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胞浆内钙浓度
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  “胞浆内钙浓度”译为未确定词的双语例句
     3. The openprobability (Po) and mean open time of this channel was markedly increased with elevation of cytoplasmic Ca 2+ concentration.
     ③胞浆内钙浓度的增高,能显著激活该通道,增加其开放概率和平均开放时间。
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  相似匹配句对
     Correlation Reseach of Concentration Diversity of Intracytoplasm Calcium Ion and Cell Apoptosis in Neuron
     神经元胞浆离子浓度变化和细胞凋亡相关性的研究
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     MAIN OUTCOME MEASURES ① Changes of neuronal cytoplasmic free calcium concentration.
     主要观察指标:①神经元胞浆游离浓度变化。
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     The effect of estrogen on intracellular calcium concentration in human spermatozoa
     雌激素对人精子胞浆游离离子浓度的影响
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     MAIN OUTCOME MEASURES: ①Cytoplasmic free Ca2+ concentration in hypothalamic neurons.
     主要观察指标:①下丘脑神经元胞浆游离浓度
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     Effect of Oral Take L-Arginine on [Ca~(2+) ]_i of Human Platelets
     口服左旋精氨酸对血小板胞浆离子浓度的影响
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  intracellular calcium concentration ([ ca 2 + ] i)
TFA significantly reduced the resting and CaCl2-induced increase of free intracellular calcium concentration ([Ca2+]i) in rabbit plateletin vitro.Conclusion: TFA has an antiplatelet effect via the inhibition on the influx of Ca2+.
      
In addition, insulin may decrease the contractile response of vascular smooth muscle cells (VSMC) to vasoactive agents by decreasing the intracellular calcium concentration [Ca2+]i.
      
These membrane perturbations, in turn, might lead to the genesis of neuronal excitotoxicity, mitochondrial energy failure, or increased intracellular calcium concentration [Ca2+]i.
      
MIN6 cells co-cultured with 3T3-L1 adipocytes had significantly reduced intracellular calcium concentration ([Ca2+]i) and lost the ability to secrete insulin in response to tolbutamide, compared to the control cells.
      
The effects of angiotensin-converting enzyme (ACE) inhibitors on intracellular calcium concentration ([Ca2+]i) were examined under resting conditions and after stimulation with bradykinin in cultured human umbilical vein endothelial cells.
      
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The basic electrophysiological characteristics of large conductance K + channels in the basolateral cell membrane of outer hair cells (OHC) from the guinea pig cochlea were studied with patch clamp technique. Acutely isolated OHC preparations were obtained by enzymatic digestion and excised patches were made in cell attached configuration to record single channel currents led by patch clamp micropipette and fed to patch clamp amplifier. Data were sampled and analyzed on line with a computer. The result...

The basic electrophysiological characteristics of large conductance K + channels in the basolateral cell membrane of outer hair cells (OHC) from the guinea pig cochlea were studied with patch clamp technique. Acutely isolated OHC preparations were obtained by enzymatic digestion and excised patches were made in cell attached configuration to record single channel currents led by patch clamp micropipette and fed to patch clamp amplifier. Data were sampled and analyzed on line with a computer. The result showed that the typical properties of single channels of large conductance K + channels were: 1. The channel was activated by depolarization of membrane and it showed a marked voltage dependence. The channel had a unitary conductance of about 133 pS and the channel current reversed at about -30mV under asymmetrical K + concentration gradient. 2. Tetraethylammonium (TEA, >10 mmol/L), a potas sium channel blocker, dose dependently abolished the outward current. 3. The openprobability (Po) and mean open time of this channel was markedly increased with elevation of cytoplasmic Ca 2+ concentration. These results suggest that a population of voltage dependent and Ca 2+ activated K + channel exists in the basolateral membrane of OHC of the guinea pig; it is characterized by a very high unitary conductance and high sensitivity to Ca 2+ and is blocked by K + channel blocker. This work provided valuable basic materials for further study on the regulation and drug influence of the type of single channels.

为了研究耳蜗外毛细胞的基本电生理特性,应用细胞膜片钳制技术对豚鼠耳蜗外毛细胞底侧膜的高电导的钾通道进行了初步研究。结果显示,其高电导钾通道有以下典型特征:①具有明显的电压依赖性。在膜去极化时,通道被激活,其去极化程度越高,通道活动越强。在非对称性钾浓度梯度下,其反转电位为-30mV,斜率电导约133±3pS(n=5);②通道活动能被特异性阻断剂四乙胺(TEA)在较高浓度下(>10mmol/L)阻断,TEA的阻断效应呈浓度依赖性;③胞浆内钙浓度的增高,能显著激活该通道,增加其开放概率和平均开放时间。上述结果表明:豚鼠耳蜗外毛细胞存在着高电导的电压依赖的钙激活的钾通道。该研究为进一步开展通道活动的调控,以及药物等因素对通道活动影响的研究,提供了有价值的资料。

Cerebellar granule cells were a good mold for electrophysiologic studies at the single neuron level. Two distinct types of high voltage activated Ca 2+ channels were present in ce ̄rebellar granule cells. These calcium chan ̄nels change their expression, gating, and pharma ̄co ̄logical properties during development, suggestiog that calcium channel must be related to the processes of granule cell maturation and excitability. Dopamine inhibited L type calcium current by activating D 4 receptor, and this effect...

Cerebellar granule cells were a good mold for electrophysiologic studies at the single neuron level. Two distinct types of high voltage activated Ca 2+ channels were present in ce ̄rebellar granule cells. These calcium chan ̄nels change their expression, gating, and pharma ̄co ̄logical properties during development, suggestiog that calcium channel must be related to the processes of granule cell maturation and excitability. Dopamine inhibited L type calcium current by activating D 4 receptor, and this effect might involve another signaling system with the exception of cAMP system. The functional D 4 receptor discovered in cerebellum not only gave a possibility to find other antipsychotics, but also supported the existence of a dopaminergic system in the granule cell involving the D 4 receptor. Pituitary adenylate cyclase activating polypeptide (PACAP) could increase intra ̄cel ̄lular Ca 2+ content by activation of Ca 2+ channel and mobilization of intracellular Ca 2+ stores. The effects were also cAMP independent. Activating Ca 2+ currents might be an important and necessary role of PACAP as a neurotropic factor involved in the control of multiplication, differentiation, and migration of granule cells.

小脑颗粒细胞是离体单细胞水平中枢神经元生物学研究的理想模型.随着细胞发育,其HVA钙电流的基因表达、门控性质和药理学特征发生明显变化,提示钙电流涉及颗粒细胞的成熟和兴奋性的产生.多巴胺通过激活膜上的D4受体抑制L型钙电流,这种抑制效应并不需要腺苷酸环化酶系统的参与.功能性D4受体的首次发现不仅有助于研究抗精神病药,更揭示了多巴胺也参与小脑神经元之间的兴奋传递过程.PACAP则通过激活其I受体增加钙内流和钙库的释放使胞浆内钙浓度提高,PACAP的钙通道刺激效应可能需要PLC系统的介导,并与颗粒细胞的成熟和成活有关.

Objective To evaluate the effect of Lacipil therapy on pulse and its relationship with intralymphocytic free calcium concentration ( [ Ca2 +] i), and plasma Angiotensin II([AT-II])in patients with essential hypertensions. Methods 68 patients with essential hypertensions, with sex and age being well matched to normotensive group, before and after taking Lacipil observed pulse pressure by ambulatory blood pressure monitoring and determined intralymphocytic free calcium concentration by Fura - 2/AM fluorescence...

Objective To evaluate the effect of Lacipil therapy on pulse and its relationship with intralymphocytic free calcium concentration ( [ Ca2 +] i), and plasma Angiotensin II([AT-II])in patients with essential hypertensions. Methods 68 patients with essential hypertensions, with sex and age being well matched to normotensive group, before and after taking Lacipil observed pulse pressure by ambulatory blood pressure monitoring and determined intralymphocytic free calcium concentration by Fura - 2/AM fluorescence technique, plasma Angiotensin II was determined by radioimmunoassay. Result After Lacipil treatment in essential hypertensions, their Bp, ([Ca2+ ]i)and ([AT- II]) were markly decreased. And pulse pressure were much lower. There was positive correlations between the intralymphocytic free calcium concentrations lowering degree any systolic blood pressure lowering,(γ= 0.876 ,p < 0.001), and there was positive correlations between △[Ca2+]i and

目的 观察拉西地平对原发性高血压(EH)患者脉压的影响及淋巴细胞胞浆内游离钙浓度([Ca2+]i)、血管紧张素Ⅱ浓度([AT-Ⅱ])的关系.方法对68例高血压患者及性别年龄严格匹配的正常对照组口服拉西地平治疗,治疗前后检测上述指标.结果EH患者用拉西地平治疗后血压显著下降(p<0.001),脉压明显缩小(p<0.01).治疗前患者([Ca2+]i)和[AT-Ⅱ]比正常对照组显著升高(p<0.001,P<0.01),用拉西地平治疗后([Ca2+]i)和[AT-Ⅱ]显著下降(p<0.01,p<0.01),([Ca2+]i)下降幅度与收缩压下降幅度呈正相关(γ=0.876,p<0.001),([Ca2+]i)的下降幅度与[AT-Ⅱ]的下降幅度呈正相关(γ=0.647).结论拉西地平可降低细胞胞浆内钙浓度及血管紧张索Ⅱ浓度,在降低收缩压的同时,亦可缩小脉压.

 
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