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肺腺癌
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  lung adenocarcinoma
    Light Microscopic and Transmission Electron Microscopic Studies on Specific in Vivo Targeting of Human Lung Adenocarcinoma with Immunotoxin CMU15A—TCS
    免疫毒素CMU15A-TCS对裸鼠移植人肺腺癌靶向杀伤效果的光电镜观察
短句来源
    Results: CMU15—TCS conjugate had significant killing effect on human lung adenocarcinoma. Its effectiveness was related with different ways of adminstration.
    结果:CMU15A—TCS对肺腺癌有明显的靶向杀伤作用,受损靶瘤细胞的分布与用药途径有关,肿瘤内用药的杀伤效果优于腹腔用药;
短句来源
  “肺腺癌”译为未确定词的双语例句
    Effects the Cyclic Mechanical Strain on the Prolifferation of Human Lung Adenocarcinona Cells Line A549
    周期性机械拉伸人肺腺癌细胞株A549增殖的影响
短句来源
    Materials and Methods: The mice bearing pulmonary adenoma(LA795)models were treated with ~(188)Re-CL58. All treatements were initiated atthe 5th day after implanation.
    材料与方法:建立LA795小鼠肺腺癌实验动物微转移模型。
短句来源
    In this model, tUmor cells had very high telomerase activity Butthe activity was significantly brought down by RJT and MLD mT wasmore efficient than SHDmT in doing so.
    (4)该模型所接种的小鼠肺腺癌细胞具有较高的端粒酶活性,与对照组比较两种放射免疫治疗均引起端粒酶活性下降,且多次小剂量组比单次大剂量组更能明显降低肿瘤细胞的端粒酶活性。
短句来源
    Objective:We were to investigate the relationship between morphological changes in targeting of solid tumor with immunotoxin and underlying anti cancer mechanism.
    目的:探讨免疫毒素对裸鼠移植人肺腺癌的抗癌机理与形态变化的关系。
短句来源
  相似匹配句对
    Preliminary Study of MR Imaging of Lung Squamous Carcinoma and Adenocarcinoma
    鳞、腺癌磁共振成像的初步研究
短句来源
    Purpose: To evaluate the MR findings of lung squamous-cel carcinoma and adenocarcinoma.
    目的:探讨鳞、腺癌的 MRI信号及形态学表现。
短句来源
    Imaging diagnosis of pulmonary embolism
    栓塞的影像学诊断
短句来源
    An Investigation and Design of Apparatus for Measuring Fetal Lung Maturity
    胎儿成熟度测定仪的研制
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    CT Diagnosis of the Prostatic Carcinoma
    前列腺癌的诊断及CT表现
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  lung adenocarcinoma
Impact of siRNA targeting pirh2 on proliferation and cell cycle control of the lung adenocarcinoma cell line A549
      
Taken together, the inhibition of pirh2 expression in the lung adenocarcinoma cell line A549 resulted in reduced tumor cell growth via the inhibition of cell proliferation, the activation of apoptosis and the interruption of cell cycle transition.
      
Arachidonic Acid Metabolism in Growth Control of A549 Human Lung Adenocarcinoma Cells
      
The role of individual eicosanoids of the arachidonic acid (AA) cascade in the growth control of A549 human lung adenocarcinoma cells has been studied.
      
They exhibit similar phototoxicities on the cells of A549 human lung adenocarcinoma, which are 40- and 100-fold higher than those of chlorin p6 and the clinically used Photogem, respectively, and are not toxic in the absence of light irradiation.
      
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Objective:We were to investigate the relationship between morphological changes in targeting of solid tumor with immunotoxin and underlying anti cancer mechanism. Methods:Tumor samples from post treated nude mice were prapared for both light microcopy and transmission electron microcopy. Results: CMU15—TCS conjugate had significant killing effect on human lung adenocarcinoma. Its effectiveness was related with different ways of adminstration. Direct intra tumor injection had a wider range of action than peritoneal...

Objective:We were to investigate the relationship between morphological changes in targeting of solid tumor with immunotoxin and underlying anti cancer mechanism. Methods:Tumor samples from post treated nude mice were prapared for both light microcopy and transmission electron microcopy. Results: CMU15—TCS conjugate had significant killing effect on human lung adenocarcinoma. Its effectiveness was related with different ways of adminstration. Direct intra tumor injection had a wider range of action than peritoneal injection. Under transmission electron microcope, the earlist and most typical change was the degeneration of mitochondriae. Conclusions: Decreased free ribsome, rough endoplasmic reticulum with unusually enlarged cisternae, and dropping of surface ribosome were present, all of which were consistent with generally recognized mechanism of TCS action.

目的:探讨免疫毒素对裸鼠移植人肺腺癌的抗癌机理与形态变化的关系。方法:对CMU15A—TCS治疗后的肺腺癌标本进行了光电镜观察。结果:CMU15A—TCS对肺腺癌有明显的靶向杀伤作用,受损靶瘤细胞的分布与用药途径有关,肿瘤内用药的杀伤效果优于腹腔用药;免疫毒素作用于细胞内核糖体,但在超微形态结构上很难确认出核糖体的病理改变,而以线粒体的病理变化出现的最早、最明显。结论:受损细胞内游离核糖体减少,粗面内质网数量明显减少且扩张,表面核糖体脱失等现象与天花粉蛋白的作用机理一致。

Purpose: To evaluate the MR findings of lung squamous-cel carcinoma and adenocarcinoma. Materials and Methods: Sixteen cases of lung cancer proved pathologically were reported. Of 16 cases, 9 were squamous-cell carcinoma and 7 were adenocarcinoma. Their MRI and the morphologic appearances were compared between the two groups. Results: In 9 cases of lung squamous-cell carcinoma, the MRI signal appeared as inhomgeneous slightly hyperintense on T2 weighted images in 5/9, which were proved pathologically as main...

Purpose: To evaluate the MR findings of lung squamous-cel carcinoma and adenocarcinoma. Materials and Methods: Sixteen cases of lung cancer proved pathologically were reported. Of 16 cases, 9 were squamous-cell carcinoma and 7 were adenocarcinoma. Their MRI and the morphologic appearances were compared between the two groups. Results: In 9 cases of lung squamous-cell carcinoma, the MRI signal appeared as inhomgeneous slightly hyperintense on T2 weighted images in 5/9, which were proved pathologically as main necrosis; in 7 cases of adenocarcinoma, the MRI signal appeared as inhomgeneous slightly hyperintense on T2 weighted images in 5/7, which were proved pathologically as main fibrous septum. There were statistical difference of signal intensity on T2 weinghted images between the two groups(P<0.05) The signs of lobulation and obstructine changes in lung squamous-cell carcinoma (diameter over 5cm) were seen more than in adenocarcinoma. Conclusion: Recognition of the MRI features of lung squamous-cell carcinoma and adenocarcinoma is help full in differential diagnosis of these tumors.

目的:探讨肺鳞、腺癌的 MRI信号及形态学表现。材料和方法:经病理证实的肺鳞、腺癌 16例, MRI可见肿块14例,其中鳞癌8例,腺癌6例,比较二者之间的MRI信号及形态学改变。结果:肺鳞癌MRI T2WI多为坏死为主的不均匀稍高信号(4/8),肺腺癌MRI T2WI多为纤维分隔为主的不均匀稍高信号(4/6),二者之间信号改变有统计学差异。T1W1二者之间无差异。肺鳞癌肿块>5cm,分叶征及阻塞性改变比肺腺癌发生率高。结论:肺鳞、腺癌的 MRI信号及形态学改变有一定鉴别价值。

Objective To elucidate the applicability 99m Tc-HL91,a hypoxic tracer to the imaging of hypoxia in tumors by animal experiment.Methods HL91 was labeled with 99m Tc by one step,and its chemical purity was >95%.15 mice with lung adenocarcinoma were used. 99m Tc-HL91(18 5MBq per mouse) was injected i p and animals were killed from 1h to 24h after injection.Blood,tumor,muscle,brain,heart,liver,spleen,kindey and bone samples were weighted and counted.The ID%/g and the ratio of tumor to nontumor...

Objective To elucidate the applicability 99m Tc-HL91,a hypoxic tracer to the imaging of hypoxia in tumors by animal experiment.Methods HL91 was labeled with 99m Tc by one step,and its chemical purity was >95%.15 mice with lung adenocarcinoma were used. 99m Tc-HL91(18 5MBq per mouse) was injected i p and animals were killed from 1h to 24h after injection.Blood,tumor,muscle,brain,heart,liver,spleen,kindey and bone samples were weighted and counted.The ID%/g and the ratio of tumor to nontumor (T/NT) were used to express the isotope retention.Besides,another mouse was used to take stationary imaging from 1h to 24h after intraperitonal injection with 99m Tc-HL91.Results The uptake and retention of HL91 in tumor was earlier and higher.The ratio of T/NT continued to increase until 24h.The tumor imaging was good and clear.Conclusions 99m Tc-HL91 is a convenient imaging tracer.Its labeling method is easy and labeling ratio is high.The uptake and retention of HL91 in tumor are higher.It is a good tracer in tumor hypoxia imaging.

目的 用99mTc -HL91乏氧显像剂对肺腺癌小鼠模型进行体内分布和显像实验 ,以探索其对肿瘤显像的适用性 .方法 99mTc -HL91一步法标记 ,放化纯 >95 % .对 15只肺腺癌动物模型腹腔注射99mTc -HL9118 5MBq ,于 1~ 2 4小时处死取血液、肿瘤、脑、肺、心、肝、脾、肾、骨等标本称重 ,测定放射性计数 ,计算ID % /g及肿瘤组织与非肿瘤组织放射性比值 (T/NT) .同时在腹腔注射99mTc-HL91后于不同时间对模型进行静态显像 .结果 肿瘤组织对99mTc-HL91有较早较高的摄取和滞留 ,T/NT比值随时间延长而有增高趋势 .显像示肿瘤组织有较好的放射性浓聚 ,图像清晰 ,对比度良好 .结论 99mTc-HL91标记简单 ,标记率高 ,使用方便 ,在肿瘤组织中有较好的摄取与滞留 ,是一种良好的肿瘤乏氧显像剂 ,但需要进一步研究其机理和改进方法 ,提高T/NT比值 ,以开展临床试验

 
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