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中心试验设计
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  “中心试验设计”译为未确定词的双语例句
     Methods A randomized parallel controlled multicenter clinical trial was conducted which cefoperazone/tazobactam compared with cefoperazone/sulbactam. Cefoperazone/tazobactam or cefoperazone/sulbactam was given 2g intravenous 30min to 60min twice or thrice daily for 7~14 days.
     方法采用区组随机、平行对照、多中心试验设计,头孢哌酮/三唑巴坦和头孢哌酮/舒巴坦均为每次给药2.0g,静脉滴注30~60min,q12h或q8h,疗程7~14d。
短句来源
     METHODS: The trial design was randomized, double blind,double modeling and multiple center.
     方法 :采用随机、对照、双盲、双模拟、多中心试验设计方法。
短句来源
     Methods A double-blind random- ized multicenter clinical trial was conducted. The foreign cefmetazole was used as the control drug.
     方法采用双盲、随机对照、多中心试验设计,以进口头孢美唑钠为对照药物。
短句来源
     METHODS: A prospective multi-center, randomized , double blind, controlled clinical trial of serrapeptase enteric-coated tablets was conducted.
     方法:用前瞻性随机双盲双模拟对照多中心试验设计,以进口舍雷肽酶肠溶片为阳性对照药。
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  相似匹配句对
     EXPERIMENTAL DESIGN
     试验设计
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     design center, Linz
     林茨设计中心
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     design of field operations;
     矿场试验设计 ;
短句来源
     A Design Centeral Algorithm
     设计中心算法
短句来源
     Designment of Randomized Scheme of Multi-center Clinical Trial
     多中心临床试验的随机化方案设计
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randomized controlled clinical trial of sulperazone as compared with efotaxime was conducted.207 patients with bacterial infections entered the study.The overall clinical efficacy rate of sulperazone and ce- fotaxime was 95.15% and 90.38% respectively. The bacterial clearance rate in the two groups was 84.7%and 80.6%respectively. The adverse drug reactions in both groups were mild with the rate of 7.77%and 8.65% respectively;there was no statistical difference between the two groups. The results of disc susceptibility...

randomized controlled clinical trial of sulperazone as compared with efotaxime was conducted.207 patients with bacterial infections entered the study.The overall clinical efficacy rate of sulperazone and ce- fotaxime was 95.15% and 90.38% respectively. The bacterial clearance rate in the two groups was 84.7%and 80.6%respectively. The adverse drug reactions in both groups were mild with the rate of 7.77%and 8.65% respectively;there was no statistical difference between the two groups. The results of disc susceptibility test showed that the sensitive rate of the clinical isolates to sulperazone was 90.9%,be-ing significantly higher than that of cefotaxime 69.3%(P<0.001).

本项临床试验旨在评价舒巴坦与头孢哌酮联合制剂(sulperazone,舒普深)的安全性与有效性。试验方法为区组随机化开放式平行对照多中心试验设计,并选用头孢噻肟作为对照药。本次试验共治疗细菌性感染207例,其中联合制剂组与头孢噻肟组分别为103与104例。两组痊愈率分别为73.79%和66.35%;有效率分别为95.15%和90.38%;细菌清除率分别为84.71%和80.64%。不良反应发生率分别为7.77%和8.65%,差异均无显著性;但临床分离到的致病菌对联合制剂敏感率为90.90%,显著高于对头孢噻肟的敏感率(69.32%)。表明该联合制剂治疗细菌性感染安全有效,可提供临床广泛应用。

Objective To evaluate the impact of valsartan on sexual function in essential hypertension. Methods Open, multi-centers clinical observation was carried out in 191 patients. Blood pressure levels and parameters of sexual function of hypertensive patients were assessed before and after valsartan treatment for 8 weeks. Side effects were observed in the treatm ent period. Results Sitting systolic blood pressure was decreased by 19.5 mmHg, total response rate was 86.9%. Sexual function was improved in both male...

Objective To evaluate the impact of valsartan on sexual function in essential hypertension. Methods Open, multi-centers clinical observation was carried out in 191 patients. Blood pressure levels and parameters of sexual function of hypertensive patients were assessed before and after valsartan treatment for 8 weeks. Side effects were observed in the treatm ent period. Results Sitting systolic blood pressure was decreased by 19.5 mmHg, total response rate was 86.9%. Sexual function was improved in both male and females, especially that in males. More significant improvement of sexual function scorces were observed in patients older than 40 years. No postual hypotension and severe side effects were found. Serum potassium was increased mildly with no clinical significance. Conclusion Valsartan decreased blood pressure eff ectively with few side effects. The fact that valsartan improved sexual function in old patients of hypertension suggested it was especially suitable for aged patients.

目的 评价缬沙坦治疗轻中度高血压的降压疗效 ,对性功能的影响及安全性。方法 开放 ,多中心试验设计。对轻中度原发性高血压患者进行缬沙坦治疗前后血压水平、性功能指标的比较 ,并观察治疗中的不良反应。结果 缬沙坦治疗 8周后 ,坐位收缩压降低 19 5mmHg ,舒张压降低 13 9mmHg ,总有效率 86 9%。治疗后男女高血压患者性功能指标均有不同程度改善 ,尤以男性明显。 40岁以上中老年患者性功能指数升高更显著。治疗中无体位性低血压和严重不良事件发生。结论 缬沙坦降压疗效确切 ,不良反应少 ,可改善性功能 ,更适用于中老年高血压患者

Objective To evaluate the clinical and bacterial efficacy and safety of cefoperazone/tazobactam versus cefoperazone/sulbactam in the treatment of acute respiratory tract,urinary tract and other system bacterial infections.Methods A randomized parallel controlled multicenter clinical trial was conducted which cefoperazone/tazobactam compared with cefoperazone/sulbactam.Cefoperazone/tazobactam or cefoperazone/sulbactam was given 2g intravenous 30min to 60min twice or thrice daily for 7~14 days.Results 220 patients...

Objective To evaluate the clinical and bacterial efficacy and safety of cefoperazone/tazobactam versus cefoperazone/sulbactam in the treatment of acute respiratory tract,urinary tract and other system bacterial infections.Methods A randomized parallel controlled multicenter clinical trial was conducted which cefoperazone/tazobactam compared with cefoperazone/sulbactam.Cefoperazone/tazobactam or cefoperazone/sulbactam was given 2g intravenous 30min to 60min twice or thrice daily for 7~14 days.Results 220 patients were enrolled in the study,13 patients withdrew from trial because of various reasons.103 cases in cefoperazone/tazobactam group and 104 cases in cefoperazone/sulbactam group were assessable for clinical response.The overall clinical efficacy rates were 96.1%and 94.2%,the bacterial clinical efficacy rates were 95.5%and 94.3%,the bacterial eradication rates were 91.0%and 89.7%,respectively.β-lactamase positive rate was 61.9%in both group.The adverse drug reaction rates were 4.1%in cefoperazone/tazobactam group and 6.4%in cefoperazone/sulbactam group.There was no statistical significant difference between two groups (P> 0.05).In vitro bacterial activity results showed that cefoperazone/tazobactam’s sensitive rate was similar to cefoperazone/sulbactam, more superior to cefoperazone’s,and there were significant differences among three drugs.Conclusions Cefoperazone/tazobactam is as effective and safe as cefoperazone/sulbactam in the treatment of sensitive bacterial infections.

目的评价国产头孢哌酮/三唑巴坦治疗急性细菌性呼吸道感染、泌尿道感染以及其他系统感染的有效性与安全性。方法采用区组随机、平行对照、多中心试验设计,头孢哌酮/三唑巴坦和头孢哌酮/舒巴坦均为每次给药2.0g,静脉滴注30~60min,q12h或q8h,疗程7~14d。结果本项试验共入选病例220例,因各种原因淘汰13例,进入疗效分析的病例数为207例,其中头孢哌酮/三唑巴坦组103例,头孢哌酮/舒巴坦组104例,治疗结束头孢哌酮/三唑巴坦与头孢哌酮/舒巴坦临床有效率分别为96.1%与94.2%,治疗各种细菌感染临床有效率分别为95.5%与94.3%,各种致病菌清除率分别为91.0%与89.7%,两组细菌产β-内酰胺酶阳性率为61.9%,两组不良反应发生率分别为4.7%与6.4%,上述结果经统计学处理均无显著性差异。药敏结果显示头孢哌酮/三唑巴坦与头孢哌酮/舒巴坦细菌敏感率结果相近,明显优于头孢哌酮,有显著差异。结论头孢哌酮/三唑巴坦与头孢哌酮/舒巴坦在治疗临床常见的敏感细菌引起的呼吸道、泌尿道以及其他系统感染均有效、安全。

 
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