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差异性表达
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  differential expression
     Differential Expression of Cyclins D1,E and A in Human Breast Diseases
     周期素D1、E、A在乳腺疾病中的差异性表达
短句来源
     Differential expression of L-type calcium channel α1 subunits on adult rat hippocampal neurons
     L-型钙通道α1亚单位在成年鼠海马神经元上的差异性表达
短句来源
     Differential Expression of Down-regulatory Activity between Subjects by CD 8 VV~(++) Contrasuppressor T Cells Induced selectively by Trichosanthin
     天花粉蛋白选择性激活人体CD8VV~+反抑制细胞造成个体间T细胞负调节功能的差异性表达
     The differential expression of tumor associated antigen CA-X in vitro and in vivo
     肿瘤相关抗原CA-X体内外的差异性表达
短句来源
     Conclusion Different α1 subunits of L-type calcium channel have differential expression in adult hippocampal neurons.
     结论L-型钙通道CaV1.2α1C和CaV1.3α1D亚单位在成年鼠海马不同亚区神经元中呈现差异性表达
短句来源
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  difference expression
     Heparin enzyme gene difference expression and lung cancer pathology type, phased and splitting up and shifting to study
     肝素酶基因的差异性表达与肺癌的病理类型、分期、分化与转移研究
短句来源
     The Spatial Difference Expression of Melatonin Receptor Mel_(1a) in the Retina of Gekko Swinhonis
     褪黑激素受体Mel_(1a)在无蹼壁虎视网膜的空间差异性表达
短句来源
     Objective: Probe into the heparin enzyme mRNA difference expression and clinic and pathology characteristic in the non_little cell cancer.
     目的:探讨肝素酶mRNA在非小细胞肺癌(non_small cell lung cancer,NSCLC)中的差异性表达及其临床和病理学特征。
短句来源
     Gene Difference Expression Between Mice and Microtus fortis Infected with Schistosoma japonicum Using cDNA Microarrays
     利用基因表达谱芯片研究东方田鼠和小鼠感染日本血吸虫前后基因的差异性表达
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  “差异性表达”译为未确定词的双语例句
     Detection of CD44v8-10/CD44v10 Ratio and Surfactant Protein-A Gene in the Cells from Ascites and Pleural Effusion for the Diagnosis of Lung Adenocarcinoma
     研究胸/腹水细胞CD44v8-10/CD44v10差异性表达和SP-A基因对肺腺癌的诊断价值
短句来源
     Results: (1)The rates of positive expressions of P-gp,MRP1,LRP and GST-πwere 69.23%, 32.02% , 56.42% and 68.31%,which showed high level expression in all specimen and various expression in every specimen.
     结果:(1)、在所检测20例标本中,P-gp、MRP1、LRP和GST-π的阳性表达率分别为69.23%、32.02%、56.42%和68.31%,均呈较高水平表达和每例间差异性表达
短句来源
     [Objectives]Screen serum protein expression maps in patients with non-Hodgkin lymphoma (NHL) by using surface enhanced laser desorption/ionization time of flight mass spectrometry (SELDI-TOF-MS), and to find the biomarkers in NHL for early stage diagnosis.
     [目的]用表面增强激光解吸电离飞行时间质谱(surface enhanced laser desorption/ ionization time of flight mass spectrometry, SELDI-TOF-MS)技术检测非霍奇金淋巴瘤(non-Hodgkin lymphoma,NHL)患者的血清蛋白质谱的差异性表达,以期寻找NHL的早期诊断标志物。
短句来源
     Fluorescent signals were scanned to detect cytochrome P450 genes differentially expressed in patients and normal subjects. (Results) Among 32 cytochrome P450 genes,six genes(CYP4F3,CYP1A1,CYP27A1,CYP1B1,CYP2B6,CYP51) were found to be differentially expressed between the cells of benzene-poisoned patients and normal controls cells,CYP4F3 gene was up-regulated among all patients.
     结果共有6条细胞色素P 450基因呈差异性表达,包括CYP 4F 3、CYP 1A 1、CYP 27A 1、CYP 1B 1、CYP 2B 6、CYP 51,其中CYP 4F 3基因在所有苯中毒工人中均表达上调。
短句来源
     Conclusions (1) Human UGT 1A genes are regulated in a tissue-specific fashion.
     结论①UGT 1A基因位点呈组织差异性表达
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  differential expression
Heterogeneity and Differential Expression of MUP Proteins as a Genetic Basis of the Physiological Activity of Androgen-Dependent
      
Differential Expression of the Isoforms of Human Vascular Endothelial Growth Factor and New Approaches to Therapeutic Angiogenes
      
Let q (x) be a positive function given on the interval I of the real axis; let P be the minimal operator generated in L2(0, +∞) by the differential expression P[·]=-d2/dx2+q(x); let Q be the operator of multiplication by the function q(x).
      
We consider a self-adjoint differential expression of even order in a space of vector-valued functions.
      
We prove that an arbitrary generalized resolvent of the minimal operator L0 induced by this differential expression is an integral operator and we derive a formula for all of the spectral functions (orthogonal and nonorthogonal) of the operator L0.
      
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  difference expression
Average intensity difference expression scores for each sequence were compared for the two cell types by scatterplot analysis.
      
Both the Affymetrix average-difference expression data and the P/A calls were used in the analyses.
      
Despite the advantages of ignoring absent/present calls, the absolute difference expression value provided by the Affymetrix software is not ideal.
      
In this analysis we preselected all genes that had positive Affymetrix average difference expression levels.
      
In this analysis we pre-selected all genes that had positive Affymetrix average difference expression levels.
      
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There are about 100 000 different genes in higher organisms, and only 15% of them are expressed in any individual cell. Thus it is very important to isolate specific genes.Comparing with substractive hybridization, differential display is a more effective approach to isolate specifically expressed genes. In differential display, reverse transcripted products of mRNA are amplified and displayed on sequencing gel. Then differentially expressed genes are isolated. Although there are many difficulties in using this...

There are about 100 000 different genes in higher organisms, and only 15% of them are expressed in any individual cell. Thus it is very important to isolate specific genes.Comparing with substractive hybridization, differential display is a more effective approach to isolate specifically expressed genes. In differential display, reverse transcripted products of mRNA are amplified and displayed on sequencing gel. Then differentially expressed genes are isolated. Although there are many difficulties in using this method, as further improved, it will be useful in various fields.

在高等生物中含有约100000个不同的基因,其中仅有15%的基因在任何个体细胞中均表达.因此分离特异的目的基因便显得十分重要差异展示是通过部分扩增mRNA的逆转录产物、经测序胶电泳,分离到差异性表达的基因它与消减杂交相比是分离特异表达基因的更有效的手段.虽然这种方法在实际运用中存在着这样或那样的困难,但随着对这种技术的不断改进,它将会有越来越广泛的用途.

It was studied the expression of IGFⅠ and its mRNA in the condylar cartilage of 10 7weekold SD male rats by using in situ hybridization and immunohistochemistry technique. The results showed both IGFⅠ and its gene expressed in growing rat condyle. IGFⅠ peptide was abundant in germinal zone, and positive reaction of its mRNA was strongest in transitional and maturational zones. These indicate that condylar cartilage has the capability of local production and secretion of IGFⅠ, mediating the command efffect...

It was studied the expression of IGFⅠ and its mRNA in the condylar cartilage of 10 7weekold SD male rats by using in situ hybridization and immunohistochemistry technique. The results showed both IGFⅠ and its gene expressed in growing rat condyle. IGFⅠ peptide was abundant in germinal zone, and positive reaction of its mRNA was strongest in transitional and maturational zones. These indicate that condylar cartilage has the capability of local production and secretion of IGFⅠ, mediating the command efffect of STH, and differential expression of IGFⅠ and its mRNA might establish the local feedback loop, which supply a direct evidence for servosystem theory of facial growth.

采用原位杂交和免疫组化技术,对10只7周龄雄性SD大鼠双侧髁突中胰岛素样生长因子Ⅰ(IGF-Ⅰ)及其mRNA表达进行研究。结果发现:生长期大鼠髁突软骨中IGF-Ⅰ及其基因均有表达,但IGF-Ⅰ阳性强度在生发层中最强,而IGF-ⅠmRNA在过渡层和成熟层中最强。表明髁突软骨具有局部合成和分泌IGF-Ⅰ的能力,可介导生长激素的命令式作用,其差异性表达建立起局部反应的反馈环路,为生长伺服理论提供了直接证据

Objective To search differentially expressed sequences correlated with pathogenesis of human nasopharyngeal carcinoma(NPC), including the candidates of tumor suppressor genes. Methods cDNA representational difference analysis (RDA) was performed to isolate differentially expressed sequences between cDNA from normal human primary cultures of nasopharyngeal epithelial cells and cDNA from NPC cell line HNE 1. The sources of differentially expressed products were proved by Southern blot and Northern blot. The...

Objective To search differentially expressed sequences correlated with pathogenesis of human nasopharyngeal carcinoma(NPC), including the candidates of tumor suppressor genes. Methods cDNA representational difference analysis (RDA) was performed to isolate differentially expressed sequences between cDNA from normal human primary cultures of nasopharyngeal epithelial cells and cDNA from NPC cell line HNE 1. The sources of differentially expressed products were proved by Southern blot and Northern blot. The fragments were cloned with pGEM T easy kit and sequenced by the chain termination reaction.Results Four differentially expressed cDNA fragments were isolated in the fourth subtractive hybridization using cDNA from normal human primary cultures of nasopharyngeal epithelial cells as tester amplicon and cDNA from NPC cell line HNE 1 as driver amplicon by cDNA RDA. These differential cDNA fragments revealed that they really came from the tester amplicon and were not expressed or down regulated in the NPC HNE 1 cells. Of these obtained clones, some are the fragments of the human known genes including house keeping genes, the others are novel genes.Conclusion NPC involves alteration of multiple genes. Some of known genes matched with the differentially expressed sequences have an effective suppressive ability on the carcinoma.

目的寻找鼻咽癌中差异性表达基因,包括与鼻咽癌发病相关的候选抑瘤基因。方法应用cDNA代表性差异分析法(RDA),分离原代培养的正常人鼻咽上皮细胞与鼻咽癌细胞株HNE1中差异表达的cDNA序列,Southern杂交和Northern杂交被用来分析差异性表达产物的来源,最后,将这些序列克隆到pGEM-Teasy载体中,并用链终止法测序。结果在第4轮杂交及扩增反应后,获得4条差异性条带。Southern杂交及Northern杂交证明,这些差异性片段来自作为“检测”扩增子的正常人鼻咽上皮,在鼻咽癌细胞株HNE1中不表达或表达降低。序列分析这些差异性片段的克隆,发现一些序列是与已知基因高度同源的基因,包括一些看家基因;另有一些基因则为新基因序列。结论鼻咽癌的发生是一个多基因参与的过程,所获得的差异性片段中,与之同源的一些已知基因具有抑瘤功能。

 
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