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   诱导分化治疗 的翻译结果: 查询用时:0.742秒
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诱导分化治疗     
相关语句
  differentiation induction therapy
     Alteration of Telomerase Activity during Differentiation Induction Therapy and Its Clinical Significance
     诱导分化治疗中端粒酶活性的改变及其意义
短句来源
     All-trans retinoic acid (ATRA) has been successfully used in differentiation induction therapy for acute promyelocytic leukemia (APL),which was pioneered in China.
     全反式维甲酸是由我国首创的诱导分化治疗急性早幼粒细胞白血病获得成功的药物。
短句来源
  differentiation therapy
     Induction differentiation therapy is a new field in tumor therapy.
     诱导分化治疗(differentiation therapy)是肿瘤学治疗的一个新领域。
短句来源
     Telomerase activety of promyelocytic cells in acute leukemia M3 was inhibited to an undetectable level during differentiation therapy.
     诱导分化治疗可使急性白血病M 3早幼粒细胞端粒酶活性水平降至正常。
短句来源
     The Expression of N-myc Downstream Regulated Gene 1 in Esophageal Squamous Cell Carcinoma and the Research to Its Inducing Differentiation Therapy
     分化相关基因NDRG1在食管鳞癌的表达及诱导分化治疗研究
短句来源
     Current Status Situation of Induction Differentiation Therapy for Solid Tumor
     实体瘤诱导分化治疗研究现状
短句来源
     Recent studies have demonstrated the efficacy of retinoic acid in inducing differentiation therapy of carcinoma.
     近来研究证实,维甲酸对头颈部鳞癌有诱导分化治疗作用,但维甲酸对头颈部腺癌诱导分化作用研究少见报道。
短句来源
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  differentiation inducing therapy
     Conclusion: peripheral blood cells of leukemia are vitamin D 3 targed cells and biological response of 1,25(OH) 2D 3 is most propably mediatied by binding to nuclear receptor in vitamin D 3.It also points out that vitamin D 3 can be used in differentiation inducing therapy for leukemia.
     结论 :白血病患者外周血细胞是维生素D3(VD3)作用的靶细胞 ,1,2 5 (OH) 2 D3 的作用可能是通过VD3 核受体 (VDR)而介导 ,提示VD3 能用于各种类型白血病的诱导分化治疗
短句来源
     Objective To observe the change of C myc protein expression in the glioma bearing rats during the differentiation inducing therapy of Dimethylformamide and its implication.
     目的 观察胶质瘤荷瘤大鼠在二甲基甲酰胺 (DMF)诱导分化治疗过程中C myc蛋白表达 ,并探讨其意义。
短句来源
     Conclusion The cell cycle dynamics was changed and the telomerase activity was inhibited after T24 cell lines induced by ATRA,which could provide the theoretical basis of bladder carcinoma differentiation inducing therapy.
     结论 人膀胱肿瘤T2 4细胞诱导分化后 ,其细胞周期动力学发生改变 ,端粒酶活性被抑制 ,这可能为膀胱肿瘤的诱导分化治疗提供理论依据。
短句来源
     Conclusions The therapeutic effects against glioma could be enhanced if the differentiation inducing therapy combined with chemotherapy and immuno therapy.
     结论 胶质瘤的诱导分化治疗需与化疗和免疫治疗等组合方可提高疗效
短句来源
  induction differentiation therapy
     Current Status Situation of Induction Differentiation Therapy for Solid Tumor
     实体瘤诱导分化治疗研究现状
短句来源
     Induction differentiation therapy is a new field in tumor therapy.
     诱导分化治疗(differentiation therapy)是肿瘤学治疗的一个新领域。
短句来源
     Induction differentiation therapy of using All-trans retinoic acid has already been the first line therapy for acute promyelocytic leukemia.
     全反式维甲酸诱导分化治疗已成为急性早幼粒细胞白血病的首选治疗手段。
短句来源

 

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      differentiation induction therapy
    For the notable performance achieved by ATRA in the differentiation induction therapy, we investigated the role of JWA in ATRA-mediated differentiation of the human myeloid leukemia HL-60 cells.
          
    On the basis of its ability to achieve high complete remission rates, ATRA has an established role in differentiation induction therapy.
          
      differentiation therapy
    A novel approach for the treatment of cancer is the differentiation therapy in which cancer cells are induced to attain a mature phenotype when exposed to differentiation inducers.
          
    Differentiation therapy with all-trans retinoic acid in combination with chemotherapy has significantly improved survival in patients with APL.
          
    Human myeloid leukemias provide models of maturation arrest and differentiation therapy of cancer.
          
    Here we outline evidence that demonstrates the inductive influence of embryonic stem cells and their microenvironment to reprogram cancer cells to exhibit a more benign phenotype, with profound implications for differentiation therapy.
          
    As all-trans-retinoic acid (RA) is successfully used in the differentiation therapy of acute promyelocytic leukaemia, we studied signal transduction in RA-differentiated HL-60 cells.
          
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    The paper reported that the use of all-trans retinoic acid (RA) in the inducing differentiation therapy in 9 patients with APL.RA 20mg 3-4/d was taken orally every day until complete remission (CR).Seven cases (77.8%) obtained CR.The time of continuous therapy with RA till CR was 20-39 days,mean 31±7.5 days;the total amount of RA taken till CR was 1.20-2.96g,mean 2.01±0.63g.Two cases obtained partial remission (PR).In one of them PR occurred on the 29th day of RA therapy,but repeated examination of BM showed...

    The paper reported that the use of all-trans retinoic acid (RA) in the inducing differentiation therapy in 9 patients with APL.RA 20mg 3-4/d was taken orally every day until complete remission (CR).Seven cases (77.8%) obtained CR.The time of continuous therapy with RA till CR was 20-39 days,mean 31±7.5 days;the total amount of RA taken till CR was 1.20-2.96g,mean 2.01±0.63g.Two cases obtained partial remission (PR).In one of them PR occurred on the 29th day of RA therapy,but repeated examination of BM showed morphologic mutation of leukemic cells into ANLL (M2a),with 78% of myeloblasts.Then we used chemotherapy of HOAP program but failed,and the patient died from sepsis.The other had suffered from hepatitis with jaundice two years ago,which relapsed on the 18th day of RA therapy,and the patient died from it.The dynamic change of leukocyte count,differential and platelet counts,the prevention and therapy for complications such as DIC and infections,and side reactions in the course of RA therapy were discussed.

    报告应用全反式维甲酸诱导分化治疗急性早幼粒白血病(APL)9例。每天口服维甲酸(RA)20mg3~4/d,至取得完全缓解(CR)为止。获得CR 7例(77.8%),至取得GR时间为20~39天,平均31±7.5天,至取得CR时,RA使用的总剂量为1.2~2.96g,平均2.01±0.63g。部分缓解(PR)者2例,其中1例入院诊断为ANLL(M3b),治疗第29天获PR,但骨髓复查显示白血病细胞形态变异,转化为ANLL(M2a),原始粒细胞78%,改用HOAP方案再化疗无效,并发败血症死亡;另1例RA治疗第18天获PR,但此时2年前患的黄疸型肝炎复发,因此死亡。讨论了RA治疗过程病人周围血白细胞计数、分类和血小板恢复正常的动力学变化,以及DIC、感染和副反应的防治。

    By immunogold technique the intracytoplasmic lysozyme content and distribution were analysed in 8 cases with acute promyelocytic leukemia (APL). The majority of granules in leukaemic cells lacked lysozyme activity, though hyperactive production of primary granules occurred. However, in some rather immature leukaemic cells were detected 1ysozyme-positive granules. In remission after the retinoic acid treatment intracytoplasmic granules exhibited frequently positivity for lysozyme with the maturation of leukaemic...

    By immunogold technique the intracytoplasmic lysozyme content and distribution were analysed in 8 cases with acute promyelocytic leukemia (APL). The majority of granules in leukaemic cells lacked lysozyme activity, though hyperactive production of primary granules occurred. However, in some rather immature leukaemic cells were detected 1ysozyme-positive granules. In remission after the retinoic acid treatment intracytoplasmic granules exhibited frequently positivity for lysozyme with the maturation of leukaemic cells. It was confirmed that there existed abnormality of the granule components in APL cells besides overproduction of primary granules. The result suggested that the measurement of intracytoplasmic lysozyme might be helpful to judge the effect of induced differentiation therapy for APL.

    本研究应用胶体金免疫电镜技术,观察了8例颗粒增多的急性早幼粒细胞白血病细胞内溶菌酶的分布及含量。观察中发现早幼粒白血病细胞中尽管有大量的初级颗粒生成,但这些颗粒多数缺乏溶菌酶活性,而少数形态较原始的白血病细胞中却查见溶菌酶阳性颗粒。维甲酸治疗后,细胞形态趋于成熟,细胞中颗粒常表现为溶菌酶阳性反应。本观察显示急性早幼粒细胞白血病不仅颗粒生成亢进,颗粒中组成成份也发生异常;并提示白血病细胞中溶菌酶活性的测定,对于判断诱导分化治疗白血病的疗效具有一定的参考价值。

    16 cases of acute promyelocytic leukemia(APL)treated with differentiation induction by all-trans retinoic acid(RA)were reported in the present paper.80%(13/16 cases)patients developed disseminated intra- vascular coagulation(DIC)at the admission and/or in the course of treat- ment,25%(4/16 cases)severe hemorrhage.All patients received by synthetical treatment including low dose heparin,fresh blood and platelets transfu- sion,dexamethasone,dehydration and antibiotics,which ensured effectively to RA brought into...

    16 cases of acute promyelocytic leukemia(APL)treated with differentiation induction by all-trans retinoic acid(RA)were reported in the present paper.80%(13/16 cases)patients developed disseminated intra- vascular coagulation(DIC)at the admission and/or in the course of treat- ment,25%(4/16 cases)severe hemorrhage.All patients received by synthetical treatment including low dose heparin,fresh blood and platelets transfu- sion,dexamethasone,dehydration and antibiotics,which ensured effectively to RA brought into play role of differentiation induction.All patients achieved complete remission in the bone marrow.

    16例急性早幼粒细胞性白血病(APL)采用全反式维甲酸(RA)进行诱导分化治疗。入院时和病程中80%(13/16例)的患者发生弥散性血管内凝血(DIC),4例发生严重出血。经配合包括肝素抗凝、新鲜血及血小板输注,并用地塞米松、脱水和防治感染等积极的综合性治疗,渡过危险期,有效保障 RA 诱导分化作用的发挥,全部病例取得骨髓完全缓解.

     
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