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   支气管诱导痰液 在 儿科学 分类中 的翻译结果: 查询用时:0.074秒
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支气管诱导痰液
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  “支气管诱导痰液”译为未确定词的双语例句
    Objective To investigate the changes of inflammatory cells in bronchial induced sputum in children with bronchial asthma.
    目的研究支气管哮喘患儿急性发作期及其缓解期支气管诱导痰液中炎细胞变化及临床意义。
短句来源
    Results The percentage of neutrophils in bronchial induced sputum was significantly higher in the acute episode group in asthmatic children than that in remission period group(P<0.01)and in normal control(P<0.01);
    结果哮喘患儿急性发作期支气管诱导痰液中,中性粒细胞占细胞总数的百分比明显高于缓解期及正常对照组(均P<0.01)。
短句来源
    The changes of substance P in induced sputum in asthmastic children
    哮喘患儿支气管诱导痰液中P物质含量变化的临床研究
短句来源
    The changes of inflammatory cells in bronchial induced sputum in asthmastic children
    哮喘患儿支气管诱导痰液中炎细胞变化的临床研究
短句来源
    Effect of inhaled corticosteroid (Budesonide)on substance P in plasma and induced sputum in children with bronchial asthma and its mechanism
    吸入糖皮质激素对哮喘患儿血浆及支气管诱导痰液中P物质含量的影响及其机制研究
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  induce sputum
Hypertonic saline will cause airway irritation that will induce sputum production and coughing.
      
The mean time required to induce sputum was 18 minutes, 75% of the patients produced sputum after 10 to 20 minutes and 21% required 30 minutes.
      
  induce sputum
Hypertonic saline will cause airway irritation that will induce sputum production and coughing.
      
The mean time required to induce sputum was 18 minutes, 75% of the patients produced sputum after 10 to 20 minutes and 21% required 30 minutes.
      


Objective To investigate the changes and clinical significance of substance P (SP) concentration in induced sputum in children with bronchial asthma.Methods Collected sputum in children with bronchial asthma and normal volunteers by way of hypertonic saline inhalation challenge.34 patients were in the acute episode and 30 in remission;22 volunteers were detected as normal control.SP concentration in induced sputum was measured by radioimmunoassy.Results The SP concentration in induced sputum was significantly...

Objective To investigate the changes and clinical significance of substance P (SP) concentration in induced sputum in children with bronchial asthma.Methods Collected sputum in children with bronchial asthma and normal volunteers by way of hypertonic saline inhalation challenge.34 patients were in the acute episode and 30 in remission;22 volunteers were detected as normal control.SP concentration in induced sputum was measured by radioimmunoassy.Results The SP concentration in induced sputum was significantly higher in the acute episode group in asthmatic children than that in remission period group (P<0.01) and in normal control (P<0.01);there was no significantly difference between in remission period and in normal control (P>0.05).Conclusion The SP concentration in induced sputum was significantly higher at the stage of acute episode in asthmatic children than both in the remission period and in normal volunteers.The results suggested that SP concentration in induced sputum has close relationship with asthma in children..

目的 研究支气管哮喘患儿急性发作期、缓解期支气管诱导痰液中P物质含量变化及临床意义。方法 用高渗盐水超声雾化吸入法留取研究组及对照组儿童支气管诱导痰液。其中哮喘急性发作期组 34例 (3d内无静脉或口服激素史 ) ;哮喘缓解期组 30例 ;健康对照组 2 2例。用放射免疫方法检测各组支气管诱导痰中P物质含量。结果 哮喘患儿急性发作期支气管诱导痰中P物质含量明显高于缓解期及正常对照组 ,差异显著 ,P均 <0 0 1。缓解期组与正常对照组比较 ,差异无显著性 ,P >0 0 5。结论 哮喘患儿急性发作期支气管诱导痰中P物质含量显著增高 ,缓解期降低 ,接近正常水平 ;提示支气管诱导痰中P物质含量与儿童哮喘的发作及缓解关系密切 ,可做为一种临床监测指标。

Objectives To investigate the effect of inhaled corticosteroid (Budesonide)on substance P(SP)in plasma and induced sputum in children with bronchial asthma and to explore its mechanisms. Methods (1)Clinical research:Fifty asthmatic children were enrolled in this study. All subjects suffered from mild to moderate asthma and had no history of corticosteroid administration 3 days prior to admission. Patients were randomly divided into group A (inhaling Budesonide)and group B (no inhalation).Twe-nty health children...

Objectives To investigate the effect of inhaled corticosteroid (Budesonide)on substance P(SP)in plasma and induced sputum in children with bronchial asthma and to explore its mechanisms. Methods (1)Clinical research:Fifty asthmatic children were enrolled in this study. All subjects suffered from mild to moderate asthma and had no history of corticosteroid administration 3 days prior to admission. Patients were randomly divided into group A (inhaling Budesonide)and group B (no inhalation).Twe-nty health children at the same age were as control. The contents of SP in plasma and induced sputum were detected by radioimmunoassay for each group before and 48 hours after treatment. (2)Animal studies:Thirty guinea pigs were sensitized and challenged with exposure to aerosolized ovalbumin for establishing animal asthma model. These animals were randomly divided into inhaled Budesonide group and no inhalation group. Normal control group (n=15)were treated with NS inhalation instead of ovalbumin and Budesonide. The contents of SP in the plasma,bronchoalveolar lavage fluid (BALF)and lung tissues were detected by radioimmunoassay,and the expression of SPmRNA in lung tissues was examined by RT- PCR. Results (1)The contents of SP in the plasma and induced sputum in children with bronchial asthma in group A were significantly lower 48 hours after treatment than those in before (P<0.01),but no significant difference in group B (P>0.05). (2)The contents of SP in the plasma and induced sputum in group A were significantly lower than those in group B 48 hours after treatment (P<0.01). (3)The contents of SP in the plasma,BALF,lung tissue and SPmRNA expression of asthma group were significantly higher than normal control group (P<0.01). (4)The contents of SP in the plasma,BALF,lung tissue and SP mRNA expression of inhaled Budesonide group were significantly lower than those of no inhalation group (P<0.01). Conclusions Inhaled corticosteroid (Budesonide)can significantly decrease the contents of SP in plasma and induced sputum in children with bronchial asthma and can significantly decrease the contents of SP in plasma,BALF and lung tissues of guinea pigs with induced asthma. The mechanism of the effect may be related to the down-regulation of SPmRNA expression in lung tissues caused by corticosteroid (Budesonide).

目的研究吸入糖皮质激素(GC)对哮喘患儿血浆及支气管诱导痰液(BIS)中P物质(SP)含量变化的影响并对其机制进行探讨。方法选择临床确诊的轻、中度哮喘患儿50例,随机分成吸入GC(布地奈德雾化溶液)治疗组(组1)及非吸入GC治疗组(组2)各25例,健康对照组20例。用放射免疫(RI)方法,测定各组治疗前及治疗后48h血浆及BIS中SP含量变化。用吸入卵蛋白致敏法制作豚鼠哮喘模型30例,随机分成吸入GC组及非吸入GC组,用RI法检测各组血浆、支气管肺泡灌洗液(BALF)及肺组织中SP含量;用RT_PCR法检测肺组织中SPmRNA相对含量。结果入院后48h比较,组1血浆及BIS中SP含量较治疗前降低明显,差异有非常显著性(P<0.01),组2较治疗前降低,但差异无显著性(P>0.05);治疗后48h同期比较,组1血浆及BIS中SP含量较组2明显降低,差异有非常显著性(P<0.001);哮喘组豚鼠血浆、BALF、肺组织中SP含量及SPmRNA表达均明显高于正常组豚鼠,差异有显著性(P<0.01);吸入GC组哮喘豚鼠,其血浆、BALF、肺组织中SP含量及SPmRNA表达均明显低于非吸入GC组哮喘豚鼠,差异...

目的研究吸入糖皮质激素(GC)对哮喘患儿血浆及支气管诱导痰液(BIS)中P物质(SP)含量变化的影响并对其机制进行探讨。方法选择临床确诊的轻、中度哮喘患儿50例,随机分成吸入GC(布地奈德雾化溶液)治疗组(组1)及非吸入GC治疗组(组2)各25例,健康对照组20例。用放射免疫(RI)方法,测定各组治疗前及治疗后48h血浆及BIS中SP含量变化。用吸入卵蛋白致敏法制作豚鼠哮喘模型30例,随机分成吸入GC组及非吸入GC组,用RI法检测各组血浆、支气管肺泡灌洗液(BALF)及肺组织中SP含量;用RT_PCR法检测肺组织中SPmRNA相对含量。结果入院后48h比较,组1血浆及BIS中SP含量较治疗前降低明显,差异有非常显著性(P<0.01),组2较治疗前降低,但差异无显著性(P>0.05);治疗后48h同期比较,组1血浆及BIS中SP含量较组2明显降低,差异有非常显著性(P<0.001);哮喘组豚鼠血浆、BALF、肺组织中SP含量及SPmRNA表达均明显高于正常组豚鼠,差异有显著性(P<0.01);吸入GC组哮喘豚鼠,其血浆、BALF、肺组织中SP含量及SPmRNA表达均明显低于非吸入GC组哮喘豚鼠,差异有显著性(P<0.05或0.01)。结论吸入GC具有明显降低哮喘患儿血浆及支气管诱导痰液中SP含量的作用,并可显著降低哮喘豚鼠血浆、BALF及肺组织中SP含量,其机制可能与吸入GC具有在转录水平下调肺组织中SPmRNA表达有关。

Objective To investigate the changes of inflammatory cells in bronchial induced sputum in children with bronchial asthma.Methods In children with bronchial asthma and normal volunteers by way of hypertonic saline inhalation challenge,34 patients in the acute episode and 30 in remission.Twenty-two volunteers were detected as normal control.Compare the differential cell counts in bronchial induced sputum.Results The percentage of neutrophils in bronchial induced sputum was significantly higher in the acute episode...

Objective To investigate the changes of inflammatory cells in bronchial induced sputum in children with bronchial asthma.Methods In children with bronchial asthma and normal volunteers by way of hypertonic saline inhalation challenge,34 patients in the acute episode and 30 in remission.Twenty-two volunteers were detected as normal control.Compare the differential cell counts in bronchial induced sputum.Results The percentage of neutrophils in bronchial induced sputum was significantly higher in the acute episode group in asthmatic children than that in remission period group(P<0.01)and in normal control(P<0.01);The percentage of eosinophils in induced sputum was significantly higher in the acute episode group and in remission period group of asthmatic children than that in normal control(P<0.01).Conclusion Bronchial asthma is a chronic airway inflammatory illness.There are differential cell counts in bronchial induced sputum in the different stage of illness.

目的研究支气管哮喘患儿急性发作期及其缓解期支气管诱导痰液中炎细胞变化及临床意义。方法选择2002-02—2002-12在中国医大二院儿童哮喘门诊就诊的哮喘患儿,其中哮喘急性发作期34例;哮喘缓解期30例;健康对照组22例。比较哮喘不同病程之间以及不同病程与正常儿童之间支气管诱导痰液细胞成分的差异。结果哮喘患儿急性发作期支气管诱导痰液中,中性粒细胞占细胞总数的百分比明显高于缓解期及正常对照组(均P<0.01)。哮喘急性发作期、缓解期诱导痰液中嗜酸细胞占总数的百分比均明显高于正常对照组,差异显著(P<0.01)。结论支气管哮喘是一种慢性气道炎症性疾病,在不同发病时期气道内的炎细胞变化不同。

 
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