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胸部照射
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  thoracic irradiation
     ObjectiveTo measure expressions of metalloproteinases and tissue inhibitors of metalloproteinases in the lung following thoracic irradiation of 12 Gy, and explore its possible role in the development of radiation-induced lung damage.
     目的通过检测基质金属蛋白酶(MMPs)和基质金属蛋白酶组织抑制物(TIMPs)在单次大剂量胸部照射小鼠肺组织中的表达,探讨全肺照射诱导的MMPs/TIMPs系统表达紊乱在放射性肺损伤发生与发展中的作用。
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  “胸部照射”译为未确定词的双语例句
     Methods:From Jan 2004 to Dec 2005,121 valid patients with oesophagus malignant tumor or lung cancer were treated with routine radiotherapy(RT)by 15 MV X-ray,DT60~68Gy,30~34 fractions,within 42~46days.
     方法:2004年1月~2005年12月,121例符合研究条件的食管癌及肺癌患者接受了15MVX线常规胸部照射,DT60~68Gy/30~34f/42~46d。
短句来源
     Loco regional recurrence rate was significantly higher in ≤45 Gy group (55.0%) than that in ≥60 Gy group (8.7%)( P <0.01).
     胸部照射≤ 45Gy和≥ 60Gy剂量组的 2年局部复发率分别为 5 5 .0 %和 8.7% ,有显著性差异 (P <0 .0 1)。
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     The latter 4 groups were radiated with linear accelerator at a dose of 15 Gy after anesthesia. The day after the radiation, RA was gastrogavaged at a dose of 20 mg·kg -1 ·d -1 in group W, RA and Flu were gastrogavaged at a dose of 10 mg·kg -1 ·d -1 in group F, and Dex was gastrogavaged at a dose of 3.33 mg·kg -1 ·d -1 in group D.
     后 4组动物经硫喷妥钠ip麻醉后 ,行直线加速器全胸部照射 ,照射后次日W组每日灌服RA 2 0mg·kg -1·d -1,F组灌服Flu、RA各 10mg·kg-1·d-1,D组灌服Dex 3.33mg·kg-1·d-1.于照射后 5 ,15 ,30 ,6 0d活杀动物 ,切片行HE和甲苯胺蓝染色 ;
短句来源
     ②Radiated group were radiated with linear accelerator at a dose of 15 Gy thoracically after anesthesia. The distance was 1 meter and the areas was 4.5 cm×4.5 cm.
     ②麻醉大鼠后,对照射组大鼠行直线加速器全胸部照射,照射剂量单次15Gy,距离1m,照射面积4.5cm×4.5cm,照射剂量率1.5Gy/min。
短句来源
     The later 2 groups rats were radiated with linear accelaretor at a dose of 15 Gy thoracically. Distance was 1 meter, and the area was 4.5cm×4.5cm, and the rate of dose was 2Gy/min. Retinoic acid was gastrogavaged at a dose of 20mg/(kg·d)in group W in the second day after radiation, which was continued to the end of the experiment.
     后 2组动物行直线加速器全胸部照射 ,单次剂量 15Gy ,距离 1m ,照射面积 4.5cm× 4.5cm ,剂量率 2Gy/min ,W组维甲酸灌服剂量 2 0mg/kg ,C、R组以等量生理盐水灌服直至活杀。
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  相似匹配句对
     Chest Carcinoid Tumors
     胸部类癌
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     Dose of thoracic radiation might be related to the loco regional recurrence.
     局部复发率与胸部照射剂量有密切关系。
短句来源
     ④thorax"two margins";
     ④胸部“双边” ;
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     Irradiation caused a distinct G2/M block and decreased G 0/G1 phase population in 293 and C.
     照射后293和C.
短句来源
     Group B:the epiqastrium was exposed to a single dose of γ-irradration at a dosage of 1,000 rad;
     B组:单纯照射
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  thoracic irradiation
TGF-beta1 transgenic mouse model of thoracic irradiation: Modulation of MMP-2 and MMP-9 in the lung tissue
      
Expressions of TGF-β1 were measured with western blot, and expressions of MMP-2 and MMP-9 were analyzed with zymography in a TGF-β1 transgenic mouse model after thoracic irradiation with 12 Gy.
      
Eight weeks after thoracic irradiation with 12 Gy, we observed a significant increase of MMP-2 and MMP-9 activity in lung homogenates from both transgenic and normal mice.
      
Randomized comparison of early versus late hyperfractionated thoracic irradiation concurrently with chemotherapy in limited dise
      
Limited disease (LD) patients with bronchoscopical, computertomographical and (re-) mediastinoscopical complete remission (CR) randomly received either a thoracic irradiation with 40 Gy or observation only.
      
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Of 65 patients with small ceIl undifferentiated carcinoma of the lung treated from April 1978 to April 1982 in Beijing Cancer Institute 15 were giyen the combination chemotherapy alone and 50 the combination chemotherapy plus radio-therapy to the primary sites,hila and mediastinum.Comparison of the results shows better results in the combined treatment group,the response rates (CR+PR) being 29·5% vs 73%, the median survival time of patients with limited diseases (LD) 9 months vs 12 months,the median survival...

Of 65 patients with small ceIl undifferentiated carcinoma of the lung treated from April 1978 to April 1982 in Beijing Cancer Institute 15 were giyen the combination chemotherapy alone and 50 the combination chemotherapy plus radio-therapy to the primary sites,hila and mediastinum.Comparison of the results shows better results in the combined treatment group,the response rates (CR+PR) being 29·5% vs 73%, the median survival time of patients with limited diseases (LD) 9 months vs 12 months,the median survival time in patients with extensive disease 6 months vs 9 months,the 1-year survival rates 6.7% vs 46%,and the 1-year NED survival 0 and 7 cases respectively. There was a significant correlation between the dosage of radiotherapy to the thorax and 1-year NED surival.The authors hold not lower than'5,000 rad/5 weeks (NSD 1569 ret or TDF 82.5)to be the suitable dosage to the thorax irrespective of the sensitivity of the tumor. Prophylactic whole brain irradiation_can effect a significant reduction in incranial metastases.Of 5 patients of this series receiving prophylactic brain irradiation,4 sur- vived over one year with NED and cne died from brain metastases 14 mcnths after treatment.

1.本文报告禾分化小细胞肺癌65例,全部进行了化疗,其中50例化疗后继而进行了胸部放疗。化疗与放疗结果对比,有效率29.5%对73%,局限期中位生存期9个月与12个月。广泛期中位生存期6个月与9个月,一年生存率6.7%与46%,一年健在率O例与7例。2.胸部放疗剂量与一年健在率有明显关系。我们认为本病虽对放射线敏感,但胸部照射量以不低于5.000rad/5周(NSD为1,569ret或TDF82.5)为宜。3.预防性全脑照射可降低脑转移率,本组5例施行了全脑预防性照射,除1例治疗后14个月仍死于脑转移外,其余4例皆健在超过一年,因病例少,难下结论。

The lung is one of the most sensitive organ. to radiotherapy. Thethoracic radiation can produce dramatic effects, both early and late. In order to valuethe effects of radiation on lung, a lot of efforts have been made by researchers. Thispeper summarized the recent progresses in experimental investigations on pulmonary ra-diationdamage, including physiological, biological, phathological and cellular changes. Inaddition. main view on mechanism of pulmonary radiation damage were also involved.

肺是肿瘤放疗中最敏感的器官之一,胸部照射可以导致肺早、晚期损伤。本文从生理、生化、病理、细胞等方面着重叙述了近年来实验性肺放射损伤的研究进展,并介绍了肺放射损伤发生机制主要观点。

The right or whole thorax of Wistar rat was irradiated with ̄60Coγ-ray(30 Gy)。Animals were sacrificed at 0.5,1,2,3,6,9,12 months after irradiation. The changes of type Ⅱpneumocyte were observed with light microscopy(LM),electron microscopy(EM)andsemi-morphometry.Increased number of type Ⅱ pneumocyte,increased lamellar bodies in typeⅡpneumocyte and giant lamellar bodies were observed under electron microscope,swelling andbreaking of mitochondrial membranes in type Ⅱ pneumocyte was also noted.The role of type Ⅱpneumocyte...

The right or whole thorax of Wistar rat was irradiated with ̄60Coγ-ray(30 Gy)。Animals were sacrificed at 0.5,1,2,3,6,9,12 months after irradiation. The changes of type Ⅱpneumocyte were observed with light microscopy(LM),electron microscopy(EM)andsemi-morphometry.Increased number of type Ⅱ pneumocyte,increased lamellar bodies in typeⅡpneumocyte and giant lamellar bodies were observed under electron microscope,swelling andbreaking of mitochondrial membranes in type Ⅱ pneumocyte was also noted.The role of type Ⅱpneumocyte in radiation pulmonary injury is discussed.

采用光镜、电镜及半定量方法,连续观察了大鼠经胸部照射30Gy后Ⅱ型肺泡上皮细胞的变化。结果显示照射后Ⅱ型肺泡上皮细胞数目增多,3个月达高峰。细胞内板层小体数目增多,体积增大,可见巨大板层体出现。Ⅱ型肺泡上皮细胞线粒体肿胀,膜破裂,嵴断裂。对Ⅱ型肺泡上皮细胞与放射性肺损伤的关系亦进行了讨论。

 
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