METHODS The susceptibilities to erythromycin and clindamycin for Staphylococcus were examined by Kirby-Bauer disc agar diffusion test and the inducible resistance of erythromycin to clindamycin was checked by D-test according to the standards of NCCLS(2004,M100-S14). msrA,Vgb,sat4,ermA,ermB And ermC resistance genes were detected by using PCR technology.
Methods The susceptibilities of Staphylococcus to erythromycin and clindamycin were determined by Kirby-Bauer disc agar diffusion test and the inducible resistance of Staphylococcus to erythromycin and clindamycin was determined by D-test according to the standards of NCCLS(2004 M100-S14).
Objective: To detect by PCR and sequence the multiple antibiotic resistant efflux acrB gene in Salmonella typhi 275(a clinically isolated strain) and its induced resistant mutant OM2(RG1),182(RG2).
results: Reserpine can inhibite the rate of resistance to quinolone in S.a, and can decrease the MIC of induced resistant strains. Reserpine can inhibit the active efflux of EB from the cytoplasm of S.a.
The mRNA level of efflux gene cdr1 and cdr2 was higher in clinical azole resistant strains and fluconazole induced resistant strains than strains reverted from resistance to sensitivity. However, all such strains had higher efflux gene expression than azole sensitive strains.
Results: The resistance mutation frequency of P.aeruginosa selected by 1×MIC or 2×MIC ciprofloxacin were 170×10 -9 and 260×10 -9 respectively, the cross resistance rate being 9.2%.
This paper summarizes the results from experiments during 12 years on effects of delayed inducible resistance of mountain birches (Betula pubescens Ehrh.
This variation could be related to life history: While all resistance enzymes were significantly induced in larger perennial plants that flower during summer, spring geophytes hardly showed inducible resistance.
Such treatment did not enhance doxorubicin activity on either inherently or induced resistant tumors, whereas it significantly enhanced doxorubicin growth inhibition in all the sensitive tumors except the Lewis lung carcinoma.
These results suggest that the increased medicarpin accumulation produced in induced resistant tissues, following challenge inoculation with virulent race, is attributable to increased expression of genes of flavonoid biosynthesis.
Moreover, P-glycoprotein has been found located in the Golgi apparatus in drug induced resistant cells and in intrinsic resistant cells, such as melanoma cells.