eukaryotes. CycDs are different from other cyclins, because their expression is not tightly cell-cycle-regulated,...

D-type cyclin (cyclinD, CycD) regulates the G1/S transition. Under the stimulation of the exogenous signals, CycD accumulates and binds to cyclin dependent kinase (CDK) to form active complexes, which phosphorylate the retinoblastoma (Rb) protein. Rb phosphorylation results in releasing the transcription fac- tor E2F and thereby drives the G1/S transition. The control pathway is conserved in all higher eukaryotes. CycDs are different from other cyclins, because their expression is not tightly cell-cycle-regulated, but rather is activated by growth factors and decline rapidly when the mitogenic signal is removed, therefore the cell is arrested in G1. Many analyses showed that CycDs are crucial growth factor sensor, the expression of these genes affects plant development. Here we reviewed the characteristics and roles in cell cycle of plant CycDs, and discussed their functions in plant development.

D型细胞周期蛋白(cyclinD,CycD)调控着细胞周期G1/S的转换,基本过程为CycD在外界环境刺激下积累,并与周期蛋白依赖激酶(cyclin-dependentkinase,CDK)形成有活性的激酶,促进成视网膜细胞瘤蛋白(retinoblastoma,Rb)磷酸化,使E2F因子释放,由此促使G1/S转换,这一调控系统在高等真核生物中具有很高的保守性。CycD与其他细胞周期蛋白表达有所不同,其受到生长因子的强烈诱导,去掉生长因子后,表达水平迅速下降,导致细胞被抑制在G1期。大量研究表明,CycD是细胞周期中一个关键的“感受因子”,CycD基因的表达是细胞周期进程中的限速因子,影响着植物的生长发育。现对植物CycD的特征以及在细胞周期中的功能进行综述,并探讨了其在植物生长发育中的作用。

 
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