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   细胞毒分子 的翻译结果: 查询用时:0.879秒
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肿瘤学
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细胞毒分子
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  cytotoxic molecules
     Conclusion The features of clinical pathology, immunophenotype, expression of cytotoxic molecules and EBV infection were similar in hepatosplenic and non hepatosplenic γδT cell lymphomas.
     结论 本组病理组织学资料中 ,3例符合肝脾γδT细胞淋巴瘤 ,2例符合非肝脾γδT细胞淋巴瘤 ,两者在临床表现、免疫表型、细胞毒分子表达和EB病毒感染等方面相似。
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     Conclusions The antitumorigenic function of paclitaxel was related to activating murine peritoneal macrophages to promote the production of the cytotoxic molecules.
     结论 紫杉醇的抗肿瘤作用与活化巨噬细胞 ,促进巨噬细胞产生细胞毒分子有关 ,若与干扰素γ联合更能发挥其免疫化学治疗作用
短句来源
     Methods The complete clinical data were collected with histology observed . With immunohistochemical stainings on fresh biopsied materials, immunophenotype and expression of cytotoxic molecules were investigated in 5 cases of γδT cell lymphoma.
     方法 在收集临床资料和观察组织学变化的基础上 ,采用新鲜组织免疫组化染色 ,分析免疫表型和细胞毒分子表达 ;
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     All cases showed expression of several cytotoxic molecules.
     所有病例均有多种细胞毒分子表达。
短句来源
  cytotoxic molecule
     Purpuric adult T-cell leukaemia/lymphoma:Expansion of unusual CD4/CD8 double-negative malignant T cells expressing CCR4 but bearing the cytotoxic molecule granzyme B
     成人紫绀性T细胞白血病/淋巴瘤:罕见的CD4/CD8双阴性恶性T细胞增多,表达CCR4并带有细胞毒分子颗粒酶B
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  “细胞毒分子”译为未确定词的双语例句
     The use of antibody-enzyme conjugates directed at tumor-associated antigens to achieve site-specific activation of prodrugs to potent cytotoxic species, termed antibody-directed enzyme prodrug therapy (ADEPT) has attracted considerable interest since the concept was first described in 1987. ADEPE may improve both the efficiency and the specificity of cytotoxic drugs to achieve selective targeting with minimized host organ toxicity.
     1987年提出的抗体导向酶—前药疗法(antibody-directed enzyme prodrug therapy,ADEPT)即抗体与前药的专一性活化酶交联,并将其特异性结合于肿瘤部位,使前药可以区域特异性地在肿瘤组织内转化为细胞毒分子,可以提高毒性药物的特异性和疗效,同时减少毒副作用。
短句来源
     NKT cells bridge the innate and adaptive immune systems.
     NKT细胞兼备固有性和适应性免疫细胞特性,被脂类或糖脂抗原激活后能迅速产生大量细胞因子,并上调表达细胞毒分子
短句来源
     The antibody, as the vector to carry the specific activating enzyme to catalyze the prodrug, can selectively conjugate to the target malignant tissue at the same time.
     ADEPT利用针对肿瘤抗原的特异性抗体作为载体,携带前体药物的专一性活化酶,使前药可以区域特异性地在肿瘤组织内被抗体所携带的酶转化为活性细胞毒分子,发挥对肿瘤细胞的杀伤作用。
短句来源
     Gene-directed enzyme prodrug therapy (GDEPT) is one of the noticeable new progresses in the research of antibody-directed treatment for tumor in recent years. The prodrug, a kind of substances has no or only lower, can be converted into actived drug when catalyzed in vivo. The virus vector or non- virus vector which carry the the specific activating enzyme to catalyze the prodrug ,can selectively conjugate to the target maligant tissue at the same time.
     基因介导的酶前体药物疗法(gene directed enzyme prodrug therapy,GDEPT),是利用病毒载体或非病毒载体,携带前体药物的专一性活化酶,使前体药物可以区域特异性地在肿瘤组织内被载体所携带的酶转化为活性细胞毒分子,发挥对肿瘤细胞的杀伤作用。
短句来源
  相似匹配句对
     Cytochalasin B
     细胞B
短句来源
     Cytotoxic T Cell
     细胞T细胞
短句来源
     CONCLUSION: NO is an effector molecule in cytotoxicity of activated macrophages.
     结论:NO是巨噬细胞细胞作用的一个效应分子
短句来源
     All cases showed expression of several cytotoxic molecules.
     所有病例均有多种细胞分子表达。
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     10 ?
     分子
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  cytotoxic molecules
The effector CD8+ T cells could release cytotoxic molecules of granzyme B and perforin after restimulation with natural HLA-A2+MAGE-A3+ HCC cell lines in the samples tested.
      
Expression of cytotoxic molecules by effector cells was measured in response to the pro-inflammatory cytokine IFN-γ; cytotoxicity was established and concomitant expression of receptor molecules was assessed on target cells.
      
Tumor-infiltrating lymphocytes in the group of mice treated with both T cell-activating bi-mAbs expressed high levels of cytokines and cytotoxic molecules such as perforin and the cytotoxic serine esterases granzyme A and B.
      
These cells express cytotoxic molecules of T-cell restricted intracellular antigen(TIA-1), and activated cytotoxic molecules of perforin, granzyme B, and FasL.
      
The study excluded anaplastic large-cell lymphomas expressing cytotoxic molecules.
      
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  cytotoxic molecule
To this end, we constructed a functional single-chain Fv fragment from the cloned TCR and fused it to a very potent cytotoxic molecule, a truncated form of Pseudomonas exotoxin A (PE38).
      
T-2 is a cytotoxic molecule inhibiting growth and macromolecular synthesis in S.
      
Intravascular large T-cell lymphoma: a case report of CD30-positive and ALK-negative anaplastic type with cytotoxic molecule exp
      
by production of the cytotoxic molecule nitric oxide (NO) from arginine with the help of the inducible nitric oxide synthase (iNOS).
      
It seems likely that concentrations of flexibilide, a highly cytotoxic molecule involved in interference competition, and sinulariolide, a known algicide probably responsible for colony maintenance, may be influenced by their environments.
      
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Objective To study the effect of Paclitaxel on TNF α production of murine macrophage.Methods 8~12 week old BALB/c female mice were used.Peritonal macrophages were collected inRPMI 1640 culture.Peritonal macrophages were divided into groups according to the reagents(Paclitaxel and/or IFN γ).Peritonal macrophages without reagents were served as control group.TNF α was measured by TNF α specific enzymelinked immunosorbent assay(ELISA).Results Paclitaxel with certain concentration could induce macrophages...

Objective To study the effect of Paclitaxel on TNF α production of murine macrophage.Methods 8~12 week old BALB/c female mice were used.Peritonal macrophages were collected inRPMI 1640 culture.Peritonal macrophages were divided into groups according to the reagents(Paclitaxel and/or IFN γ).Peritonal macrophages without reagents were served as control group.TNF α was measured by TNF α specific enzymelinked immunosorbent assay(ELISA).Results Paclitaxel with certain concentration could induce macrophages to produc TNF α and the effect became strong with concentration increasing.Paclitaxel showed stronger effect on macrophages in combination with IFN-γ.Conclusions The antitumorigenic function of paclitaxel was related to activating murine peritoneal macrophages to promote the production of the cytotoxic molecules.

目的 研究紫杉醇对小鼠巨噬细胞产生TNF α的影响。方法 按常规方法收集纯化 8~ 12周龄BALB/C雌性小鼠腹腔巨噬细胞 ,用RPMI16 4 0培养基培养 ,按所用药物紫杉醇不同浓度和 (或 )干扰素γ进行分组并设对照组。TNF α测定用ELISA试剂盒。结果 一定浓度的紫杉醇能够诱导巨噬细胞产生TNF α ,且随浓度的增加而增加 ;紫杉醇联合干扰素γ时 ,诱导作用明显增加。结论 紫杉醇的抗肿瘤作用与活化巨噬细胞 ,促进巨噬细胞产生细胞毒分子有关 ,若与干扰素γ联合更能发挥其免疫化学治疗作用

Objective The features of clinical pathology, immunology and Epstein Barr virus (EBV) infection in 5 cases of γδT cell lymphoma were evaluated. Methods The complete clinical data were collected with histology observed . With immunohistochemical stainings on fresh biopsied materials, immunophenotype and expression of cytotoxic molecules were investigated in 5 cases of γδT cell lymphoma. EBV infection was observed with EBER 1 in situ hybridization. Results All 5 cases were male with a mean age of 47.4...

Objective The features of clinical pathology, immunology and Epstein Barr virus (EBV) infection in 5 cases of γδT cell lymphoma were evaluated. Methods The complete clinical data were collected with histology observed . With immunohistochemical stainings on fresh biopsied materials, immunophenotype and expression of cytotoxic molecules were investigated in 5 cases of γδT cell lymphoma. EBV infection was observed with EBER 1 in situ hybridization. Results All 5 cases were male with a mean age of 47.4 years. Involvement of liver, spleen and bone marrow was confirmed in 3 cases at the time of diagnosis. One case presented an intestinal tumor and another presented gingival lesion. All 5 patients died within 5 months after diagnosis, even through intensive chemotherapy. All 5 cases showed an immunophenotype of γδT cell (CD2+, CD3+, TCRδ1+, TCRβF1-). 4 out of 5 cases showed positive CD56 reaction, a natural killer associated antigen. All cases showed expression of several cytotoxic molecules. EBV was found positive in 4 of 5 cases. Conclusion The features of clinical pathology, immunophenotype, expression of cytotoxic molecules and EBV infection were similar in hepatosplenic and non hepatosplenic γδT cell lymphomas.

目的 总结 5例γδT细胞淋巴瘤的临床病理、免疫学及EB病毒相关性的特征。方法 在收集临床资料和观察组织学变化的基础上 ,采用新鲜组织免疫组化染色 ,分析免疫表型和细胞毒分子表达 ;采用EBER 1原位杂交法检查肿瘤细胞EB病毒感染情况。结果  5例均为男性 ,平均年龄 4 7.4岁。 3例首发部位为肝、脾及骨髓 ,1例表现为肠道肿瘤 ,1例表现为牙龈病变。 5例均在 5个月内死于肿瘤。所有病例均为γδT细胞表型(CD2 +,CD3+,TCRδ1+,TCRβF1- )。 5例中有 4例自然杀伤细胞相关抗原CD5 6阳性。所有病例均有多种细胞毒分子表达。 5例中 4例肿瘤细胞EB病毒阳性。结论 本组病理组织学资料中 ,3例符合肝脾γδT细胞淋巴瘤 ,2例符合非肝脾γδT细胞淋巴瘤 ,两者在临床表现、免疫表型、细胞毒分子表达和EB病毒感染等方面相似。

 
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