RESULTS: HSP60 expression was moderately positive in gastric mucosa with typeⅠ and Ⅱ and Ⅲ IM; the positive rate was 35.19% and 51.32% and 75.61%,and the over-expression rate was 1.9%,3.9% and 19.5%,respectively.
Results Compared with GI-R group,the electrical stimulation of PVN markedly decreased gastric mucosal cellular apoptosis,increased the proliferation,and promoted the protein expression of BCL-2,but markedly inhibited the protein expression of BAX at 30 min,1 h,3 h after reperfusion respectively.
Conclusion The protective effect of PVN on GI-R injury is associated with up-regulation of expression of BCL-2 and down-regulation expression of BAX,and so inhibited gastric mucosal cellular apoptosis and promoted proliferation.
All the derivatives were significantly less irritating to the gastric mucosa than the parent drug.
Proteinases from Gastric Mucosa of European Sheatfish, Silirus Glanis L.
Three proteinases (P1, P2, and P3) were isolated from the gastric mucosa of European sheatfish (Silurus glanis L.) by (NH4)2SO4 precipitation, gel chromatography on Sephadex G-75, and ion-exchange chromatography on DEAE cellulose.
The optimum pH for the three peptidases isolated from sheatfish gastric mucosa and the maximum stability of these enzymes were found to be at acidic pH.
The increased production of nitric oxide (NO) in the August strain prevents the appearance of ulcerous lesions of gastric mucosa and behavioral changes induced by restraint stress.
These results indicated that the oxytocin could significantly protect gastric mucosal against injury induced by ischemia-reperfusion, and the oxytocin receptor was involved.
The potency of NFS to induce unscheduled DNA synthesis (UDS) in human normal gastric mucosal cells was increased about fivefold compared with FS.
Portal hypertensive gastropathy (PHG) and gastric antral vascular ectasia (GAVE) are two distinct gastric mucosal lesions that may cause acute and/or chronic upper gastrointestinal hemorrhage in patients with cirrhosis.
Upper gastrointestinal hemorrhage is one of the most important complications in portal hypertension secondary to schistosomiasis, Esophageal varices and gastric mucosal lesions are additional sources of bleeding.
Role of injury of gastric parietal vessels by immunocomplexes in the mechanism of gastric mucosal lesion in portal hypertension