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急性肾损害
相关语句
  acute kidney lesion
    The relationship between gene expression of Toll-like receptor 2 and acute kidney lesion in mice with sepsis
    脓毒症小鼠急性肾损害与TLR2受体基因表达的关系
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  “急性肾损害”译为未确定词的双语例句
    Objective:To observe the relationship of the expression of Toll-like 2 receptor(TLR2) with kidney injury in abdominal infection-induced sepsis.
    目的:探讨TLR2受体(Toll-like receptor 2)基因表达与严重感染所致急性肾损害的关系。
短句来源
    The protective effect of melatonin on gentamycin-induced nephrotoxicity
    褪黑素对庆大霉素致急性肾损害的保护作用
短句来源
    Objective To investigate the therapeutical effect and possible mechanism of melatonin on gentamycin induced nephrotoxicity in rats.
    目的 探讨褪黑素对庆大霉素所引起的急性肾损害的治疗作用及其机理。
短句来源
    There is a marked correlation between the changes of TLR2 expression and the actue kidney lesion.
    结论:脓毒症时肾脏组织TLR2mRNA表达上调与急性肾损害密切相关。
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Objective To investigate the therapeutical effect and possible mechanism of melatonin on gentamycin induced nephrotoxicity in rats.Methods The nephrotoxicitic model of rat was created by injecting gentamycin into muscles of one thigh. At the same time and after five days later,melatonin was given(5mg/kg body weight,i.m) into other thigh. Renal function and oxygen radical scavenger enzymes in renal tissue were measured.Meanwhile, the effect of this agent on renoprotection were estimate by PAS staining.Results...

Objective To investigate the therapeutical effect and possible mechanism of melatonin on gentamycin induced nephrotoxicity in rats.Methods The nephrotoxicitic model of rat was created by injecting gentamycin into muscles of one thigh. At the same time and after five days later,melatonin was given(5mg/kg body weight,i.m) into other thigh. Renal function and oxygen radical scavenger enzymes in renal tissue were measured.Meanwhile, the effect of this agent on renoprotection were estimate by PAS staining.Results In two treated groups by different time,blood urea nitrogen,creatinine and urinary NAG as well as superoxide diamutase(SOD),catalase(CAT),glutathione peroxidase(GSH Px) were much better than those in model group.In rats of model group there was a widespread tubular damage,but in rats in groups of treatment there was a marked reduction in the intensity of bubular damage.Conclusion melatonin has therapeutic effect on rat gentamycin induced nephrotoxicity probably related to improved activity of oxygen radical scavenger enzymes in the kidney.

目的 探讨褪黑素对庆大霉素所引起的急性肾损害的治疗作用及其机理。方法 通过肌注庆大霉素诱导急性肾损害模型 ,分别在给予庆大霉素同时和第五天给予褪黑素治疗。检测肾功能、肾组织氧自由基清除酶及肾组织病理学变化 ,比较各组差异。结果 在两治疗组 ,血尿素氮、血肌酐、尿NAG酶降低 ;肾组织超氧化物歧化酶、过氧化氢酶及谷胱甘肽过氧化物酶升高 ;肾组织氧化应激标志物MDA降低 ;肾小管病变减轻 ,尤以早期治疗组效果更佳。结论 褪黑素可能通过其抗氧化作用而减轻庆大霉素的肾毒性损害

Objective:To observe the relationship of the expression of Toll-like 2 receptor(TLR2) with kidney injury in abdominal infection-induced sepsis.Methods:30 mice were randomly divided into 2 groups as follows: cecal ligation puncture group(CLP group,n=15) and sham operation group(control group,n =15).To adopt cecal ligation puncture(CLP) to establish the mice sepsis model,and the expression of TLR2 mRNA and TLR2 protein in kidney tissue were detected by reverse respectively.transcription and polymerase chain reaction(RT-PCR)...

Objective:To observe the relationship of the expression of Toll-like 2 receptor(TLR2) with kidney injury in abdominal infection-induced sepsis.Methods:30 mice were randomly divided into 2 groups as follows: cecal ligation puncture group(CLP group,n=15) and sham operation group(control group,n =15).To adopt cecal ligation puncture(CLP) to establish the mice sepsis model,and the expression of TLR2 mRNA and TLR2 protein in kidney tissue were detected by reverse respectively.transcription and polymerase chain reaction(RT-PCR) and Western blo.The TNFαlevel in the kidney tissue and the creatinine(Cr)in the serum were also measured.Results:The expression of TLR2 mRNA in kidney tissues was markedly upregulated at 6h after CLP,peaked at 12h and kept in high level up to 24h,and the expression change of TLR2 protein was identical with the TLR2 mRNA expression.The expression of TLR2 mRNA was significantly correlated with TNFαand Cr levels.Conclusion:Severe infection could lead to marked up-regulation of TLR2mRNA and its protein expression in kidney tissue.There is a marked correlation between the changes of TLR2 expression and the actue kidney lesion.

目的:探讨TLR2受体(Toll-like receptor 2)基因表达与严重感染所致急性肾损害的关系。方法:采用盲肠结扎穿孔术(cecal ligation puncture,CLP)复制小鼠脓毒症急性肾功能损害模型。将30只小鼠随机分为假手术组(对照组)和脓毒症组(实验组),通过逆转录酶联反应(Reverse transcription and polymerase chain reaction,RT-PCR)检测肾组织TLR2mRNA表达,采用Western blot检测TLR2蛋白表达。采用ELISA法检测肾组织内肿瘤坏死因子α(TNFα)水平,同时测定血浆中肌酐(Cr)水平。结果:CLP术后8、12、24hTLR2mRNA表达均明显高于假手术组,TLR2蛋白表达与TLR2mRNA表达的变化规律相一致,均是12h达峰值,持续至伤后24h;肾组织TNFα水平和血清Cr水平于术后8h即显著升高达峰值,至24h,TNFα水平与假手术组无差异,而血清Cr仍维持高水平。并且TLR2 mRNA表达与肾组织TNFα和血清Cr水平呈显著正相关。结论:脓毒症时肾脏组织TLR2mRNA表达上调与急性肾...

目的:探讨TLR2受体(Toll-like receptor 2)基因表达与严重感染所致急性肾损害的关系。方法:采用盲肠结扎穿孔术(cecal ligation puncture,CLP)复制小鼠脓毒症急性肾功能损害模型。将30只小鼠随机分为假手术组(对照组)和脓毒症组(实验组),通过逆转录酶联反应(Reverse transcription and polymerase chain reaction,RT-PCR)检测肾组织TLR2mRNA表达,采用Western blot检测TLR2蛋白表达。采用ELISA法检测肾组织内肿瘤坏死因子α(TNFα)水平,同时测定血浆中肌酐(Cr)水平。结果:CLP术后8、12、24hTLR2mRNA表达均明显高于假手术组,TLR2蛋白表达与TLR2mRNA表达的变化规律相一致,均是12h达峰值,持续至伤后24h;肾组织TNFα水平和血清Cr水平于术后8h即显著升高达峰值,至24h,TNFα水平与假手术组无差异,而血清Cr仍维持高水平。并且TLR2 mRNA表达与肾组织TNFα和血清Cr水平呈显著正相关。结论:脓毒症时肾脏组织TLR2mRNA表达上调与急性肾损害密切相关。

 
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