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冷保存损伤
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  cold preservation damage
     The correlation between the efllyebt levels of hvaluronic acid of grafts and the cold preservation damage or the survival rate
     供肝灌洗液中透明质酸含量与肝脏冷保存损伤及术后成活率的关系
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  “冷保存损伤”译为未确定词的双语例句
     Melatonin (MT) is the active material that has various biological effects.
     2.MT与供肝冷保存损伤保护
短句来源
     The related report of MT has not been seen in liver cold preservation and liver transplant.
     提示MT对供肝冷保存损伤有保护作用。
短句来源
     The non-heart-beating donor(NHBD) liver graft suffers not only the warm ischemina injury but also the cold preservation and reperfusion injury. In the pathophysiological process, a number of cyokines, such as , TNF-α. et which are released with the activation of Kupffer cell, the obstruction of microcirculation, and the injury of liver cells and sinusoidal endothelial cells(SEC) become the major cause of primary non-function(PNF) of transplantating liver.
     心脏停搏供肝由于遭受热缺血损伤、冷保存损伤和再灌注损伤,在这一病理生理过程中Kupffer细胞被激活释放TNF-α等细胞因子引起微循环障碍,及肝细胞和内皮细胞受损是移植后原发性移植物无功能(primary nonfunction, PNF)的主要原因。
短句来源
     GDCL 3 inhibits the activation of KC and protects the function and ultrastructure of the liver cell in cold preservation. [WT5”HZ]
     氯化钆可以抑制KC的激活 ,对肝脏冷保存损伤有一定的保护作用。
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     Conclusion: Inhibiting kupffer cell can alleviate the injury of lipid peroxide in livers of rats during cold preservation.
     结论:抑制枯否细胞对鼠肝的冷保存损伤有一定的保护作用。
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  相似匹配句对
     Melatonin (MT) is the active material that has various biological effects.
     2.MT与供肝保存损伤保护
短句来源
     The related report of MT has not been seen in liver cold preservation and liver transplant.
     提示MT对供肝保存损伤有保护作用。
短句来源
     At the same time, we studied the effects of MT at different concentration and different time on liver cold preservation.
     4.MT与供肝保存再灌注损伤保护
短句来源
     ② Indexes of the liver function and the sinusoidal lining cell functio n in the Mel solution cold preservation group were lower than that in the UW sol ution cold preservation group.
     ②Mel对供肝保存损伤有保护作用。
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     Conclusion The injury degree of SEC is more obvious along with the prolongation of cold preservation.
     结论 SEC的损伤随着保存时间的延长而加重 ;
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Objective [WT5”BZ] To investigate the effects of gadolinium chloride hexahydrate (GDCL 3 ) on kuppfer cell (KC) of rat liver in cold storage.[WT5”HZ] Method [WT5”BZ] Forty rats were randomized into 8 groups(5 in each group). As a control, the livers in group 1,2,3 and 4 were preserved 1?h,2?h,3?h and 4?h in cold saline solution respectively.The group 5 through 8 served as experimental group treated by GDCL 3 instead (7?mg/kg).LPO level was measured, optical and electron micrscope observation were performed....

Objective [WT5”BZ] To investigate the effects of gadolinium chloride hexahydrate (GDCL 3 ) on kuppfer cell (KC) of rat liver in cold storage.[WT5”HZ] Method [WT5”BZ] Forty rats were randomized into 8 groups(5 in each group). As a control, the livers in group 1,2,3 and 4 were preserved 1?h,2?h,3?h and 4?h in cold saline solution respectively.The group 5 through 8 served as experimental group treated by GDCL 3 instead (7?mg/kg).LPO level was measured, optical and electron micrscope observation were performed. [WT5”HZ]Results [WT5”BZ] Ultrastructural examination showed abnormaly activated KC and injury of hepatocellular mitochondria along with the prolongation of cold storage. While treated by GDCL 3), the level of LPO in hepatic tissue was lower (compared with group 1 and 2, P <0 05) and the injury of liver cell mitochondria was less severe.[WT5”HZ] Conclusion [WT5”BZ] Our findings suggest that there is a close relation between activation of KC and the function and construction of the liver in cold storage.GDCL 3 inhibits the activation of KC and protects the function and ultrastructure of the liver cell in cold preservation. [WT5”HZ]

目的 研究枯否细胞抑制剂氯化钆在大鼠肝脏冷保存时对枯否细胞 (kupffercell,以下简称KC)的影响。方法 将Wistar大鼠随机分成 8组 ,每组 5只。A、B、C、D组为对照组 ,肝脏保存时间分别为 1、2、3、4h ,其余 4组为相应的实验组 ,各组大鼠经手术灌注、取肝后于 0~ 4℃生理盐水中保存。测定各组动物肝组织脂质过氧化物 (LPO)含量 ,做组织学和超微结构的观察。结果 随着保存时间的延长 ,KC呈激活状态 ,肝组织线粒体脂质过氧化程度增加 ,肝细胞尤其是肝细胞线粒体损伤逐渐加重。与对照组比较 ,实验组预用氯化钆后 ,肝脏组织学及超微结构病理损伤程度较轻。肝组织LPO水平较低 (P <0 0 5 )。结论 KC的激活与冷保存肝脏的结构和功能的变化关系密切。氯化钆可以抑制KC的激活 ,对肝脏冷保存损伤有一定的保护作用。

Objective; Our aim was to study the effects on Kupffer cell and hepatocellular mitocondria by the inhibition of Kupffer cell. Methods: The rats in the experimental group were pretreated with gadolinium(7 mg/kg) by intro-veinal injection for 2 days, and the rats in the control group were treated with saline solution. The livers of rats were cut off by operation and preserved in the saline at 0 to 4℃for 1, 2, 3, and 4 hours. The changes of ultrastructure of Kupffer cell and hepatocellular mitochondria were observed,...

Objective; Our aim was to study the effects on Kupffer cell and hepatocellular mitocondria by the inhibition of Kupffer cell. Methods: The rats in the experimental group were pretreated with gadolinium(7 mg/kg) by intro-veinal injection for 2 days, and the rats in the control group were treated with saline solution. The livers of rats were cut off by operation and preserved in the saline at 0 to 4℃for 1, 2, 3, and 4 hours. The changes of ultrastructure of Kupffer cell and hepatocellular mitochondria were observed, and the contents of lipid peroxide (LPO) in hepatic tissue and hepatoceliu-lar mitochondria were determined. Results: Ultrastructural observation showed that the processes of cellular membrane and granular substance in Kupffer cell increased in the control. Swelling,break of the ridge of inner membrane, formation of bubbles and damage in mitochondria could be seen. In the experiment group, the content of LPO of liver tissues and mitochondria in cold preservation for 1 and 2 hours reduced extraordinarily compared with the control ( P < 0. 05 ). Conclusion: Inhibiting kupffer cell can alleviate the injury of lipid peroxide in livers of rats during cold preservation.

目的:研究抑制枯否细胞对冷保存的鼠肝枯否细胞和肝细胞线粒体的影响。方法:实验组连续2 d静注氯化钆,7 mg/kg,对照组静注等量生理盐水。3 d后手术取肝,保存时间分别为1,2,3和4 h。观察各组枯否细胞和肝细胞线粒体的形态变化,测定肝组织和肝细胞线粒体脂质过氧化物(LPO)的含量。结果:对照组枯否细胞表现为细胞膜突起增多,细胞内颗粒物质增多等。肝细胞线粒体普遍肿胀,内膜嵴断裂,空泡形成以及破坏等。实验组肝组织和肝细胞线粒体脂质过氧化程度在冷保存1 h和2 h显著低于对照组(P<0.05)。结论:抑制枯否细胞对鼠肝的冷保存损伤有一定的保护作用。

AIMTo study whether Mel has protective role in liver c old preservation and its mechanism. METHODSTo study the role of Mel at the different concentration and time in liver cold preservation, we colle cted liver washing liquid and liver tissue from male SD rats. We analysed ALT, AST, LDH, HA, ET 1, MDA and SOD to see the function of liver cell and sinusoida l lining cell and mechanism of cell injury. At the same time, we studied the eff ects of Mel at different concentration and different time on liver cold...

AIMTo study whether Mel has protective role in liver c old preservation and its mechanism. METHODSTo study the role of Mel at the different concentration and time in liver cold preservation, we colle cted liver washing liquid and liver tissue from male SD rats. We analysed ALT, AST, LDH, HA, ET 1, MDA and SOD to see the function of liver cell and sinusoida l lining cell and mechanism of cell injury. At the same time, we studied the eff ects of Mel at different concentration and different time on liver cold preserva tion. RESULTS① The damage to liver function and change of its histology was aggravated with the prolongation of UW co ld preservation time, and injury of the sinusoidal lining cell was also aggravated gr adually. ② Indexes of the liver function and the sinusoidal lining cell functio n in the Mel solution cold preservation group were lower than that in the UW sol ution cold preservation group. These suggest protective role of Mel against live r injury caused by cold preservation. Its mechanism may be related to powerful a nti-oxidative effect of Mel. ③ The protective effect of Mel at 1×10 -5 m ol·L -1 ,1×10 -7 mol·L -1 was better than that of Mel at 1×10 -9 mol·L -1 . We found no obvious difference between the protection of Mel 1×10 -5 mol·L -1 and 1×10 -7 mol·L -1 indicati ng a concentration-effect relationship. CONCLUSIONProtective ef fect of UW solution used in clinic weakens gradually as cold preservation time increases. Mel solution has protective effect on liver cold preservation injury and is better than the simple UW solution. Its mechanism is related to anti-oxi dative effect of Mel.

目的 探讨MT对肝脏冷保存有无保护作用及其机制。方法 收集SD♂大鼠肝脏灌洗液 ,对反映肝细胞功能的ALT、AST、LDH和反映内皮细胞功能的HA、ET1和反映细胞氧化性损伤的MDA、SOD及光镜和电镜下肝组织形态学变化进行分析 ,同时设立UW液 +褪黑素 (Mel)不同时间及不同Mel浓度冷保存组 ,比较分析Mel的冷保存保护作用及不同时间及不同浓度的Mel对肝脏冷保存保护作用的影响。结果 ①UW冷保存随着时间延长肝细胞和内皮细胞损害逐渐加重。②Mel对供肝冷保存损伤有保护作用。其保护机制可能与Mel强大的抗氧化损伤作用有关。③Mel 1× 10 - 5 mol·L- 1、1× 10 - 7mol·L- 1浓度时其保护作用优于Mel 1× 10 - 9mol·L- 1,而Mel 1× 10 - 5 mol·L- 1、1× 10 - 7mol·L- 1浓度间没有差异。提示Mel对肝脏冷保存损伤保护存在着浓度效应 ,随着时间延长Mel对肝脏冷保存损伤保护作用逐渐减弱 ,但优于单纯UW液冷保存组。结论 UW冷保存液对肝脏的冷保存随时间延长保护作用逐渐减弱 ,Mel液对肝脏...

目的 探讨MT对肝脏冷保存有无保护作用及其机制。方法 收集SD♂大鼠肝脏灌洗液 ,对反映肝细胞功能的ALT、AST、LDH和反映内皮细胞功能的HA、ET1和反映细胞氧化性损伤的MDA、SOD及光镜和电镜下肝组织形态学变化进行分析 ,同时设立UW液 +褪黑素 (Mel)不同时间及不同Mel浓度冷保存组 ,比较分析Mel的冷保存保护作用及不同时间及不同浓度的Mel对肝脏冷保存保护作用的影响。结果 ①UW冷保存随着时间延长肝细胞和内皮细胞损害逐渐加重。②Mel对供肝冷保存损伤有保护作用。其保护机制可能与Mel强大的抗氧化损伤作用有关。③Mel 1× 10 - 5 mol·L- 1、1× 10 - 7mol·L- 1浓度时其保护作用优于Mel 1× 10 - 9mol·L- 1,而Mel 1× 10 - 5 mol·L- 1、1× 10 - 7mol·L- 1浓度间没有差异。提示Mel对肝脏冷保存损伤保护存在着浓度效应 ,随着时间延长Mel对肝脏冷保存损伤保护作用逐渐减弱 ,但优于单纯UW液冷保存组。结论 UW冷保存液对肝脏的冷保存随时间延长保护作用逐渐减弱 ,Mel液对肝脏冷保存损伤有保护作用 ,其机制与Mel的抗氧化损伤作用有关

 
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