All-trans retinoic acid (ATRA) has been successfully used in differentiation induction therapy for acute promyelocytic leukemia (APL),which was pioneered in China.
Conclusion: peripheral blood cells of leukemia are vitamin D 3 targed cells and biological response of 1,25(OH) 2D 3 is most propably mediatied by binding to nuclear receptor in vitamin D 3.It also points out that vitamin D 3 can be used in differentiation inducing therapy for leukemia.
Objective To observe the change of C myc protein expression in the glioma bearing rats during the differentiation inducing therapy of Dimethylformamide and its implication.
Conclusion The cell cycle dynamics was changed and the telomerase activity was inhibited after T24 cell lines induced by ATRA,which could provide the theoretical basis of bladder carcinoma differentiation inducing therapy.
Conclusions The therapeutic effects against glioma could be enhanced if the differentiation inducing therapy combined with chemotherapy and immuno therapy.
For the notable performance achieved by ATRA in the differentiation induction therapy, we investigated the role of JWA in ATRA-mediated differentiation of the human myeloid leukemia HL-60 cells.
On the basis of its ability to achieve high complete remission rates, ATRA has an established role in differentiation induction therapy.
A novel approach for the treatment of cancer is the differentiation therapy in which cancer cells are induced to attain a mature phenotype when exposed to differentiation inducers.
Differentiation therapy with all-trans retinoic acid in combination with chemotherapy has significantly improved survival in patients with APL.
Human myeloid leukemias provide models of maturation arrest and differentiation therapy of cancer.
Here we outline evidence that demonstrates the inductive influence of embryonic stem cells and their microenvironment to reprogram cancer cells to exhibit a more benign phenotype, with profound implications for differentiation therapy.
As all-trans-retinoic acid (RA) is successfully used in the differentiation therapy of acute promyelocytic leukaemia, we studied signal transduction in RA-differentiated HL-60 cells.
The paper reported that the use of all-trans retinoic acid (RA) in the inducing differentiation therapy in 9 patients with APL.RA 20mg 3-4/d was taken orally every day until complete remission (CR).Seven cases (77.8%) obtained CR.The time of continuous therapy with RA till CR was 20-39 days,mean 31±7.5 days;the total amount of RA taken till CR was 1.20-2.96g,mean 2.01±0.63g.Two cases obtained partial remission (PR).In one of them PR occurred on the 29th day of RA therapy,but repeated examination of BM showed...
The paper reported that the use of all-trans retinoic acid (RA) in the inducing differentiation therapy in 9 patients with APL.RA 20mg 3-4/d was taken orally every day until complete remission (CR).Seven cases (77.8%) obtained CR.The time of continuous therapy with RA till CR was 20-39 days,mean 31±7.5 days;the total amount of RA taken till CR was 1.20-2.96g,mean 2.01±0.63g.Two cases obtained partial remission (PR).In one of them PR occurred on the 29th day of RA therapy,but repeated examination of BM showed morphologic mutation of leukemic cells into ANLL (M2a),with 78% of myeloblasts.Then we used chemotherapy of HOAP program but failed,and the patient died from sepsis.The other had suffered from hepatitis with jaundice two years ago,which relapsed on the 18th day of RA therapy,and the patient died from it.The dynamic change of leukocyte count,differential and platelet counts,the prevention and therapy for complications such as DIC and infections,and side reactions in the course of RA therapy were discussed.
By immunogold technique the intracytoplasmic lysozyme content and distribution were analysed in 8 cases with acute promyelocytic leukemia (APL). The majority of granules in leukaemic cells lacked lysozyme activity, though hyperactive production of primary granules occurred. However, in some rather immature leukaemic cells were detected 1ysozyme-positive granules. In remission after the retinoic acid treatment intracytoplasmic granules exhibited frequently positivity for lysozyme with the maturation of leukaemic...
By immunogold technique the intracytoplasmic lysozyme content and distribution were analysed in 8 cases with acute promyelocytic leukemia (APL). The majority of granules in leukaemic cells lacked lysozyme activity, though hyperactive production of primary granules occurred. However, in some rather immature leukaemic cells were detected 1ysozyme-positive granules. In remission after the retinoic acid treatment intracytoplasmic granules exhibited frequently positivity for lysozyme with the maturation of leukaemic cells. It was confirmed that there existed abnormality of the granule components in APL cells besides overproduction of primary granules. The result suggested that the measurement of intracytoplasmic lysozyme might be helpful to judge the effect of induced differentiation therapy for APL.
16 cases of acute promyelocytic leukemia(APL)treated with differentiation induction by all-trans retinoic acid(RA)were reported in the present paper.80%(13/16 cases)patients developed disseminated intra- vascular coagulation(DIC)at the admission and/or in the course of treat- ment,25%(4/16 cases)severe hemorrhage.All patients received by synthetical treatment including low dose heparin,fresh blood and platelets transfu- sion,dexamethasone,dehydration and antibiotics,which ensured effectively to RA brought into...
16 cases of acute promyelocytic leukemia(APL)treated with differentiation induction by all-trans retinoic acid(RA)were reported in the present paper.80%(13/16 cases)patients developed disseminated intra- vascular coagulation(DIC)at the admission and/or in the course of treat- ment,25%(4/16 cases)severe hemorrhage.All patients received by synthetical treatment including low dose heparin,fresh blood and platelets transfu- sion,dexamethasone,dehydration and antibiotics,which ensured effectively to RA brought into play role of differentiation induction.All patients achieved complete remission in the bone marrow.
16例急性早幼粒细胞性白血病(APL)采用全反式维甲酸(RA)进行诱导分化治疗。入院时和病程中80%(13/16例)的患者发生弥散性血管内凝血(DIC),4例发生严重出血。经配合包括肝素抗凝、新鲜血及血小板输注,并用地塞米松、脱水和防治感染等积极的综合性治疗,渡过危险期,有效保障 RA 诱导分化作用的发挥,全部病例取得骨髓完全缓解.
诱导分化治疗
differentiation induction therapy
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