Objective:This study aimed to investigate DNA ploidy and the expression of TGFβ1 in the endometrioid adenocarcinoma was for the view of neoplasm heterogeneity,to explore the machinery of molecular biology and genetics for the endometrioid adenocarcinoma.
Objective To investigate the expression and clinical significance of matrix metalloproteinase-2(MMP-2) and tissue inhibitor of matrix metalloproteinase-2 (TiMP-2) and their correlations with angiogenesis in epithelial ovarian neoplasm.
This indicated that part of P~16 gene changed. The rate of the mutation was 53.57%（15/28）. Of all these ，the rate of P~16 genetic alteration of the benign ovarian tumors was 72.7%（8/11）and that of the neutral ovarian tumors was 75%（3/4），and that of the ovarian cancers was 30.8%（4/13）.
Since first described in 1982, intraductal papillary mucinous neoplasm (IPMN) has been the preferred term to describe the proliferation of the pancreatic ductal epithelium.
An analysis of clinico-pathologic features of intraductal papillary mucinous neoplasm of the pancreas
The data considered in the paper indicate that a tumor clone resulting from cell transformation, in order to develop into an overt neoplasm, should overcome a microenvironmental constraint.
Cases of a hereditary malignant neoplasm giving rise to the formation of multiple macrovilli in the cardiac portion of the stomach have been found in Microtus abbreviatus (Microtinae, Cricetidae), a vole endemic to St.
The pathogenic neoplasm serves as a preadaptation for the growth of symbiotic flora in the stomach.
The complex nature of DNA methylation patterns extends to carcinogenesis because global DNA hypomethylation is found in the same cancers displaying hypermethylation elsewhere in the genome.
A wide variety of cancers display both DNA hypomethylation and hypermethylation, and either of these types of changes can be significantly associated with tumor progression.
Furthermore, various DNA demethylation methodologies have been shown to increase the formation of certain types of cancers in animals, and paradoxically, DNA hypermethylation can cause carcinogenesis in other model systems.
Hypermethylation of RASSF1A was frequently found in most major types of human tumors including lung, breast, prostate, pancreas, kidney, liver, cervical, thyroid and many other cancers.
The thermostable fraction of serum samples from patients with ovarian, uterus, and breast cancers and benign ovarian tumor was analyzed using two-dimensional electrophoresis combined with MALDI-TOF(-TOF)-mass spectrometry.