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   声门上型喉鳞癌 的翻译结果: 查询用时:0.012秒
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声门上型喉鳞癌
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  supraglottic squamous cell carcinoma
     Background &Objective:To the authorsknowledge,the relationship between inducible nitric ox ide synthase(iNOS)and basic fibroblast growth factor(bFGF)and cervical lymph node metastasis o f supraglottic squamous cell carcinoma (SGSCC)has not been addressed to date.
     背景与目的:目前,有关诱导型一氧化氮合酶(induciblenitricoxidesynthase,iNOS)和碱性成纤维细胞生长因子(basicfibroblastgrowthfactor,bFGF)的表达与声门上型喉鳞癌颈淋巴结转移关系的研究很少。
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  “声门上型喉鳞癌”译为未确定词的双语例句
     Based on the theory, we applied SABC immunohis-tochemistry on 60 cases of paraffin samples of SGLSCC from 1994 to 1996 to detect the expression of TGF -β1 and E - cd in SGLSCC and analyzed their biological relation in order to evaluate their diagnosis value in the metastasis of cervical lymph nodes and their prognosis.
     基于以上的理论基础,我们应用SABC免疫酶标记技术,以94~96年间60例声门上型喉鳞癌(Supraglottic larynx squamous cell carcinoma,SGLSCC)术后存档蜡块标本作研究对象,通过对TGF-β_1和E-cd在SGLSCC中的表达及与其生物学行为关系的分析,研究它们对颈部淋巴结转移、预后的诊断价值。
短句来源
     Methods: An immunohistochemical study was performed using the polyclonal antibody against nm23/NDPK and three monoclonal antibodies against human typeⅣcollagen (CTⅣ),laminin (LN) and fibronectin (FN) to observe the expression and the distribution of nm23/NDPK and extracellular matrix (ECM) antigens in 72 cases of supraglottic laryngeal squamous cell carcinomas,and to assess the relationship with the metastasis of cervical lymph node.
     方法:分别应用nm23/NDPK多克隆抗体、抗Ⅳ型胶原纤维(typeIVcollagen,CTⅣ)单克隆抗体、抗层黏连蛋白(laminin,LN)单克隆抗体、抗纤维连接蛋白(fibronectin,FN)单克隆抗体以链霉素亲生物素—过氧化酶免疫组织化学法观察nm23/NDPK和这3种抗原在72例声门上型喉鳞癌中的表达与分布及其与颈淋巴结转移的关系。
短句来源
     Basement membrane in squamous cell carcinomas of the larynx: an immunohistochemical study
     基底膜抗原在声门上型喉鳞癌中表达的意义
短句来源
     The expression of extracellular matrix in squamous cell carcinoma of the larynx: An immunohistochemical study
     细胞外基质抗原在声门上型喉鳞癌中表达的意义
短句来源
     The MVD and VEGF was higher in supraglottic cancer or with lymph node metastasis than that of glottic cancer or without lymph node metastasis.
     声门上型喉鳞癌与有淋巴结转移组其MVD和VEGF均明显高于声门型和无淋巴结转移组(P<0.05)。 而有淋巴结转移组及声门上型喉鳞癌组较无淋巴结转移和声门癌组的PV和CER虽有增高趋势,但无统计学意义(P>0.05)。
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  相似匹配句对
     Reconstruction of laryngeal function by epiglottis car-tilage in partial laryngectomy for glottic carcinoma
     会厌成形术治疗声门
短句来源
     Basement membrane in squamous cell carcinomas of the larynx: an immunohistochemical study
     基底膜抗原在声门中表达的意义
短句来源
     The expression of extracellular matrix in squamous cell carcinoma of the larynx: An immunohistochemical study
     细胞外基质抗原在声门中表达的意义
短句来源
     Supracricoid partial laryngectomy in the treatment of supraglottic laryngeal carcinoma
     环状软骨部分切除术治疗声门
短句来源
     The treatment of T3N0M0 glottic squamous cell carcinoma
     声门Ⅲ期病变临床治疗
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  supraglottic squamous cell carcinoma
Initial treatment of the early stages (I, II) of supraglottic squamous cell carcinoma: partial laryngectomy versus radiotherap
      
Horizontal partial laryngectomy for supraglottic squamous cell carcinoma
      
Horizontal supraglottic laryngectomy remains an adequate therapeutic alternative for supraglottic squamous cell carcinoma, offering an excellent oncological outcome.
      


Abstract A prospective randomized study of 8 1 patients with N+ supraglottic squamous carcino-ma was performed to evaluate the control of regional recurrence by 4 0 Gy dose preoperative radiotherapy. All patients were followed up for at least 3 years. Surgery alone was used to treat 49 patients,and combined therapy in 32 patients. Occurence of failure in the neck was 30.6%and 21.8%respectively,which is no statistically significance(P=0. 9).The T and N stages did not alter the rate of regional recurrence,excluding...

Abstract A prospective randomized study of 8 1 patients with N+ supraglottic squamous carcino-ma was performed to evaluate the control of regional recurrence by 4 0 Gy dose preoperative radiotherapy. All patients were followed up for at least 3 years. Surgery alone was used to treat 49 patients,and combined therapy in 32 patients. Occurence of failure in the neck was 30.6%and 21.8%respectively,which is no statistically significance(P=0. 9).The T and N stages did not alter the rate of regional recurrence,excluding N3 lesions. We propose that routine neck dissection is performed on the N+ side and increasing the radiation dose up to 60Gy for postoperative or 50Gy for preoperative radiotherapy.

声门上型喉鳞癌临床颈淋巴结阳性患者81例,随机对照研究术前放疗40Gy对控制颈部复发的意义。放疗加手术32例,单纯手术49例,随诊3年以上。颈部为复发的主要部位占62.9%,放疗加手术组颈部复发率21.8%,单纯手术组30.6%,但无统计学差异(P=0.9)。两组颈部复发率与T分期和N分期(除N_3外)大小无明显关系。因此术前40Gy对颈部复发无显著意义,建议对所有患者做临床阳性侧颈清扫术,术前放疗剂量提高到50Gy,或术后放疗60Gy以上。

Objective The study was to assess the distribution of basement membrane(BM)in laryngeal squamous cell carcinomas(LSCC) Correlation of BM and clinical parameters (TNM stage, histological grading, invasion mode, lymph node metastasis) was also examined Methods The expression of BM around tumor cell was determined in 40 cases of LSCC by using monoclonal antibody against human type IV collagen An intact continuous BM was found in 17 cases (42 5%), while partial or widespread loss of the BM was detected...

Objective The study was to assess the distribution of basement membrane(BM)in laryngeal squamous cell carcinomas(LSCC) Correlation of BM and clinical parameters (TNM stage, histological grading, invasion mode, lymph node metastasis) was also examined Methods The expression of BM around tumor cell was determined in 40 cases of LSCC by using monoclonal antibody against human type IV collagen An intact continuous BM was found in 17 cases (42 5%), while partial or widespread loss of the BM was detected in the other 23 cases (57 5%) Results In cases with poor histological differentiation, the defect of BM was more severe than that in cases with high or middle histological differentiation ( P <0 05) Moreover, diffuse invasion carcinomas revealed lower type IV collagen expression comparing with cases with better tumor-host border ( P <0 05) There was a higher risk of regional lymph node metastasis among cases with poor BM expression ( P <0 01), but there was no association of clinical stage with BM defect ( P >0 05) Conclusion These observations indicated that testing the distribution of BM seems to be useful to evaluate the histological grading of malignancy of laryngeal carcinoma and be helpful to prognosticate the frequency of regional lymph node metastasis

目的 探讨基底膜 (basementmembrane,BM)抗原的表达及其在声门上型喉鳞癌中的屏障意义。方法 应用抗IV型胶原纤维单克隆抗体以链霉素亲生物素 过氧化酶免疫组化法观察IV型胶原在声门上型喉鳞癌中的表达分布情况 ,以评价BM完整性与声门上型喉鳞癌的临床分期、分级、细胞分化程度、浸润方式及颈淋巴结转移的关系。结果 BM完整者占 42 5 % ,BM缺失者占5 7 5 %。在低分化和肿瘤弥散浸润的喉癌组织中 ,BM缺失率明显高于分化良好及肿瘤边界良好的组织 (P <0 0 5 )。BM缺失者发生颈淋巴结转移率高于BM完整者 ,二者之间有较强相关性 (P <0 0 1)。BM表达与临床分期之间并未表现出明确的相关性 (P >0 0 5 )。结论 BM完整性可以用来评价声门上型喉鳞癌细胞分化程度及喉癌组织浸润能力 ,也可作为预测声门上型喉鳞癌发生颈淋巴结转移的重要参数之一。

Background &Objective:To the authorsknowledge,the relationship between inducible nitric ox ide synthase(iNOS)and basic fibroblast growth factor(bFGF)and cervical lymph node metastasis o f supraglottic squamous cell carcinoma (SGSCC)has not been addressed to date.This s tudy was designed to investigate the effect of iNOS and bFGF on biological behavior of cervical lymph node metastasis in SGSCC.Methods:The authors conducted a contrast analysis for 64patients w ith SGSCC(experimental group)and 33patients with...

Background &Objective:To the authorsknowledge,the relationship between inducible nitric ox ide synthase(iNOS)and basic fibroblast growth factor(bFGF)and cervical lymph node metastasis o f supraglottic squamous cell carcinoma (SGSCC)has not been addressed to date.This s tudy was designed to investigate the effect of iNOS and bFGF on biological behavior of cervical lymph node metastasis in SGSCC.Methods:The authors conducted a contrast analysis for 64patients w ith SGSCC(experimental group)and 33patients with chronic laryngeal mucositis(control group).Pathologic imaging analysis was used for quantitative determination.Results:①Positive staining site of iNOS and bFGF was concentrated in c ytoplasm;bFGF was also expressed in nuclei and intracellular substance.②The expressions of iNOS and bFGF were significantly higher in experiment al group than in control group.③The expression in cervical lymph node positive group was significantly high er than that in negative group.However,there was no statistical significance between primary negative-follow positive group and primary positive group.Conclusion:The expression of iNOS and bFGF was closely associated with SGSCC,and can be considered to be a pr edictor for lymph node metastasis of SGSCC.

背景与目的:目前,有关诱导型一氧化氮合酶(induciblenitricoxidesynthase,iNOS)和碱性成纤维细胞生长因子(basicfibroblastgrowthfactor,bFGF)的表达与声门上型喉鳞癌颈淋巴结转移关系的研究很少。本文旨在探讨iNOS和bFGF在声门上喉鳞癌颈淋巴结转移等生物学行为中的作用。方法:应用iNOS和bFGF的多克隆抗体,以LSAB法对64例声门上喉鳞癌(实验组)和33例喉粘膜慢性炎症组织(对照组)进行对照研究,同时应用病理图像分析系统进行定量检测。结果:①iNOS和bFGF的阳性染色部位集中于细胞浆,bFGF也可表达于细胞核和细胞间质。②实验组iNOS和bFGF的表达明显高于对照组。③颈淋巴结阳性组的表达明显高于颈淋巴结阴性组,但初治阴性随诊阳性组与初诊阳性组的差异无统计学意义。结论:iNOS和bFGF的表达与声门上喉鳞癌关系密切,测定iNOS和bFGF的表达有助于预测声门上喉鳞癌颈淋巴结转移情况。

 
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