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rb抗癌基因
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  rb antioncogene
     With the establishment of primary culture and the sub-culture method for human arterial SMC,we have observed the effects of LDL,VLDL,HDL,ox-LDL,ox-VLDL and ox-HDL on the transcriptional expression of sis,jun,ras oncogenes and Rb antioncogene of cultured human arterial SMC.
     我们在建立人主动脉SMC体外培养方法的基础上,观察了LDL,VLDL及HDL和相应的氧化修饰型脂蛋白对培养人SMCsis,jun,H-ras原癌基因及Rb抗癌基因转录表达的影响。
短句来源
  “rb抗癌基因”译为未确定词的双语例句
     Significance of expression of c-myc oncogene and retinoblastoma gene in oral squamous cell carcinoma and premalignant lesions
     口腔癌及癌前病变中C-myc癌基因与Rb抗癌基因表达的意义
短句来源
     The Rb gene protein was detected in 30%,0 and 7% of the oral SCC,leukoplakia and lichen planus,respectively.
     Rb抗癌基因在口腔癌、白斑、扁平苔藓中表达的阳性率分别为 30 %、0和 7%。
短句来源
     DNA samples were digested with EcoRI enzyme and subjected to Southern blotting ,and hybridized with EGFr and Rb genes probed .
     EcoRI酶切 ,Southern转移 ,与EGFr癌基因 ,Rb抗癌基因探针杂交。
短句来源
     Study of the c-myc and Rb gene amplification in human fetal esophageal epithelium treated by altenariol
     交链孢酚(AOH)处理人胎食管上皮组织c-myc癌基因,Rb抗癌基因扩增的研究
短句来源
     DELETION OF RB GENE IN HUMAN GASTRIC CANCER CELL LINES
     人胃癌细胞株Rb抗癌基因缺失的研究
短句来源
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  相似匹配句对
     EXPRESSION OF RETINOBLASTOMA SUSCEPTIBILITY GENE IN E.COLI
     抗癌基因Rb在大肠杆菌中的表达
短句来源
     DELETION OF RB GENE IN HUMAN GASTRIC CANCER CELL LINES
     人胃癌细胞株Rb抗癌基因缺失的研究
短句来源
     Discussion for RB functions
     RB功能探讨
短句来源
     Research on cancer-resistant gene
     抗癌基因的研究进展
短句来源
     _R N,Ext_R~n(M,N),Tor_n~R(M,N)and N_(?)
     _RB,Ext(?)
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Retinoblastoma (Rb) is the most common malignant cancer of the eye. SO-Rb50 is the first Rbcell line established in China in 1988. It has passed to the 387th generation now. we collected cells ofthe 327th generation of SO-Rb50, Purified their genomic DNA and detected them with Rb and c-myccDNA probes respectively (normal human white blood cells DNA was the control). We found theRb gene was deleted while c-myc gene was three fold amplified, Which provides a basis for furtherstudy of the regulation of tumor development...

Retinoblastoma (Rb) is the most common malignant cancer of the eye. SO-Rb50 is the first Rbcell line established in China in 1988. It has passed to the 387th generation now. we collected cells ofthe 327th generation of SO-Rb50, Purified their genomic DNA and detected them with Rb and c-myccDNA probes respectively (normal human white blood cells DNA was the control). We found theRb gene was deleted while c-myc gene was three fold amplified, Which provides a basis for furtherstudy of the regulation of tumor development and tumor reversal with this cell line in vitro.

以SO-Rb50第327代细胞,提取其基因组DNA,以正常人血细胞为对照,检测其Rb抗癌基因和c-myc癌基因。结果表明,该细胞株Rb基因完全缺失,c-myc原癌基因扩增3倍。此为以该细胞株在体外进一步研究肿瘤生长调控和逆转提供依据。

To investigate the correlation between Rb tumor suppressor gene and bladder and renal cell carcinoma,the gene in primary RCC, baldder carcinoma and cell lines Were analyzed by northern blot,One RCC and two bladder carcinoma cell lines showed noramal Rb expression.One of 13 RCC,and two hing-grade bladder carcinomas lacked Rb mRNA expression. None of the low-grade carcimomas showed an altration in Rb gene,The result suggests that the loss of Rb gene corrclates with bladder carcinoma and is more frequent in high-grade...

To investigate the correlation between Rb tumor suppressor gene and bladder and renal cell carcinoma,the gene in primary RCC, baldder carcinoma and cell lines Were analyzed by northern blot,One RCC and two bladder carcinoma cell lines showed noramal Rb expression.One of 13 RCC,and two hing-grade bladder carcinomas lacked Rb mRNA expression. None of the low-grade carcimomas showed an altration in Rb gene,The result suggests that the loss of Rb gene corrclates with bladder carcinoma and is more frequent in high-grade ones Rb loss might have a role in certain renal cell carcinoma.

对正常肾和肾细胞癌组织,正常膀胱粘膜和膀胱移行细胞癌组织以及肾癌细胞和膀胱癌细胞株BIU-87和E-J中的抗癌基因Rb进行Northernblot分析。肾和膀胱癌细胞都表达正常的RbmRNA。1/13例肾癌组织和2/8例膀胱癌组织中发现Rb基因缺失。此2例Rb缺失的膀胱癌均为低分化肿瘤,在分化较高的膀胱癌中未发现Rb基因缺失。结果表明,Rb基因缺失与膀胱癌的关系密切,同时与肿瘤的分化程度有关。结合文献对Rb抗癌基因与泌尿系肿瘤的关系及其在肿瘤发生中的作用进行讨论。

The proliferation of smooth muscle cells(SMCs)within the arterial walls plays an important role in the process of atheroselerosis(AS)genesis.With the establishment of primary culture and the sub-culture method for human arterial SMC,we have observed the effects of LDL,VLDL,HDL,ox-LDL,ox-VLDL and ox-HDL on the transcriptional expression of sis,jun,ras oncogenes and Rb antioncogene of cultured human arterial SMC.The results showed that(1)HDL had no effect on sis,jun and ras gene expression.(2)LDL and VLDL induced...

The proliferation of smooth muscle cells(SMCs)within the arterial walls plays an important role in the process of atheroselerosis(AS)genesis.With the establishment of primary culture and the sub-culture method for human arterial SMC,we have observed the effects of LDL,VLDL,HDL,ox-LDL,ox-VLDL and ox-HDL on the transcriptional expression of sis,jun,ras oncogenes and Rb antioncogene of cultured human arterial SMC.The results showed that(1)HDL had no effect on sis,jun and ras gene expression.(2)LDL and VLDL induced a slight but not signifieant increase in the expression of those genes (P>0.05).(3)ox-LDL,ox-VLDL and ox-HDL promoted the expossion of those oneogenes significantly (P<0.01).(4)the native and oxidized lipoproteins had no influence on the expression of the Rb antioncogene.These results saggest that the atheroge.nic role of LDL,VLDL,ox-LDL,ox-HDL and ox-NLDL are probably related to their stimulating effects on the transcriptional expression of sis,jun and ras oncogenes of the arterial SMCs.

动脉平滑肌细胞(SMC)的增殖在动脉粥样硬化(AS)的形成过程中极其重要。我们在建立人主动脉SMC体外培养方法的基础上,观察了LDL,VLDL及HDL和相应的氧化修饰型脂蛋白对培养人SMCsis,jun,H-ras原癌基因及Rb抗癌基因转录表达的影响。结果表明:(1)HDL对SMCsis,jun,ras基因表达无影响;(2)LDL和VLDL有使这些基因表达增加的趋势;(3)ox-LDL,ox-VLDL和ox-HDL具有使SMCsis,jun,和ras基因表达显著增强的作用(P<0.01),且其作用较相应的天然脂蛋白大(P<0.01);(4)天然和氧化修饰型脂蛋白对Rb基因表达均无影响。据上述结果推测:LDL,VLDL,ox-LDL,ox-VLDL和ox-HDL的致AS作用可能与刺激SMCsis,jun和ras原癌基因表达增加有关。

 
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