助手标题  
全文文献 工具书 数字 学术定义 翻译助手 学术趋势 更多
查询帮助
意见反馈
   抗心肌梗死 在 药学 分类中 的翻译结果: 查询用时:0.063秒
图标索引 在分类学科中查询
所有学科
药学
有机化工
更多类别查询

图标索引 历史查询
 

抗心肌梗死
相关语句
  “抗心肌梗死”译为未确定词的双语例句
    The current and potential uses of the eight structural types of K ATP activators open a new field for developing the novel drugs against angina pectoris, cardiac ischemia and hypertension.
    依结构特征激活剂分8大类,对于研制新型抗心绞痛、抗心肌梗死和抗高血压药物开辟了一个新方向。
短句来源
查询“抗心肌梗死”译词为用户自定义的双语例句

    我想查看译文中含有:的双语例句
例句
没有找到相关例句


ATP sensitive potassium channel (K ATP ) in cardiovascular system is an inward rectifier potassium ion channel which could be modulated by intracellular ATP concentration. K ATP is closely linked to membrane excitability and the bioenergetic states of the cell. Under physiological conditions it remains closed, while it plays an important regulatory role under hypoxic conditions. K ATP is highly K + selective with a single channel conductance of 80 and 135 pS in cardiomyocytes and vascular smooth...

ATP sensitive potassium channel (K ATP ) in cardiovascular system is an inward rectifier potassium ion channel which could be modulated by intracellular ATP concentration. K ATP is closely linked to membrane excitability and the bioenergetic states of the cell. Under physiological conditions it remains closed, while it plays an important regulatory role under hypoxic conditions. K ATP is highly K + selective with a single channel conductance of 80 and 135 pS in cardiomyocytes and vascular smooth muscles and opens in clusters of bursts separated by long close periods. Various factors known to regulate K ATP functions include channel gate, transducer unit, ATP binding inhibitory unit, presumed phosphorylation site and nucleoside diphosphate binding site. The dual effects of ATP on K ATP include the ligand actions and hydrolysis dependent actions. The first actions require the binding of ATP to the inhibitory unit to close the channels,while the second actions require phosphorylation of transducer unit caused by ATP in presence of Mg 2+ to restore the channel opening. Intracellular nucleoside diphosphate can antagonize the ATP induced inhibition of the channel opening and stimulate the channel to open. The pharmaco logical profiles of the three types of the channel activators depend on the channel functional states,especially nucleoside diphosphate binding site,presumed phosphorylation sites and inhibitory effects of ATP. The current and potential uses of the eight structural types of K ATP activators open a new field for developing the novel drugs against angina pectoris, cardiac ischemia and hypertension. Sulfonylurea drugs such as glibenclamide are selective K ATP antagonists. The molecular target of glibenclamide may be sulfonylurea receptors which belong to ATP-binding cassette protein family. More and more attentions have been paid to study the physiological actions of sulfonylurea receptors.

心血管ATP敏感性钾通道(KATP)是受细胞内ATP浓度调控的一种内向整流钾通道。在生理状态下,处于关闭状态;在缺氧的病理状态下,发挥重要的调节作用。心血管KATP对钾离子通透的选择性高,在心脏和血管平滑肌中其单通道电导分别为80和135pS,通道开放呈簇状并为长时间阻断状态所间隔。KATP功能性结构包括通道闸门、转换亚单位、ATP结合抑制亚单位、磷酸化位点和二磷酸核苷结合位点。ATP对KATP功能具有双向调节作用:其中配体作用是指与ATP结合抑制亚单位结合,使通道关闭;水解依赖性作用是指在Mg2+存在时,ATP使转换亚单位磷酸化,使通道开放。二磷酸核苷与其特异性位点结合,不仅降低通道对ATP的敏感性,而且可直接诱导通道开放。依对KATP作用特征激活剂分3大类,其药理作用依赖于通道的功能状态,尤其是磷酸化位点、二磷酸核苷结合位点和ATP的生物效应。依结构特征激活剂分8大类,对于研制新型抗心绞痛、抗心肌梗死和抗高血压药物开辟了一个新方向。以格列本脲为代表的硫脲类药物是KATP选择性拮抗剂,其作用环节可能是作用于硫脲受体后才发挥拮抗效应的,硫脲受体隶属ATP结合蛋白家族,其生理学作用已形成又一个研究热点

Five new compounds were synthesized from diosgenin succinic mono-ester via condensation with Amino acids,their structures were determined by 1HNMR?MS and IR as disodium diosgeninyl 4-L-(N-succinic acid-2-yl)amino-4-oxo butyrate(1),sodium diosgeninyl 4-(N-acetic acid-2-yl)amino-4-oxo butyrate(2),diosgeninyl 4- L-(N-(5-guanidino)pentanoic acid-2-yl)amino-4-oxo butyrate acetate(3),diosgeninyl 4-(N-3-(4-imidazolyl)propionic acid-2-yl)amino-4-oxo butyrate acetate(4),disodium diosgeninyl 4-(N-glutaric acid-2-yl)amino-4-oxo...

Five new compounds were synthesized from diosgenin succinic mono-ester via condensation with Amino acids,their structures were determined by 1HNMR?MS and IR as disodium diosgeninyl 4-L-(N-succinic acid-2-yl)amino-4-oxo butyrate(1),sodium diosgeninyl 4-(N-acetic acid-2-yl)amino-4-oxo butyrate(2),diosgeninyl 4- L-(N-(5-guanidino)pentanoic acid-2-yl)amino-4-oxo butyrate acetate(3),diosgeninyl 4-(N-3-(4-imidazolyl)propionic acid-2-yl)amino-4-oxo butyrate acetate(4),disodium diosgeninyl 4-(N-glutaric acid-2-yl)amino-4-oxo butyrate(5).All of these compounds show anti-infarction activity on rat.

以薯蓣皂甙元丁二酸单酯为原料 ,经过与氨基酸缩合 ,合成了 5个新化合物 ,4 L (N 丁二酸 2 基 )胺基 4 氧代丁酸薯蓣皂甙元酯二钠盐 (1) ,4 (N 乙酸 2 基 )胺基 4 氧代丁酸薯蓣皂甙元酯钠盐(2 ) ,4 L (N (5 胍基 )戊酸 2 基 )胺基 4 氧代丁酸薯蓣皂甙元酯醋酸盐 (3) ,4 (N (3 咪唑 4 基 )丙酸 2 基 )胺基 4 氧代丁酸薯蓣皂甙元酯醋酸盐 (4) ,4 (N 戊二酸 2 基 )胺基 4 氧代丁酸薯蓣皂甙元酯二钠盐(5 ) ,并对其进行了结构鉴定 ,同时发现这 5个化合物对大鼠都具有抗心肌梗死活性。

 
图标索引 相关查询

 


 
CNKI小工具
在英文学术搜索中查有关抗心肌梗死的内容
在知识搜索中查有关抗心肌梗死的内容
在数字搜索中查有关抗心肌梗死的内容
在概念知识元中查有关抗心肌梗死的内容
在学术趋势中查有关抗心肌梗死的内容
 
 

CNKI主页设CNKI翻译助手为主页 | 收藏CNKI翻译助手 | 广告服务 | 英文学术搜索
版权图标  2008 CNKI-中国知网
京ICP证040431号 互联网出版许可证 新出网证(京)字008号
北京市公安局海淀分局 备案号:110 1081725
版权图标 2008中国知网(cnki) 中国学术期刊(光盘版)电子杂志社