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细胞信号分子
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  cell signal molecule
     The mechanisms through which surgical stress induces the immunosuppression are closely related to hypothalamus-pituitary-adrenocortical axis,sympathetic nervous system,cytokines,opioids and T cell signal molecule.
     目前认为,手术引起免疫抑制的机制主要与下丘脑-垂体-肾上腺皮质轴、交感神经系统、细胞因子、阿片肽和T细胞信号分子有关。
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  “细胞信号分子”译为未确定词的双语例句
     The activation of signal molecules in Daudi cell stimulated by anti IgM antibody was measured by Western blot.
     Westernblot检测anti IgM刺激引起Daudi细胞信号分子的变化。
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     [Conclusion]The mechanism of adaptive response induced by low concentrtration of ECPs maybe include protein of main-taining homeostasis,antioxidation system,DNA damage-repair system,signaling molecules and so on.
     [结论]低剂量环境化学污染物诱导机体的适应性反应可能有维持细胞稳态、抗氧化系统、DNA损伤修复级激活细胞信号分子等过程的参与。
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     Ten plots of protein were only observed in taxol-induced cells and there were differences at expression level of some plots between control and taxol-induced cells using two dimension electrophoresis, which reflect those differential protein were highly relevant to signal moleculars of cell defense responses, suggesting cellapoptosis and taxol biosynthesis might be parallel or two events in the same pathway of defense responses.
     采用二维凝胶电泳技术,分析了taxol诱导细胞产生早期防御响应的蛋白表达差异,发现taxol诱导了10个新蛋白点的表达,其中一些新蛋白点的分子量与细胞信号分子G-蛋白、Ca2+依赖蛋白激酶的分子量接近。
短句来源
     Although several factors (signaling molecules, gustatory nerve fibers, etc. ) have many affinities with the development of the papillae and taste buds, the specific mechanism that regulate initiation, growth, and maintenance of the papillae and taste buds are still not clear yet.
     味乳头和味蕾的发育过程与细胞信号分子(signaling molecules)、味觉神经(gustatory nerve fibers)等许多因素有着密切的关系,其中有些作用机理至今尚无定论.
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     From above results,it was concluded that the PAP developed immunity through cells proliferation and signal molecules and free radicals such as Ca~(2+),NO,O_2~-·,However, the relationship between them need to be discussed future.
     综上所述,委陵菜多糖通过促进免疫细胞增殖和影响细胞信号分子,从细胞增殖和细胞信号转导两个途径发挥其免疫调节作用,而且通过抗O_2~-·产生实现对机体细胞功能的调控,但两者之间的关系有待进一步探讨。
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     Apoplast Signal Molecules that Affect the Growth of the Plant′s Cells
     影响植物细胞生长发育的质外体信号分子
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     Cellular signal transduction and cancer
     细胞信号传导和肿瘤
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     So SPK is a key signal molecule in regulation of cell migration.
     因此,SPK是细胞迁移活动中的重要信号分子
短句来源
     Signal Regulation of B Cell Homeostasis
     B细胞稳态的信号调节
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     Effect of curcumin on STAT5 signaling molecule in K562 cells
     姜黄素对K562细胞STAT5信号分子的影响
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  cell signaling molecule
The properties of nitric oxide as an endogenous cell signaling molecule in vascular biology are described.
      
For example, a cell signaling molecule added by the user as input into the system falls in the environment interface.
      
Furthermore TCRV region selectivity in T cell signaling molecule loss was often maintained during disease progression.
      


Objective To investigate the mechanism of apoptosis of human B lymphoma Daudi cell line mediated by B cell antigen receptor (BCR). Methods Cell growth was examined by 3H TdR incorporation, cell cycle and apoptosis were analysed by fluorescence activated cell sorter(FACS). The activation of signal molecules in Daudi cell stimulated by anti IgM antibody was measured by Western blot. Results anti IgM antibody induced human B lymphoma Daudi cell towards apoptosis. The number of apoptotic cells was correlated...

Objective To investigate the mechanism of apoptosis of human B lymphoma Daudi cell line mediated by B cell antigen receptor (BCR). Methods Cell growth was examined by 3H TdR incorporation, cell cycle and apoptosis were analysed by fluorescence activated cell sorter(FACS). The activation of signal molecules in Daudi cell stimulated by anti IgM antibody was measured by Western blot. Results anti IgM antibody induced human B lymphoma Daudi cell towards apoptosis. The number of apoptotic cells was correlated with the concentration of anti IgM antibody. The result of Western blot indicated that the phosphorylation level of the tyrosine protein in Daudi cell was related to the concentration of the anti IgM stimulation. After stimulating 48 to 72 hours, much tyrosine proteins and phosphorylation return to low phosphorylation level or dephosphorylation. Even though the level of JNK1 and ERK2 protein changed little, but the level of phosphorylation at its 63/73 serine and total protein of c Jun,one of downstream molecules from JNK, increased immediately and kept for long time. Conclusion anti IgM antibody can induce apoptosis of Daudi cell, and activation of JNK/SAPK can also be stimulated by anti IgM antibody in Daudi cell. The JNK/SAPK pathway may be involved in the apoptosis of Daudi was induced by anti IgM antibody.

目的 研究B细胞抗原受体 (BCR)介导的细胞凋亡 ,探索其可能的信号传导通路 ,阐明B细胞凋亡的分子机制。方法 3H掺入法检测细胞生长 ,应用FACS方法分析细胞周期和细胞凋亡。Westernblot检测anti IgM刺激引起Daudi细胞信号分子的变化。结果 anti IgM可导致人B淋巴瘤Daudi细胞发生凋亡。细胞凋亡的数量与anti IgM浓度呈正相关。Westernblot结果显示 ,anti IgM刺激引起Daudi细胞内酪氨酸蛋白分子磷酸化水平的变化速度与浓度相关 ;但随时间的延长 ,变化状况趋于稳定 ;在 48~ 72h ,许多被激活的、呈现磷酸化的酪氨酸蛋白分子又回复到低磷酸化或去磷酸化的静止状态。另外 ,虽然JNK1和ERK2蛋白水平未发生明显改变 ,但JNK/SAPK的重要下游分子之一 ,c Jun的蛋白表达水平及其 6 3和 73位点的丝氨酸磷酸化水平立即升高并维持在高水平状态。结论 anti IgM刺激激活JNK/SAPK ,JNK/SAPK通路可能参与了anti IgM引起的Daudi细胞的凋亡过程

At the cellular level, JAK2 plays a important role in signal transdution mediated by growth hormone. Growth hormone(GH) is known to bind to the membrane-bound receptor of the growth hormone and activate a cytoplasmic tyrosine kinase called Janus kinase2 (JAK2). The activated JAK2 in turn phosphorylates tyrosines within itself and the associated GH receptor, forming high-affinity binding sites for a variety of signaling molecules such as signal transducers and activators of transcription(STATs), and the adapter...

At the cellular level, JAK2 plays a important role in signal transdution mediated by growth hormone. Growth hormone(GH) is known to bind to the membrane-bound receptor of the growth hormone and activate a cytoplasmic tyrosine kinase called Janus kinase2 (JAK2). The activated JAK2 in turn phosphorylates tyrosines within itself and the associated GH receptor, forming high-affinity binding sites for a variety of signaling molecules such as signal transducers and activators of transcription(STATs), and the adapter protein Shc.JAK2 is also known to phosphorylate the insulin receptor substrates, leading to activation of phosphatidy-1-inositol-3-kinase and likely other molecules that have been implicated in the regulation of metabolism. Finally,JAK2 is known to activate the adapter protein SH2-B. Presumably these proteins and pathways initiated by GH result in its ability to regulate body growth and metabolism.

在细胞水平上,JAK2在生长激素介导的信号传导中具重要作用。生长激素与生长激素膜蛋白受体结合,激活胞质酪氨酸激酶JAK2后,JAK2自身磷酸化,同时磷酸化生长激素膜蛋白受体,从而形成信号传导因子与转录激活因子、适配蛋白Shc等细胞信号分子高亲和位点。生长激素刺激下的JAK2也会磷酸化胰岛素受体底物,从而激活磷酯酰肌糖3激酶以及其它相关的调节新陈代谢的生物分子活性。而且JAK2还能激活适配蛋白SH2_B。这些因子和激活途径可能是生长激素作用于机体并调节机体生长代谢的基础。

Taste buds on the mammalian tongue are confined to the epithelium of three types of gustatory papillae: the fungiform(FF), circumvallate(CV), and foliate(FL) . Because taste bud cells are periodically renewed, the morphogenesis, number and function of taste buds are changing with the age. Gustatory papillae are unique in the tongue in their ability to support the formation and to maintain taste buds. Evidence showed that the taste papillae play a major role in determining the number, location and size of taste...

Taste buds on the mammalian tongue are confined to the epithelium of three types of gustatory papillae: the fungiform(FF), circumvallate(CV), and foliate(FL) . Because taste bud cells are periodically renewed, the morphogenesis, number and function of taste buds are changing with the age. Gustatory papillae are unique in the tongue in their ability to support the formation and to maintain taste buds. Evidence showed that the taste papillae play a major role in determining the number, location and size of taste buds, as well as their maintenance. Although several factors (signaling molecules, gustatory nerve fibers, etc. ) have many affinities with the development of the papillae and taste buds, the specific mechanism that regulate initiation, growth, and maintenance of the papillae and taste buds are still not clear yet.

根据近年来有关大鼠、小鼠味觉发育方面的大量研究,对哺乳动物味蕾(taste buds)发育的情况进行了综述和讨论.哺乳动物舌面上的味蕾分布在菌状乳头(fungiform papillae,FF)、叶状乳头(foliate papillae,FL)、轮廓状乳头(circumvallate papillae,CV)之中,味蕾细胞(taste bud cells)不断地进行着周期性的更新,味蕾的形态、数量和功能随动物随年龄而变化.有关味孔头的研究表明,味乳头(gustatory papillae)在味蕾形成和维持味蕾存在及正常发育方面有着独特的功能.味乳头和味蕾的发育过程与细胞信号分子(signaling molecules)、味觉神经(gustatory nerve fibers)等许多因素有着密切的关系,其中有些作用机理至今尚无定论.

 
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