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肾间质容量
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  renal interstitial volume
     Significance of renal interstitial volume and urinary human epidermal growth factor determination in IgA nephropathy
     IgA肾病患者肾间质容量和尿表皮生长因子测定的意义
短句来源
     The Significance of Urinary hEGF Determination and Renal Interstitial Volume in IgA Nephropathy
     尿EGF测定及肾间质容量在IgA肾病中的意义
短句来源
  “肾间质容量”译为未确定词的双语例句
     There was significantly difference among the three groups, p<0.01. 10 hEGF urinary concentration correlated with Ccr, r=0.56, P<0.01. Model equation was EGF= 7.1218+0.5099Ccr, P<0.01. With the increase of Ccr, hEGF urinary concentration increased gradually.
     ⑤与血压:肾间质容量与收缩压相关系数r=0.53,P<0.01; 回归方程IV=-8.2344+0.3031SBp,P<0.01。
短句来源
     There was negative correlation between hEGF urinary concentration and Scr, r=-0.45, P<0.01. With Scr increasing, hEGF urinary concentration decreased gradually.
     肾间质容量与舒张压相关系数r=0.68,P<0.01; 回归方程IV=-22.5947+0.6486DBp,P<0.01。
短句来源
     11 IV correlated with proteinuria , r=0.62,P﹤0.01. Model equation was Upro=-0.0404+0.0948IV,P﹤0.01. With increase of severity of tubulointerstitial lesion, the level of proteinuria increased gradually.
     12尿表皮生长因子浓度与肾间质容量及年龄的关系:尿表皮生长因子与肾间质容量之间相关分析,r=-0.79,P<0.01; 回归方程EGF=113.170-1.9094IV,P<0.01。
短句来源
     IV correlated with Ccr, r=-0.73, P<0.01. Model equation was IV=55.9350-0.2167Ccr, P<0.01. With increase of severity of tubulointerstitial lesion, Ccr decreased gradually.
     把年龄引入回归方程,得三者之间的回归方程EGF=126.512-0.4947AGE -1.8757IV, P<0.01。 计算标准化偏回归系数bAGE= -0.14,bIV=-0.77,可知肾间质容量对尿表皮生长因子浓度的影响较年龄因素显著。
短句来源
     Interstitial volume(IV) in control group was((18.6)±(1.8)) %,in mild lesion group((23.0)±(2.9)) %,in moderate lesion group((36.2)±(6.7)) %,and in severe lesion group((55.0)±(6.5)) %.
     肾间质容量:对照组为(18.6±1.8)%,轻度病变组为(23.0±2.9)%,中度病变组为(36.2±6.7)%,重度病变组为(55.0±6.5)%。
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     Hyperemia was found in the kidney mesenchyme.
     间质血管充血。
短句来源
     Significance of renal interstitial volume and urinary human epidermal growth factor determination in IgA nephropathy
     IgA病患者间质容量和尿表皮生长因子测定的意义
短句来源
     The Significance of Urinary hEGF Determination and Renal Interstitial Volume in IgA Nephropathy
     尿EGF测定及间质容量在IgA病中的意义
短句来源
     ALTERATION OF TUBULOINTERSTITIALVOLUME IN LUPUS NEPHRITIS
     小管间质容量改变在狼疮性炎中的意义
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     MORPHOLOGICAL OBSERVATION OF THE RAT RENAL INTERSTITIUM
     大鼠间质的形态学研究
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  renal interstitial volume
Serum creatinine concentration and renal interstitial volume
      


ix-eight patients of lupus nephritis, divided intothose

对68例狼疮性肾炎(LN)患者行肾活检检查,以定性、定量的方法观察了其小管间质损害程度、间质容量变化及肾小球病变各自对狼疮性肾炎肾功能状态的影响。结果发现:(1)伴有明显肾间质损害及肾功能异常者,肾间质容量(Ⅳ)明显增加(34.7±14.3%vs14.8±4.8%△Ⅳ为21.9±10.9%);(2)肾间质容量变化与肾功能改变之间呈明显相关关系;(3)不同的肾小球病变类型、肾小球病变活动性指数及有无IgG在小管基膜上沉积对Ⅳ及肾功能均无明显影响。提示肾间质容量改变可以直接反映肾小管间质损害程度乃至肾功能的变化。在LN伴明显肾间质损害时,肾功能的变化主要与肾小管间质改变程度有关,而与同期存在的肾小球病变类型、严重程度及活动性关系不大。Ⅳ的定量分析可作为临床判断肾脏损害程度及功能状态的一项颇有价值的指标。

Objective To Further clarify the role of cell proliferation and apoptosis in the patho genesis of renal tubulinterstitial fibrosis. Methods The time course of the fibrotic process in rats with unilateral ureteral obstruction(UUO) was examined and the expressions of proliferative cell muclear antigen (PCNA), α-smooth muscle actin(α-SMA) and apoptosis in renal tubulointerstitium were observed. Results Through day 3 to day 11 an increase in apoptotic cells was defected by in situ end-labeling of cleaved DNA in...

Objective To Further clarify the role of cell proliferation and apoptosis in the patho genesis of renal tubulinterstitial fibrosis. Methods The time course of the fibrotic process in rats with unilateral ureteral obstruction(UUO) was examined and the expressions of proliferative cell muclear antigen (PCNA), α-smooth muscle actin(α-SMA) and apoptosis in renal tubulointerstitium were observed. Results Through day 3 to day 11 an increase in apoptotic cells was defected by in situ end-labeling of cleaved DNA in foe obstructed kidney. Most of the apoptotic cells were detected individually in tubular epithelial cells, but apoptotic nuclei were also found in the interstitial area. The expression of PCNA in both tubular epithelial and interstitial cells peaked at day 3, and then declined. Though there was a transient increase in both proliferative and apoptotic activity of tubulointerstitial cells, the proliferation/apoptosis index of tubular epithelial cells finally decreased to a level lower than normal, while the index of interstitial cells sustained to a level higher than normal. These changes were consistent with the sustained to a level higher than normal. These changes were consistent with the expression of α-SMA, and with the persistent increase of the relative volume of the conical interstitium (Vv). Conclusions Cell proliferation and apoptosis participate in renal interstitial fibrogenesis in UUO models. They are two important parameters in this process.

目的 了解细胞增殖与凋亡在肾小管间质纤维化中的意义。方法动态观察单侧输尿管梗阻(UUO)大鼠模型中梗阻侧肾脏及假手术组肾脏肾小管细胞及间质细胞的增殖细胞核抗原(PCNA)表达及细胞凋亡情况,以及间质α平滑肌肌动蛋白(α-SMA)表达水平。结果UU0大鼠梗阻肾从第3天至第11天 ,均可见较大量的细胞凋亡,以肾小管上皮细胞居多,其中亦有间质细胞。无论紧小管或间质细胞,PCNA的表达在第3天已达高峰,随后下降。尽管肾小管、间质细胞的增殖与凋亡水平有一过性升高,但肾小管上皮细胞增殖/凋指数最终降至低于正常,而间质细胞的该指数则一直高于正常。这与间质。α-SMA的大量表达和肾间质容量不断增加的病理改变一致.结论 细胞的增殖与凋亡参与UUO大鼠模型肾间质纤维化过程,是这一过程的两个重要参数。

Objective To investigate the preventive effect of soybean isoflacone genistein on rats with unilateral ureteral obstruction (UUO) and the related mechanisms. Methods Rats were randomly divided into the following groups: sham-operation (group S, n=18), UUO group (group C, n=30), and geinstein treatment group (group G, n=42, at the dose of 200 mg·kg -1 ·d -1 ). At 5, 10, 15, 20, 25, and 30 d after operation, the pathological changes of the ligated kidneys were observed and the expression of mRNA of TGF-β...

Objective To investigate the preventive effect of soybean isoflacone genistein on rats with unilateral ureteral obstruction (UUO) and the related mechanisms. Methods Rats were randomly divided into the following groups: sham-operation (group S, n=18), UUO group (group C, n=30), and geinstein treatment group (group G, n=42, at the dose of 200 mg·kg -1 ·d -1 ). At 5, 10, 15, 20, 25, and 30 d after operation, the pathological changes of the ligated kidneys were observed and the expression of mRNA of TGF-β 1 in renal tissues was examined by RT-PCR. Results Genistein treatment significantly reduced the section percentage of interstitial fibrosis in ligated kidneys at different time after operation (P<0.05). The expression of TGF-β 1 mRNA in group G decreased at 5-30 d after UUO. The quantity of TGF-β 1 in rats in group G was lower than that in group C at 5-25 d (P<0.05). Conclusion Soybean isoflacone genistein could inhibit the development of renal interstitial fibrosis in the UUO model. The mechanism might be associated with the inhibitory effect of genistein on the expression of TGF-β 1 mRNA.

目的 探讨大豆异黄酮对单侧输尿管梗阻 (unilateralureteralobstruction ,UUO)大鼠梗阻肾脏肾间质纤维化的防治作用及机制。方法 观察大鼠结扎侧肾脏的病理改变 ,应用HE和PAS染色观测肾间质容量 ,应用RT PCR法检测肾组织内TGF β1mRNA的表达。结果 异黄酮组梗阻肾肾间质容量明显低于对照组 ;异黄酮组TGF β1mRNA表达明显低于对照组 ,统计学分析差异显著 (P <0 0 5 ) ,异黄酮组肾间质纤维化程度轻于对照组。结论 大豆异黄酮对UUO大鼠梗阻肾肾间质纤维化有一定的抑制作用 ,其机制与大豆异黄酮可抑制TGF β1mRNA的表达有关。

 
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