Results In the 40 patients with lung cancer,the TTF-1 gene expression rate in adenocarcinoma by using RT-PCR was 72.2%(13/18),the expression rate in small cell lung cancer was 83.3%(5/6),the big cell lung cancer was 50%(1/2),the expression rate in squamous cell carcinoma was 0%(0/14).
NSE expresssion was the highest in small cell lung cancer, (36.21±19.01) μg/L, CEA expresssion was the highest in adenocarcinoma, (50.09±25.36) μg/L, and CYFRA21-1 expresssion was the highest in squamous cell carcinoma, (17.72±12.05) μg/L.
Impact of siRNA targeting pirh2 on proliferation and cell cycle control of the lung adenocarcinoma cell line A549
Taken together, the inhibition of pirh2 expression in the lung adenocarcinoma cell line A549 resulted in reduced tumor cell growth via the inhibition of cell proliferation, the activation of apoptosis and the interruption of cell cycle transition.
Arachidonic Acid Metabolism in Growth Control of A549 Human Lung Adenocarcinoma Cells
The role of individual eicosanoids of the arachidonic acid (AA) cascade in the growth control of A549 human lung adenocarcinoma cells has been studied.
They exhibit similar phototoxicities on the cells of A549 human lung adenocarcinoma, which are 40- and 100-fold higher than those of chlorin p6 and the clinically used Photogem, respectively, and are not toxic in the absence of light irradiation.
Inhibition of expression of vascular endothelial growth factor and its receptors in pulmonary adenocarcinoma cell by TNP-470 in
The inhibition effects of O-(chloroacetyl-carbamoyl) fumagillol (TNP-470), an angiogenesis inhibitor, and gemcitabine, a chemotherapeutic agent, on expression of growth factors were investigated using human pulmonary adenocarcinoma cell line, A549.
Objective: To investigate the effect of selenium dioxide (SeO2) on human pulmonary adenocarcinoma GLC-82 cell lines to reveal its probable mechanism and the relationship between apoptosis and SeO2.
Some differentiating effects of selenium on the cultured human hepatoma cells and human pulmonary adenocarcinoma cells in vitro
Two human hepatoma cell lines, QGY-7703 and SMMC-7721, and two human pulmonary adenocarcinoma cell lines, LTEP-a-2 and SPC-A-1, were found to respond to 1 μg/mL Na2SeO3, 24 h, in-vitro treatment by decreasing its confluent saturation density.
The aim of this study was to investigate the role of pirh2 (p53-induced RING-H2) protein in the proliferation, apoptosis and cell cycle control of the lung cancer cell line A549.
Loss of heterozygosity of a segment at 3p21.3 is frequently observed in lung cancer and several other carcinomas.
Methylation Profile of Several Tumor Suppressor Genes in Non-Small-Cell Lung Cancer
Multiplex methylation-sensitive PCR was employed in studying the methylation of CpG islands in the RB1, p16/CDKN2A, p15/CDKN2B, p14/ARF, CDH1, HIC1, and N33 5' regions in non-small cell lung cancer (51 tumors).
Molecular Markers of Various Stages of Non-Small-Cell Lung Cancer