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病毒     
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  virus
    A Study on CTL clone with specificity of Hantaan virus nucleocapsid protein from peripheral blood of patients with HFRS
    我国疫区HFRS患者汉滩病毒核蛋白特异性CTL克隆的建立及其初步研究
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    Clinical Significance of Gene Quasispecies of Transfusion Transmitted Virus
    输血传播病毒(TTV)基因变异的临床意义
短句来源
    Expression and Immunological Characterization of the Chimeric G1S0.7 and G2S0.7 Gene of Hantaan Virus 76-118 Strain
    汉滩病毒76-118株G1S0.7和G2S0.7不同嵌合基因的表达及免疫学特性研究
短句来源
    Molecular Epidemiological Study on the Intrauterine Transmission of Hepatitis B Virus Through Placental Infection
    乙肝病毒经胎盘感染致宫内传播的分子流行病学研究
短句来源
    Use of colloidal gold probes in studies of the expression of viral antigens in the liver of individuals with chronic asymptomatic hepatitis B virus infection
    胶体金法观察慢性无症状乙型肝炎病毒感染者肝组织内病毒抗原的表达
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  viral
    Use of colloidal gold probes in studies of the expression of viral antigens in the liver of individuals with chronic asymptomatic hepatitis B virus infection
    胶体金法观察慢性无症状乙型肝炎病毒感染者肝组织内病毒抗原的表达
短句来源
    Study on Location of Viral Antigens on Skin Micrangium at the Early Stage of Hemorrhagic Fever with Renal Syndromes and Observation with Electromicroscopy
    肾综合征出血热发病初期皮肤微血管的病毒抗原定位研究和电镜观察
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    INTERLEUKIN 2 ACTIVITY IN HEPATITIS B VIRUS INFECTION: RELATIONSHIP WITH VIRAL REPLICATION
    乙型肝炎病毒感染者白细胞介素2活性的改变及其与病毒复制的关系
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    Immunocytochemical study of the viral antigens and antibody in thetissues of the naturally infected rats with hemorrhagic fever with re-nal syndrome virus
    自然感染肾综合征出血热病毒大鼠组织中病毒抗原及抗体的定位研究
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    Study on the Relationship between Uterine Bleeding with Intrauterine Device and Viral Infection
    放置宫内节育器后出血与病毒感染的关系
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  virological
    2,Virological surveillance:In 2005,total 188 measles viral isolates were collected from 16 Provincial Measles Laboratories,all belong to H1 genotype,which showed that H1 genotype was still the predominant genotype circulating in China.
    ②病毒学监测:2005年16个省级CDC麻疹实验室共送检188株麻疹病毒,经证实全部属于麻疹野病毒H1基因型,显示H1基因型仍是中国麻疹流行的绝对优势基因型。
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    Virological, Epidemiological and Clinical Features of Influenza A, B, C Virus and Influenza Vaccine
    A、B、C三型流感病毒病毒学、流行病学、临床特征和流感疫苗
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    Peginterferon α-2b and ribavirin therapy in chronic hepatitis C genotype 4: Impact of treatment duration and viral kinetics on sustained virological response
    聚乙二醇干扰素α-2b和利巴韦林治疗慢性丙型肝炎基因型4:治疗耐受和病毒动力学对持续的病毒学反应的影响
短句来源
    Predicting sustained virological responses in chronic hepatitis C patients treated with peginterferon alfa- 2a (40 KD)/ribavirin
    聚乙二醇干扰素α-2a(40kD)/利巴韦林治疗的慢性丙型肝炎患者的持续性病毒应答预测
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    Virological and pathogenic detection of influenza virus in Taizhou area
    泰州地区流感病毒病原学检测分析
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  a virus
    The Study on Infection Level of Hepatitis A Virus and Analysis of Simple Catalytic Model in Normal Population of Henan Province
    河南省正常人群甲型肝炎病毒感染水平调查及催化模型分析
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    Inactivation of Hepatitis A Virus by Vitamin CCopper System
    维生素C-铜体系对甲型肝炎病毒的灭活作用
短句来源
    The Clinical Analysis of 136 Cases with Co infection of Hepatitis A Virus and Hepatitis E Virus
    甲型肝炎病毒合并戊型肝炎病毒感染136例临床分析
短句来源
    The Comparison of Infectious Titers of Hepatitis A Virus (H 2 Strain) in Three Kinds of Cells
    甲型肝炎病毒(H_2株)在三种细胞中的感染性滴度比较
短句来源
    DYNAMIC DETECTION OF HEPATITIS A VIRUS ANTIGEN OR ANTIBODY IN SERA AND FAECES OF 19 PATIENTS WITH HEPATITIS A
    19例甲型肝炎病人血清和粪便中甲型肝炎病毒感染标记的动态检测
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      virus
    Human immunodeficiency virus type 1 (HIV-1) integrase is a potential target for anti-HIV therapy.
          
    It is an essential enzyme required for replication of the acquired immunodeficiency syndrome (AIDS) virus.
          
    Efavirenz is a trifluoromethylated inhibitor of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) that shows good results in anti-HIV chemotherapy.
          
    Derivatives on Herpes simplex virus type 1 (HSV-1), Mayaro virus (MAY) and vesicular stomatitis virus (VSV) were investigated.
          
    Compounds 2d, 3f, 3a, and 3c exhibited antiviral activity against HSV-1, MAY, and VSV virus with EC50 values of 6.8, 2.2, 4.8, 0.52, 2.5, and 1.0.
          
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      viral
    cyclotriazadisulfonamides), viral envelope gp120-binding agents such as plant lectins and glycopeptide antibiotics, HIV integrase inhibitors such as the pyranodipyrimidine V-165, and two new classes of compounds (i.e.
          
    Both genes were determined to be nonessential in viral replication and infection.
          
    Pseudorabies virus (PRV), an alpha-herpesvirus, has been developed as a live viral vector for animal vaccines.
          
    Meanwhile, other findings reveal a relationship between host miRNA and viral infection.
          
    These findings suggest a tight relationship between host and viral infection via miRNA pathway.
          
    更多          
      virological
    Cytological and molecular genetics methods were used to study sperm from patients with sperm infected with herpes simplex virus (HSV) as indicated by virological and immunocytochemical tests.
          
    The rescued viruses from the full-length cDNA clones displayed the same virological and molecular properties.
          
    The drug resistance strains were highly prevalent in antiretroviral-treated patients, and increased with the continuation of therapy, with many patients encountering virological failure after 6 months therapy.
          
    A boy was suspected of having meningoencephalitis, probably of viral origin, although all microbiological, including virological, tests were negative.
          
    Special pharmacological and virological conditions predominate in the central nervous system (CNS).
          
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      其他


    Recent studies on viral hepatitis showed that the pathogenesis and the out-come of viral hepatitis are closely related to the immunologic reactions of the patients.Since 1974 we have observed the immunologic states of normal subject, acute hepatitis, chronic hepatitis and cirrhosis with 7 different immunologic tests including those of cellular immunity, humoral immunity and auto-immunity. The results were as follows: Acute hepatitis had a relative good immunologic conditions. While that of chronic hepatitis...

    Recent studies on viral hepatitis showed that the pathogenesis and the out-come of viral hepatitis are closely related to the immunologic reactions of the patients.Since 1974 we have observed the immunologic states of normal subject, acute hepatitis, chronic hepatitis and cirrhosis with 7 different immunologic tests including those of cellular immunity, humoral immunity and auto-immunity. The results were as follows: Acute hepatitis had a relative good immunologic conditions. While that of chronic hepatitis were rather complex (effect of virus, formation of antigen-antibody complex, auto immune reactions, immuno-pathologic lesions act to different extents on the mechanism and pathogenesis of chronic hepatitis.) Cirrhosis showed depression of cellular immunity and disterbances of humoral immunity.

    近年来关于病毒性肝炎的研究表明,其发病机理及转归与机体的免疫反应密切相关。五年来我们应用七项免疫学检查指标(包括细胞免疫、体液免疫、自家免疫),对正常人、急性肝炎、慢性肝炎,肝硬化患者的机体免疫状态进行了观察。其结果:急性肝炎患者机体免疫状况尚好,慢性肝炎患者机体免疫情况较复杂。病毒的作用,免疫复合物的产生,自身免疫反应,免疫病理损害不同程度地参与慢性肝炎的发病;肝硬化患者是细胞免疫低下,体液免疫失调。

    ~3H-Tdr incorporation in lymphocyte transformation test (~3H-Tdr. LCT) with PHA as stimulating antigen was used to study the cellular immunity patterns in 90 cases of various types of viral hepatitis, 13 asymptomatic HBsAg carriers and 41 normal adults. The mean value of ~3H-Tdr. LCT in 18 cases of chronic active hepatitis, 13 carriers, and 5 gravis form were 86.9±9.3, 74.9±8.7 and 23.4±4.8, respectively. As compared with that of normal adults (105.5±10.2), there was a significant difference (p<0.01). The mean...

    ~3H-Tdr incorporation in lymphocyte transformation test (~3H-Tdr. LCT) with PHA as stimulating antigen was used to study the cellular immunity patterns in 90 cases of various types of viral hepatitis, 13 asymptomatic HBsAg carriers and 41 normal adults. The mean value of ~3H-Tdr. LCT in 18 cases of chronic active hepatitis, 13 carriers, and 5 gravis form were 86.9±9.3, 74.9±8.7 and 23.4±4.8, respectively. As compared with that of normal adults (105.5±10.2), there was a significant difference (p<0.01). The mean value of ~3H-Tdr. LCT in acute icteric form was significantly lower than that of acute anicteric form (p<0.05), and the mean value in the early stage of 5 acute icteric hepatitis was significantly lower than that of the late stage (p<0.01). 4 of these 5 were re-examined during the course of disease, 3 returned to normal level associated with a complete clinical recovery, the other one with persistent low level progressed into gravis form. 4 of the 5 gravis form died, the only survived patient was one whose ~3H-Tdr. LCT value returned to normal level. The results indicated that there was a positive correlation between the cellular immunologic response of the patient and the clinical manifestation and the outcome of the disease. When the individual was infected by the hepatitis virus, his cellular immunity was significantly inhibited. If the immunity was rapidly restored, the disease ended in recovery, whereas if the immunity was seriously inhibited, the patient could be prompted to death ultimately, and if inhibition of cellular immunity persisted or if the patient had pre-existing lowered cellular immunity, the test reaction would reveal a subnormal level for a long time, and a chronic form of hepatitis may develop. However, the mean value of lymphocyte transformation test presented no significent difference between the various types of hepatitis patients and the carriers. Though the erythrocyte rosette cycle formation test may also be used to study the immunity, it is not so sensitive as ~3H-Tdr. LCT.

    本文报道应用植物血凝素(PHA)为刺激原的氚化胸腺嘧啶核苷掺入淋巴细胞转化试验(~3H-TdR·LCT)检测90例各型肝炎、13例无症状HBsAg携带者,以及41名正常人的细胞免疫状况,并与形态学淋巴细胞转化试验(LCT)、玫瑰花环形成试验(E·RFC)相比较.结果提示,细胞免疫状态与病情预后关系密切.机体受肝炎病毒感染后,细胞免疫受明显抑制,若能迅速恢复,则病程终止;若抑制非常严重,终将促使患者死亡;若受持续抑制或原来机体细胞免疫功能较差,长期未能恢复正常者,则导致慢性化.在各型肝炎及携带者中,LCT均值无明显差异;E·RFC的结果虽与~3H—TdR·LCT相近,但灵敏性不及后者.本文并讨论了细胞免疫增强剂的可能适应证。

    A virus has been isolated by ultracentrifugation from sera of the ducks more than 2 years old. This virus is spherical in form and approximately 50 nm in diameter and shows endogenous DNA polymerase activity. The livers of the ducks showed histologically pathogenic changes parallel to the virus positive sera. By radioimmunoassay, some of the virus preparations revealed an ability of competing with the combining of HBsAg to anti-HBs. By mixing the viral preparations with anti-HBs, aggregation was observed by...

    A virus has been isolated by ultracentrifugation from sera of the ducks more than 2 years old. This virus is spherical in form and approximately 50 nm in diameter and shows endogenous DNA polymerase activity. The livers of the ducks showed histologically pathogenic changes parallel to the virus positive sera. By radioimmunoassay, some of the virus preparations revealed an ability of competing with the combining of HBsAg to anti-HBs. By mixing the viral preparations with anti-HBs, aggregation was observed by electron microscopy. It is postulated that there is a class of virus associated with hepatitis and hepatoma in nature. The virus in the ducks thus obtained is possibly a member of them.

    本文报告从鸭血清中分离到一种可能与鸭肝炎和肝癌有关的病毒,此病毒为直径50毫微米左右的球形颗粒,含有内源DNA聚合酶。含有病毒颗粒的肝组织都发现不同程度的病理变化。含有病毒颗粒的某些血清对HBsAg与抗-HBs的结合率有抑制作用,抗-HBs能使病毒颗粒聚集。作者提出,自然界中可能存在一类与肝炎和肝癌相关的病毒,此文报告的鸭病毒可能是这类病毒之一。

     
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