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肺腺癌
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  human lung adenocarcinoma
    DYNAMIC CHANGE OF ULTRASTRUCTURE OF HUMAN LUNG ADENOCARCINOMA CELL LINE (SPC-A-1) IN VITRO
    体外人肺腺癌细胞(SPC-A-1)超微结构的动态变化
短句来源
    A High-resolution Study of Chromosomes in a Human Lung Adenocarcinoma Cell Line (LTEP-a1)
    人体肺腺癌细胞系LTEP-a1的高分辨染色体研究
短句来源
    Chromosomal Analysis on a Human Lung Adenocarcinoma Cell Line GLC-82
    人体肺腺癌细胞系GLC-82的染色体分析
短句来源
    CYTOPATHIC ACTION OF SPIDER (Lycosa singoriensis) VENOM AND ITS FRACTIONS ON THE CULTURED HUMAN LUNG ADENOCARCINOMA CELL(SPC-A1 )
    穴居狼蛛毒的某些组分对培养的人肺腺癌细胞(SPC-A_1)的致伤作用
短句来源
    Construction cDNA Libraries of Human Lung Adenocarcinoma Cell Lines
    人肺腺癌细胞系cDNA文库的建立
短句来源
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  “肺腺癌”译为未确定词的双语例句
    Study of Chromosomes of a Transplantable Lung Adenocarcmoma
    小鼠可移植性肺腺癌染色体的研究
短句来源
    Comparative Studies of the Biological Properties of Low and High Metastatic Potential Sublines(C_6/C_7)
    小鼠肺腺癌高、低转移潜能亚系(C_6/C_7)生物学特性的比较
短句来源
    MUTATION ANALYSIS OF p16 GENE EXON 2 IN HUMAN LUNG ADENOCARCINOMAS
    肺腺癌中 p16 基因外显子2的突变分析
短句来源
    Change of Cell Cycle and Resistance of A_( 549) Cells to Cisplatin.
    肺腺癌A_(549)/DDP细胞周期变化及其多药耐药性
短句来源
    The Preliminary Study on the Isolation, Identification And Application of Fragment of Monoclonal Antibody Lc-
    抗人肺腺癌单克隆抗体LC-1的IgM片段的分离鉴定及其初步应用研究
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  human lung adenocarcinoma
Arachidonic Acid Metabolism in Growth Control of A549 Human Lung Adenocarcinoma Cells
      
The role of individual eicosanoids of the arachidonic acid (AA) cascade in the growth control of A549 human lung adenocarcinoma cells has been studied.
      
They exhibit similar phototoxicities on the cells of A549 human lung adenocarcinoma, which are 40- and 100-fold higher than those of chlorin p6 and the clinically used Photogem, respectively, and are not toxic in the absence of light irradiation.
      
Selective gene therapy for human lung adenocarcinoma by tumor-specific expression of herpes simplex virus thymidine kinase gene
      
Alteration of membrane lipid biophysical properties and resistance of human lung adenocarcinoma A549 cells to cisplatin
      
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Electron microscopy is of advan-tage for diagnosis and identification of the histogenetic classification of lung tumors.Using this techniques,an ultrastructural observation on the cha-racteristics and its dynamic changes during cultivation from 1~(st) to 5~(th) day of human lung adenocarcinoma cell line (SPC-A-1) was made. The cultivated cells of 3~(rd)-4~(th) day were more complicated in structure than that of 1~(st)-2~(nd) and 5~(th) day.They showed higher activity of secreting func-tion and more increased...

Electron microscopy is of advan-tage for diagnosis and identification of the histogenetic classification of lung tumors.Using this techniques,an ultrastructural observation on the cha-racteristics and its dynamic changes during cultivation from 1~(st) to 5~(th) day of human lung adenocarcinoma cell line (SPC-A-1) was made. The cultivated cells of 3~(rd)-4~(th) day were more complicated in structure than that of 1~(st)-2~(nd) and 5~(th) day.They showed higher activity of secreting func-tion and more increased in cytoplas-mic constituents.At this stage,the nuclei of cells appeared more hetero-morphic.The majority of nuclei were irregular in contour.Only a small ??amount of short rough endoplasmic reticulum dispersed in cytoplasm,some were extended with very few riboso-mes forming flat empty spaces.Mi-tochondria were swollen,showing dis-solution of cristae and vacuolation.The amount of mucous granules in-creased gradually with the increase of days of subculture.They often fused with each other and some were connected with the intracellular spa-ces.Some mucus accumulated peculiar-ly in the degenerated mitochondria.In peripheral region,many microvilli and short cytoplasmic processes existed,a number of pinocytotic vesicles,coated vesicles and many intracellular cannules could be seen,extending deeply into cytoplasm.All these indicated the en-hanced activity of cellular metabo-lism.However,the cells of 1~(st)-2~(nd) and 5~(th) day were seen simplified in structures.Mucous granules were very few at these stages. It should be pointed out,the in-creased production of mucous gra-nules closely related to cellular activity and their unusual accumulation in degenerated mitochondria and rough endoplasmic reticulum appeared in quite different pan from normal mucin-secreting cells. Besides,mucous granules and va-rious forms and sizes of lamellar bo-dies similar to that of Type II alveolar epithelial cells indicated that this cell line was probably originated from human bronchiolar epithelial cells with mucous metaplasia during carcino-genesis.

本文对体外培养的人肺腺癌细胞(SP-C-A-l)进行了传代周期1—5天的超微结构观察。从第49、61、68和84代细胞的观察结果表明,传代培养5天过程中,细胞的超微结构发生明显变化。主要表现在胞质内粘液颗粒的数量随着细胞进入对数生长期(3—4天)逐渐增多,并有粘液在异常的部位(变性的线粒体)积聚;与此同时,线粒体的数量相应增加,内部结构出现明显改变。当细胞生长活动处于相对稳定阶段(1—2天和5天),粘液颗粒和变性的线粒体明显减少。细胞的高尔基复合体不发达以及正常形态的粗面内质网少的情况,在传代5天内变化不大,提示该系腺癌细胞粘液颗粒的形成与正常的粘液腺细胞不尽相同。结合细胞内有肺泡Ⅱ型上皮细胞特有的板层体的存在,文中进一步讨论了SP-C-A-l细胞系可能来源于人的细支气管上皮细胞在细胞癌变过程中发生粘液化生,而使细胞具有合成和分泌粘液的功能。

Three hybridoma lines secreting McAbs against the lung cancer cell line (LTEP-78) have been established. One of them, BLTI-01, has been subcloned six times and cultured more than eight months in vitro.The experimental data showed that the BLTI-01 has no crossreaction with human lymphocyte surface Ags (within 140 samples) , human erythrocyte surface Ags (100 samples) , marrow cell surface Ags (10 samples) , CEA and AFP. Further experiments with 24 human normal and tumour cell lines indicated that the McAb from...

Three hybridoma lines secreting McAbs against the lung cancer cell line (LTEP-78) have been established. One of them, BLTI-01, has been subcloned six times and cultured more than eight months in vitro.The experimental data showed that the BLTI-01 has no crossreaction with human lymphocyte surface Ags (within 140 samples) , human erythrocyte surface Ags (100 samples) , marrow cell surface Ags (10 samples) , CEA and AFP. Further experiments with 24 human normal and tumour cell lines indicated that the McAb from BLTI-01 has strong positive reaction with three lung cell lines, one liver cancer, one osteoblastic sarcoma and one breast cancer lines, on the contrary, it hardly reacts with four normal tissue cell lines and the ther human caneer lines.We suggest that the corresponding Ag of McAb from BLTI-01 is a tumour associated Ag.

用人肺鳞癌细胞LTEP-78细胞系免疫Blab/c小鼠获得3株抗人肺癌细胞的单克隆抗体杂交瘤系。其中BLTI-01株经六次克隆化培养,体外传代8个月以上。BLTI-01与白细胞抗原及血型抗原基本上无交叉反应;与骨髓细胞无交叉反应;与癌胚抗原和胎甲球蛋白不相关;与肺鳞癌、肺腺癌细胞系及部分其它肿瘤细胞呈阳性反应。

The chromosome patterns of LA-795 lung adenocarcinoma cells were studied. The chromosome number of LA-795 cells is 52-162. The karyotypes of major stemlines are 82=47/83=48/84 = 22.82, YY,-X,-X,-5,-5,-14,+15,+marl,+mar2,+mar3+ar4, +2mar5=4/83, YY,-X,-X,-5-5,-14,+15, +marl,+mar2, +mar4y +4mar5,=10/84,YY,-X,X,-5,-5,-14,+15, +marl,+mar2, +mar3, +mar4, +4mar5.Y chromosome and other chromosomes of each stemline show C-bands. But there is no C-bands on chromosome of normal cells in the same strain of mice. The meaning...

The chromosome patterns of LA-795 lung adenocarcinoma cells were studied. The chromosome number of LA-795 cells is 52-162. The karyotypes of major stemlines are 82=47/83=48/84 = 22.82, YY,-X,-X,-5,-5,-14,+15,+marl,+mar2,+mar3+ar4, +2mar5=4/83, YY,-X,-X,-5-5,-14,+15, +marl,+mar2, +mar4y +4mar5,=10/84,YY,-X,X,-5,-5,-14,+15, +marl,+mar2, +mar3, +mar4, +4mar5.Y chromosome and other chromosomes of each stemline show C-bands. But there is no C-bands on chromosome of normal cells in the same strain of mice. The meaning of chromosome aberration of LA-795 cells was briefly discussed.

小鼠肺腺癌LA-795细胞有多个干系,主要干系染色体为82、83、84。现查明这3个干系的G带核型是一个近四倍体的雄性细胞,有相同的标记染色体6—8个。各干系所有染色体均具C带,Y染色体亦有C带,这和正常小鼠Y染色体不具C带不同。

 
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