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肺腺癌
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  lung adenocarcinoma
    Among them,oleic acid(24.89%),palmitic acid (24.82%)and linoleic acid(16.86%) were major components. It is reported that linoleic acid had growth inhibition effect against lung adenocarcinoma cells.
    其中油酸(Oleic acid,24.89%)、棕榈酸(Palmitic acid,24.82%)和亚油酸(Linoleic acid,16.86%)为主要成分,据文献报道亚油酸具有肺腺癌细胞生长抑制活性。
短句来源
    Inhibition on proliferation of human lung adenocarcinoma cell line A549 by alkaloids from tripterygium hypoglaucum hutch
    昆明山海棠总生物碱对肺腺癌A549细胞株增殖抑制作用的实验研究
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    The Effects of Rensenoside Rh2 on Lung Adenocarcinoma Cells
    人参单体Rh2对肺腺癌耐药细胞促凋亡作用的研究
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    Influence of Serum Containing Hechan Tablets on Proliferation and Apoptosis of Human Lung Adenocarcinoma Cell Line
    鹤蟾片含药血清对人肺腺癌细胞株增殖和凋亡的影响
短句来源
    Effect of Qingjin Desheng Tablets on Proliferation and Apoptosis of Human Lung Adenocarcinoma Cells
    清金得生片对人肺腺癌细胞(LAC)抑制与凋亡的诱导作用
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  “肺腺癌”译为未确定词的双语例句
    MATERIALS AND METHODS: In vitro, anti-tumor assay was performed with human pulmonary adenoma cells A549 and liver cancer cells Bel-7402, MTT method was employed, and half-inhibitory concentration (IC50) were recorded.
    材料与方法:体外蛇床子素对人肺腺癌细胞A549和人肝癌细胞Bel-7402的抗肿瘤实验采用MTT法,并计算IC50;
短句来源
    Studies on Effects of Qiongyu Extract on Cell Cycle and Apoptosis of GLC-82 Cell Strain
    琼玉膏对肺腺癌细胞珠GLC-82的细胞周期及凋亡的影响
短句来源
    The inhibitory rate of neoplasia growth on mice with tumor of lung adenocarc- inoma LA-795 was 38.3% (P<0.05) and 52.4% (P<0.01)on the first and tenth day after subcutaneous administration of BM530 in the dose of 0.2mg /mouse/day for ten days.
    对LA-795肺腺癌带瘤小鼠,每天皮下注射0.2mg/只,连用10天,在停药第1天和停药第10天时,肿瘤生长的抑制率为38.3%(P<0.05)和52.4%(P<0.01);
短句来源
    Objective:To observe the effects of Qiongyu Extract on the inhibition action of DDP in cells' division of GLC 82 cell strain culture.
    目的 :观察琼玉膏对顺氨氯铂在肺腺癌细胞珠GLC 82培养中的细胞增殖抑制的影响。
短句来源
    Methods:Using the methods of cell culture, FACS, and serum pharmacology to research the effects of Qiongyu Extract on cell's cycle and apoptosis of GLC 82 cell strain.
    方法 :用血清药理学 ,流式细胞等方法技术研究古方琼玉膏对肺腺癌细胞株GLC 82的细胞周期及凋亡的影响。
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  lung adenocarcinoma
Impact of siRNA targeting pirh2 on proliferation and cell cycle control of the lung adenocarcinoma cell line A549
      
Taken together, the inhibition of pirh2 expression in the lung adenocarcinoma cell line A549 resulted in reduced tumor cell growth via the inhibition of cell proliferation, the activation of apoptosis and the interruption of cell cycle transition.
      
Arachidonic Acid Metabolism in Growth Control of A549 Human Lung Adenocarcinoma Cells
      
The role of individual eicosanoids of the arachidonic acid (AA) cascade in the growth control of A549 human lung adenocarcinoma cells has been studied.
      
They exhibit similar phototoxicities on the cells of A549 human lung adenocarcinoma, which are 40- and 100-fold higher than those of chlorin p6 and the clinically used Photogem, respectively, and are not toxic in the absence of light irradiation.
      
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PSK (Krestin), an inimunomodulative agent, is now widely used in Japan as an effective drug when combined with anti-cancer chemotherapy radiotherapy and postoperative immuuochemotherapy. It is extracted from mycelia of Coriolus versicolor (Fr.) Quel.PSP (polysocoharibe-peptide) is similar to PSK and was recently discovered by Prof. Yang Qiug Yao. It has been found to possess a structure similar to PSK. In the present study the anti-cancer effect of PSP was compared with PSK using four human tumor cell line targets...

PSK (Krestin), an inimunomodulative agent, is now widely used in Japan as an effective drug when combined with anti-cancer chemotherapy radiotherapy and postoperative immuuochemotherapy. It is extracted from mycelia of Coriolus versicolor (Fr.) Quel.PSP (polysocoharibe-peptide) is similar to PSK and was recently discovered by Prof. Yang Qiug Yao. It has been found to possess a structure similar to PSK. In the present study the anti-cancer effect of PSP was compared with PSK using four human tumor cell line targets (SGG 7901, gastric cancer cell; SPO, lung cancer cell; SLY, human monocyto leukemia cell; and MEI, human skin histiocytic lymphoma cell) in vitro.PSP showed similar cytotoxic effects upon human tumor cells as PSK, both inhibiting cell growth, but to a lesser degree than alkylating agents.In comparison to controls specimens of the SPO cell line treated by PSP (1000 μg/ml)for 72 hrs at 37℃ showed marked morphological changes in the polynuclear cells, their nuclei became irregular in shape and there was chromatin aggregation.

本文应用四株人体肿瘤细胞株作为靶细胞,比较了云芝糖肽PSP与PSK在体外对它们的作用。结果表明PSP与PSK的抗癌生物活性基本相同,二者均对靶细胞增殖具有中等抑制作用。PSP在1000μg/ml的浓度时对人肺腺癌细胞株(SPC)仍能引起一系列的形态学异常变化,如细胞肿大,核染色质凝聚,锯齿状核和多核现象。

The carcinogenesis of the Urethan has been widely known, but so far, no report shows that Chinese herbs may inhibit it. We first observe the effects of the yi Qi and yang yin herbs on the mouse bearing bronchgenic adenocarcinoma induced by the Uretnan. We find that the mice which drink the Yi Qi and Yang yin herbs in a long time can partly check the carcinogecinity of the Urethan. We also find that immunity of the mice was increased and the rate of micronucleus of polychromatic erythrocytes in the mice bone...

The carcinogenesis of the Urethan has been widely known, but so far, no report shows that Chinese herbs may inhibit it. We first observe the effects of the yi Qi and yang yin herbs on the mouse bearing bronchgenic adenocarcinoma induced by the Uretnan. We find that the mice which drink the Yi Qi and Yang yin herbs in a long time can partly check the carcinogecinity of the Urethan. We also find that immunity of the mice was increased and the rate of micronucleus of polychromatic erythrocytes in the mice bone marrow was reduced .So we suppose that the Yi Qi and Yang Yin herbs may restrain the carcinogecinity of the Urethan through strengthening the immunity and resisting the chromosomal aberration caused by mutagens .This study indicates that some Chinese herbs which can strengthen the body's energe can be used in proventing as well as treating cancer.

本文采用一次性突击剂量的氨基甲酸乙酯诱发小鼠肺腺癌模型,通过观察益气、养阴中药对氨基甲酸乙酯诱发肺腺癌的影响,发现长期服用益气、养阴药的小鼠能部份地抑制氨基甲酸乙酯的致癌作用。同时还发现服药小鼠不仅细胞免疫功能增强,而且骨髓多染红细胞中的微核出现率下降。因此,服正中药有可能是通过提高机体免疫功能和增强机体抗诱变的能力等途径而发挥抑癌作用的。这一实验结果提示:扶正中药不仅能用于肿瘤的治疗,也可用于肿瘤的预防。

Two kinds glycoproteins from the root tubers of fresh Wanggua were isolated by fractional precipitation with acetone,one being acidic while the other basic.The acid glycoprotein showed a single band at pH 3.2 section of the isoelectric point focusing gel and the molecular weight showed was 6.7610~4 dalton by SDS-PAGE witha serics of reference standards.The basic glycoprotein showed P~I 9.3 and molecular weight 1.5810~4 determined at the same time.The acid glycoprotein showed 58% killing effect to the lung cancer...

Two kinds glycoproteins from the root tubers of fresh Wanggua were isolated by fractional precipitation with acetone,one being acidic while the other basic.The acid glycoprotein showed a single band at pH 3.2 section of the isoelectric point focusing gel and the molecular weight showed was 6.7610~4 dalton by SDS-PAGE witha serics of reference standards.The basic glycoprotein showed P~I 9.3 and molecular weight 1.5810~4 determined at the same time.The acid glycoprotein showed 58% killing effect to the lung cancer cells.The basic glyproteins showed significant effect on terminating early pregnancy in mice and 47.6% killing effect of lung cancer on 120μg/ml dosage. The crude original juice of Wanggua showed a striking contrast of 74.2% killing effect of lung cancer on 105μg/ml dosage.So the killing effect of lung cancer wants yet to be confirmed.The methods of isolation and purifi- cation of potysaccharide of Wanggua were developed.We removed the proteins from the glycoproteins with sevage reagent.dialyzed against distilled water, precipitated with alcohal and further purified by chromatography on a sephadex G-75 column.The pure polysaccharide is given the name Polysaccharide (WGPS).The chemical composition of isolated Wanggua glycoproteins were predominantly of protein 76.1% and polysaccharide 13.9%.After hydrolysis of the polysaccharide.it was found by thin-layer chromatography and paper chromatography that xylose and Galactose were compoments.

经电泳分析,王瓜根活性蛋白可分为两种:其一是酸性蛋白,具细胞毒作用,等电点测定 P~I 为3.2,PAGE 电泳测定分子量为6.76×10~4道尔顿;其二是碱性蛋白,等电点为9.3,PAGE 电泳测定分子量为1.58×10~4道尔顿;微具细胞毒作用。王瓜根活性蛋白属糖蛋白,经纸层析和薄层硅胶 H 层析证实含半乳糖和木糖。扫描电镜观察和光镜连续观察,显示酸性蛋白对肺腺癌细胞的体外培齐有杀伤作用,当培养液含120μg/ml 时杀伤率达58%,对正常肺细胞作用弱;碱性蛋白对肺腺癌细胞杀伤作用较差,在同样剂量时只有47.6%杀伤率。新鲜王瓜根原汁有很强的杀伤肺腺癌细胞作用,剂量在26g/ml 时,杀伤率达60%;当提高到105g/ml 时,杀伤率达74%。试验结果提示:王瓜根活性抗癌物质,除指三萜—葫芦素之外,可能还存在另一种活性物质。这种活性抗癌物质对肺腺癌细胞表面微绒毛无作用,经处理24小时后,癌细胞开始变形,表现为不同程度内陷,32小时癌细胞膜开始溶解,48小时癌细胞溶成团块。

 
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